Published in J Biol Chem on June 04, 1999
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Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev (2010) 2.28
An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci U S A (2004) 2.28
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Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71
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Existence of the canonical Wnt signaling pathway in the human trabecular meshwork. Invest Ophthalmol Vis Sci (2012) 1.53
c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol (2007) 1.50
Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest (2003) 1.42
Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget (2010) 1.42
The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical Wnts. Mol Cell Biol (2005) 1.39
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High-frequency canonical Wnt activation in multiple sarcoma subtypes drives proliferation through a TCF/β-catenin target gene, CDC25A. Cancer Cell (2011) 1.22
Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1. Nat Struct Mol Biol (2011) 1.21
Aging of signal transduction pathways, and pathology. Exp Cell Res (2008) 1.16
Wnt pathway-related gene expression in inflammatory bowel disease. Dig Dis Sci (2007) 1.15
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol (2009) 1.14
Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. J Gastrointest Surg (2008) 1.12
Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol (2008) 1.11
Regulation of Wnt/β-catenin signaling within and from osteocytes. Bone (2013) 1.08
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Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol (2011) 1.02
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SFRP4 was overexpressed in colorectal carcinoma. J Cancer Res Clin Oncol (2010) 0.96
A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling. PLoS One (2008) 0.96
Secreted frizzled-related protein 4: an angiogenesis inhibitor. Am J Pathol (2010) 0.94
Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain. Neural Dev (2009) 0.92
Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. Int J Clin Exp Pathol (2012) 0.92
Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. PLoS One (2012) 0.91
SFRP-4 abrogates Wnt-3a-induced beta-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation. J Mol Signal (2008) 0.91
Increased expression of secreted frizzled-related protein 4 in polycystic kidneys. J Am Soc Nephrol (2008) 0.89
Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers. Int J Cancer (2009) 0.89
Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. Br J Cancer (2009) 0.88
The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate. Neural Dev (2008) 0.87
The Wnt antagonist sFRP1 as a favorable prognosticator in human biliary tract carcinoma. PLoS One (2014) 0.85
Aberrant activation of Wnt/β-catenin signaling drives proliferation of bone sarcoma cells. Oncotarget (2015) 0.85
NC1 domain of collagen α3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier dynamics. Spermatogenesis (2013) 0.84
sFRP-1 binds via its netrin-related motif to the N-module of thrombospondin-1 and blocks thrombospondin-1 stimulation of MDA-MB-231 breast carcinoma cell adhesion and migration. Arch Biochem Biophys (2011) 0.84
Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration. PLoS One (2013) 0.84
Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci (2013) 0.84
Expression profiling of prostate cancer tissue delineates genes associated with recurrence after prostatectomy. Sci Rep (2015) 0.84
Downregulation of sFRP-2 by epigenetic silencing activates the β-catenin/Wnt signaling pathway in esophageal basaloid squamous cell carcinoma. Virchows Arch (2014) 0.83
Loss of SFRP1 promotes ductal branching in the murine mammary gland. BMC Dev Biol (2012) 0.83
Sexually dimorphic expression of secreted frizzled-related (SFRP) genes in the developing mouse Müllerian duct. Mol Reprod Dev (2006) 0.82
Inhibition of canonical Wnt signaling increases microvascular hemorrhaging and venular remodeling in adult rats. Microcirculation (2010) 0.82
Crosstalk of the Wnt/β-catenin pathway with other pathways in cancer cells. Genes Dis (2016) 0.81
Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse. Mech Dev (2009) 0.81
Differential gene expression profiling of enriched human spermatogonia after short- and long-term culture. Biomed Res Int (2014) 0.81
Tyrosine-based signal mediates LRP6 receptor endocytosis and desensitization of Wnt/β-catenin pathway signaling. J Biol Chem (2014) 0.81
Association of Wnt2 and sFRP4 expression in the third trimester placenta in women with severe preeclampsia. Reprod Sci (2013) 0.81
Involvement of Wnt signaling pathways in the metamorphosis of the bryozoan Bugula neritina. PLoS One (2012) 0.81
Secreted frizzled related protein 1 (Sfrp1) and Wnt signaling in innervated and denervated skeletal muscle. J Mol Histol (2008) 0.81
Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells. J Transl Med (2012) 0.80
Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. J Biol Chem (2012) 0.80
Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules. PLoS One (2008) 0.79
Beta-catenin and epithelial tumors: a study based on 374 oropharyngeal cancers. Biomed Res Int (2014) 0.79
Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer. Cancers (Basel) (2016) 0.78
Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem (2015) 0.78
Olfactomedin 4 deletion induces colon adenocarcinoma in Apc(Min/+) mice. Oncogene (2016) 0.76
SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer. BMC Med Genomics (2016) 0.76
An anterior signaling center patterns and sizes the anterior neuroectoderm of the sea urchin embryo. Development (2016) 0.76
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol (2016) 0.76
Expression of signaling components in embryonic eyelid epithelium. PLoS One (2014) 0.75
Expression patterns of Wnt signaling component, secreted frizzled‑related protein 3 in astrocytoma and glioblastoma. Mol Med Rep (2016) 0.75
Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells. Stem Cells Dev (2016) 0.75
Number and brightness analysis of sFRP4 domains in live cells demonstrates vesicle association signal of the NLD domain and dynamic intracellular responses to Wnt3a. Int J Biochem Cell Biol (2015) 0.75
Inhibition of Wnt/β-catenin signal is alleviated reactive gliosis in rats with hydrocephalus. Childs Nerv Syst (2015) 0.75
The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1. Mol Cancer (2014) 0.75
Modulating the wnt signaling pathway with small molecules. Protein Sci (2017) 0.75
Correlation of blood bone turnover biomarkers and Wnt signaling antagonists with AS, DISH, OPLL, and OYL. BMC Musculoskelet Disord (2017) 0.75
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling. World J Stem Cells (2015) 0.75
Activation and Inhibition of The Wnt3A Signaling Pathway in Buffalo (Bubalus bubalis) Embryonic Stem Cells: Effects of WNT3A, Bio and Dkk1. Int J Fertil Steril (2015) 0.75
The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted frizzled-related proteins. J Biol Chem (2017) 0.75
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