Published in Nature on July 25, 1991
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
The first 30 years of p53: growing ever more complex. Nat Rev Cancer (2009) 8.00
Cyclin G is a transcriptional target of the p53 tumor suppressor protein. EMBO J (1994) 6.83
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci U S A (1992) 5.94
p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A (1994) 5.49
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci U S A (1992) 5.43
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A (1994) 5.11
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol (1994) 4.36
Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J Virol (1995) 4.22
A proinflammatory cytokine inhibits p53 tumor suppressor activity. J Exp Med (1999) 4.15
Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer (2009) 4.06
Toward an understanding of the molecular mechanisms of physiological cell death. Proc Natl Acad Sci U S A (1993) 3.80
Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1. Mol Biol Cell (2001) 3.59
Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer (2009) 3.45
The molecular biology of apoptosis. Proc Natl Acad Sci U S A (1996) 3.39
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A (2001) 3.16
The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes. Mol Cell Biol (1994) 3.16
Telomeres, stem cells, senescence, and cancer. J Clin Invest (2004) 2.87
GADD45 induction of a G2/M cell cycle checkpoint. Proc Natl Acad Sci U S A (1999) 2.80
The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J (1996) 2.71
Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J Cell Biol (1994) 2.63
Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol Cell Biol (1995) 2.62
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene (2005) 2.50
Regulation of transcription functions of the p53 tumor suppressor by the mdm-2 oncogene. Mol Med (1995) 2.44
Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J (1994) 2.43
Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A (1994) 2.37
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J (1996) 2.36
p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol (2010) 2.34
mdm2 Is critical for inhibition of p53 during lymphopoiesis and the response to ionizing irradiation. Mol Cell Biol (2003) 2.32
Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proc Natl Acad Sci U S A (1996) 2.30
p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol (1993) 2.27
Apoptosis (the 1992 Frank Rose Memorial Lecture). Br J Cancer (1993) 2.20
p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci U S A (1999) 2.16
The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. Br J Cancer (1994) 2.14
Li-Fraumeni syndrome--a molecular and clinical review. Br J Cancer (1997) 2.14
Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J Virol (1994) 2.14
Molecular biology of breast cancer metastasis. Inflammatory breast cancer: clinical syndrome and molecular determinants. Breast Cancer Res (2000) 2.13
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J (1996) 2.12
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc Natl Acad Sci U S A (2001) 2.10
Bcl-2 blocks p53-dependent apoptosis. Mol Cell Biol (1994) 2.06
Epstein-Barr virus latent membrane protein 1 blocks p53-mediated apoptosis through the induction of the A20 gene. J Virol (1996) 2.03
Induction of apoptosis by the transcription factor c-Jun. EMBO J (1997) 2.02
WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis. EMBO J (1995) 2.02
Overexpression of the death-promoting gene bax-alpha which is downregulated in breast cancer restores sensitivity to different apoptotic stimuli and reduces tumor growth in SCID mice. J Clin Invest (1996) 2.00
Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol (1996) 1.99
Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol (1994) 1.99
Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death. J Exp Med (1996) 1.98
p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci U S A (1993) 1.93
A single chicken anemia virus protein induces apoptosis. J Virol (1994) 1.91
Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1. Proc Natl Acad Sci U S A (2002) 1.91
Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J (1995) 1.88
Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis. EMBO J (1997) 1.85
Cell-free reconstitution of Fas-, UV radiation- and ceramide-induced apoptosis. EMBO J (1995) 1.85
Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1. Proc Natl Acad Sci U S A (2002) 1.83
Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J (1996) 1.82
bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer (1994) 1.81
Cooperative effects of genes controlling the G(2)/M checkpoint. Genes Dev (2000) 1.80
NQO1 stabilizes p53 through a distinct pathway. Proc Natl Acad Sci U S A (2002) 1.80
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol Cell Biol (1993) 1.79
Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes. EMBO J (1993) 1.77
Modulation of p53-mediated transcriptional repression and apoptosis by the adenovirus E1B 19K protein. Mol Cell Biol (1995) 1.76
Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression. Mol Cell Biol (1995) 1.73
Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc Natl Acad Sci U S A (1997) 1.73
A systematic strategy for large-scale analysis of genotype phenotype correlations: identification of candidate genes involved in African trypanosomiasis. Nucleic Acids Res (2007) 1.73
