Published in J Neurochem on January 01, 1999
Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci U S A (2001) 1.98
Oxidative neuronal injury. The dark side of ERK1/2. Eur J Biochem (2004) 1.81
Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease. J Neurochem (2001) 1.47
Tocotrienols in health and disease: the other half of the natural vitamin E family. Mol Aspects Med (2007) 1.41
ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol (2004) 1.38
Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3. Biochem J (2001) 1.30
Double jeopardy: both overexpression and suppression of a redox-activated plant mitogen-activated protein kinase render tobacco plants ozone sensitive. Plant Cell (2002) 1.27
Signal transduction pathways involved in oxidative stress-induced intestinal epithelial cell apoptosis. Pediatr Res (2005) 1.23
Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol (2003) 1.21
Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2. J Surg Res (2010) 1.08
Tocotrienols: the emerging face of natural vitamin E. Vitam Horm (2007) 1.08
A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease. Front Microbiol (2010) 1.00
Molecular regulation of NADPH oxidase 5 via the MAPK pathway. Am J Physiol Heart Circ Physiol (2011) 0.93
Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. PLoS One (2008) 0.91
Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε. J Biol Chem (2012) 0.91
Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model. J Surg Res (2011) 0.89
The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin. Free Radic Biol Med (2007) 0.89
Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. Br J Pharmacol (2002) 0.87
A radical approach to stroke therapy. Proc Natl Acad Sci U S A (2001) 0.84
Promotion of behavior and neuronal function by reactive oxygen species in C. elegans. Nat Commun (2016) 0.82
Post-transcriptional regulation of placenta growth factor mRNA by hydrogen peroxide. Microvasc Res (2012) 0.82
The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells. J Neurochem (2009) 0.82
Association of active extracellular signal-regulated protein kinase with paired helical filaments of inclusion-body myositis muscle suggests its role in inclusion-body myositis tau phosphorylation. Am J Pathol (2000) 0.80
Role of the ERK pathway for oxidant-induced parthanatos in human lymphocytes. PLoS One (2014) 0.80
Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein. Cell Mol Neurobiol (2011) 0.79
ERK-mediated phosphorylation of BIS regulates nuclear translocation of HSF1 under oxidative stress. Exp Mol Med (2016) 0.79
Picroside II Inhibits Neuronal Apoptosis and Improves the Morphology and Structure of Brain Tissue following Cerebral Ischemic Injury in Rats. PLoS One (2015) 0.76
Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice. Brain Res Bull (2016) 0.76
ROS Production and ERK Activity Are Involved in the Effects of d-β-Hydroxybutyrate and Metformin in a Glucose Deficient Condition. Int J Mol Sci (2017) 0.75
Removal of Phenol from Synthetic and Industrial Wastewater by Potato Pulp Peroxidases. Water Air Soil Pollut (2015) 0.75
Cytoprotective Mechanism of Cyanidin and Delphinidin against Oxidative Stress-Induced Tenofibroblast Death. Biomol Ther (Seoul) (2016) 0.75
Phosphorylation of extracellular signal-regulated kinases 1/2 predominantly enhanced in the microglia of the rat spinal cord following lipopolysaccharide injection. Cell Mol Neurobiol (2008) 0.75
Sigma 1 receptor regulates ERK activation and promotes survival of optic nerve head astrocytes. PLoS One (2017) 0.75
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A (1997) 5.44
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (1999) 5.15
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev (1995) 4.87
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet (2001) 4.79
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol (2001) 4.56
Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell (1995) 4.48
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet (2000) 3.67
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
The impact of clean indoor-air laws and cigarette smuggling on demand for cigarettes: an empirical model. Health Econ (2000) 3.31
CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol (1998) 3.19
Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood (2001) 2.73
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet (1997) 2.64
An evidence ontology for use in pathway/genome databases. Pac Symp Biocomput (2004) 2.63
Modular nature of abscisic acid (ABA) response complexes: composite promoter units that are necessary and sufficient for ABA induction of gene expression in barley. Plant Cell (1996) 2.56
The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution. Biochemistry (1992) 2.43
Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem (2001) 2.42
A universal nucleoside for use at ambiguous sites in DNA primers. Nature (1994) 2.38
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev (2000) 2.21
Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut (2008) 1.86
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry (2012) 1.84
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem (2001) 1.81
Absence of a holelike fermi surface for the iron-based K0.8F1.7Se2 superconductor revealed by angle-resolved photoemission spectroscopy. Phys Rev Lett (2011) 1.81
PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene (1995) 1.76
Congenital muscular dystrophy with rigid spine syndrome: a clinical, pathological, radiological, and genetic study. Ann Neurol (2000) 1.75
Molecular basis for specific recognition of both RNA and DNA by a zinc finger protein. Science (1993) 1.75
Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol (2000) 1.74
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia (2010) 1.68
Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics (1997) 1.68
Evaluation of a unique oral contraceptive in the treatment of premenstrual dysphoric disorder. J Womens Health Gend Based Med (2001) 1.65
Biochemically functionalized silica nanoparticles. Analyst (2001) 1.64
Wheat genetic diversity trends during domestication and breeding. Theor Appl Genet (2005) 1.63
Regulated processing of hepatitis C virus core protein is linked to subcellular localization. J Virol (1997) 1.63
The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up. J Clin Endocrinol Metab (2015) 1.61
Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B. Blood (1995) 1.60
Selection and validation of differentially expressed genes in head and neck cancer. Cell Mol Life Sci (2004) 1.58
Characterization of the glutamate receptor-interacting proteins GRIP1 and GRIP2. J Neurosci (1999) 1.55
Contribution of tyrosine 6 to the catalytic mechanism of isoenzyme 3-3 of glutathione S-transferase. J Biol Chem (1992) 1.54
Detection of hypoxia in human squamous cell carcinoma by EF5 binding. Cancer Res (2000) 1.53
The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes. J Biol Chem (1999) 1.53
Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death. J Biol Chem (1998) 1.52
Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. J Clin Invest (1998) 1.52
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome. Genes Dev (1999) 1.51
The lethal(1)TW-6cs mutation of Drosophila melanogaster is a dominant antimorphic allele of nod and is associated with a single base change in the putative ATP-binding domain. Genetics (1991) 1.48
Open versus laparoscopic pyloromyotomy for pyloric stenosis: a meta-analysis of randomized controlled trials. Eur J Pediatr Surg (2010) 1.45
The impact of pancreas transplantation on kidney allograft survival. Am J Transplant (2011) 1.42
Surveillance for morbidity and mortality among older adults--United States, 1995-1996. MMWR CDC Surveill Summ (1999) 1.40
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res (2001) 1.37
Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr Biol (2001) 1.36
MiR-100 regulates cell differentiation and survival by targeting RBSP3, a phosphatase-like tumor suppressor in acute myeloid leukemia. Oncogene (2011) 1.35
Regulation of cementoblast gene expression by inorganic phosphate in vitro. Calcif Tissue Int (2006) 1.35
Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth. Cancer Res (2001) 1.34
GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Neuron (2000) 1.33
Regulation of the PU.1 gene by distal elements. Blood (2001) 1.28
Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience (1993) 1.27
Reported changes in health-related behaviours in Chinese urban residents in response to an influenza pandemic. Epidemiol Infect (2009) 1.23
Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152. Oncogene (2007) 1.23
TNFalpha potentiates IFNgamma-induced cell death in oligodendrocyte progenitors. J Neurosci Res (1998) 1.22
A novel PCNA-binding motif identified by the panning of a random peptide display library. Biochemistry (2001) 1.22
Acute ethanol intoxication suppresses lung chemokine production following infection with Streptococcus pneumoniae. J Infect Dis (2001) 1.20
Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion. Oncogene (2011) 1.18
Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha. Nucleic Acids Res (1998) 1.17
Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein. Genomics (2001) 1.17
An iPod treatment of amblyopia: an updated binocular approach. Optometry (2012) 1.17
The contribution of founder mutations to early-onset breast cancer in French-Canadian women. Clin Genet (2009) 1.17
Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities. J Med Chem (1998) 1.14
Relative contributions of the zinc fingers of transcription factor IIIA to the energetics of DNA binding. J Mol Biol (1994) 1.14
Ferrographic tracking of bacterial transport in the field at the narrow channel focus area, Oyster, VA. Environ Sci Technol (2001) 1.13
Biology and augmentation of tendon-bone insertion repair. J Orthop Surg Res (2010) 1.13
Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta. J Med Chem (1998) 1.12
Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. Mol Cell Biol (1999) 1.09
A novel Robertsonian translocation event leads to transfer of a stem rust resistance gene (Sr52) effective against race Ug99 from Dasypyrum villosum into bread wheat. Theor Appl Genet (2011) 1.08
Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells. Am J Physiol Heart Circ Physiol (2012) 1.07
Podocyte expression of the CDK-inhibitor p57 during development and disease. Kidney Int (2001) 1.07
Docetaxel-cisplatin might be superior to docetaxel-capecitabine in the first-line treatment of metastatic triple-negative breast cancer. Ann Oncol (2012) 1.07
Identification of DNA replication and cell cycle proteins that interact with PCNA. Nucleic Acids Res (1997) 1.07
Development of wheat lines carrying stem rust resistance gene Sr39 with reduced Aegilops speltoides chromatin and simple PCR markers for marker-assisted selection. Theor Appl Genet (2009) 1.06
Nestin-containing cells express glial fibrillary acidic protein in the proliferative regions of central nervous system of postnatal developing and adult mice. Brain Res Dev Brain Res (2002) 1.06
Expression of the simian virus 40 large tumor antigen (Tag) and formation of Tag-p53 and Tag-pRb complexes in human brain tumors. Cancer (1999) 1.06
A structure-function analysis of NOD, a kinesin-like protein from Drosophila melanogaster. Mol Gen Genet (1994) 1.05
Comparison of methods for monitoring bacterial transport in the subsurface. J Microbiol Methods (2001) 1.05
Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Endocrinology (2003) 1.05
Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid. J Neurophysiol (2006) 1.04
Comparison of the base pairing properties of a series of nitroazole nucleobase analogs in the oligodeoxyribonucleotide sequence 5'-d(CGCXAATTYGCG)-3'. Nucleic Acids Res (1997) 1.04
Dissection of abscisic acid signal transduction pathways in barley aleurone layers. Plant Mol Biol (2001) 1.04
Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3. J Virol (1995) 1.04
Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta. Nucleic Acids Res (1992) 1.03
Lanthanum carbonate vs. sevelamer hydrochloride for the reduction of serum phosphorus in hemodialysis patients: a crossover study. Clin Nephrol (2009) 1.02
The synthesis and stability of oligodeoxyribonucleotides containing the deoxyadenosine mimic 1-(2'-deoxy-beta-D-ribofuranosyl)imidazole-4-carboxamide. Nucleic Acids Res (1997) 1.01
Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model. Leukemia (2011) 1.01
Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma. Genes Chromosomes Cancer (2001) 1.00
Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis. Mol Endocrinol (2000) 0.99
Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose. Clin Pharmacol Ther (2011) 0.99