Published in Development on September 28, 2010
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell (2011) 1.76
Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos. Nat Protoc (2012) 1.58
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region. J Exp Med (2011) 1.48
Identification of the hemogenic endothelial progenitor and its direct precursor in human pluripotent stem cell differentiation cultures. Cell Rep (2012) 1.46
Hematopoietic stem cell development requires transient Wnt/β-catenin activity. J Exp Med (2012) 1.35
Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators. Nat Commun (2014) 1.27
Gata2 is required for HSC generation and survival. J Exp Med (2013) 1.26
Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region. J Exp Med (2011) 1.25
CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells. Blood (2011) 1.23
Three-dimensional biomimetic patterning in hydrogels to guide cellular organization. Adv Mater (2012) 1.19
Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nat Cell Biol (2015) 1.16
Hematopoietic specification from human pluripotent stem cells: current advances and challenges toward de novo generation of hematopoietic stem cells. Blood (2013) 1.14
Endothelio-mesenchymal interaction controls runx1 expression and modulates the notch pathway to initiate aortic hematopoiesis. Dev Cell (2013) 1.13
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs. Blood (2013) 1.07
Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor. Stem Cell Reports (2014) 1.06
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells. Development (2013) 1.05
A short history of hemogenic endothelium. Blood Cells Mol Dis (2013) 1.05
Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters. Blood (2011) 1.04
Tracing haematopoietic stem cell formation at single-cell resolution. Nature (2016) 1.03
Identity and fate of Tbx4-expressing cells reveal developmental cell fate decisions in the allantois, limb, and external genitalia. Dev Dyn (2011) 0.97
Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation. J Exp Med (2014) 0.97
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells. J Clin Invest (2015) 0.97
Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition. Nat Commun (2015) 0.97
Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta. Blood (2014) 0.92
Deciphering the hierarchy of angiohematopoietic progenitors from human pluripotent stem cells. Cell Cycle (2013) 0.92
Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity. Stem Cells (2015) 0.92
Effect of developmental stage of HSC and recipient on transplant outcomes. Dev Cell (2014) 0.91
GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1. Nat Cell Biol (2015) 0.91
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol (2014) 0.90
Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (2015) 0.87
Identification of the niche and phenotype of the first human hematopoietic stem cells. Stem Cell Reports (2014) 0.87
Fusing VE-cadherin to α-catenin impairs fetal liver hematopoiesis and lymph but not blood vessel formation. Mol Cell Biol (2014) 0.85
Intra-aortic clusters undergo endothelial to hematopoietic phenotypic transition during early embryogenesis. PLoS One (2012) 0.85
Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open (2013) 0.85
The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes Dev (2014) 0.85
Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. Development (2014) 0.84
Generating human hematopoietic stem cells in vitro -exploring endothelial to hematopoietic transition as a portal for stemness acquisition. FEBS Lett (2016) 0.84
Hypoxia and HIFs in regulating the development of the hematopoietic system. Blood Cells Mol Dis (2013) 0.84
HIF1α is a regulator of hematopoietic progenitor and stem cell development in hypoxic sites of the mouse embryo. Stem Cell Res (2013) 0.84
Endothelial Smad4 restrains the transition to hematopoietic progenitors via suppression of ERK activation. Blood (2014) 0.83
Specification and function of hemogenic endothelium during embryogenesis. Cell Mol Life Sci (2016) 0.83
Biomechanical force in blood development: extrinsic physical cues drive pro-hematopoietic signaling. Differentiation (2013) 0.83
BMP signalling differentially regulates distinct haematopoietic stem cell types. Nat Commun (2015) 0.83
Hedgehog signaling in the posterior region of the mouse gastrula suggests manifold roles in the fetal-umbilical connection and posterior morphogenesis. Dev Dyn (2011) 0.82
Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int (2015) 0.80
Mapping mouse hemangioblast maturation from headfold stages. Dev Biol (2012) 0.80
A view of human haematopoietic development from the Petri dish. Nat Rev Mol Cell Biol (2016) 0.80
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells. Nat Commun (2016) 0.79
Lack of Phenotypical and Morphological Evidences of Endothelial to Hematopoietic Transition in the Murine Embryonic Head during Hematopoietic Stem Cell Emergence. PLoS One (2016) 0.79
Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. J Exp Med (2014) 0.78
Early hematopoiesis and macrophage development. Semin Immunol (2016) 0.77
Functional and molecular characterization of mouse Gata2-independent hematopoietic progenitors. Blood (2016) 0.77
Murine hemogenic endothelial precursors display heterogeneous hematopoietic potential ex vivo. Exp Hematol (2017) 0.76
