Published in Science on November 29, 1968
A cis-acting element from the Epstein-Barr viral genome that permits stable replication of recombinant plasmids in latently infected cells. Proc Natl Acad Sci U S A (1984) 10.91
Monoclonal antibodies against simian virus 40 T antigens: evidence for distinct sublcasses of large T antigen and for similarities among nonviral T antigens. J Virol (1980) 7.51
Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin. Proc Natl Acad Sci U S A (1979) 5.32
Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys J (2005) 4.91
Restoration of contact-inhibited growth to transformed cells by dibutyryl adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1971) 3.44
Surface-specific characteristics of a contact-inhibited cell line containing the SV40 viral genome. Proc Natl Acad Sci U S A (1969) 2.86
Mouse leukemia virus: "spontaneous" release by mouse embryo cells after long-term in vitro cultivation. Proc Natl Acad Sci U S A (1969) 2.68
Plasminogen activator production accompanies loss of anchorage regulation in transformation of primary rat embryo cells by simian virus 40. Proc Natl Acad Sci U S A (1974) 2.59
Increased concentration of an apparently identical cellular protein in cells transformed by either Abelson murine leukemia virus or other transforming agents. J Virol (1981) 2.56
A scanning electron microscope study of surface features of viral and spontaneous transformants of mouse Balb-3T3 cells. J Cell Biol (1973) 2.30
Host nuclear proteins expressed in simian virus 40-transformed and -infected cells. Proc Natl Acad Sci U S A (1980) 1.82
Gangliosides in DNA virus-transformed and spontaneously transformed tumorigenic mouse cell lines. Proc Natl Acad Sci U S A (1969) 1.76
Antigenic properties of murine sarcoma virus-transformed BALB-3T3 nonproducer cells. J Exp Med (1972) 1.75
Intercellular contact and cell-surface galactosyl transferase activity (cell culture-mouse-radioautography-contact inhibition-cis-and trans-galactosylation). Proc Natl Acad Sci U S A (1972) 1.70
Characterization of mouse 45S ribosomal RNA subspecies suggests that the first processing cleavage occurs 600 +/- 100 nucleotides from the 5' end and the second 500 +/- 100 nucleotides from the 3' end of a 13.9 kb precursor. Nucleic Acids Res (1985) 1.51
Quantitation of a transformation-sensitive, adhesive cell surface glycoprotein. Decrease of several untransformed permanent cell lines. J Cell Biol (1977) 1.48
Selection and adaptation during metastatic cancer progression. Nature (2013) 1.46
Physiological induction and reversal of focus formation and tumorigenicity in NIH 3T3 cells. Proc Natl Acad Sci U S A (1990) 1.42
Relation of spontaneous transformation in cell culture to adaptive growth and clonal heterogeneity. Proc Natl Acad Sci U S A (1990) 1.39
Antigenic properties of endogenous type-C viruses from spontaneously transformed clones of BALB-3T3. Proc Natl Acad Sci U S A (1973) 1.36
Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media. Mol Cell Biol (1986) 1.25
Differential expression of helper viral structural polypeptides in cells transformed by clonal isolates of woolly monkey sarcoma virus. J Virol (1975) 1.22
A diffusible factor restoring contact inhibition of growth to malignant melanocytes. Proc Natl Acad Sci U S A (1974) 1.18
Polypeptides of cells transformed by RNA or DNA tumor viruses. Proc Natl Acad Sci U S A (1977) 1.17
Murine sarcoma virus gene expression: transformants which express viral envelope glycoprotein in the absence of the major internal protein and infectious particles. Proc Natl Acad Sci U S A (1974) 1.16
Cellular epigenetics: effects of passage history on competence of cells for "spontaneous" transformation. Proc Natl Acad Sci U S A (1993) 1.15
Different calcium requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells. Proc Natl Acad Sci U S A (1976) 1.14
Specific changes in the collagen phenotype of BALB 3T3 cells as a result of transformation by sarcoma viruses or a chemical carcinogen. Proc Natl Acad Sci U S A (1977) 1.10
Glucocorticoid-induced alteration of the surface membrane of cultured hepatoma cells. J Cell Biol (1970) 1.05
Characterization of morphologic revertants of murine and avian sarcoma virus-transformed cells. J Virol (1973) 1.04
Variants of simian virus 40-transformed 3T3 cells that are resistant to concanavalin A. J Virol (1973) 1.03
Density dependent inhibition of both growth and T-antigen expression in revertants isolated from simian virus 40-transformed mouse SVT2 cells. J Virol (1979) 1.03
Adaptive evolution of degrees and kinds of neoplastic transformation in cell culture. Proc Natl Acad Sci U S A (1992) 1.00
Changes in membrane structure associated with cell contact. Proc Natl Acad Sci U S A (1973) 1.00
Tumor induction by simian virus 40 in mice is controlled by long-term persistence of the viral genome and the immune response of the host. J Virol (1984) 0.99
Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo. Mol Cell Biol (1998) 0.98
Pre-crisis mouse cells show strain-specific covariation in the amount of 54-kilodalton phosphoprotein and in susceptibility to transformation by simian virus 40. Proc Natl Acad Sci U S A (1983) 0.97
Mechanisms of Kirsten murine sarcoma virus transformation-induced changes in the collagen phenotype and synthetic rate of BALB 3T3 cells. Proc Natl Acad Sci U S A (1981) 0.95
Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis. Proc Natl Acad Sci U S A (2005) 0.94
Cell-cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype. Proc Natl Acad Sci U S A (2008) 0.92
Transformation-related antigens identified by monoclonal antibodies. Proc Natl Acad Sci U S A (1980) 0.91
