Published in Proc Natl Acad Sci U S A on January 01, 1985
SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol (1988) 12.84
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A (1993) 11.95
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med (1989) 11.36
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 6.16
Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 4.59
T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56
Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. Proc Natl Acad Sci U S A (1985) 3.31
Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J (1985) 3.04
Characterization of a murine lymphokine distinct from interleukin 2 and interleukin 3 (IL-3) possessing a T-cell growth factor activity and a mast-cell growth factor activity that synergizes with IL-3. Proc Natl Acad Sci U S A (1986) 2.84
ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J (1989) 2.62
Efficient screening of retroviral cDNA expression libraries. Proc Natl Acad Sci U S A (1995) 2.46
Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase. Mol Cell Biol (1986) 1.81
Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities. Nucleic Acids Res (1987) 1.70
Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect Immun (1994) 1.39
Codon reiteration and the evolution of proteins. Proc Natl Acad Sci U S A (1994) 1.29
Regulatory anatomy of the murine interleukin-2 gene. Nucleic Acids Res (1990) 1.26
Peripheral tolerance to alloantigen results from altered regulation of the interleukin 2 pathway. J Exp Med (1991) 1.23
Interleukin 4 is a growth factor for activated thymocytes: possible role in T-cell ontogeny. Proc Natl Acad Sci U S A (1987) 1.22
High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library. J Virol (1994) 1.21
Cloning vectors for expression of cDNA libraries in mammalian cells. Proc Natl Acad Sci U S A (1987) 1.19
Identification of three critical regions within mouse interleukin 2 by fine structural deletion analysis. EMBO J (1988) 1.16
Immunity to Trichinella spiralis infection in vitamin A-deficient mice. J Exp Med (1992) 1.13
Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivo. Proc Natl Acad Sci U S A (1991) 1.13
An antigen receptor-driven, interleukin 2-independent pathway for proliferation of murine cytolytic T lymphocyte clones. J Exp Med (1986) 1.12
Cloning, sequence, and expression of bovine interleukin 2. Proc Natl Acad Sci U S A (1986) 1.10
Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor. Proc Natl Acad Sci U S A (1991) 1.06
Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proc Natl Acad Sci U S A (1995) 1.03
Regulation of cytokine production during the expression phase of the anticryptococcal delayed-type hypersensitivity response. Infect Immun (1994) 1.03
Differential regulation of colony-stimulating factors and interleukin 2 production by cyclosporin A. Proc Natl Acad Sci U S A (1987) 1.02
Interleukin-1 synergy with phosphoinositide pathway agonists for induction of interleukin-2 gene expression: molecular basis of costimulation. Mol Cell Biol (1990) 1.01
Structural homologies among the hemopoietins. Proc Natl Acad Sci U S A (1986) 1.00
Cloning and expression of the rat interleukin-3 gene. Nucleic Acids Res (1986) 0.99
Secretion of human interleukin 2 by recombinant Mycobacterium bovis BCG. Infect Immun (1995) 0.96
Cloning and characterization of deer mouse (Peromyscus maniculatus) cytokine and chemokine cDNAs. BMC Immunol (2004) 0.95
Expression of v-src in a murine T-cell hybridoma results in constitutive T-cell receptor phosphorylation and interleukin 2 production. Proc Natl Acad Sci U S A (1991) 0.94
Superantigen-induced anergy of V beta 8+ CD4+ T cells induces functional but non-proliferative T cells in vivo. Immunology (1994) 0.90
Inducibility of interleukin-2 RNA expression in individual mature and immature T lymphocytes. EMBO J (1987) 0.90
Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines. Mol Cell Biol (1991) 0.89
Characterization of apoptosis-resistant antigen-specific T cells in vivo. J Exp Med (1996) 0.89
Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures. J Clin Invest (1992) 0.88
Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alterations due to other genetic factors. Immunology (1991) 0.86
A cDNA encoding feline CD4 has a unique repeat sequence downstream of the V-like region. Immunology (1992) 0.82
Screening of retroviral cDNA libraries for factors involved in protein phosphorylation in signaling cascades. Nucleic Acids Res (2005) 0.81
Sequence of a rat MHC class II-associated invariant chain cDNA clone containing a 64 amino acid thyroglobulin-like domain. Nucleic Acids Res (1989) 0.81