BMP and Hedgehog Regulate Distinct AGM Hematopoietic Stem Cells Ex Vivo. Stem Cell Reports (2016) 0.76
Single-cell resolution of morphological changes in hemogenic endothelium. Development (2015) 0.76
Subregional localization and characterization of Ly6aGFP-expressing hematopoietic cells in the mouse embryonic head. Dev Biol (2016) 0.76
Hematopoietic (stem) cell development - how divergent are the roads taken? FEBS Lett (2016) 0.75
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta. Sci Rep (2016) 0.75
Restricted intra-embryonic origin of bona fide hematopoietic stem cells in the chicken. Development (2017) 0.75
Cell cycle dynamics and complement expression distinguishes mature hematopoietic subsets arising from hemogenic endothelium. Cell Cycle (2017) 0.75
Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice. Nat Commun (2017) 0.75
AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell (1996) 9.74
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A (1996) 6.29
Definitive hematopoiesis is autonomously initiated by the AGM region. Cell (1996) 5.75
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature (2009) 5.34
Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development (1999) 4.93
Haematopoietic stem cells derive directly from aortic endothelium during development. Nature (2010) 4.42
Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature (2009) 4.32
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters. Development (1999) 4.21
The purification and characterization of fetal liver hematopoietic stem cells. Proc Natl Acad Sci U S A (1995) 4.21
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature (2010) 4.16
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity (2002) 4.15
Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature (2010) 4.14
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
Development of hematopoietic stem cell activity in the mouse embryo. Immunity (1994) 3.91
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature (2009) 3.88
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59
Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo. EMBO J (2000) 3.10
Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny. Development (1998) 3.09
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development (2003) 3.09
Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta. Immunity (2002) 3.06
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94
Hematopoietic stem cell development is dependent on blood flow. Cell (2009) 2.77
Lymphoid potential, probed before circulation in mouse, is restricted to caudal intraembryonic splanchnopleura. Cell (1996) 2.60
In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Immunity (1998) 2.54
Extensive hematopoietic stem cell generation in the AGM region via maturation of VE-cadherin+CD45+ pre-definitive HSCs. Cell Stem Cell (2008) 2.43
All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac. Blood (2007) 2.31
Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo. Immunity (2000) 2.10
Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo. Immunity (1996) 2.08
Aorta-associated CD34+ hematopoietic cells in the early human embryo. Blood (1996) 2.02
Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta. Proc Natl Acad Sci U S A (2007) 1.93
Potential intraembryonic hemogenic sites at pre-liver stages in the mouse. Anat Embryol (Berl) (1995) 1.76
Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis. Development (1996) 1.66
Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells. Genes Cells (2001) 1.65
An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells. Dev Cell (2006) 1.55
Smooth muscle of the dorsal aorta shares a common clonal origin with skeletal muscle of the myotome. Development (2006) 1.54
From hemangioblast to hematopoietic stem cell: an endothelial connection? Exp Hematol (2005) 1.53
PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5. J Histochem Cytochem (1997) 1.49
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med (2005) 1.44
Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc Natl Acad Sci U S A (2007) 1.42
Definitive hematopoietic commitment within the embryonic vascular endothelial-cadherin(+) population. Exp Hematol (2002) 1.35
Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region. Blood (2000) 1.25
Somite-derived cells replace ventral aortic hemangioblasts and provide aortic smooth muscle cells of the trunk. Development (2006) 1.21
Antigenic profiles of endothelial and hemopoietic lineages in murine intraembryonic hemogenic sites. Dev Comp Immunol (1998) 1.12
Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo. Development (1999) 1.11
Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development. Development (2009) 1.04
Involvement of Runx1 in the down-regulation of fetal liver kinase-1 expression during transition of endothelial cells to hematopoietic cells. Blood (2005) 1.03
Whole-mount immunohistochemistry. Methods Enzymol (1993) 1.02
Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling. Blood (2009) 1.01
The embryonic origins of human haematopoiesis. Br J Haematol (2001) 0.92
Overcoming obstacles in the search for the site of hematopoietic stem cell emergence. Cell Stem Cell (2008) 0.85
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature (2009) 5.34
