Published in Mol Pathol on August 01, 1998
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol (2001) 3.32
CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J (2002) 2.05
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. Crit Rev Oncol Hematol (2010) 1.82
Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J (2011) 1.63
A physical sciences network characterization of non-tumorigenic and metastatic cells. Sci Rep (2013) 1.33
Sequential expression of putative stem cell markers in gastric carcinogenesis. Br J Cancer (2011) 1.22
Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein. Am J Hum Genet (2000) 1.16
The Role of CD44 in the Pathogenesis, Diagnosis, and Therapy of Gastric Cancer. Gut Liver (2011) 1.11
Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance. World J Gastroenterol (2008) 1.08
Tumor-targeted hyaluronan nanoliposomes increase the antitumor activity of liposomal Doxorubicin in syngeneic and human xenograft mouse tumor models. Neoplasia (2004) 1.08
Molecular mechanisms of metastasis in prostate cancer. Asian J Androl (2008) 1.06
easyExon--a Java-based GUI tool for processing and visualization of Affymetrix exon array data. BMC Bioinformatics (2008) 1.05
Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression. Mol Cancer (2012) 1.04
FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk. Int J Colorectal Dis (2012) 1.01
The role of the membrane cytoskeleton cross-linker ezrin in medulloblastoma cells. Neuro Oncol (2008) 0.94
Clinicopathological significance of fascin and CD44v6 expression in endometrioid carcinoma. Diagn Pathol (2012) 0.94
Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey. Cancer Microenviron (2014) 0.92
Quantitative proteomic analysis of single or fractionated radiation-induced proteins in human breast cancer MDA-MB-231 cells. Cell Biosci (2015) 0.92
Review: Alternative Splicing (AS) of Genes As An Approach for Generating Protein Complexity. Curr Genomics (2013) 0.91
Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a case report and immunohistochemical studies. Virchows Arch (2006) 0.90
Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas. Mol Cancer (2007) 0.90
Cancer stem cells in colorectal cancer from pathogenesis to therapy: controversies and perspectives. World J Gastroenterol (2014) 0.90
Visualization of CD44 and CD133 in normal pancreas and pancreatic ductal adenocarcinomas: non-overlapping membrane expression in cell populations positive for both markers. J Histochem Cytochem (2011) 0.89
Prognostic significance of CD44 expression in diffuse large B cell lymphoma of activated and germinal centre B cell-like types: a tissue microarray analysis of 90 cases. J Clin Pathol (2003) 0.88
Cancer Stem Cell Hierarchy in Glioblastoma Multiforme. Front Surg (2016) 0.87
Width of gene expression profile drives alternative splicing. PLoS One (2008) 0.85
Lipid-Based Nanovectors for Targeting of CD44-Overexpressing Tumor Cells. J Drug Deliv (2013) 0.85
Immunohistochemical expression of CD44s in human neuroblastic tumors: Moroccan experience and highlights on current data. Diagn Pathol (2013) 0.84
Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells. PLoS One (2012) 0.83
The engagement of selectins and their ligands in colorectal cancer liver metastases. J Cell Mol Med (2010) 0.82
Significance of CD44 expression in gastrointestinal stromal tumors in relation to disease progression and survival. World J Surg (2007) 0.81
Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease. Mol Cancer (2014) 0.80
Expression of CD44 on bile ducts in primary sclerosing cholangitis and primary biliary cirrhosis. J Clin Pathol (1999) 0.79
Immunohistochemical Analysis of p53, Ki-67, CD44, HER-2/neu Expression Patterns in Gastric Cancer, and Their Association with One Year Survival in North-West of Iran. Int J Hematol Oncol Stem Cell Res (2013) 0.79
Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells. Sci Rep (2016) 0.78
Expression and Function of CD44 in Epithelial Ovarian Carcinoma. Biomolecules (2015) 0.78
