Published in Oncogene on January 21, 1999
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A (2004) 3.27
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Res (2001) 3.24
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice. J Clin Invest (2001) 2.90
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73
The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol (2005) 2.18
High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol Cell Biol (2002) 1.95
Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J (2001) 1.91
Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem (2010) 1.64
The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol (1999) 1.48
A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem (2005) 1.30
Regulation of gene expression in osteoblasts. Biofactors (2010) 1.23
Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta. Arthritis Res (2001) 1.22
Parathyroid hormone increases activating transcription factor 4 expression and activity in osteoblasts: requirement for osteocalcin gene expression. Endocrinology (2008) 1.13
Developmental mechanisms in articular cartilage degradation in osteoarthritis. Arthritis (2010) 1.10
A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation. J Cell Biol (2001) 1.07
HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression. J Biol Chem (2010) 1.05
Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Mol Endocrinol (2009) 0.97
The potential of signal transduction inhibitors for the treatment of arthritis: Is it all just JNK? J Clin Invest (2001) 0.97
Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease. Osteoarthritis Cartilage (2007) 0.96
c-Fos-dependent induction of the small ras-related GTPase Rab11a in skin carcinogenesis. Am J Pathol (2005) 0.93
JunB is required for endothelial cell morphogenesis by regulating core-binding factor beta. J Cell Biol (2006) 0.92
Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway. J Bone Miner Res (2010) 0.82
Agonist-regulated cleavage of the extracellular domain of parathyroid hormone receptor type 1. J Biol Chem (2010) 0.77
Cytokine-Induced MMP13 Expression in Human Chondrocytes is dependent on Activating Transcription Factor 3 (ATF3) regulation. J Biol Chem (2016) 0.76
MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton. Bone (2016) 0.75
GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/9 expression. Mol Hum Reprod (2015) 0.75
Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis. Eur J Histochem (2017) 0.75
Expression array analysis of the hepatocyte growth factor invasive program. Clin Exp Metastasis (2015) 0.75
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell (1987) 20.61
Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell (1997) 13.53
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46
Generation and analysis of 280,000 human expressed sequence tags. Genome Res (1996) 8.27
Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia. Cell (1997) 7.47
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell (1991) 6.89
DNA binding of the glucocorticoid receptor is not essential for survival. Cell (1998) 6.40
High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psychiatry (1999) 5.54
De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia. Mol Psychiatry (2011) 4.91
12-O-tetradecanoyl-phorbol-13-acetate induction of the human collagenase gene is mediated by an inducible enhancer element located in the 5'-flanking region. Mol Cell Biol (1987) 4.86
Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet (2000) 4.83
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J (1987) 4.56
Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature (1989) 4.42
ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J (1995) 4.28
Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell (1989) 4.17
Enhanced immunogenicity for CD8+ T cell induction and complete protective efficacy of malaria DNA vaccination by boosting with modified vaccinia virus Ankara. Nat Med (1998) 4.13
A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis. Gastroenterology (1999) 4.10
Primary structure of human transferrin receptor deduced from the mRNA sequence. Nature (1984) 4.04
The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet (2005) 4.02
The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Mol Psychiatry (2009) 3.59
Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice. Genes Dev (2001) 3.43
Comparison of human stromelysin and collagenase by cloning and sequence analysis. Biochem J (1986) 3.31
Picosecond kinetics of the initial photochemical electron-transfer reaction in bacterial photosynthetic reaction centers. Biochemistry (1985) 3.30
Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J (1993) 3.28
Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse. EMBO J (1985) 3.25
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol Psychiatry (2008) 3.01
Biosynthesis of HLA-A and HLA-B antigens in vivo. J Biol Chem (1980) 2.94
Large-scale reductions in speeding and accidents in Canada and Israel: a behavioral ecological perspective. J Appl Behav Anal (1985) 2.93
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science (1992) 2.90
Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein. EMBO J (1993) 2.83
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder. Nature (1990) 2.80
Molecular cloning of the human T-lymphocyte surface CD2 (T11) antigen. Proc Natl Acad Sci U S A (1986) 2.76
T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol (1997) 2.76
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol (1990) 2.73
Combination therapy with efavirenz, nelfinavir, and nucleoside reverse-transcriptase inhibitors in children infected with human immunodeficiency virus type 1. Pediatric AIDS Clinical Trials Group 382 Team. N Engl J Med (1999) 2.67
