Published in J Exp Med on August 01, 1993
T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol (1996) 1.91
Mechanics of T cell receptor gene rearrangement. Curr Opin Immunol (2009) 1.78
T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. J Exp Med (1995) 1.72
Immunodominance of major histocompatibility complex class I-restricted influenza virus epitopes can be influenced by the T-cell receptor repertoire. J Virol (1995) 1.71
Direct evidence for thymic function in adult humans. J Exp Med (1999) 1.70
Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire. J Exp Med (2002) 1.62
Receptor selection in B and T lymphocytes. Annu Rev Immunol (2000) 1.49
T cells with two functional antigen-specific receptors. Proc Natl Acad Sci U S A (1995) 1.41
FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor. EMBO J (2000) 1.38
Molecular mimicry as a mechanism of autoimmune disease. Clin Rev Allergy Immunol (2012) 1.37
Thymic involution in aging. J Clin Immunol (2000) 1.37
T cell receptor (TCR)-beta gene recombination: dissociation from cell cycle regulation and developmental progression during T cell ontogeny. J Exp Med (1997) 1.30
rag-1 and rag-2 are components of a high-molecular-weight complex, and association of rag-2 with this complex is rag-1 dependent. Mol Cell Biol (1995) 1.28
Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis. J Cell Biol (1998) 1.28
The role of recombination activating gene (RAG) reinduction in thymocyte development in vivo. J Exp Med (2001) 1.27
Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation. Proc Natl Acad Sci U S A (1998) 1.26
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes. EMBO J (2006) 1.18
Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire. Front Immunol (2013) 1.14
Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination. Proc Natl Acad Sci U S A (2007) 1.11
Restricting Zap70 expression to CD4+CD8+ thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection. J Exp Med (2003) 1.07
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL. J Immunol (2010) 1.05
Revision of T cell receptor {alpha} chain genes is required for normal T lymphocyte development. Proc Natl Acad Sci U S A (2005) 1.04
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway. J Immunol (2011) 1.00
Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease. J Immunol (2009) 0.99
Small cortical thymocytes are subject to positive selection. J Exp Med (1994) 0.99
Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes. J Exp Med (1996) 0.97
Two distinct pathways of positive selection for thymocytes. Proc Natl Acad Sci U S A (1998) 0.96
The role of the thymus in tolerance. Transplantation (2010) 0.95
Identification of a late stage of small noncycling pTalpha- pre-T cells as immediate precursors of T cell receptor alpha/beta+ thymocytes. J Exp Med (1998) 0.92
Immune tolerance and transplantation. Semin Oncol (2012) 0.90
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med (2000) 0.90
T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. J Exp Med (2003) 0.90
Lack of nonfunctional B-cell receptor rearrangements in a patient with normal B cell numbers despite partial RAG1 deficiency and atypical SCID/Omenn syndrome. J Clin Immunol (2008) 0.86
The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires. J Immunol (2014) 0.85
Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes. Proc Natl Acad Sci U S A (2012) 0.85
Ly-6A is required for T cell receptor expression and protein tyrosine kinase fyn activity. EMBO J (1994) 0.83
Regulatory T cells for tolerance therapy: revisiting the concept. Crit Rev Immunol (2011) 0.81
Coupling of the cell cycle and apoptotic machineries in developing T cells. J Biol Chem (2010) 0.81
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function. Front Immunol (2015) 0.79
Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells. Front Immunol (2014) 0.79
Numerical modelling of the V-J combinations of the T cell receptor TRA/TRD locus. PLoS Comput Biol (2010) 0.78
Single-cell analysis of glandular T cell receptors in Sjögren's syndrome. JCI Insight (2016) 0.78
A relation between the principal axes of inertia and ligand binding. Proc Natl Acad Sci U S A (2000) 0.77
The highly alloreactive nature of dual TCR T cells. Curr Opin Organ Transplant (2016) 0.75
Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis. Dev Comp Immunol (2015) 0.75
Derivation of T-cell receptor alpha-chain double expresser lines from normal murine mature T cells. Immunology (1996) 0.75
Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL. Blood (2015) 0.75
RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell (1992) 17.50
The V(D)J recombination activating gene, RAG-1. Cell (1989) 9.79
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell (1991) 8.27
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell (1991) 8.13
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages. Nature (1992) 7.66
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (1989) 6.70
The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Annu Rev Immunol (1986) 6.23
Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice. Cell (1991) 3.66
Molecular and cellular events of T cell development. Adv Immunol (1989) 3.50
Exclusion and inclusion of alpha and beta T cell receptor alleles. Cell (1992) 3.34
Kinetics of mature T-cell development in the thymus. Proc Natl Acad Sci U S A (1990) 3.02
