Published in J Immunol on April 15, 1999
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Mol Cell (2009) 1.95
Interaction of calcineurin with substrates and targeting proteins. Trends Cell Biol (2010) 1.84
A conserved docking site modulates substrate affinity for calcineurin, signaling output, and in vivo function. Mol Cell (2007) 1.38
Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506? Cell Commun Signal (2009) 1.06
Calmodulin-dependent phosphatase, kinases, and transcriptional corepressors involved in T-cell activation. Immunol Rev (2009) 0.93
Distinct activation properties of the nuclear factor of activated T-cells (NFAT) isoforms NFATc3 and NFATc4 in neurons. J Biol Chem (2012) 0.91
Regulator of calcineurin 1 mediates pathological vascular wall remodeling. J Exp Med (2011) 0.90
Mutational analyses of the signals involved in the subcellular location of DSCR1. BMC Cell Biol (2002) 0.86
Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK. Pflugers Arch (2014) 0.83
The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. Eukaryot Cell (2011) 0.82
The LQLP calcineurin docking site is a major determinant of the calcium-dependent activation of human TRESK background K+ channel. J Biol Chem (2014) 0.79
The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain. Structure (2014) 0.79
SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol (1988) 12.84
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81
Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem (1990) 5.36
High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol (1987) 5.08
IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci U S A (1988) 5.03
Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 4.59
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (1993) 4.39
Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J (1985) 4.37
Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proc Natl Acad Sci U S A (1985) 3.95
The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol (2000) 3.71
Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A (1990) 3.36
Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science (1990) 3.35
Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. Proc Natl Acad Sci U S A (1985) 3.31
Cytokine receptors and signal transduction. Annu Rev Immunol (1992) 3.27
Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. J Exp Med (1987) 3.22
Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J (1985) 3.04
Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell (1991) 2.84
Primary structure of elongation factor Tu from Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.72
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene (1988) 2.71
Structure, expression and divergence of T-cell receptor beta-chain variable regions. Nature (1984) 2.71
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med (2000) 2.68
ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J (1989) 2.62
Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54
Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54
Unique primed start of phage phi X174 DNA replication and mobility of the primosome in a direction opposite chain synthesis. Proc Natl Acad Sci U S A (1981) 2.44
Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med (1989) 2.37
Structure of the chromosomal gene for murine interleukin 3. Proc Natl Acad Sci U S A (1985) 2.33
B cell growth-promoting activity of recombinant human interleukin 4. J Immunol (1987) 2.31
Neuropathology of Alzheimer's disease: what is new since A. Alzheimer? Eur Arch Psychiatry Clin Neurosci (1999) 2.30
Small hepatocellular carcinoma: treatment with subsegmental transcatheter arterial embolization. Radiology (1993) 2.30
Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins. Proc Natl Acad Sci U S A (1988) 2.22
Ectopic expression of activated Stat6 induces the expression of Th2-specific cytokines and transcription factors in developing Th1 cells. Immunity (1999) 2.21
Immunologically distinct p53 molecules generated by alternative splicing. Mol Cell Biol (1986) 2.20
Molecular basis for heterogeneity of the human p53 protein. Mol Cell Biol (1986) 2.14
Recombinant interleukin 4 promotes the growth of human T cells. J Immunol (1987) 2.13
NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol Cell Biol (1995) 2.13
Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity (1995) 2.12
Signal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J (1993) 2.11
T-cell activation signals and human T-cell leukemia virus type I-encoded p40x protein activate the mouse granulocyte-macrophage colony-stimulating factor gene through a common DNA element. Mol Cell Biol (1988) 2.08
A comparative study of the vasodilator effects of prostaglandin E1 in patients with pulmonary hypertension after mitral valve replacement and with adult respiratory distress syndrome. Anesth Analg (1997) 2.06
The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression. Genomics (1999) 2.04
Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q). Blood (1989) 1.98
Regulation of the yeast pheromone response pathway by G protein subunits. EMBO J (1990) 1.97
Mechanism of dnaB protein action. I. Crystallization and properties of dnaB protein, an essential replication protein in Escherichia coli. J Biol Chem (1981) 1.96
Interleukin 4 (B-cell stimulatory factor 1) can enhance or antagonize the factor-dependent growth of hemopoietic progenitor cells. Proc Natl Acad Sci U S A (1987) 1.96
Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells. J Immunol (1988) 1.94
Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proc Natl Acad Sci U S A (1991) 1.91
Optical magnetic imaging of living cells. Nature (2013) 1.89
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication. EMBO J (1995) 1.89
Genetically engineered mutant of the cyanobacterium Synechococcus PCC 7942 defective in nitrate transport. Proc Natl Acad Sci U S A (1989) 1.88
Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. EMBO J (1995) 1.88
A general priming system employing only dnaB protein and primase for DNA replication. Proc Natl Acad Sci U S A (1979) 1.85
Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc Natl Acad Sci U S A (1990) 1.85
Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem (2000) 1.85
Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol Rev (1988) 1.84
Mutations of the epigenetics-modifying gene (DNMT3a, TET2, IDH1/2) at diagnosis may induce FLT3-ITD at relapse in de novo acute myeloid leukemia. Leukemia (2012) 1.82
Variability and repertoire size of T-cell receptor V alpha gene segments. Nature (1985) 1.81
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J (1997) 1.78
Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. Eur J Immunol (1989) 1.76
Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma. Cancer Res (1996) 1.74
Movement and site selection for priming by the primosome in phage phi X174 DNA replication. Proc Natl Acad Sci U S A (1981) 1.73
Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities. Nucleic Acids Res (1987) 1.70
Hepatic hepatitis C virus RNA as a predictor of a long-term response to interferon-alpha therapy. Ann Intern Med (1995) 1.62
Focal cervical poliopathy causing juvenile muscular atrophy of distal upper extremity: a pathological study. J Neurol Neurosurg Psychiatry (1987) 1.62
Definition of oriR, the minimum DNA segment essential for initiation of R1 plasmid replication in vitro. Proc Natl Acad Sci U S A (1983) 1.61
Signalling into the T-cell nucleus: NFAT regulation. Cell Signal (1998) 1.58
Role of STE genes in the mating factor signaling pathway mediated by GPA1 in Saccharomyces cerevisiae. Mol Cell Biol (1988) 1.56
Escherichia coli PriA protein is essential for inducible and constitutive stable DNA replication. EMBO J (1994) 1.56
Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae: autocrine cell-cycle arrest results from forced expression of STE2. EMBO J (1987) 1.54
Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int Immunol (1998) 1.54
Cytoplasmic and nuclear polyglutamine aggregates in SCA6 Purkinje cells. Neurology (2001) 1.53
The granulocyte-macrophage colony-stimulating factor promoter cis-acting element CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT. Mol Cell Biol (1993) 1.52
Nucleotide sequence of dnaB and the primary structure of the dnaB protein from Escherichia coli. J Biol Chem (1984) 1.51
Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. Blood (1999) 1.51
Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release. J Clin Invest (1988) 1.50
Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif. Oncogene (1997) 1.50
Transcriptional activator Tax of HTLV-1 binds to the NF-kappa B precursor p105. Oncogene (1992) 1.49
Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2. Blood (1995) 1.48
Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4). J Immunol (1987) 1.48
Structural and functional studies of the dnaB protein using limited proteolysis. Characterization of domains for DNA-dependent ATP hydrolysis and for protein association in the primosome. J Biol Chem (1984) 1.46
GATA-3 significantly downregulates IFN-gamma production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin Immunol (1999) 1.46