Published in Lancet on April 24, 1999
An Arrhythmia Risk Stratification and Genetic Trial (EUTrigTreat) | NCT01209494
Autonomic Regulation Trial (ART) | NCT00196274
An Arrhythmia Risk Predictor Trial | NCT02010515
Innovative Stratification of Arrhythmic Risk (ISAR-Trial): Eldery | NCT00196300
Innovative Stratification of Arrhythmic Risk (ISAR-Trial): Female Patients | NCT00196287
Innovative Stratification of Arrhythmic Risk (ISAR-Trial): Long-Term Prediction | NCT00196261
Innovative Stratification of Arrhythmic Risk (ISAR-Trial): Diabetes Mellitus | NCT00196235
Practical challenges of systems thinking and modeling in public health. Am J Public Health (2006) 3.23
Relationship of abnormal heart rate turbulence and elevated CRP to cardiac mortality in low, intermediate, and high-risk older adults. J Cardiovasc Electrophysiol (2010) 1.98
Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction. Eur Heart J (2009) 1.92
Association of Holter-based measures including T-wave alternans with risk of sudden cardiac death in the community-dwelling elderly: the Cardiovascular Health Study. J Electrocardiol (2010) 1.59
Heart rate turbulence parameters correlate with post-premature ventricular contraction changes in muscle sympathetic activity. Heart Rhythm (2006) 1.54
SCD-HeFT: Use of R-R interval statistics for long-term risk stratification for arrhythmic sudden cardiac death. Heart Rhythm (2015) 1.47
Review and classification of variability analysis techniques with clinical applications. Biomed Eng Online (2011) 1.43
Arrhythmia risk stratification based on QT interval instability: an intracardiac electrocardiogram study. Heart Rhythm (2013) 1.42
The Wedensky test predicts malignant ventricular arrhythmias after myocardial infarction. Scand Cardiovasc J (2013) 1.39
Improved Stratification of Autonomic Regulation for risk prediction in post-infarction patients with preserved left ventricular function (ISAR-Risk). Eur Heart J (2008) 1.37
Autonomic aspects of arrhythmogenesis: the enduring and the new. Curr Opin Cardiol (2004) 1.35
Cardiac innervation and sudden cardiac death. Circ Res (2015) 1.29
Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation? Environ Health Perspect (2012) 1.18
Sympathetic-parasympathetic interaction in health and disease: abnormalities and relevance in heart failure. Heart Fail Rev (2011) 1.17
Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation (2005) 1.15
Novel measures of heart rate variability predict cardiovascular mortality in older adults independent of traditional cardiovascular risk factors: the Cardiovascular Health Study (CHS). J Cardiovasc Electrophysiol (2008) 1.14
Heart rate, autonomic markers, and cardiac mortality. Heart Rhythm (2009) 1.11
Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression. Psychosom Med (2010) 1.07
Depression and heart rate variability in patients with coronary heart disease. Cleve Clin J Med (2009) 1.07
Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspective. Heart Rhythm (2008) 1.04
Methods of assessing vagus nerve activity and reflexes. Heart Fail Rev (2011) 0.99
Origin of heart rate variability and turbulence: an appraisal of autonomic modulation of cardiovascular function. Front Physiol (2011) 0.98
Autonomic changes in patients with heart failure and in post-myocardial infarction patients. Heart (2004) 0.98
Heart rate variability and its changes over 5 years in older adults. Age Ageing (2009) 0.96
Postextrasystolic regulation patterns of blood pressure and heart rate in patients with idiopathic dilated cardiomyopathy. J Physiol (2002) 0.96
Role of editing of R-R intervals in the analysis of heart rate variability. Front Physiol (2012) 0.96
Electrocardiologic and related methods of non-invasive detection and risk stratification in myocardial ischemia: state of the art and perspectives. Ger Med Sci (2010) 0.95
Cardiac autonomic function in type 1 and type 2 myotonic dystrophy. Clin Auton Res (2017) 0.94
Reflex and tonic autonomic markers for risk stratification in patients with type 2 diabetes surviving acute myocardial infarction. Diabetes Care (2011) 0.94
Sudden Cardiac Risk Stratification with Electrocardiographic Indices - A Review on Computational Processing, Technology Transfer, and Scientific Evidence. Front Physiol (2016) 0.93
Clinical neurocardiology defining the value of neuroscience-based cardiovascular therapeutics. J Physiol (2016) 0.92
Psychobiology of depression/distress in congestive heart failure. Heart Fail Rev (2008) 0.92
Unstable QT interval dynamics precedes ventricular tachycardia onset in patients with acute myocardial infarction: a novel approach to detect instability in QT interval dynamics from clinical ECG. Circ Arrhythm Electrophysiol (2011) 0.91
Guidelines for Reporting Articles on Psychiatry and Heart rate variability (GRAPH): recommendations to advance research communication. Transl Psychiatry (2016) 0.89