Posttranscriptional regulation of c-fos mRNA expression. Nucleic Acids Res (1987) 2.66
Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene (1995) 2.64
Induction of metallothionein and other mRNA species by carcinogens and tumor promoters in primary human skin fibroblasts. Mol Cell Biol (1986) 2.63
The genetic basis of complex human behaviors. Science (1994) 2.62
Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J Exp Med (1999) 2.58
Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proc Natl Acad Sci U S A (1988) 2.51
Susceptibility locus for Alzheimer's disease on chromosome 10. Science (2000) 2.49
Structural brain abnormalities associated with deletion at chromosome 22q11: quantitative neuroimaging study of adults with velo-cardio-facial syndrome. Br J Psychiatry (2001) 2.49
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev (1996) 2.47
Concurrent validity of the OPCRIT diagnostic system. Comparison of OPCRIT diagnoses with consensus best-estimate lifetime diagnoses. Br J Psychiatry (1996) 2.42
Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or "schizoaffective") psychoses. Schizophr Bull (2009) 2.39
Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry (2008) 2.38
Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. Gut (2008) 2.36
c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell (2000) 2.35
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J (2001) 2.34
A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy. Cancer Res (2000) 2.32
Cooperative binding of Ets-1 and core binding factor to DNA. Mol Cell Biol (1994) 2.27
Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Hum Genet (2000) 2.26
A full genome scan for late onset Alzheimer's disease. Hum Mol Genet (1999) 2.26
Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits. EMBO J (1986) 2.25
Different requirements for formation of Jun: Jun and Jun: Fos complexes. Genes Dev (1989) 2.22
Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder. Mol Psychiatry (2010) 2.21
Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC. Mol Psychiatry (2012) 2.20
Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21. Hum Mol Genet (2000) 2.20
T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. Immunity (1994) 2.20
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate. Clin Auton Res (2001) 2.10
Primordial role of CD34+ 38- cells in early and late trilineage haemopoietic engraftment after autologous blood cell transplantation. Br J Haematol (1998) 2.10
Low infection rate and long durability of nontunneled silastic catheters. A safe and cost-effective alternative for long-term venous access. Arch Intern Med (1993) 2.10
Genomics: the next psychiatric revolution? Br J Psychiatry (1996) 2.09
The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res (1996) 2.09
Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry (2008) 2.07
A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Cell (1993) 2.04
Chromosome 22qII deletions. An under-recognised cause of idiopathic learning disability. Br J Psychiatry (1998) 2.03
Biosynthesis and molecular nature of the T3 antigen of human T lymphocytes. EMBO J (1983) 2.03
Polydactyly and psychosis. Five cases of co-occurrence. Br J Psychiatry (1998) 2.02
The structure of the human CD2 gene and its expression in transgenic mice. EMBO J (1988) 2.00
Predisposing locus for Alzheimer's disease on chromosome 21. Lancet (1989) 1.99
Three genes coding for subunits of the membrane sector (F0) of the Escherichia coli adenosine triphosphatase complex. J Bacteriol (1981) 1.97
Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in alpha beta(+) T cells. Nature (1994) 1.94
Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children. J Am Acad Child Adolesc Psychiatry (1998) 1.94
Inducible expression and phosphorylation of coactivator BOB.1/OBF.1 in T cells. Science (1997) 1.93
T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc Natl Acad Sci U S A (1996) 1.92
Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene (2001) 1.91
Patient characteristics and ICU organizational factors that influence frequency of pulmonary artery catheterization. JAMA (2000) 1.87
UV-induced activation of AP-1 involves obligatory extranuclear steps including Raf-1 kinase. EMBO J (1993) 1.86
Biosynthesis and maturation of HLA-DR antigens in vivo. J Biol Chem (1981) 1.86
A genome-wide scan of 1842 DNA markers for allelic associations with general cognitive ability: a five-stage design using DNA pooling and extreme selected groups. Behav Genet (2001) 1.86
Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain. Mol Psychiatry (2011) 1.84
Identification of nucleotide preferences in DNA sequences recognised specifically by c-Ets-1 protein. Nucleic Acids Res (1992) 1.82
Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis. JAMA (2001) 1.81
Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha. J Biol Chem (1995) 1.81
Chronic myeloid leukemia with increased granulocyte progenitors in mice lacking junB expression in the myeloid lineage. Cell (2001) 1.79
Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. Nature (1994) 1.79
The Fos and Jun/AP-1 proteins are involved in the downregulation of Fos transcription. Oncogene (1989) 1.78
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep (2001) 1.76
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO J (1992) 1.74
Enhancement of MHC class I-restricted peptide-specific T cell induction by a DNA prime/MVA boost vaccination regime. Vaccine (1998) 1.74
Alpha-2 macroglobulin gene and Alzheimer disease. Nat Genet (1999) 1.73
Support for genetic variation in neuregulin 1 and susceptibility to schizophrenia. Mol Psychiatry (2003) 1.73