Targeting gonadotropin-releasing hormone receptor inhibits the early step of ovarian cancer metastasis by modulating tumor-mesothelial adhesion. Mol Ther (2012) 0.78
Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer. J Cancer Res Clin Oncol (2004) 0.77
Hyaluronan receptors in the human ocular surface: a descriptive and comparative study of RHAMM and CD44 in tissues, cell lines and freshly collected samples. Histochem Cell Biol (2011) 0.77
Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? PLoS One (2012) 0.77
CD44 expression in curettage and postoperative specimens of endometrial cancer. Arch Gynecol Obstet (2014) 0.77
CD44: A Multifunctional Cell Surface Adhesion Receptor Is a Regulator of Progression and Metastasis of Cancer Cells. Front Cell Dev Biol (2017) 0.77
CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives. Respir Res (2017) 0.75
Prognostic Evaluation of Vimentin Expression in Correlation with Ki67 and CD44 in Surgically Resected Pancreatic Ductal Adenocarcinoma. Gastroenterol Res Pract (2017) 0.75
CD44 Expression Level and Isoform Contributes to Pancreatic Cancer Cell Plasticity, Invasiveness, and Response to Therapy. Clin Cancer Res (2016) 0.75
Prognostic impact of CD44-positive cancer stem-like cells at the invasive front of gastric cancer. Br J Cancer (2016) 0.75
Isoform switch of CD44 induces different chemotactic and tumorigenic ability in gallbladder cancer. Int J Oncol (2017) 0.75
CD44 is the principal cell surface receptor for hyaluronate. Cell (1990) 11.01
A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell (1991) 7.29
Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. J Cell Biol (1987) 4.85
A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell (1989) 4.39
Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science (1996) 3.84
Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol (1987) 3.84
Proteoglycans: many forms and many functions. FASEB J (1992) 3.57
A lymphoid cell surface glycoprotein involved in endothelial cell recognition and lymphocyte homing in man. Eur J Immunol (1986) 3.49
The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J (1991) 3.20
Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics (1982) 3.18
CD44 variant exon epitopes in primary breast cancer and length of survival. Lancet (1995) 3.07
Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science (1992) 3.05
Monoclonal antibodies to Pgp-1/CD44 block lympho-hemopoiesis in long-term bone marrow cultures. J Exp Med (1990) 3.05
CD44--a molecule involved in leukocyte adherence and T-cell activation. Immunol Today (1989) 2.96
Osteopontin--a possible anchor of osteoclasts to bone. Proc Natl Acad Sci U S A (1990) 2.90
Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells. J Biol Chem (1988) 2.72
Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. J Cell Biol (1991) 2.57
Dual role of the CD44 molecule in T cell adhesion and activation. J Immunol (1989) 2.53
CD44 contributes to T cell activation. J Immunol (1989) 2.44
Biochemical properties of glycoproteins involved in lymphocyte recognition of high endothelial venules in man. J Immunol (1988) 2.39
Cell surface heparan sulfate proteoglycans. J Biol Chem (1992) 2.39
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol (1995) 2.38
Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med (1994) 2.37
CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res (1991) 2.36
Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J Exp Med (1992) 2.30
Normal human tissues, in addition to some tumors, express multiple different CD44 isoforms. Cancer Res (1994) 2.21
Expression and modulation of CD44 variant isoforms in humans. J Cell Biol (1994) 2.17
A human homologue of the rat metastasis-associated variant of CD44 is expressed in colorectal carcinomas and adenomatous polyps. J Cell Biol (1993) 2.06
Adhesion molecules in tumor metastasis. Semin Cancer Biol (1993) 2.05
Prevention of tumor metastasis formation by anti-variant CD44. J Exp Med (1993) 2.03
Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1. Exp Cell Res (1990) 1.90
The gene, MIC4, which controls expression of the antigen defined by monoclonal antibody F10.44.2, is on human chromosome 11. Eur J Immunol (1982) 1.86
The transmembrane hyaluronate receptor (CD44): multiple functions, multiple forms. Cancer Cells (1991) 1.85
Cell aggregation: role of acid mucopolysaccharides. Science (1972) 1.82
Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol (1993) 1.77
Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. J Exp Med (1993) 1.77
De-novo expression of CD44 and survival in gastric cancer. Lancet (1993) 1.75
CD44: the hyaluronan receptor. J Cell Sci (1992) 1.74
Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo. J Exp Med (1990) 1.70
The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity. Exp Cell Res (1989) 1.67
Murine cell surface glycoproteins. Characterization of a major component of 80,000 daltons as a polymorphic differentiation antigen of mesenchymal cells. J Biol Chem (1981) 1.66
Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J (1994) 1.64
Glycosylation of CD44 negatively regulates its recognition of hyaluronan. J Exp Med (1995) 1.62
Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium. Proc Natl Acad Sci U S A (1989) 1.60
Expression of CD44 isoforms in human prostate tumor cell lines. Prostate (1996) 1.52
Adhesion molecules in the prognosis of diffuse large-cell lymphoma: expression of a lymphocyte homing receptor (CD44), LFA-1 (CD11a/18), and ICAM-1 (CD54). Leukemia (1990) 1.48
Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. J Cell Biol (1995) 1.43
Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential. J Cell Physiol (1994) 1.38
CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol (1992) 1.37
Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro. Int J Cancer (1996) 1.36
Regulated expression of exon v6 containing isoforms of CD44 in man: downregulation during malignant transformation of tumors of squamocellular origin. J Cell Biol (1993) 1.34
The hyaluronate receptor is preferentially expressed on proliferating epithelial cells. J Cell Biol (1989) 1.33
The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent-insoluble cytoskeleton of fibroblasts. J Cell Biol (1993) 1.32
A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. J Cell Biol (1992) 1.29
A link between ras and metastatic behavior of tumor cells: ras induces CD44 promoter activity and leads to low-level expression of metastasis-specific variants of CD44 in CREF cells. Cancer Res (1993) 1.26
CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13. Cancer Res (1997) 1.25
Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent. J Immunol (1995) 1.25
The hyaluronate receptor is identical to a glycoprotein of Mr 85,000 (gp85) as shown by a monoclonal antibody that interferes with binding activity. J Biol Chem (1987) 1.24
The role of hyaluronic acid in intercellular adhesion of cultured mouse cells. Exp Cell Res (1978) 1.21
Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody. Cancer Res (1994) 1.19
A PCR-based method for the analysis of human CD44 splice products. PCR Methods Appl (1993) 1.18
CD44 isoforms correlate with cellular differentiation but not with prognosis in human breast cancer. Cancer Res (1995) 1.18
The complex CD44 transcriptional unit; alternative splicing of three internal exons generates the epithelial form of CD44. Biochem Biophys Res Commun (1992) 1.16
Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody. Eur J Immunol (1993) 1.13
Receptors for hyaluronate on the surface of parent and virus-transformed cell lines: binding and aggregation studies. Exp Cell Res (1981) 1.12
Identification of mRNA that encodes an alternative form of H-CAM(CD44) in lymphoid and nonlymphoid tissues. Immunogenetics (1990) 1.11
Retardation of metastatic tumor growth after immunization with metastasis-specific monoclonal antibodies. Int J Cancer (1990) 1.11
Physical characteristics of hyaluronate binding to the surface of simian virus 40-transformed 3T3 cells. J Biol Chem (1980) 1.10
Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction. J Immunol (1993) 1.09
Expression and prognostic value of the CD44 splicing variants v5 and v6 in gastric cancer. J Pathol (1997) 1.09
The cell surface hyaluronate binding sites of invasive human bladder carcinoma cells. Biochem Biophys Res Commun (1987) 1.09
Expression of a CD44 variant containing exons 8 to 10 is a useful independent factor for the prediction of prognosis in colorectal cancer patients. J Clin Oncol (1996) 1.09
Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury. J Clin Invest (1996) 1.08
Molecular interactions between stromal cells and B lymphocyte precursors. Semin Immunol (1991) 1.08
Interaction of hyaluronate with the surface of simian virus 40-transformed 3T3 cells: aggregation and binding studies. J Cell Sci (1982) 1.07
To metastasize or not? Selection of CD44 splice sites. Nat Med (1995) 1.04
Osteopontin-stimulated vascular smooth muscle cell migration is mediated by beta 3 integrin. Exp Cell Res (1994) 1.02
Aggregation of macrophages and fibroblasts is inhibited by a monoclonal antibody to the hyaluronate receptor. Exp Cell Res (1988) 1.02
Immunohistochemical and serological evaluation of CD44 splice variants in human ovarian cancer. Br J Cancer (1995) 1.00
Phosphorylation of CD44 in vivo requires both Ser323 and Ser325, but does not regulate membrane localization or cytoskeletal interaction in epithelial cells. EMBO J (1992) 1.00
H blood group antigen carried by CD44V modulates tumorigenicity of rat colon carcinoma cells. Cancer Res (1994) 0.99
CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas. Oncogene (1995) 0.97
Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan. Lab Invest (1995) 0.95
CD44 and cancer screening. Lancet (1993) 0.92
Cell locomotion and chemotaxis. Curr Opin Cell Biol (1989) 0.91
Differential expression of CD44 splice variants in human pancreatic adenocarcinoma and in normal pancreas. Cancer Res (1995) 0.90
Altered expression of CD44 isoforms in squamous-cell carcinomas and cell lines derived from them. Int J Cancer (1996) 0.89
Importance of different CD44v6 expression in human gastric intestinal and diffuse type cancers for metastatic lymphogenic spreading. J Mol Med (Berl) (1995) 0.89
Automated and quantitative immunocytochemical assays of CD44v6 in breast carcinomas. Hum Pathol (1997) 0.89
CD44: physiological expression of distinct isoforms as evidence for organ-specific metastasis formation. J Mol Med (Berl) (1995) 0.88
Expression of CD44 variant exons 8-10 in gastric cancer. Jpn J Cancer Res (1995) 0.86
Common pattern of CD44 isoforms is expressed in morphogenetically active epithelia. Dev Dyn (1997) 0.86
Human mammary carcinomas express homologues of rat metastasis-associated variants of CD44. Breast Cancer Res Treat (1995) 0.85
Mechanism of peripheral T cell activation by coengagement of CD44 and CD2. J Immunol (1992) 0.84
Increased serum levels of soluble CD44 standard, but not of variant isoforms v5 and v6, in B cell chronic lymphocytic leukemia. Leukemia (1997) 0.84
The role of CD44 splice variants in human metastatic cancer. Ciba Found Symp (1995) 0.83
Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res (1993) 0.82
Evaluation of CD44 transcription variants in human digestive tract carcinomas and normal tissues. Int J Cancer (1996) 0.82
Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas. Anticancer Res (1997) 0.80
The protein and proteoglycan guises of Hermes/CD44. Glycobiology (1992) 0.79
Intraosseous lipoma: report of 35 new cases and a review of the literature. Skeletal Radiol (2003) 2.13
Giant lipomatous tumours of the hand and forearm. J Hand Surg Br (2005) 1.96
Risk factors for survival and local control in chondrosarcoma of bone. J Bone Joint Surg Br (2002) 1.89
TP53 mutations and outcome in osteosarcoma: a prospective, multicenter study. J Clin Oncol (2005) 1.50
Primary synovial chondromatosis and synovial chondrosarcoma: a pictorial review. Eur Radiol (2002) 1.33