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell (2010) 5.05
In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium. Nature (2010) 4.16
Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo. Immunity (2002) 4.15
Hematopoietic stem cells localize to the endothelial cell layer in the midgestation mouse aorta. Immunity (2002) 3.06
GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med (2004) 2.94
The murine placenta contains hematopoietic stem cells within the vascular labyrinth region. Dev Cell (2005) 2.91
Hematopoietic stem cell development is dependent on blood flow. Cell (2009) 2.77
Efficient hematopoietic differentiation of human embryonic stem cells on stromal cells derived from hematopoietic niches. Cell Stem Cell (2008) 2.74
Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development. Cell Stem Cell (2009) 1.85
Erythroid/myeloid progenitors and hematopoietic stem cells originate from distinct populations of endothelial cells. Cell Stem Cell (2011) 1.76
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
Sca-1 negatively regulates proliferation and differentiation of muscle cells. Dev Biol (2005) 1.66
Whole-mount three-dimensional imaging of internally localized immunostained cells within mouse embryos. Nat Protoc (2012) 1.58
The Ly-6A (Sca-1) GFP transgene is expressed in all adult mouse hematopoietic stem cells. Stem Cells (2002) 1.56
An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells. Dev Cell (2006) 1.55
Mesenchymal lineage potentials of aorta-gonad-mesonephros stromal clones. Haematologica (2006) 1.51
Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells. Proc Natl Acad Sci U S A (2007) 1.42
Hematopoietic stem cell development requires transient Wnt/β-catenin activity. J Exp Med (2012) 1.35
Gata2 is required for HSC generation and survival. J Exp Med (2013) 1.26
CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells. Blood (2011) 1.23
Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny. Development (2005) 1.16
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med (2012) 1.13
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization. Blood (2011) 1.12
Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis. Cell Stem Cell (2012) 1.11
Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development. Development (2009) 1.04
Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters. Blood (2011) 1.04
Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling. Blood (2009) 1.01
Impaired hematopoiesis in mice lacking the transcription factor Sp3. Blood (2003) 0.99
Comparative study of stromal cell lines derived from embryonic, fetal, and postnatal mouse blood-forming tissues. Exp Hematol (2002) 0.97
Analysis and manipulation of hematopoietic progenitor and stem cells from murine embryonic tissues. Curr Protoc Stem Cell Biol (2008) 0.94
Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo. Blood (2008) 0.93
Expression of the Ly-6A (Sca-1) lacZ transgene in mouse haematopoietic stem cells and embryos. Br J Haematol (2002) 0.91
Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase. Genes Dev (2008) 0.91
Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region. Blood (2002) 0.90
Bcl-2 expression and apoptosis in the regulation of hematopoietic stem cells. Leuk Lymphoma (2007) 0.89
Hematopoietic stem cell enrichment from the AGM region of the mouse embryo. Methods Mol Med (2005) 0.89
Ontogeny and genetics of the hemato/lymphopoietic system. Curr Opin Immunol (2002) 0.89
The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression. Blood (2004) 0.89
Maintenance of HSC by Wnt5a secreting AGM-derived stromal cell line. Exp Hematol (2010) 0.89
Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis. J Cell Sci (2002) 0.88
A Role for PML in Innate Immunity. Genes Cancer (2011) 0.88
Interleukin-1 regulates hematopoietic progenitor and stem cells in the midgestation mouse fetal liver. Haematologica (2009) 0.86
Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta. Biol Open (2013) 0.85
Cell-cell contact and anatomical compatibility in stromal cell-mediated HSC support during development. Stem Cells (2004) 0.84
Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation. Blood (2002) 0.84
Hypoxia and HIFs in regulating the development of the hematopoietic system. Blood Cells Mol Dis (2013) 0.84
Promotion of haematopoietic activity in embryonic stem cells by the aorta-gonad-mesonephros microenvironment. Exp Cell Res (2006) 0.84
Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells. Haematologica (2012) 0.83
Isolation of early hematopoietic stem cells from murine yolk sac and AGM. J Vis Exp (2008) 0.83
Embryonic beginnings of adult hematopoietic stem cells. Haematologica (2005) 0.81
Multipotential hematopoietic progenitor cells from embryos developed in vitro engraft unconditioned W41/W41 neonatal miceB. Haematologica (2005) 0.77
Preparation of hematopoietic stem and progenitor cells from the human placenta. Curr Protoc Stem Cell Biol (2010) 0.76
Analysis of the mouse placenta as a hematopoietic stem cell niche. Methods Mol Biol (2009) 0.76
The placenta as a haematopoietic organ. Int J Dev Biol (2010) 0.76
Corrigendum: BMP signalling differentially regulates distinct haematopoietic stem cell types. Nat Commun (2015) 0.75
Hematopoietic (stem) cell development-how divergent are the roads taken? FEBS Lett (2017) 0.75