Published in Semin Cancer Biol on January 01, 1998
PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci U S A (2003) 4.46
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A (2000) 4.01
Identification and classification of p53-regulated genes. Proc Natl Acad Sci U S A (1999) 3.07
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage. EMBO J (2000) 2.38
Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study. Blood (2008) 2.00
Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies. J Virol (2000) 1.96
WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes Dev (2002) 1.80
Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer. Proc Natl Acad Sci U S A (2002) 1.41
The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner. PLoS One (2017) 1.39
Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and Alzheimer's disease: many pathways to neurodegeneration. J Alzheimers Dis (2010) 1.34
Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis. EMBO J (2001) 1.32
mRTVP-1, a novel p53 target gene with proapoptotic activities. Mol Cell Biol (2002) 1.27
Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death. Free Radic Biol Med (2008) 1.23
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci U S A (2003) 1.20
Versatile functions of p53 protein in multicellular organisms. Biochemistry (Mosc) (2007) 1.11
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells. Arch Biochem Biophys (2008) 1.10
p53's believe it or not: lessons on transcription-independent death. J Clin Immunol (2003) 1.06
Elevated levels of pro-apoptotic p53 and its oxidative modification by the lipid peroxidation product, HNE, in brain from subjects with amnestic mild cognitive impairment and Alzheimer's disease. J Cell Mol Med (2008) 1.03
DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis. J Zhejiang Univ Sci B (2007) 0.99
Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways. J Am Chem Soc (2013) 0.91
Small interfering RNA-directed knockdown of uracil DNA glycosylase induces apoptosis and sensitizes human prostate cancer cells to genotoxic stress. Mol Cancer Res (2009) 0.83
Expression of apoptosis-related proteins in endometriomas and benign and malignant ovarian tumours. Virchows Arch (2003) 0.82
A dual-targeting, p53-independent, apoptosis-inducing platinum(II) anticancer complex, [Pt(BDI(QQ))]Cl. Metallomics (2014) 0.81
The cell cycle: a critical therapeutic target to prevent vascular proliferative disease. Can J Cardiol (2006) 0.79
Snowball: resampling combined with distance-based regression to discover transcriptional consequences of a driver mutation. Bioinformatics (2014) 0.79
Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein. Cell Cycle (2009) 0.79
Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells. Proc Natl Acad Sci U S A (2003) 0.78
Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway. PLoS One (2012) 0.78
Anti-tumor effect of β-glucan from Lentinus edodes and the underlying mechanism. Sci Rep (2016) 0.78
Expression of inhibitors of apoptosis family protein in 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell carcinogenesis is associated with mutant p53 accumulation and epigenetic changes. Int J Exp Pathol (2008) 0.76
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (1991) 9.21
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol (1988) 6.44
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell (1990) 6.37
Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A (1989) 5.40
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature (1999) 3.50
Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad Sci U S A (1991) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev (1995) 3.40
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol (1983) 3.39
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
p53 in growth control and neoplasia. Biochim Biophys Acta (1996) 3.19
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J (1985) 3.18
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol (1985) 3.13
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene (1993) 3.08
A single gene and a pseudogene for the cellular tumour antigen p53. Nature (1984) 2.98
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature (1986) 2.94
Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J (1984) 2.94
Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem (2001) 2.93
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med (1998) 2.91
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev (1994) 2.88
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ (2009) 2.80
Differential affinities of simian virus 40 large tumor antigen for DNA. Proc Natl Acad Sci U S A (1980) 2.75
Overproduction of p53 antigen makes established cells highly tumorigenic. Nature (1985) 2.72
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene (1988) 2.71
Non-visualization of the cavum septi pellucidi is not synonymous with agenesis of the corpus callosum. Ultrasound Obstet Gynecol (2012) 2.65
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
Localization of gene for human p53 tumour antigen to band 17p13. Nature (1986) 2.56
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene (1999) 2.43
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell (2000) 2.30
p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol (1993) 2.27
TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ (2005) 2.25
