Published in Mol Cell Biol on May 01, 1999
A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity (2007) 3.54
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev (1999) 2.28
The nicking step in V(D)J recombination is independent of synapsis: implications for the immune repertoire. Mol Cell Biol (2000) 1.38
A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals. Mol Cell Biol (2002) 1.36
Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination. Genes Dev (2002) 1.35
The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination. Mol Cell Biol (2001) 1.29
Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice. Nucleic Acids Res (2004) 1.26
The RAG proteins in V(D)J recombination: more than just a nuclease. Nucleic Acids Res (2001) 1.24
A functional analysis of the spacer of V(D)J recombination signal sequences. PLoS Biol (2003) 1.21
Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficiencies. Mol Cell Biol (2000) 1.20
Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase. Mol Cell Biol (2002) 1.19
Fine structure and activity of discrete RAG-HMG complexes on V(D)J recombination signals. Mol Cell Biol (2002) 1.15
Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex. Mol Cell (2009) 1.13
A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1. Nucleic Acids Res (2000) 1.07
A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination. Mol Cell Biol (2001) 1.06
RAG transposase can capture and commit to target DNA before or after donor cleavage. Mol Cell Biol (2001) 1.00
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Requirements for DNA hairpin formation by RAG1/2. Proc Natl Acad Sci U S A (2007) 0.97
Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaks. Mol Cell Biol (2009) 0.96
Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription. Mol Cell (2008) 0.95
Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination. Mol Cell Biol (2001) 0.93
Genetic modulation of T cell receptor gene segment usage during somatic recombination. J Exp Med (2000) 0.93
Ordered DNA release and target capture in RAG transposition. EMBO J (2004) 0.91
The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination. Mol Cell Biol (2007) 0.90
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Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination. Mol Cell Biol (2004) 0.86
RAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes. Nucleic Acids Res (2013) 0.84
DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated. Mol Cell Biol (2004) 0.84
Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavage. EMBO Rep (2003) 0.84
Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination. Mol Cell Biol (2001) 0.84
Footprint analysis of recombination signal sequences in the 12/23 synaptic complex of V(D)J recombination. Mol Cell Biol (2002) 0.84
Collaboration of RAG2 with RAG1-like proteins during the evolution of V(D)J recombination. Genes Dev (2016) 0.82
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