A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol (2000) 1.72
Relief of p53-mediated transcriptional repression by the adenovirus E1B 19-kDa protein or the cellular Bcl-2 protein. Proc Natl Acad Sci U S A (1994) 1.69
Inflammation and cancer: advances and new agents. Nat Rev Clin Oncol (2015) 1.65
p53 is covalently linked to 5.8S rRNA. Mol Cell Biol (1992) 1.65
Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J (1994) 1.64
Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. Proc Natl Acad Sci U S A (1993) 1.62
Inhibition of apoptosis by the retinoblastoma gene product. EMBO J (1995) 1.58
The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol Cell Biol (1998) 1.57
Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J Med Genet (2002) 1.57
Complementation by wild-type p53 of interleukin-6 effects on M1 cells: induction of cell cycle exit and cooperativity with c-myc suppression. Mol Cell Biol (1993) 1.56
Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2. J Exp Med (1996) 1.55
Mechanism and its regulation of tumor-induced angiogenesis. World J Gastroenterol (2003) 1.55
Lysosomal destabilization in p53-induced apoptosis. Proc Natl Acad Sci U S A (2002) 1.54
p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes. J Clin Invest (1997) 1.51
A temperature-sensitive mutant of human p53. EMBO J (1994) 1.51
Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways. Biochem J (1996) 1.50
Apoptosis is inversely related to necrosis and determines net growth in tumors bearing constitutively expressed myc, ras, and HPV oncogenes. Am J Pathol (1994) 1.50
Apoptosis induced by inhibition of intercellular contact. J Cell Biol (1994) 1.49
Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J (1992) 1.49
Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells. Mol Cell Biol (1993) 1.48
Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene. Proc Natl Acad Sci U S A (1996) 1.47
A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies. Theor Biol Med Model (2006) 1.46
The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein. J Virol (1994) 1.46
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc Natl Acad Sci U S A (2009) 1.45
Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol (1992) 1.44
SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). Proc Natl Acad Sci U S A (1999) 1.44
Interaction of p53 with the human Rad51 protein. Nucleic Acids Res (1997) 1.43
Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids. Mol Cell Biol (1995) 1.43
Bax alpha perturbs T cell development and affects cell cycle entry of T cells. EMBO J (1996) 1.43
From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther (2008) 1.43
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene (2009) 1.43
ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol (2000) 1.42
Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression. Mol Cell Biol (1993) 1.42
Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med (1994) 1.41
Mdm2 promotes the rapid degradation of p53. Nature (1997) 21.26
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature (1985) 6.86
Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol (1988) 6.44
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell (1990) 6.37
The cloning of normal "mast" cells in tissue culture. J Cell Physiol (1965) 5.47
Wild-type p53 can inhibit oncogene-mediated focus formation. Proc Natl Acad Sci U S A (1989) 5.40
Interaction of the carbohydrate-binding protein concanavalin A with normal and transformed cells. Proc Natl Acad Sci U S A (1969) 5.39
Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ (2009) 5.28
Characterization of the simian virus 40-specific RNA in virus-yielding and transformed cells. J Mol Biol (1968) 4.65
The induction of cellular DNA synthesis by simian virus 40 in contact-inhibited and in x-irradiated cells. Proc Natl Acad Sci U S A (1966) 4.64
In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons. J Natl Cancer Inst (1965) 4.53
In vitro control of the development of macrophage and granulocyte colonies. Proc Natl Acad Sci U S A (1966) 4.13
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev (2001) 4.06
Structural difference in sites on the surface membrane of normal and transformed cells. Nature (1969) 3.81
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci U S A (2000) 3.74
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature (1999) 3.50
Wild-type p53 can down-modulate the activity of various promoters. Proc Natl Acad Sci U S A (1991) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev (1995) 3.40
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol (1983) 3.39
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol Cell Biol (1992) 3.37
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev (1995) 3.37
p53 in growth control and neoplasia. Biochim Biophys Acta (1996) 3.19
Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J (1985) 3.18
p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol (1985) 3.13
Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene (1993) 3.08
Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev (1997) 3.02
The induction of clones of normal mast cells by a substance from conditioned medium. Exp Cell Res (1966) 3.01
A single gene and a pseudogene for the cellular tumour antigen p53. Nature (1984) 2.98
Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia. Nature (1978) 2.97
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature (1986) 2.94