A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res (1995) 2.23
Different tumor-derived p53 mutants exhibit distinct biological activities. Science (1990) 2.20
The 5' region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. EMBO J (1985) 2.17
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J (1996) 2.12
Properties of permissive monkey cells transformed by UV-irradiated simian virus 40. J Virol (1977) 2.03
MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol (1999) 2.00
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol (1996) 1.98
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature (1996) 1.98
Oligomerization of oncoprotein p53. J Virol (1988) 1.98
SV40 large tumor antigen can regulate some cellular transcripts in a positive fashion. Cell (1982) 1.85
Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J (1996) 1.82
Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny. Mol Cell Biol (1982) 1.82
Transcription regulation by mutant p53. Oncogene (2007) 1.78
Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes. EMBO J (1993) 1.77
Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif. Oncogene (1993) 1.77
Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA. J Virol (1982) 1.72
Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation. EMBO J (2001) 1.69
Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene (2000) 1.67
Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen. Proc Natl Acad Sci U S A (1983) 1.65
Physical and functional interaction between p53 and the Werner's syndrome protein. J Biol Chem (1999) 1.64
The structural relationships between 54,000-molecular-weight cellular tumor antigens detected in viral- and nonviral-transformed cells. Virology (1981) 1.64
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J (1994) 1.64
Excess beta-catenin promotes accumulation of transcriptionally active p53. EMBO J (1999) 1.63
Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. Mol Cell Biol (1991) 1.61
Down-regulation of beta-catenin by activated p53. Mol Cell Biol (2001) 1.60
Ketamine enhances local anesthetic and analgesic effects of bupivacaine by peripheral mechanism: a study in postoperative patients. Neurosci Lett (1996) 1.56
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene (1999) 1.56
Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression. Mol Cell Biol (1993) 1.56
Analysis of recombinant DNA clones specific for the murine p53 cellular tumor antigen. EMBO J (1983) 1.55
The Mdm2 oncoprotein interacts with the cell fate regulator Numb. Mol Cell Biol (1998) 1.53
Inhibition of cell growth mediated by plasmids encoding p53 anti-sense. Oncogene (1987) 1.52
The p53 cellular tumor antigen: gene structure, expression and protein properties. Biochim Biophys Acta (1985) 1.50
Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J (1992) 1.49
SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). Proc Natl Acad Sci U S A (1999) 1.44
Biochemical properties and biological effects of p53. Curr Opin Genet Dev (1995) 1.44
Identification of p53 target genes through immune selection of genomic DNA: the cyclin G gene contains two distinct p53 binding sites. Oncogene (1995) 1.44
Inhibition of presenilin 1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nat Med (1998) 1.44
Physical and functional interaction between p53 mutants and different isoforms of p73. J Biol Chem (2000) 1.43
Mdm2: the ups and downs. Mol Med (1999) 1.43
Tissue-specific inactivation of p53 tumor suppression in the mouse. Genes Dev (1996) 1.42
Understanding wild-type and mutant p53 activities in human cancer: new landmarks on the way to targeted therapies. Cancer Gene Ther (2010) 1.41
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression. Proc Natl Acad Sci U S A (1996) 1.40
Loss of p53 function through PAX-mediated transcriptional repression. EMBO J (1995) 1.38
Regulation of the level of the oncoprotein p53 in non-transformed and transformed cells. Oncogene (1990) 1.37
Activated Ha-ras can cooperate with defective simian virus 40 in the transformation of nonestablished rat embryo fibroblasts. J Virol (1987) 1.36
p53-mediated apoptosis in HeLa cells can be overcome by excess pRB. Oncogene (1995) 1.36
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. J Biol Chem (1994) 1.35
p53 mutations: gains or losses? J Cell Biochem (1991) 1.33
Siah-1 binds and regulates the function of Numb. Proc Natl Acad Sci U S A (2001) 1.33
p53; from inductive signal to cellular effect. Curr Opin Genet Dev (1997) 1.32
The loss of mdm2 induces p53-mediated apoptosis. Oncogene (2000) 1.31
Regulation of AIF expression by p53. Cell Death Differ (2006) 1.31
Expression of the mouse p53 cellular tumor antigen in monkey cells. Mol Cell Biol (1984) 1.30
Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ (2005) 1.29
Protein-binding elements in the promoter region of the mouse p53 gene. Oncogene (1990) 1.27
Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma. Oncogene (1995) 1.27
DNA binding and sedimentation properties of SV40 T antigens synthesized in vivo and in vitro. Cold Spring Harb Symp Quant Biol (1980) 1.27
Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation. EMBO J (1993) 1.25
Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis. Exp Cell Res (1986) 1.24
A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. EMBO J (1997) 1.24
Overproduction of protein p53 contributes to simian virus 40-mediated transformation. Mol Cell Biol (1986) 1.24