MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.

PubWeight™: 2.04‹?› | Rank: Top 2%

🔗 View Article (PMID 11685209)

Published in Nat Genet on November 01, 2001

Authors

A Trockenbacher1, V Suckow, J Foerster, J Winter, S Krauss, H H Ropers, R Schneider, S Schweiger

Author Affiliations

1: Institute of Biochemistry, Peter-Mayr-Strasse 1a, 6020 Innsbruck, Austria.

Articles citing this

TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol (2008) 4.21

The interferon response inhibits HIV particle production by induction of TRIM22. PLoS Pathog (2008) 2.06

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved. Proc Natl Acad Sci U S A (2008) 1.72

Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence? Immunology (2005) 1.68

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. BMC Evol Biol (2008) 1.59

Alpha4 is an essential regulator of PP2A phosphatase activity. Mol Cell (2009) 1.55

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A (2010) 1.46

Morphogenesis of the C. elegans Intestine Involves Axon Guidance Genes. PLoS Genet (2016) 1.41

Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am J Hum Genet (2007) 1.41

The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD. Mol Biol Cell (2007) 1.33

Degradation of postsynaptic scaffold GKAP and regulation of dendritic spine morphology by the TRIM3 ubiquitin ligase in rat hippocampal neurons. PLoS One (2010) 1.28

Targeting protein serine/threonine phosphatases for drug development. Mol Pharmacol (2009) 1.25

Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development. Oncogene (2010) 1.21

The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nat Med (2013) 1.20

Regulation of the MID1 protein function is fine-tuned by a complex pattern of alternative splicing. Hum Genet (2004) 1.12

E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). Proc Natl Acad Sci U S A (2005) 1.11

The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. Dev Cell (2010) 1.10

Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5alpha. Virology (2007) 1.09

Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. BMC Cell Biol (2004) 1.08

Alpha4 is a ubiquitin-binding protein that regulates protein serine/threonine phosphatase 2A ubiquitination. Biochemistry (2010) 1.06

Control of mTORC1 signaling by the Opitz syndrome protein MID1. Proc Natl Acad Sci U S A (2011) 1.05

TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells. Oncogene (2010) 1.04

The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in Drosophilia. Genetics (2005) 1.02

The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. J Biol Chem (2011) 1.02

Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia. PLoS One (2009) 1.02

The Opitz syndrome gene product MID1 assembles a microtubule-associated ribonucleoprotein complex. Hum Genet (2008) 1.00

Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PLoS One (2008) 0.99

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex. Nat Commun (2013) 0.99

TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP). J Biol Chem (2011) 0.98

Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3. Mol Cell Biol (2007) 0.97

Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover. Dev Biol (2010) 0.96

Duplication of the MID1 first exon in a patient with Opitz G/BBB syndrome. Hum Genet (2003) 0.96

Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. Eur J Hum Genet (2008) 0.95

Increasing expression and decreasing degradation of SMN ameliorate the spinal muscular atrophy phenotype in mice. Hum Mol Genet (2011) 0.94

Mechanisms of RNA-induced toxicity in CAG repeat disorders. Cell Death Dis (2013) 0.91

The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila. Genetics (2005) 0.89

Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation. J Biol Chem (2012) 0.89

Vegetally localized Xenopus trim36 regulates cortical rotation and dorsal axis formation. Development (2009) 0.89

Μyospryn: a multifunctional desmin-associated protein. Histochem Cell Biol (2013) 0.89

Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1). J Biol Chem (2011) 0.88

Alternative polyadenylation signals and promoters act in concert to control tissue-specific expression of the Opitz Syndrome gene MID1. BMC Mol Biol (2007) 0.88

Adaptive responses of androgen receptor signaling in castration-resistant prostate cancer. Oncotarget (2015) 0.87

Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation. Cell Death Dis (2014) 0.87

Point mutations in GLI3 lead to misregulation of its subcellular localization. PLoS One (2009) 0.86

The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A. J Biol Chem (2013) 0.84

The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex. PLoS One (2014) 0.84

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells. BMC Cancer (2014) 0.83

Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella. J Biol Chem (2011) 0.83

Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus. Brain Res (2014) 0.82

MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac. PLoS One (2014) 0.81

The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division. Cell Rep (2015) 0.80

The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu. J Biol Chem (2014) 0.80

A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling. Mol Cancer (2014) 0.80

The role of Cullin3-mediated ubiquitination of the catalytic subunit of PP2A in TRAIL signaling. Cell Cycle (2014) 0.79

Microcystin-LR (MCLR) induces a compensation of PP2A activity mediated by α4 protein in HEK293 cells. Int J Biol Sci (2011) 0.79

NMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2A. PLoS One (2011) 0.78

Genotype phenotype correlation of 30 patients with Smith-Magenis syndrome (SMS) using comparative genome hybridisation array: cleft palate in SMS is associated with larger deletions. J Med Genet (2007) 0.78

