A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2.

PubWeight™: 1.29‹?› | Rank: Top 10%

🔗 View Article (PMID 9989807)

Published in Oncogene on January 21, 1999

Authors

V Sexl1, J A Diehl, C J Sherr, R Ashmun, D Beach, M F Roussel

Author Affiliations

1: Department of Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Articles citing this

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc Natl Acad Sci U S A (2002) 4.06

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability. EMBO J (2002) 2.39

microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells. Cancer Res (2009) 2.32

Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep (2003) 2.21

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep (2000) 1.72

Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol (2003) 1.71

Multifaceted regulation of cell cycle progression by estrogen: regulation of Cdk inhibitors and Cdc25A independent of cyclin D1-Cdk4 function. Mol Cell Biol (2001) 1.57

Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol (2001) 1.50

Normal cell cycle and checkpoint responses in mice and cells lacking Cdc25B and Cdc25C protein phosphatases. Mol Cell Biol (2005) 1.43

Cytokine-driven cell cycling is mediated through Cdc25A. J Cell Biol (2005) 1.15

Interlinking interleukin-7. Cytokine (2007) 1.14

DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol (2006) 1.13

NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12

A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Genetics (2000) 1.11

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells. Mol Biol Cell (2003) 1.08

Regulation of CDK4. Cell Div (2006) 1.06

Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest. J Virol (2002) 1.05

The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease. Am J Pathol (2000) 0.99

Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". Mol Cell Biol (2006) 0.98

Increased mitotic rate coincident with transient telomere lengthening resulting from pim-1 overexpression in cardiac progenitor cells. Stem Cells (2012) 0.96

The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2. Biochem Biophys Res Commun (2005) 0.94

Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity. J Lipid Res (2010) 0.90

Transgenic and knockout mice models to reveal the functions of tumor suppressor genes. Clin Med Insights Oncol (2011) 0.85

Cdc25A activity is required for the metaphase II arrest in mouse oocytes. J Cell Sci (2013) 0.83

Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication. Mol Cell Biol (2012) 0.80

Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2. Mol Cell Biol (2001) 0.78

Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition. Cell Cycle (2009) 0.77

High-risk human papillomavirus type 16 E7 oncogene associates with Cdc25A over-expression in oral squamous cell carcinoma. Virchows Arch (2006) 0.76

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function. Elife (2017) 0.75

Articles by these authors

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature (2000) 23.17

p21 is a universal inhibitor of cyclin kinases. Nature (1993) 15.55

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature (1993) 13.68

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev (1998) 12.55

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 12.41

Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell (1985) 10.17

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev (1998) 9.03

RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell (1999) 8.55

Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (1995) 8.53

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev (1994) 8.52

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (1994) 8.22

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell (1991) 8.00

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev (1993) 7.41

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev (1993) 7.40

D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol (1994) 7.35

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell (1995) 7.34

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (1995) 7.25

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell (1993) 7.19

Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell (1988) 6.88

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev (1999) 6.87

Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J (1994) 6.83

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell (1988) 6.45

mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell (1991) 6.25

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell (1992) 6.08

Nucleolar Arf sequesters Mdm2 and activates p53. Nat Cell Biol (1999) 5.78

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci U S A (1998) 5.74

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (1993) 5.70

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging. Oncogene (1997) 5.64

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell (1992) 5.51

Human D-type cyclin. Cell (1991) 5.47

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science (1995) 5.46

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts. EMBO J (1999) 5.44

Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell (1989) 5.35

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev (1993) 5.32

Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway. Genes Dev (1997) 5.22

Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation. Mol Gen Genet (1982) 5.17

Four mating-type genes control sexual differentiation in the fission yeast. EMBO J (1988) 5.00

Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell (1989) 4.68

E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev (1998) 4.60

The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. EMBO J (1987) 4.45

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell (1989) 4.43

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A (1996) 4.33

Cdc25 cell-cycle phosphatase as a target of c-myc. Nature (1996) 4.23

cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF. Cell (1988) 4.12

p21-containing cyclin kinases exist in both active and inactive states. Genes Dev (1994) 4.08

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell (1995) 4.08

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J (1987) 3.91

Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sci U S A (1998) 3.85

Functionally homologous cell cycle control genes in budding and fission yeast. Nature (1982) 3.78

Myc activates telomerase. Genes Dev (1998) 3.74

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation. Cell (1994) 3.74

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev (2000) 3.72

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev (1993) 3.70

Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61

Construction of an improved host strain for two hybrid screening. Nucleic Acids Res (1994) 3.43

Transforming potential of the c-fms proto-oncogene (CSF-1 receptor). Nature (1987) 3.37

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell (1991) 3.37

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell (1991) 3.34

Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J (1988) 3.27

Nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. Proc Natl Acad Sci U S A (1984) 3.21

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature (1994) 3.21

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol (1995) 3.19

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell (1987) 3.12

Tumor spectrum in ARF-deficient mice. Cancer Res (1999) 3.11

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell (1989) 3.08

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature (1989) 3.07

PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc Natl Acad Sci U S A (2000) 2.87

CDC25 phosphatases as potential human oncogenes. Science (1995) 2.84

Nucleotide sequences of feline retroviral oncogenes (v-fes) provide evidence for a family of tyrosine-specific protein kinase genes. Cell (1982) 2.78

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proc Natl Acad Sci U S A (1990) 2.77

McDonough feline sarcoma virus: characterization of the molecularly cloned provirus and its feline oncogene (v-fms). J Virol (1982) 2.76

Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J (1989) 2.75

p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev (2000) 2.74

Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc Natl Acad Sci U S A (1975) 2.71

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication. Nature (1989) 2.67

Repression of cyclin D1: a novel function of MYC. Mol Cell Biol (1994) 2.67

Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe. Mol Cell Biol (1986) 2.66