Induction of hyperthyroidism in mice by intradermal immunization with DNA encoding the thyrotropin receptor. Clin Exp Immunol (2004) 0.80
A role for protein kinase C activity in interleukin-1 (IL-1) induction of IL-2 gene expression but not in IL-1 signal transduction. Mol Cell Biol (1990) 0.80
Inhibition of murine nephritogenic effector T cells by a clone-specific suppressor factor. J Clin Invest (1994) 0.78
A novel functional gene selection method provides a systematic view of cell migration. Cell Adh Migr (2010) 0.77
Alteration of tumour response to radiation by interleukin-2 gene transfer. Br J Cancer (2000) 0.77
Cloning and analysis of murine cDNA that encodes a fibrogenic lymphokine, fibrosin. Proc Natl Acad Sci U S A (1995) 0.77
Activation of a murine T-cell hybridoma by cationized bacteria. Immunology (1989) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods (1983) 114.35
Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA. Proc Natl Acad Sci U S A (1972) 57.06
Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J Mol Biol (1980) 41.18
T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol (1978) 28.92
A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells. Mol Cell Biol (1983) 18.32
Selective in vitro growth of T lymphocytes from normal human bone marrows. Science (1976) 15.73
Pyrimidine-specific chemical reactions useful for DNA sequencing. Nucleic Acids Res (1980) 9.12
SEQ: a nucleotide sequence analysis and recombination system. Nucleic Acids Res (1982) 8.73
Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J Exp Med (1979) 7.20
Structure and expression of a cloned cDNA for human interleukin-2. Nature (1983) 7.04
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81
Biochemical and biological characterization of lymphocyte regulatory molecules. I. Purification of a class of murine lymphokines. J Exp Med (1979) 5.22
Purification and some characteristics of human T-cell growth factor from phytohemagglutinin-stimulated lymphocyte-conditioned media. Proc Natl Acad Sci U S A (1980) 4.91
Biochemical and biological characterization of lymphocyte regulatory molecules. V. Identification of an interleukin 2-producing human leukemia T cell line. J Exp Med (1980) 4.32
Inducer T lymphocytes synthesize a factor that stimulates proliferation of cloned mast cells. Nature (1981) 3.71
Structure of the human interleukin 2 gene. Proc Natl Acad Sci U S A (1983) 3.45
Biochemical characterization of lymphocyte regulatory molecules. II. Purification of a class of rat and human lymphokines. J Immunol (1980) 3.28
Proliferation of murine thymic lymphocytes in vitro is mediated by the concanavalin A-induced release of a lymphokine (costimulator). J Immunol (1976) 1.92
Purification to homogeneity and partial characterization of interleukin 2 from a human T-cell leukemia. Proc Natl Acad Sci U S A (1984) 1.47
Partial purification and molecular characterization of a lymphokine (costimulator) required for the mitogenic response of mouse thymocytes in vitro. J Immunol (1978) 1.46
Production by murine spleen cells of an activity stimulating the PHA-responsiveness of thymus lymphocytes. Cell Immunol (1975) 1.15
Characterization of chicken T cell growth factor. Eur J Immunol (1983) 0.95
Properties of sodium dodecyl sulfate-denatured Interleukin 2. J Immunol (1981) 0.95
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods (1983) 114.35
Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science (1994) 39.60
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03
SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol Cell Biol (1988) 12.84
Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs. Cell (1979) 12.83
Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell (1997) 11.35
Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells. J Mol Appl Genet (1983) 8.94
Role of an altered penicillin-binding protein in methicillin- and cephem-resistant Staphylococcus aureus. Antimicrob Agents Chemother (1985) 8.66
Glucocorticoids regulate expression of dihydrofolate reductase cDNA in mouse mammary tumour virus chimaeric plasmids. Nature (1981) 8.66
Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera. J Clin Microbiol (1988) 8.09
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
Requirement of adenosine 3', 5'-cyclic phosphate for flagella formation in Escherichia coli and Salmonella typhimurium. J Bacteriol (1970) 6.33
Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 6.16
Transcription termination at the trp operon attenuators of Escherichia coli and Salmonella typhimurium: RNA secondary structure and regulation of termination. Proc Natl Acad Sci U S A (1977) 6.08
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proc Natl Acad Sci U S A (1984) 5.81