Increased non-gaussianity of heart rate variability predicts cardiac mortality after an acute myocardial infarction. Front Physiol (2011) 0.87
Autonomic dysfunction and risk stratification assessed from heart rate pattern. Open Neurol J (2010) 0.87
Non-invasive evaluation of arrhythmic risk in dilated cardiomyopathy: From imaging to electrocardiographic measures. World J Cardiol (2014) 0.85
Heart rate turbulence: a review. Indian Pacing Electrophysiol J (2003) 0.84
Interplay between heart rate and its variability: a prognostic game. Front Physiol (2014) 0.84
Non-gaussianity of low frequency heart rate variability and sympathetic activation: lack of increases in multiple system atrophy and Parkinson disease. Front Physiol (2012) 0.84
ECG morphological variability in beat space for risk stratification after acute coronary syndrome. J Am Heart Assoc (2014) 0.83
Nonlinear measures of heart rate variability and mortality risk in hemodialysis patients. Clin J Am Soc Nephrol (2012) 0.82
Heart rate variability indices for very short-term (30 beat) analysis. Part 1: survey and toolbox. J Clin Monit Comput (2013) 0.82
Sudden cardiac death risk stratification. Circ Res (2015) 0.81
Heart rate variability and non-linear dynamics in risk stratification. Front Physiol (2011) 0.81
Phase-rectified signal averaging as a sensitive index of autonomic changes with aging. J Appl Physiol (1985) (2010) 0.80
Clinical and haemodynamic correlates of heart rate turbulence as a non-invasive index of baroreflex sensitivity in chronic heart failure. Clin Sci (Lond) (2011) 0.80
Heart rhythm turbulence and NT-proBNP in decompensated liver cirrhosis--a pilot study. Med Sci Monit (2011) 0.80
Postextrasystolic blood pressure potentiation predicts poor outcome of cardiac patients. J Am Heart Assoc (2014) 0.80
Usefulness of the heart-rate variability complex for predicting cardiac mortality after acute myocardial infarction. BMC Cardiovasc Disord (2014) 0.80
Heart rate turbulence as risk-predictor after myocardial infarction. Front Physiol (2011) 0.80
Influence of home-based telemonitored Nordic walking training on autonomic nervous system balance in heart failure patients. Arch Med Sci (2015) 0.79
Noninvasive risk stratification after myocardial infarction: rationale, current evidence and the need for definitive trials. Can J Cardiol (2009) 0.79
Renaissance in electrocardiography. Lancet (1999) 0.79
New methods for the analysis of heartbeat behavior in risk stratification. Front Physiol (2011) 0.78
Exercise training preserves vagal preganglionic neurones and restores parasympathetic tonus in heart failure. J Physiol (2016) 0.77
Computer software tool for heart rate variability (HRV), T-wave alternans (TWA) and heart rate turbulence (HRT) analysis from ECGs. Med Sci Monit (2011) 0.77
Pharmacologic modulation of parasympathetic activity in heart failure. Heart Fail Rev (2011) 0.77
Ambulatory ECG-based T-wave alternans and heart rate turbulence can predict cardiac mortality in patients with myocardial infarction with or without diabetes mellitus. Cardiovasc Diabetol (2012) 0.77
Spontaneous baroreflex sensitivity and heart rate turbulence parameters: parallel responses to orthostasis. Clin Auton Res (2008) 0.77
Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop. Europace (2015) 0.77
Short-term heart rate turbulence analysis versus variability and baroreceptor sensitivity in patients with dilated cardiomyopathy. Indian Pacing Electrophysiol J (2004) 0.76
The St. Louis African American health-heart study: methodology for the study of cardiovascular disease and depression in young-old African Americans. BMC Cardiovasc Disord (2013) 0.76
Prognostic value of heart rate turbulence for risk assessment in patients with unstable angina and non-ST elevation myocardial infarction. Vasc Health Risk Manag (2013) 0.76
Heart rate turbulence and deceleration capacity for risk prediction of serious arrhythmic events in Marfan syndrome. Clin Res Cardiol (2015) 0.76
Acute Changes in Ambient Temperature Are Associated With Adverse Changes in Cardiac Rhythm. Air Qual Atmos Health (2014) 0.76
Severe autonomic failure in moderate to severe aortic stenosis: prevalence and association with hemodynamics and biomarkers. Clin Res Cardiol (2012) 0.75
Evaluation of cardiac autonomic function by various indices in patients with primary premature ovarian failure. Clin Res Cardiol (2012) 0.75
HRVanalysis: A Free Software for Analyzing Cardiac Autonomic Activity. Front Physiol (2016) 0.75
Implications of turbulence slope variations in different approaches. Heart Int (2011) 0.75
Increased ventricular premature contraction frequency during rem sleep in patients with coronary artery disease and obstructive sleep apnea. Indian Pacing Electrophysiol J (2008) 0.75