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science (1992) 2.90
Regulation of TCR alpha and beta gene allelic exclusion during T-cell development. Immunol Today (1992) 2.71
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65
Self-nonself discrimination by T cells. Science (1990) 2.17
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes. J Immunol (1991) 2.00
The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells. J Exp Med (1991) 1.97
The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell (1989) 1.91
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science (1990) 1.89
Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice. Curr Top Microbiol Immunol (1990) 1.86
Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro. J Exp Med (1990) 1.64
Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development. Cell (1993) 1.59
T cell receptor (TCR) beta chain homodimers on the surface of immature but not mature alpha, gamma, delta chain deficient T cell lines. EMBO J (1992) 1.49
Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc Natl Acad Sci U S A (1992) 1.43
Surface expression of a T cell receptor beta (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins. J Exp Med (1991) 1.39
Development of immature thymocytes: initiation of CD3, CD4, and CD8 acquisition parallels down-regulation of the interleukin 2 receptor alpha chain. Eur J Immunol (1990) 1.21
Commitment to the T cell receptor-alpha beta or -gamma delta lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes. Eur J Immunol (1992) 1.19
Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation. Eur J Immunol (1989) 1.09
T cell receptor expression on immature thymocytes with in vivo and in vitro precursor potential. Eur J Immunol (1989) 1.06
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science (1999) 11.96
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33
Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J (1998) 7.17
BH3-Only proteins-essential initiators of apoptotic cell death. Cell (2000) 7.04
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell (1999) 5.92
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system. Nature (1998) 5.47
Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified. J Exp Med (1996) 5.32
Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res (1994) 5.14
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ (2002) 4.64
The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells. J Exp Med (1992) 4.58
CD4 and CD8 expression by dendritic cell subtypes in mouse thymus and spleen. J Immunol (2000) 4.41
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. Science (2001) 4.29
The RAG proteins and V(D)J recombination: complexes, ends, and transposition. Annu Rev Immunol (2000) 4.17
A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci U S A (1995) 3.80
An evolutionary perspective on apoptosis. Cell (1994) 3.77
Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. J Immunol (1997) 3.71
A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis. J Exp Med (1996) 3.66
The dendritic cell populations of mouse lymph nodes. J Immunol (2001) 3.57
Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature (1993) 3.48
Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol (2001) 3.39
The molecular biology of apoptosis. Proc Natl Acad Sci U S A (1996) 3.39
Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. Cell (1997) 3.13
The separation of different cell classes from lymphoid organs. V. Simple procedures for the removal of cell debris. Damaged cells and erythroid cells from lymphoid cell suspensions. J Immunol Methods (1972) 3.08
Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron (2001) 3.07
Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J Immunol (2001) 3.05
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell (2001) 3.03
Kinetics of mature T-cell development in the thymus. Proc Natl Acad Sci U S A (1990) 3.02
The separation of different cell classes from lymphoid organs. IX. A simple and rapid method for removal of damaged cells from lymphoid cell suspensions. J Immunol Methods (1973) 2.96
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J (1998) 2.82
The role of nonlymphoid accessory cells in the immune response to different antigens. J Exp Med (1970) 2.82
The development, maturation, and turnover rate of mouse spleen dendritic cell populations. J Immunol (2000) 2.76
Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature (1996) 2.71
The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry. EMBO J (1996) 2.71
Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene (1997) 2.70
A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc Natl Acad Sci U S A (1991) 2.68
The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ (2011) 2.66
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65
RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Cell (1997) 2.58
Expression and functional significance of the J11d marker on mouse thymocytes. J Immunol (1987) 2.56
The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells. Am J Pathol (2000) 2.53
T cell development in the adult murine thymus: changes in the expression of the surface antigens Ly2, L3T4 and B2A2 during development from early precursor cells to emigrants. Immunol Rev (1984) 2.53
Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature (2000) 2.48
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev (1996) 2.47
