Published in Development on June 01, 1999
Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci (2001) 11.40
Molecular determinants of the face map development in the trigeminal brainstem. Anat Rec A Discov Mol Cell Evol Biol (2006) 1.02
Differential effects of NGF and NT-3 on embryonic trigeminal axon growth patterns. J Comp Neurol (2000) 0.91
BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo. BMC Dev Biol (2007) 0.89
Peripheral somatosensation: a touch of genetics. Curr Opin Genet Dev (2011) 0.87
New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am J Pathol (2000) 0.87
Nerve injury induces glial cell line-derived neurotrophic factor (GDNF) expression in Schwann cells through purinergic signaling and the PKC-PKD pathway. Glia (2013) 0.85
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. Oncotarget (2016) 0.78
Activation by GDNF of a transcriptional program repressing neurite growth in dorsal root ganglia. Proc Natl Acad Sci U S A (2001) 0.77
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 9.19
The integrated state of viral DNA in SV40-transformed cells. Proc Natl Acad Sci U S A (1968) 8.38
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science (2000) 5.44
Viral DNA in polyoma- and SV40-transformed cell lines. Proc Natl Acad Sci U S A (1968) 4.24
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
SV40 DNA strand selection by Escherichia coli RNA polymerase. J Mol Biol (1970) 3.77
Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62
Sonic hedgehog is essential to foregut development. Nat Genet (1998) 3.50
Oncogenesis of the lens in transgenic mice. Science (1987) 3.40
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27
Spliced adenovirus-associated virus RNA. Proc Natl Acad Sci U S A (1979) 2.99
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol (1998) 2.94
Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med (1997) 2.79
The structure of adenovirus 2 early nuclear and cytoplasmic RNAs. J Mol Biol (1980) 2.74
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A (1998) 2.71
E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA. Mol Cell Biol (1985) 2.68
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development (1997) 2.66
Functions of LIM-homeobox genes. Trends Genet (2000) 2.66
Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet (1995) 2.64
Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA. Proc Natl Acad Sci U S A (1977) 2.60
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell (1998) 2.50
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
A cascade of adenovirus early functions is required for expression of adeno-associated virus. Cell (1981) 2.33
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Learning deficit in BDNF mutant mice. Eur J Neurosci (1997) 2.20
Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science (1996) 2.18
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science (1993) 2.06
Length measurements of RNA synthesized in vitro by Escherichia coli RNA polymerase. J Mol Biol (1973) 2.02
Distinct but overlapping roles of histone acetylase PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis. Proc Natl Acad Sci U S A (2000) 1.99
An enhancer/locus control region is not sufficient to open chromatin. Mol Cell Biol (1993) 1.93
Functions of purified E1A protein microinjected into mammalian cells. Proc Natl Acad Sci U S A (1984) 1.92
Intervening polyadenylate sequences in RNA transcripts of vesicular stomatitis virus. Cell (1978) 1.92
Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type-1a mouse. Nat Genet (1996) 1.88
Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice. New Biol (1989) 1.82
Site-independent expression of the chicken beta A-globin gene in transgenic mice. Nature (1991) 1.82
Multistep control of pituitary organogenesis. Science (1997) 1.82
Formation of Rathke's pouch requires dual induction from the diencephalon. Development (1998) 1.68
Targeting bacteriophage T7 RNA polymerase to the mammalian cell nucleus. Gene (1988) 1.67
Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res (1992) 1.64
Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences. Science (1986) 1.64
The LIM homeobox gene Lhx9 is essential for mouse gonad formation. Nature (2000) 1.61
Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice. J Clin Invest (1998) 1.59
Mapping of adenovirus messenger RNA by electron microscopy. Proc Natl Acad Sci U S A (1976) 1.56
Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A (1999) 1.54
Mapping of functional domains in adenovirus E1A proteins. Proc Natl Acad Sci U S A (1985) 1.53
Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol Endocrinol (1998) 1.52
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience (1992) 1.52
Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature (1993) 1.51
Timing of SV40 oncogene activation by site-specific recombination determines subsequent tumor progression during murine lens development. Oncogene (1993) 1.51
Use of the Cre/lox recombination system to develop a non-lethal knock-in murine model for osteogenesis imperfecta with an alpha1(I) G349C substitution. Variability in phenotype in BrtlIV mice. J Biol Chem (1999) 1.50
A milk protein gene promoter directs the expression of human tissue plasminogen activator cDNA to the mammary gland in transgenic mice. Proc Natl Acad Sci U S A (1988) 1.49
Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice. Proc Natl Acad Sci U S A (1991) 1.48
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice. Proc Natl Acad Sci U S A (1996) 1.48
Interactions between LIM domains and the LIM domain-binding protein Ldb1. J Biol Chem (1998) 1.47
Requirement for either early region 1a or early region 1b adenovirus gene products in the helper effect for adeno-associated virus. J Virol (1984) 1.45
Electron microscopy of late adenovirus type 2 mRNA hybridized to double-stranded viral DNA. J Virol (1977) 1.45
Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. Proc Natl Acad Sci U S A (2000) 1.44
MyoD and myogenin are coexpressed in regenerating skeletal muscle of the mouse. Dev Dyn (1992) 1.41
Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature (1995) 1.41
Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet (1997) 1.41
Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Dev Biol (1997) 1.40
Quantitative electron microscopy of early adenovirus RNA. J Mol Biol (1977) 1.40
Lingual deficits in BDNF and NT3 mutant mice leading to gustatory and somatosensory disturbances, respectively. Development (1997) 1.38
Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin. Science (1997) 1.37
Localization of brain-derived neurotrophic factor mRNA to neurons in the brain by in situ hybridization. Exp Neurol (1990) 1.37
Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Mol Cell Biol (1990) 1.36
Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. Science (1999) 1.35
Cell-free synthesis of adenovirus coat proteins. J Biol Chem (1974) 1.34
Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.34
Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile. Development (1996) 1.33
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med (1999) 1.31
Suppressed epileptogenesis in BDNF mutant mice. Exp Neurol (1995) 1.30
Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Dev Biol (1998) 1.29
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma. Proc Natl Acad Sci U S A (1992) 1.29
Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease. Proc Natl Acad Sci U S A (1994) 1.28
Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse. Eur J Neurosci (1997) 1.26
Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1992) 1.24
Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev Dyn (1994) 1.24
Vero cells injected with adenovirus type 2 mRNA produce authentic viral polypeptide patterns: early mRNA promotes growth of adenovirus-associated virus. Proc Natl Acad Sci U S A (1980) 1.23
Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure. Proc Natl Acad Sci U S A (1998) 1.23
A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta -globin locus. Proc Natl Acad Sci U S A (2000) 1.23
Environmental enrichment and the brain. Prog Brain Res (2002) 1.20
Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons. J Neurosci (2000) 1.19
Adenovirus early gene regulation and the adeno-associated virus helper effect. Curr Top Microbiol Immunol (1984) 1.17
Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice. J Neurosci (1996) 1.17
Prenatal lethality in a transgenic mouse line is the result of a chromosomal translocation. Proc Natl Acad Sci U S A (1988) 1.17
The human immunodeficiency virus long terminal repeat is preferentially expressed in Langerhans cells in transgenic mice. AIDS Res Hum Retroviruses (1989) 1.17
Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Nucleic Acids Res (1988) 1.15
Targeting of the T-cell receptor zeta-chain gene in embryonic stem cells: strategies for generating multiple mutations in a single gene. Proc Natl Acad Sci U S A (1992) 1.14
Role for GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron (2000) 1.14
Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: responses to injury and infusion of NGF. J Neurosci (1992) 1.14
Disruption of dopamine D1 receptor gene expression attenuates alcohol-seeking behavior. Eur J Pharmacol (1998) 1.14
Increased production of the TrkB protein tyrosine kinase receptor after brain insults. Neuron (1993) 1.13