Published in Nucleic Acids Res on February 25, 1988
Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 9.19
Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proc Natl Acad Sci U S A (1991) 2.16
Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice. Proc Natl Acad Sci U S A (1989) 1.69
Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Mol Cell Biol (1990) 1.36
Efficient production of human immunodeficiency virus proteins in transgenic mice. J Virol (1992) 0.90
UV activation of human immunodeficiency virus gene expression in transgenic mice. J Virol (1992) 0.75
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III). Science (1985) 12.75
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA. Cell (1986) 12.74
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator protein. Cell (1987) 11.15
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell (1986) 10.71
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III. Science (1985) 10.36
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product. Nature (1988) 10.15
Germ-line transformation of mice. Annu Rev Genet (1986) 8.67
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science (1985) 6.51
Expression and characterization of the trans-activator of HTLV-III/LAV virus. Science (1986) 5.15
Trans-activation of the human immunodeficiency virus long terminal repeat sequence by DNA viruses. Proc Natl Acad Sci U S A (1986) 4.89
The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science (1987) 4.01
Oncogenesis of the lens in transgenic mice. Science (1987) 3.40
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Three novel genes of human T-lymphotropic virus type III: immune reactivity of their products with sera from acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A (1986) 2.16
A transgenic mouse model for human neurofibromatosis. Science (1987) 2.05
Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia. Proc Natl Acad Sci U S A (1985) 1.65
Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.34
Differential effects of polyadenylation regions on gene expression in mammalian cells. DNA (1986) 1.24
Regulatory sequences involved in the promotion and termination of RNA transcription. Annu Rev Genet (1979) 54.83
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature (1998) 24.69
Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A (1996) 12.92
The antigenic structure of the HIV gp120 envelope glycoprotein. Nature (1998) 12.44
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci U S A (1992) 9.19
The integrated state of viral DNA in SV40-transformed cells. Proc Natl Acad Sci U S A (1968) 8.38
A system to study promoter and terminator signals recognized by Escherichia coli RNA polymerase. Gene Amplif Anal (1981) 8.21
Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol (1995) 7.12
A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure (2000) 5.57
Regulation of cell fate decision of undifferentiated spermatogonia by GDNF. Science (2000) 5.44
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science (2001) 5.40
The relationship between function and DNA sequence in an intercistronic regulatory region in phage lambda. Nature (1978) 5.38
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet (1995) 5.02
Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature (1984) 4.61
Purified lambda regulatory protein cII positively activates promoters for lysogenic development. Nature (1981) 4.60
Energetics of the HIV gp120-CD4 binding reaction. Proc Natl Acad Sci U S A (2000) 4.44
Termination of transcription in E. coli. Cell (1983) 4.42
Binding of soluble CD4 proteins to human immunodeficiency virus type 1 and infected cells induces release of envelope glycoprotein gp120. Proc Natl Acad Sci U S A (1991) 4.40
Efficient expression of Escherichia coli galactokinase gene in mammalian cells. Proc Natl Acad Sci U S A (1982) 4.25
Viral DNA in polyoma- and SV40-transformed cell lines. Proc Natl Acad Sci U S A (1968) 4.24
Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem (1992) 4.22
Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med (1977) 4.14
Efficient translation of prokaryotic mRNAs in a eukaryotic cell-free system requires addition of a cap structure. Nature (1979) 4.11
The use of pKc30 and its derivatives for controlled expression of genes. Methods Enzymol (1983) 3.90
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem (1998) 3.88
Defects in enteric innervation and kidney development in mice lacking GDNF. Nature (1996) 3.82
Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells. Cell (1984) 3.81
SV40 DNA strand selection by Escherichia coli RNA polymerase. J Mol Biol (1970) 3.77
Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor. Proc Natl Acad Sci U S A (1987) 3.72
Termination of transcription in bacteriophage lambda. Heterogeneous, 3'-terminal oligo-adenylate additions and the effects of rho factor. J Biol Chem (1975) 3.71
Identification of the residues in human CD4 critical for the binding of HIV. Cell (1989) 3.71
Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62
Surveillance and prevention of residential-fire injuries. N Engl J Med (1996) 3.60
Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon. Cell (1982) 3.56
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature (1989) 3.54
Sonic hedgehog is essential to foregut development. Nat Genet (1998) 3.50
A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol Microbiol (2000) 3.50
Oncogenesis of the lens in transgenic mice. Science (1987) 3.40
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell (2001) 3.30
Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN. Science (1978) 3.29
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci U S A (1997) 3.27
Expression and characterization of the human c-myc DNA-binding protein. Mol Cell Biol (1985) 3.24
Constitutive function of a positively regulated promoter reveals new sequences essential for activity. J Biol Chem (1987) 3.23
Spliced adenovirus-associated virus RNA. Proc Natl Acad Sci U S A (1979) 2.99
Role of adherence in growth of Acinetobacter calcoaceticus RAG-1 on hexadecane. J Bacteriol (1981) 2.96
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol Pharmacol (1998) 2.94
gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (2000) 2.90
Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1). J Biol Chem (1999) 2.85
Nucleotide sequence homology at the 3' termini of RNA from vesicular stomatitis virus and its defective interfering particles. Proc Natl Acad Sci U S A (1978) 2.82
Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1. J Exp Med (1997) 2.79
Sequence of Cro gene of bacteriophage lambda. Nature (1977) 2.78
Copper metallothionein of yeast, structure of the gene, and regulation of expression. Proc Natl Acad Sci U S A (1984) 2.74
Adherence of Acinetobacter calcoaceticus RAG-1 to human epithelial cells and to hexadecane. Infect Immun (1981) 2.74
The structure of adenovirus 2 early nuclear and cytoplasmic RNAs. J Mol Biol (1980) 2.74
Bacterial adherence to polystyrene: a replica method of screening for bacterial hydrophobicity. Appl Environ Microbiol (1981) 2.73
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A (1998) 2.71
E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA. Mol Cell Biol (1985) 2.68
Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development (1997) 2.66
Functions of LIM-homeobox genes. Trends Genet (2000) 2.66
Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism. Nat Genet (1995) 2.64
Endocytosis in Chang liver cells. Quantitation by sucrose- 3 H uptake and inhibition by cytochalasin B. J Cell Biol (1971) 2.63
Loop structures in hybrids of early RNA and the separated strands of adenovirus DNA. Proc Natl Acad Sci U S A (1977) 2.60
A rho-dependent termination site in the gene coding for tyrosine tRNA su3 of Escherichia coli. Nature (1978) 2.58
Affecting gene expression by altering the length and sequence of the 5' leader. Proc Natl Acad Sci U S A (1984) 2.58
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature (1996) 2.57
Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A (1977) 2.57
Microinjected c-myc as a competence factor. Science (1985) 2.56
Evolution of two-component signal transduction. Mol Biol Evol (2000) 2.55
Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4. Proc Natl Acad Sci U S A (1991) 2.54
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. J Bacteriol (2000) 2.50
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell (1998) 2.50
Adenovirus E1a gene product expressed at high levels in Escherichia coli is functional. Science (1984) 2.38
Structure and function of the cy control region of bacteriophage lambda. J Mol Biol (1980) 2.37
A promoter of pBR322 activated by cAMP receptor protein. Nucleic Acids Res (1981) 2.37
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
A cascade of adenovirus early functions is required for expression of adeno-associated virus. Cell (1981) 2.33
Pentapeptide nuclear localization signal in adenovirus E1a. Mol Cell Biol (1987) 2.30
The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med (1994) 2.23
Promoter for the establishment of repressor synthesis in bacteriophage lambda. Proc Natl Acad Sci U S A (1980) 2.23
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Efficient expression of influenza virus NS1 nonstructural proteins in Escherichia coli. Proc Natl Acad Sci U S A (1983) 2.19
Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science (1996) 2.18
Removal of a terminator structure by RNA processing regulates int gene expression. J Mol Biol (1984) 2.13
Bacteriophage lambda protein cII binds promoters on the opposite face of the DNA helix from RNA polymerase. Nature (1983) 2.13
Nucleotide sequences of the 5' and 3' termini of bacteriophage T7 early messenger RNAs synthesized in vivo: evidence for sequence specificity in RNA processing. J Mol Biol (1974) 2.10
T cell development in mice that lack the zeta chain of the T cell antigen receptor complex. Science (1993) 2.06