The separation of different cell classes from lymphoid organs. II. The purification and analysis of lymphocyte populations by equilibrium density gradient centrifugation. Aust J Exp Biol Med Sci (1968) 2.45
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry. EMBO J (1997) 2.44
RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells. Immunity (1998) 2.42
Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity (1995) 2.40
Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector. Mol Cell Biol (1987) 2.33
The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell (1991) 2.33
RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell (1996) 2.31
The requirement for macrophages in the in vitro immune response. Cell Immunol (1971) 2.24
Growth of B lymphocyte colonies in vitro from mouse lymphoid organs. Nature (1975) 2.24
Selective retention of activated CD8+ T cells by the normal liver. J Immunol (1999) 2.23
The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo. Immunity (1994) 2.11
Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med (2000) 2.09
The influence of granulocyte/macrophage colony-stimulating factor on dendritic cell levels in mouse lymphoid organs. Eur J Immunol (1997) 2.08
Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. J Exp Med (2000) 2.07
Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science (1996) 2.03
Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci U S A (1997) 2.02
B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. J Exp Med (1998) 2.00
Differentiation potential of subsets of CD4-8- thymocytes. Nature (1987) 2.00
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L). Proc Natl Acad Sci U S A (1999) 1.99
The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane. Cell Growth Differ (1994) 1.98
Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J Exp Med (1996) 1.94
Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Mol Cell (2000) 1.93
A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. Proc Natl Acad Sci U S A (1989) 1.92
T-cell receptor alpha locus V(D)J recombination by-products are abundant in thymocytes and mature T cells. Mol Cell Biol (1996) 1.91
GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line. EMBO J (1992) 1.90
Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev (1996) 1.89
Developmental potential of the earliest precursor cells from the adult mouse thymus. J Exp Med (1991) 1.88
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ (2002) 1.85
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? Cell Death Differ (2007) 1.84
Developmental status and reconstitution potential of subpopulations of murine thymocytes. Immunol Rev (1988) 1.82
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute. Cell Death Differ (2008) 1.81
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes. Cell Death Differ (2004) 1.81
CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus. Nature (1991) 1.80
Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci U S A (1996) 1.79
The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J (2000) 1.79
The separation of different cell classes from lymphoid organs. 1. The use of glass bead columns to separate small lymphocytes, remove damaged cells and fractionate cell suspensions. Aust J Exp Biol Med Sci (1966) 1.78
bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells. J Exp Med (2000) 1.76
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis. Cell Death Differ (2009) 1.75
Separation of stages in the development of the "T" cells involved in cell-mediated immunity. J Exp Med (1972) 1.73
T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production. J Exp Med (1995) 1.72
The separation of different cell classes from lymphoid organs. IV. The separation of lymphocytes from phagocytes on glass bead columns, and its effect on subpopulations of lymphocytes and antibody-forming cells. J Cell Biol (1971) 1.72
Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation. Eur J Immunol (1995) 1.71
Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Cell (1991) 1.68
A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production. J Immunol (1996) 1.67
Subpopulations of T-lymphocytes. Physical separation, functional specialisation and differentiation pathways of sub-sets of thymocytes and thymus-dependent peripheral lymphocytes. Transplant Rev (1975) 1.66
A suggested control function for the animal tissue ribonuclease-ribonuclease inhibitor system, based on studies of isolated cells and phytohaemagglutinin-transformed lymphocytes. Biochim Biophys Acta (1970) 1.64
Induction of immunity and tolerance in vitro in the absence of phagocytic cells. Nature (1970) 1.64
Lineage relationships and developmental kinetics of immature thymocytes: CD3, CD4, and CD8 acquisition in vivo and in vitro. J Exp Med (1990) 1.64
Fas death receptor signalling: roles of Bid and XIAP. Cell Death Differ (2011) 1.63
The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement. Genes Dev (1988) 1.61
Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim. Cell Death Differ (2008) 1.60
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF. EMBO J (1999) 1.59
Polyethylene glycol-modified GM-CSF expands CD11b(high)CD11c(high) but notCD11b(low)CD11c(high) murine dendritic cells in vivo: a comparative analysis with Flt3 ligand. J Immunol (2000) 1.58
Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes. J Exp Med (1995) 1.57
Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A (1998) 1.56