Rationale and study design of the prospective, longitudinal, observational cohort study "rISk strAtification in end-stage renal disease" (ISAR) study. BMC Nephrol (2016) 0.75
Heart rate turbulence and variability in patients with ventricular arrhythmias. Heart Int (2007) 0.75
Heart Rate Turbulence Analysis in Subclinical Hypothroidism Heart Rate Turbulence in Hypothyroidism. Zhonghua Minguo Xin Zang Xue Hui Za Zhi (2015) 0.75
Positive Psychotherapy to Improve Autonomic Function and Mood in ICD Patients (PAM-ICD): Rationale and Design of an RCT Currently Underway. Pacing Clin Electrophysiol (2016) 0.75
Impact of sleep-disordered breathing on heart rate turbulence in heart failure patients. PLoS One (2014) 0.75
Heart rate turbulence analysis in female patients with fibromyalgia. Clinics (Sao Paulo) (2015) 0.75
Periodic Repolarisation Dynamics: A Natural Probe of the Ventricular Response to Sympathetic Activation. Arrhythm Electrophysiol Rev (2016) 0.75
Assessment of heart rate turbulence in hypertensive patients: rationale, perspectives, and insight into autonomic nervous system dysfunction. Heart Views (2014) 0.75
[Ischemic cardiomyopathy. Parameters of the autonomic tone]. Herzschrittmacherther Elektrophysiol (2015) 0.75
[Long term electrocardiography (Holter monitoring)]. Herzschrittmacherther Elektrophysiol (2008) 0.75
Autonomic effects of spironolactone and MR blockers in heart failure. Heart Fail Rev (2005) 0.75
Heart rate turbulence for guiding electric therapy in patients with cardiac failure. J Clin Monit Comput (2010) 0.75
Retracted Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet (1998) 36.93
Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins (1991) 32.50
Selection of representative protein data sets. Protein Sci (1992) 15.62
The HSSP database of protein structure-sequence alignments and family profiles. Nucleic Acids Res (1998) 9.59
Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol (1987) 9.10
Cardiopulmonary resuscitation skills of preregistration house officers. Br Med J (Clin Res Ed) (1985) 8.45
Rb targets histone H3 methylation and HP1 to promoters. Nature (2001) 8.26
Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology (1997) 7.81
PHD--an automatic mail server for protein secondary structure prediction. Comput Appl Biosci (1994) 6.71
Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ (1995) 6.28
A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med (1996) 6.05
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial--the Losartan Heart Failure Survival Study ELITE II. Lancet (2000) 5.42
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res (2003) 5.39
Correlated mutations and residue contacts in proteins. Proteins (1994) 5.20
Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry (2001) 5.16
Prophylactic use of implanted cardiac defibrillators in patients at high risk for ventricular arrhythmias after coronary-artery bypass graft surgery. Coronary Artery Bypass Graft (CABG) Patch Trial Investigators. N Engl J Med (1997) 4.85
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (2001) 4.18
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature (1988) 4.04
The intern and sleep loss. N Engl J Med (1971) 3.45
Differences in genotypes of Helicobacter pylori from different human populations. J Bacteriol (2000) 3.39
Relation of Helicobacter pylori infection and coronary heart disease. Br Heart J (1994) 3.13
DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage. J Mol Biol (1996) 3.08
Concerns about game ranching. Can Vet J (1990) 3.07
Dofetilide in patients with congestive heart failure and left ventricular dysfunction. Danish Investigations of Arrhythmia and Mortality on Dofetilide Study Group. N Engl J Med (1999) 2.99
Renal cell cancer correlated with occupational exposure to trichloroethene. J Cancer Res Clin Oncol (1998) 2.96
Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction. Circulation (1997) 2.95
Task Force on Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J (2001) 2.93
Chlamydia pneumoniae and coronary heart disease. BMJ (1997) 2.73
Colour Doppler flow mapping. BMJ (1990) 2.69
Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch Toxicol (1995) 2.64
Phytoremediation of soil metals. Curr Opin Biotechnol (1997) 2.60
Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J Biol Chem (2000) 2.58
Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature (1994) 2.57
Left atrial appendage: structure, function, and role in thromboembolism. Heart (1999) 2.52
Protein fold recognition by prediction-based threading. J Mol Biol (1997) 2.51
Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart (1997) 2.50
Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation (2001) 2.50
A sensitive and rapid gel retention assay for nuclear factor I and other DNA-binding proteins in crude nuclear extracts. Nucleic Acids Res (1986) 2.45
The relationships among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation (1984) 2.45
