Published in Proc Natl Acad Sci U S A on June 09, 2003
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In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest (2008) 3.35
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood (2005) 3.32
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Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat Rev Immunol (2008) 2.98
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. J Exp Med (2007) 2.84
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Decision checkpoints in the thymus. Nat Immunol (2010) 1.75
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An important role for RUNX3 in human L1 transcription and retrotransposition. Nucleic Acids Res (2003) 1.51
The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development. Mol Cell Biol (2005) 1.51
Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc Natl Acad Sci U S A (2005) 1.43
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CD4-CD8 lineage differentiation: Thpok-ing into the nucleus. J Immunol (2009) 1.21
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc Natl Acad Sci U S A (2013) 1.21
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Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proc Natl Acad Sci U S A (2006) 1.06
Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity (2008) 1.04
TOX is required for development of the CD4 T cell lineage gene program. J Immunol (2011) 1.01
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol (2008) 1.00
Epigenetics of human T cells during the G0-->G1 transition. Genome Res (2009) 0.99
The role of EZH2 and DNA methylation in the silencing of the tumour suppressor RUNX3 in colorectal cancer. Carcinogenesis (2010) 0.99
Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus. J Exp Med (2012) 0.99
AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cells. J Biol Chem (2008) 0.97
Subnuclear targeting of the Runx3 tumor suppressor and its epigenetic association with mitotic chromosomes. J Cell Physiol (2009) 0.97
Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus. Arthritis Res Ther (2004) 0.97
Dynamic repositioning of CD4 and CD8 genes during T cell development. J Exp Med (2004) 0.96
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Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function. EMBO Mol Med (2011) 0.95
Developmentally regulated promoter-switch transcriptionally controls Runx1 function during embryonic hematopoiesis. BMC Dev Biol (2007) 0.95
CD4 CTL: living up to the challenge. Semin Immunol (2013) 0.93
Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas. J Cancer Res Clin Oncol (2008) 0.93
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Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination. Cancer Res (2009) 0.92
The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation. Immunity (2012) 0.88
Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. J Biol Chem (2012) 0.88
Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer. Oncogene (2014) 0.88
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood (2006) 0.87
Runx3-mediated transcriptional program in cytotoxic lymphocytes. PLoS One (2013) 0.87
Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunology (2010) 0.87
Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J (2011) 0.86
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Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Blood (2014) 0.84
The genetics of systemic lupus erythematosus: understanding how SNPs confer disease susceptibility. Springer Semin Immunopathol (2006) 0.84
Expanding roles for ThPOK in thymic development. Immunol Rev (2010) 0.83
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'Runxs and regulations' of sensory and motor neuron subtype differentiation: implications for hematopoietic development. Blood Cells Mol Dis (2009) 0.81
The RUNX complex: reaching beyond haematopoiesis into immunity. Immunology (2015) 0.81
Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation. Nucleic Acids Res (2015) 0.80
A germline point mutation in Runx1 uncouples its role in definitive hematopoiesis from differentiation. Exp Hematol (2013) 0.80
Transcriptomic analysis supports similar functional roles for the two thymuses of the tammar wallaby. BMC Genomics (2011) 0.79
A novel HMM-based method for detecting enriched transcription factor binding sites reveals RUNX3 as a potential target in pancreatic cancer biology. PLoS One (2010) 0.78
Tyrosyl phosphorylation toggles a Runx1 switch. Genes Dev (2012) 0.78
Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. PLoS One (2015) 0.78
Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility. Semin Immunol (2011) 0.78
Transcription Factor Runx3 Is Induced by Influenza A Virus and Double-Strand RNA and Mediates Airway Epithelial Cell Apoptosis. Sci Rep (2015) 0.77
The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development. J Immunol (2014) 0.76
TOX gene: a novel target for human cancer gene therapy. Am J Cancer Res (2015) 0.76
A proximity-based method to identify genomic regions correlated with a continuously varying environmental variable. Evol Bioinform Online (2013) 0.76
What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function. J Immunol (2016) 0.76
Runt-related transcription factor 3 is involved in the altered phenotype and function in ThPok-deficient invariant natural killer T cells. Cell Mol Immunol (2014) 0.75
Transcriptional Auto-Regulation of RUNX1 P1 Promoter. PLoS One (2016) 0.75
Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs. Immunobiology (2016) 0.75
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells. Immunology (2017) 0.75
Transcriptional regulators dictate innate lymphoid cell fates. Protein Cell (2017) 0.75
Runx2 Deletion in Smooth muscle Cells Inhibits Vascular Osteochondrogenesis and Calcification but not Atherosclerotic Lesion Formation. Cardiovasc Res (2016) 0.75
Goldmine integrates information placing genomic ranges into meaningful biological contexts. Nucleic Acids Res (2016) 0.75
Domain analyses of the Runx1 transcription factor responsible for modulating T-cell receptor-beta/CD4 and interleukin-4/interferon-gamma expression in CD4(+) peripheral T lymphocytes. Immunology (2009) 0.75
Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLoS Genet (2017) 0.75
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