X-linked microtubule-associated protein, Mid1, regulates axon development. Proc Natl Acad Sci U S A (2013) 0.78

De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP. Int J Physiol Pathophysiol Pharmacol (2014) 0.78

Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia. Clin Lymphoma Myeloma Leuk (2014) 0.77

XLOS-observed mutations of MID1 Bbox1 domain cause domain unfolding. PLoS One (2014) 0.77

17β-estradiol modulates gene expression in the female mouse cerebral cortex. PLoS One (2014) 0.76

The ubiquitin E3 ligase NOSIP modulates protein phosphatase 2A activity in craniofacial development. PLoS One (2014) 0.76

Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast. BMC Syst Biol (2017) 0.75

Protein monoubiquitylation: targets and diverse functions. Genes Cells (2015) 0.75

Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice. Front Mol Neurosci (2012) 0.75

Mid1/Mid2 expression in craniofacial development and a literature review of X-linked opitz syndrome. Mol Genet Genomic Med (2015) 0.75

Midline 1 controls polarization and migration of murine cytotoxic T cells. Immun Inflamm Dis (2015) 0.75

Regulation of mRNA Translation by MID1: A Common Mechanism of Expanded CAG Repeat RNAs. Front Cell Neurosci (2016) 0.75

Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development. Proc Natl Acad Sci U S A (2016) 0.75

Molecular dynamics simulation reveals insights into the mechanism of unfolding by the A130T/V mutations within the MID1 zinc-binding Bbox1 domain. PLoS One (2015) 0.75

Activation of cancerous inhibitor of PP2A (CIP2A) contributes to lapatinib resistance through induction of CIP2A-Akt feedback loop in ErbB2-positive breast cancer cells. Oncotarget (2017) 0.75

Articles by these authors

Database of homology-derived protein structures and the structural meaning of sequence alignment. Proteins (1991) 32.50

Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus. Lancet (1998) 16.30

Selection of representative protein data sets. Protein Sci (1992) 15.62

Avian-to-human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics. J Virol (1989) 10.63

The HSSP database of protein structure-sequence alignments and family profiles. Nucleic Acids Res (1998) 9.59

Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong? Proc Natl Acad Sci U S A (1999) 8.62

Molecular basis for the generation in pigs of influenza A viruses with pandemic potential. J Virol (1998) 8.44

Rb targets histone H3 methylation and HP1 to promoters. Nature (2001) 8.26

Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology (1998) 7.99

Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol (1999) 7.72

Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc Natl Acad Sci U S A (2005) 7.12

PHD--an automatic mail server for protein secondary structure prediction. Comput Appl Biosci (1994) 6.71

Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc Natl Acad Sci U S A (2002) 6.17

Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. Proc Natl Acad Sci U S A (2000) 5.36

Correlated mutations and residue contacts in proteins. Proteins (1994) 5.20

H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern China. J Virol (2000) 5.17

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell (2001) 5.13

Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science (1993) 5.05

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell (2001) 4.58

H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificity. Virology (2001) 4.46

Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia. Virology (2000) 4.37

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (2001) 4.18

T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens. Nature (1988) 4.04

Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet (1998) 4.01

Toward early diagnosis of myotonic dystrophy: construction and characterization of a somatic cell hybrid with a single human der(19) chromosome. Cytogenet Cell Genet (1986) 3.76

Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus. Cell (1995) 3.72

Cell-type-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture. Brain Res (1979) 3.66

Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet (1996) 3.53

Differences in genotypes of Helicobacter pylori from different human populations. J Bacteriol (2000) 3.39

Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet (1999) 3.38

Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1? J Virol (2000) 3.35

Cloning of a gene that is rearranged in patients with choroideraemia. Nature (1990) 3.21

Concerns about game ranching. Can Vet J (1990) 3.07

Report of the Committee on the Genetic Constitution of the X and Y Chromosomes. Cytogenet Cell Genet (1985) 3.07

Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22. Nat Genet (1997) 3.03

Origin and molecular changes associated with emergence of a highly pathogenic H5N2 influenza virus in Mexico. Virology (1995) 2.99

Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection. J Infect Dis (1999) 2.76

Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids. Am J Hum Genet (1984) 2.58

Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J Biol Chem (2000) 2.58

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3) J Clin Invest (2000) 2.57

Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature (1994) 2.57

Protein fold recognition by prediction-based threading. J Mol Biol (1997) 2.51

Molecular analysis of male-viable deletions and duplications allows ordering of 52 DNA probes on proximal Xq. Am J Hum Genet (1988) 2.47

A sensitive and rapid gel retention assay for nuclear factor I and other DNA-binding proteins in crude nuclear extracts. Nucleic Acids Res (1986) 2.45

Emergence of avian H1N1 influenza viruses in pigs in China. J Virol (1996) 2.44

Association between X-linked mixed deafness and mutations in the POU domain gene POU3F4. Science (1995) 2.38

Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience (1994) 2.36

Fluconazole prophylaxis prevents intra-abdominal candidiasis in high-risk surgical patients. Crit Care Med (1999) 2.35

Molecular changes associated with the transmission of avian influenza a H5N1 and H9N2 viruses to humans. J Med Virol (2002) 2.35

Progress in protein structure prediction? Trends Biochem Sci (1993) 2.34

Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nat Genet (1998) 2.34

Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol (1998) 2.28

The use of a token system in project Head Start. J Appl Behav Anal (1970) 2.20

Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Neurosci (1988) 2.18

Respiratory medicine: fighting for survival. BMJ (1992) 2.15

MECP2 is highly mutated in X-linked mental retardation. Hum Mol Genet (2001) 2.12

Contribution of interleukin-1 beta to the inflammation-induced increase in nerve growth factor levels and inflammatory hyperalgesia. Br J Pharmacol (1995) 2.12

Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Nat Genet (2000) 2.10

Antimicrobial resistance and R-factor transfer among isolates of Salmonella in the northeastern United States: a comparison of human and animal isolates. J Infect Dis (1975) 2.09

Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst (1968) 2.08

Emergence of H3N2 reassortant influenza A viruses in North American pigs. Vet Microbiol (2000) 2.06

Bacterial community associated with Pfiesteria-like dinoflagellate cultures. Environ Microbiol (2001) 2.06

First pass annotation of promoters on human chromosome 22. Genome Res (2001) 1.99

Outbreak of Legionnaires' disease in Glasgow Royal Infirmary: microbiological aspects. J Hyg (Lond) (1986) 1.99

Continued evolution of H1N1 and H3N2 influenza viruses in pigs in Italy. Virology (1997) 1.98

Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture. J Cell Biol (1980) 1.98

A supernova origin for dust in a high-redshift quasar. Nature (2004) 1.97

A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation. Nat Genet (2000) 1.97

The HSSP database of protein structure-sequence alignments. Nucleic Acids Res (1994) 1.96

Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome. Nature (1983) 1.94

Clinical features and outcome of pediatric Wegener's granulomatosis. Arthritis Rheum (2007) 1.91

Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1. Hum Mol Genet (1996) 1.90

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. J Mol Biol (1999) 1.90

Quantitative imaging study of extent of surgical resection and prognosis of malignant astrocytomas. Neurosurgery (1997) 1.90

Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 trial. J Natl Cancer Inst Monogr (1992) 1.89

Homeopathic proving symptoms: result of a local, non-local, or placebo process? A blinded, placebo-controlled pilot study. Homeopathy (2004) 1.88

Deletion of self-reactive T cells before entry into the thymus medulla. Nature (1988) 1.88

Assignment by deletion mapping of the steroid sulfatase X-linked ichthyosis locus to Xp223. Hum Genet (1980) 1.87

Positive selection of CD4+ thymocytes controlled by MHC class II gene products. Nature (1988) 1.86

Gluten subfractions in coeliac disease. Lancet (1972) 1.86

Transfer of responsiveness to hapten conjugates of poly-L-lysine and of a copolymer of L-glutamic acid and L-lysine to lethally irradiated nonresponder guinea pigs by bone marrow or lymph node and spleen cells from responder guinea pigs. J Exp Med (1969) 1.86

Transmission of Eurasian avian H2 influenza virus to shorebirds in North America. J Gen Virol (1999) 1.85

The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans. Nat Genet (1993) 1.84

The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. Hum Mol Genet (2000) 1.84

Redefining the goals of protein secondary structure prediction. J Mol Biol (1994) 1.84

Complete degradation of carbohydrate to carbon dioxide and methane by syntrophic cultures of Acetobacterium woodii and Methanosarcina barkeri. Arch Microbiol (1979) 1.79

Prader-Willi syndrome and Angelman syndrome in cousins from a family with a translocation between chromosomes 6 and 15. N Engl J Med (1992) 1.78

Role of beta-catenin in the developing cortical and hippocampal neuroepithelium. Neuroscience (2003) 1.78

Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion. Hum Mol Genet (2000) 1.78

First evidence of pep solar neutrinos by direct detection in Borexino. Phys Rev Lett (2012) 1.77

Cerebral metabolism and atrophy in Huntington's disease determined by 18FDG and computed tomographic scan. Ann Neurol (1982) 1.77

Osteoid osteomas of the femoral neck: report of four cases evaluated with isotopic bone scanning, CT, and MR imaging. Radiology (1993) 1.76

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Neuroscience (2005) 1.76

Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor. Proc Natl Acad Sci U S A (1988) 1.75

Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology. Mol Microbiol (1995) 1.74

Molecular basis of choroideremia (CHM): mutations involving the Rab escort protein-1 (REP-1) gene. Hum Mutat (1997) 1.74

Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice. J Virol (1999) 1.71

A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nat Genet (1999) 1.68

Identification of a hot spot for microdeletions in patients with X-linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4. Hum Mol Genet (1996) 1.67