The 'penumbra sign' on T1-weighted MR imaging in subacute osteomyelitis: frequency, cause and significance. Clin Radiol (1998) 1.29
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Experience in the treatment of dedifferentiated chondrosarcoma. J Bone Joint Surg Br (2000) 1.19
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Epstein-Barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas. Br J Cancer (1993) 1.03
Malignant chondroblastoma of the os calcis. Sarcoma (1998) 1.00
Ewing's sarcoma presenting as a solitary bone cyst. Skeletal Radiol (1997) 0.99
Bone healing response to a synthetic calcium sulfate/β-tricalcium phosphate graft material in a sheep vertebral body defect model. J Biomed Mater Res B Appl Biomater (2012) 0.97
Clear cell chondrosarcoma of bone. Sarcoma (1999) 0.96
Soft-tissue amyloidoma. A case report. J Bone Joint Surg Br (1998) 0.94
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SAPHO syndrome: 20-year follow-up. Skeletal Radiol (1999) 0.93
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Tumour volume as a predictor of necrosis after chemotherapy in Ewing's sarcoma. J Bone Joint Surg Br (1999) 0.89
Solitary fibrous tumour of the thyroid gland. J Laryngol Otol (2001) 0.88
Primary synovial osteochondromatosis presenting as constrictive capsulitis. Skeletal Radiol (2005) 0.88
Epstein-Barr virus in B-cell lymphomas associated with chronic suppurative inflammation. J Pathol (1997) 0.88
Autologous bone grafting in staged scoliosis surgery. The patient as bone bank. Spine (Phila Pa 1976) (1998) 0.88
Role of glutathione in cisplatin resistance in osteosarcoma cell lines. J Orthop Res (1998) 0.86
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Fifty years of paediatric malignant bone tumours in the West Midlands, UK, 1957-2006: incidence, treatment and outcome. Paediatr Perinat Epidemiol (2010) 0.82
Synovial sarcoma arising in association with a popliteal cyst. Skeletal Radiol (2000) 0.81
Fluid-fluid level in an intraosseous ganglion. Skeletal Radiol (1997) 0.81
Chondrosarcoma of bone. J Bone Joint Surg Am (2000) 0.81
Subperiosteal schwannomas of the femur. Skeletal Radiol (2002) 0.80
Osteoid osteoma and osteoblastoma: novel histological and immunohistochemical observations as evidence for a single entity. J Clin Pathol (2013) 0.79
Diffuse pigmented villonodular synovitis (diffuse-type giant cell tumour) of the foot and ankle. Bone Joint J (2013) 0.79
Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma. Int J Pancreatol (1995) 0.79
Oxygen scavengers in simple bone cysts. Clin Orthop Relat Res (1994) 0.79
Sclerotome distribution of melorheostosis and multicentric fibromatosis. Skeletal Radiol (1998) 0.78
Coxiella burneti endocarditis in a patient with positive chlamydial serology. J Infect (1992) 0.77
Reactivation of tumor after 19 years? A case of local recurrence in clear cell chondrosarcoma. Int Orthop (2000) 0.77
Scintigraphically negative skip metastasis in osteosarcoma. Eur Radiol (1997) 0.76
Telomerase activity in soft-tissue and bone sarcomas. Clin Cancer Res (2000) 0.76
Calcific haemorrhagic bursitis anterior to the knee mimicking a soft tissue sarcoma: report of two cases. Skeletal Radiol (2004) 0.75
CD44 isoform expression in synovial sarcoma correlates with epitheliogenesis but not prognosis. Histopathology (2000) 0.75
Parosteal osteosarcoma of a metatarsal with intramedullary invasion. Skeletal Radiol (1999) 0.75
Liposarcoma: diagnosis and management. Hosp Med (1998) 0.75
Distal tibial giant cell tumour treated with curettage and stabilisation with an Ilizarov frame. Foot Ankle Surg (2008) 0.75
Metal-containing lymph nodes following prosthetic replacement of osseous malignancy: potential role of MR imaging in characterisation. Eur Radiol (2001) 0.75
Pencil-core granuloma of the distal radio-ulnar joint: an unusual presentation as soft-tissue sarcoma after 45 years. J Bone Joint Surg Br (2003) 0.75
Epstein-Barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas. Br J Cancer (2016) 0.75