Cost implications of the British Pacing and Electrophysiology Group's recommendations for pacing. BMJ (1992) 2.42
Risk stratification for arrhythmic events in postinfarction patients based on heart rate variability, ambulatory electrocardiographic variables and the signal-averaged electrocardiogram. J Am Coll Cardiol (1991) 2.42
Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients. Crit Care Med (1999) 2.35
Progress in protein structure prediction? Trends Biochem Sci (1993) 2.34
Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO) trial. Circulation (2001) 2.34
Pathophysiology and prevention of atrial fibrillation. Circulation (2001) 2.31
Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol (1998) 2.28
The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens. Eur Heart J (1998) 2.28
Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval. Heart (2002) 2.23
The QT interval. Prog Cardiovasc Dis (2001) 2.22
Short- and long-term reproducibility of QT, QTc, and QT dispersion measurement in healthy subjects. Pacing Clin Electrophysiol (1994) 2.21
Increased neutrophil-platelet adhesion in patients with unstable angina. Circulation (1996) 2.20
The use of a token system in project Head Start. J Appl Behav Anal (1970) 2.20
Atrial arrhythmias. Lancet (1993) 2.13
Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst (1968) 2.08
Bacterial community associated with Pfiesteria-like dinoflagellate cultures. Environ Microbiol (2001) 2.06
Maintenance of sinus rhythm after electrical cardioversion of persistent atrial fibrillation; sotalol vs bisoprolol. Eur Heart J (2001) 2.06
Electrophysiological effects of diphenylhydantoin on canine purkinje fibers. Circ Res (1968) 2.05
MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nat Genet (2001) 2.04
The rhythm of the heart in active elderly subjects. Am Heart J (1980) 2.02
Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Saf (2001) 2.02
Complete denervation of the heart in a child with congenital long QT and deafness. Am J Cardiol (1988) 2.00
First pass annotation of promoters on human chromosome 22. Genome Res (2001) 1.99
Cardiac arrhythmia suppression trial and flecainide. Lancet (1989) 1.98
Urokinase (uPA) and its inhibitor PAI-1 are strong and independent prognostic factors in node-negative breast cancer. Breast Cancer Res Treat (1993) 1.97
A supernova origin for dust in a high-redshift quasar. Nature (2004) 1.97
Electrophysiologial and beta-receptor blocking effects of MJ 1999 on dog and rabbit cardiac tissue. Circ Res (1970) 1.96
Adjuvant xamoterol or metoprolol in patients with malignant ventricular arrhythmia resistant to amiodarone. Lancet (1989) 1.96
The HSSP database of protein structure-sequence alignments. Nucleic Acids Res (1994) 1.96
Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells. Circulation (1998) 1.95
Accuracy of endoscopic ultrasonography in upper gastrointestinal submucosal lesions: a prospective multicenter study. Scand J Gastroenterol (2002) 1.94
The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology. Eur Heart J (2000) 1.92
Clinical features and outcome of pediatric Wegener's granulomatosis. Arthritis Rheum (2007) 1.91
Components of heart rate variability--what they really mean and what we really measure. Am J Cardiol (1993) 1.91
Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. J Mol Biol (1999) 1.90
Homeopathic proving symptoms: result of a local, non-local, or placebo process? A blinded, placebo-controlled pilot study. Homeopathy (2004) 1.88
Deletion of self-reactive T cells before entry into the thymus medulla. Nature (1988) 1.88
Positive selection of CD4+ thymocytes controlled by MHC class II gene products. Nature (1988) 1.86
Gluten subfractions in coeliac disease. Lancet (1972) 1.86
Premature atrial stimulation as a key to the understanding of sinoatrial conduction in man. Presentation of data and critical review of the literature. Circulation (1973) 1.85
Comparison of 24-hour parasympathetic activity in endurance-trained and untrained young men. J Am Coll Cardiol (1992) 1.85
Predictive factors of restenosis after coronary stent placement. J Am Coll Cardiol (1997) 1.84
Redefining the goals of protein secondary structure prediction. J Mol Biol (1994) 1.84
Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy. Thromb Haemost (1997) 1.78
Osteoid osteomas of the femoral neck: report of four cases evaluated with isotopic bone scanning, CT, and MR imaging. Radiology (1993) 1.76
Platelet function in acute myocardial infarction treated with direct angioplasty. Circulation (1996) 1.75
Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor. Proc Natl Acad Sci U S A (1988) 1.75
Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology. Mol Microbiol (1995) 1.74
Risk of patent foramen ovale for thromboembolic events in all age groups. Am J Cardiol (1992) 1.74