New features of the regulation of the tryptophan operon. Science (1975) 5.40
Cytokines: coordinators of immune and inflammatory responses. Annu Rev Biochem (1990) 5.36
High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol (1987) 5.08
IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proc Natl Acad Sci U S A (1988) 5.03
Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proc Natl Acad Sci U S A (1986) 4.59
Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice. Science (1989) 4.57
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J (1999) 4.55
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (1993) 4.39
Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from Saccharomyces cerevisiae. EMBO J (1985) 4.37
Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Lett (1992) 4.31
The nucleotide sequence of the cloned tufA gene of Escherichia coli. Gene (1980) 4.17
RNA polymerase interaction at the promoter--operator region of the tryptophan operon of Escherichia coli and Salmonella typhimurium. J Mol Biol (1978) 3.84
Survey of methicillin-resistant clinical strains of coagulase-negative staphylococci for mecA gene distribution. Antimicrob Agents Chemother (1992) 3.73
The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol (2000) 3.71
Nucleotide sequence of the 5' end of tryptophan messenger RNA of Escherichia coli. J Mol Biol (1976) 3.60
A new endoscopic mucosal resection procedure using an insulation-tipped electrosurgical knife for rectal flat lesions: report of two cases. Gastrointest Endosc (1999) 3.55
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43
Benzoate metabolism in Pseudomonas putida(arvilla) mt-2: demonstration of two benzoate pathways. J Bacteriol (1973) 3.41
Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci U S A (1990) 3.36
Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science (1990) 3.35
Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. Proc Natl Acad Sci U S A (1985) 3.31
Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J Exp Med (1989) 3.28
Cytokine receptors and signal transduction. Annu Rev Immunol (1992) 3.27
Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. J Exp Med (1987) 3.22
Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. EMBO J (1985) 3.04
Isolation of TOL and RP4 recombinants by integrative suppression. J Bacteriol (1978) 3.00
The Arabidopsis deetiolated2 mutant is blocked early in brassinosteroid biosynthesis. Plant Cell (1997) 3.00
Role of penicillinase plasmids in the stability of the mecA gene in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother (1990) 2.93
Comparison of the nucleotide sequences of the initial transcribed regions of the tryptophan operons of Escherichia coli and Salmonella typhimurium. J Mol Biol (1978) 2.86
Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell (1991) 2.84
Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia. Infect Immun (1995) 2.80
The tomato DWARF enzyme catalyses C-6 oxidation in brassinosteroid biosynthesis. Proc Natl Acad Sci U S A (1999) 2.72
Primary structure of elongation factor Tu from Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.72
Meth A fibrosarcoma cells express two transforming mutant p53 species. Oncogene (1988) 2.71
Structure, expression and divergence of T-cell receptor beta-chain variable regions. Nature (1984) 2.71
Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J Immunol (1991) 2.70
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J Exp Med (2000) 2.68
ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction. EMBO J (1989) 2.62
Transcription of the Arabidopsis CPD gene, encoding a steroidogenic cytochrome P450, is negatively controlled by brassinosteroids. Plant J (1998) 2.57
A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3. J Immunol (1985) 2.56
Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation. Cell (1983) 2.54
Expression of the Fas ligand in cells of T cell lineage. J Immunol (1995) 2.54
Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54
Analysis of borderline-resistant strains of methicillin-resistant Staphylococcus aureus using polymerase chain reaction. Microbiol Immunol (1992) 2.53
Management of peritoneal tear during endoscopic extraperitoneal inguinal hernioplasty. Surg Endosc (2002) 2.52
IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J Immunol (1997) 2.50
Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans. J Biol Chem (1984) 2.48
Unique primed start of phage phi X174 DNA replication and mobility of the primosome in a direction opposite chain synthesis. Proc Natl Acad Sci U S A (1981) 2.44
Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development (2001) 2.42
The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis. Plant Cell (1998) 2.39