Analysis of the gene coding for the murine cellular tumour antigen p53. EMBO J (1984) 2.94
Physical interaction with Yes-associated protein enhances p73 transcriptional activity. J Biol Chem (2001) 2.93
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med (1998) 2.91
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes Dev (1994) 2.88
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci U S A (1999) 2.87
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ (2009) 2.80
In vitro cell transformation by x-irradiation. Nature (1966) 2.75
Differential affinities of simian virus 40 large tumor antigen for DNA. Proc Natl Acad Sci U S A (1980) 2.75
Overproduction of p53 antigen makes established cells highly tumorigenic. Nature (1985) 2.72
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene (1988) 2.71
Induction of colony formation in vitro by human lymphocytes. Nature (1976) 2.71
The death domain: a module shared by proteins with diverse cellular functions. Trends Biochem Sci (1995) 2.70
DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity. EMBO J (1997) 2.69
On the mechanism of polyoma virus-induced synthesis of cellular DNA. Proc Natl Acad Sci U S A (1965) 2.67
Non-visualization of the cavum septi pellucidi is not synonymous with agenesis of the corpus callosum. Ultrasound Obstet Gynecol (2012) 2.65
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J (1999) 2.64
Localization of gene for human p53 tumour antigen to band 17p13. Nature (1986) 2.56
Close link between reduction of c-myc expression by interferon and, G0/G1 arrest. Nature (1985) 2.47
Destruction of mouse and rat embryo cells in tissue culture by lymph node cells from unsensitized rats. J Cell Physiol (1965) 2.44
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene (1999) 2.43
DAP kinase links the control of apoptosis to metastasis. Nature (1997) 2.39
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha. EMBO J (1996) 2.36
Specific inhibition by N-acetyl-D-galactosamine of the interaction between soybean agglutinin and animal cell surfaces. Biochim Biophys Acta (1970) 2.33
Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell (2000) 2.30
p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol (1993) 2.27
TAp73/Delta Np73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma. Cell Death Differ (2005) 2.25
Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Proc Natl Acad Sci U S A (1990) 2.25
A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res (1995) 2.23
In vitro induction of granulocyte differentiation in hematopoietic cells from leukemic and non-leukemic patients. Proc Natl Acad Sci U S A (1970) 2.22
Different tumor-derived p53 mutants exhibit distinct biological activities. Science (1990) 2.20
The 5' region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. EMBO J (1985) 2.17
Regulation of normal differentiation in mouse and human myeloid leukemic cells by phorbol esters and the mechanism of tumor promotion. Proc Natl Acad Sci U S A (1979) 2.17
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J (1996) 2.12
Cervical competence as a continuum: a study of ultrasonographic cervical length and obstetric performance. Am J Obstet Gynecol (1995) 2.10
Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc Natl Acad Sci U S A (2001) 2.10
DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol (2001) 2.09
Properties of permissive monkey cells transformed by UV-irradiated simian virus 40. J Virol (1977) 2.03
MDM2 suppresses p73 function without promoting p73 degradation. Mol Cell Biol (1999) 2.00
DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Cell Death Differ (2008) 1.99
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis. Mol Cell Biol (1996) 1.98
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature (1996) 1.98
Oligomerization of oncoprotein p53. J Virol (1988) 1.98
Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase. Proc Natl Acad Sci U S A (1978) 1.97
Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells. Proc Natl Acad Sci U S A (1976) 1.96
Hybridization between SV40 DNA and cellular DNA's. J Mol Biol (1969) 1.92
DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death. Mol Cell Biol (1997) 1.90
Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood (1993) 1.90
A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Science (1991) 1.89
Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene. Proc Natl Acad Sci U S A (1966) 1.86
SV40 large tumor antigen can regulate some cellular transcripts in a positive fashion. Cell (1982) 1.85
DAP-kinase participates in TNF-alpha- and Fas-induced apoptosis and its function requires the death domain. J Cell Biol (1999) 1.85
Cell type-specific inhibition of p53-mediated apoptosis by mdm2. EMBO J (1996) 1.82
Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny. Mol Cell Biol (1982) 1.82
Control of lysozyme induction in the differentiation of myeloid leukemic cells. Cell (1976) 1.79
Reversion of properties in cells transformed by polyoma virus. Nature (1968) 1.79
Transcription regulation by mutant p53. Oncogene (2007) 1.78
Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes. EMBO J (1993) 1.77
Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the binding of basal transcription factors to the TATA motif. Oncogene (1993) 1.77
DNA rearrangement of a homeobox gene in myeloid leukaemic cells. EMBO J (1988) 1.75
Autocrine beta-related interferon controls c-myc suppression and growth arrest during hematopoietic cell differentiation. Cell (1986) 1.73