Spontaneous and chemically induced transformation of rat embryo cell cultures. Br J Cancer (1975) 0.91
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells. Proc Natl Acad Sci U S A (1982) 0.89
Cell contact dependence of surface galactosyltransferase activity as a function of the cell cycle. J Cell Biol (1974) 0.89
Cellular differentiation and neoplasia: characterization of subpopulations of cells that have neoplasia-related growth properties in Syrian hamster embryo cell cultures. Proc Natl Acad Sci U S A (1981) 0.87
Evolution and modes of transmission of RNA tumor viruses. Parke-Davis Award lecture. Am J Pathol (1975) 0.87
Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons. Environ Health Perspect (1979) 0.86
RNA interference as a key to knockdown overexpressed cyclooxygenase-2 gene in tumour cells. Br J Cancer (2006) 0.86
Cellular aging, destabilization, and cancer. Proc Natl Acad Sci U S A (1996) 0.85
Incipient and overt stages of neoplastic transformation. Proc Natl Acad Sci U S A (1994) 0.85
Expression of tumor-specific transplantation antigen in cell lines transformed by wild-type of tsA mutant simian virus 40. J Virol (1977) 0.84
Cell contact-dependent increase in membrane D-galactopyranosyl-like residues on normal, but not virus- or spontaneously-transformed, murine fibroblasts. Proc Natl Acad Sci U S A (1973) 0.84
Rapid development of a cancer-like antigen in normal tissue in vitro. Br J Cancer (1973) 0.84
Resistance of simian virus 40-transformed hamster cells to the cytolytic effect of activated macrophages: a possible factor in species-specific viral oncogenicity. Proc Natl Acad Sci U S A (1980) 0.83
Characterization of cell cycle and biological parameters of transplantable glioma cell lines and clones. Acta Neuropathol (1980) 0.80
Rat cells transformed by simian virus 40 give rise to tumor cells which contain no viral proteins and often no viral DNA. Mol Cell Biol (1983) 0.80
High rate of diversification and reversal among subclones of neoplastically transformed NIH 3T3 clones. Proc Natl Acad Sci U S A (1992) 0.80
RNA-tumour-virus genes and transforming genes: patterns of transmission. Br J Cancer (1978) 0.78
Cells determine cell density using a small protein bound to a unique tissue-specific phospholipid. PeerJ (2013) 0.77
Production of B-tropic murine leukemia virus by somatic cell hybrids between mouse peritoneal macrophages and simian virus 40-transformed human cells. J Virol (1976) 0.77
Studies on morphological transformation of BALB/3T3-derived clones by murine leukemia virus. J Virol (1975) 0.75
Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma. Oncotarget (2017) 0.75
A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity. Chromosome Res (2015) 0.75
A novel styryl diphenylamine derivative reverts the transformed phenotype of human fibrosarcoma HT1080 cells. Br J Cancer (1995) 0.75
Immunochemical characterization of surface antigens of TerC, a teratocarcinoma-derived cell line. Proc Natl Acad Sci U S A (1979) 0.75
Collagen I and the fibroblast: high protein expression requires a new paradigm of post-transcriptional, feedback regulation. Biochem Biophys Rep (2015) 0.75
The initiation of cell division in a contact-inhibited mammalian cell line. J Cell Physiol (1965) 12.07
Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol (1969) 11.78
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst (1973) 11.26
Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40. J Cell Physiol (1968) 10.54
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (1983) 9.06
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science (1991) 8.68
Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A (1978) 8.01
Oncogenes of RNA tumor viruses as determinants of cancer. Proc Natl Acad Sci U S A (1969) 7.69
Autocrine secretion and malignant transformation of cells. N Engl J Med (1980) 7.49
A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells. Science (1971) 6.71
Nerve growth factor receptors on human melanoma cells in culture. Proc Natl Acad Sci U S A (1977) 6.62
Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science (1985) 6.56
Mink cell line Mv 1 Lu (CCL 64). Focus formation and the generation of "nonproducer" transformed cell lines with murine and feline sarcoma viruses. Virology (1974) 6.53
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science (1987) 6.36
Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc Natl Acad Sci U S A (1980) 6.32
Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 5.80
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (1982) 5.11
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells. J Gen Virol (1971) 5.01
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science (1989) 4.79
Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors. Nature (1979) 4.72
A type-C virus in human rhabdomyosarcoma cells after inoculation into NIH Swiss mice treated with antithymocyte serum. Proc Natl Acad Sci U S A (1973) 4.55
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature (1982) 4.54
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50
Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. Proc Natl Acad Sci U S A (1973) 4.39
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38
Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 4.37
PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature (1989) 4.36
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene. Nature (1983) 4.34
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol (2000) 4.33
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A (1989) 4.17
gag Gene of mammalian type-C RNA tumour viruses. Nature (1976) 4.11
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene (1995) 4.10
Nonproducer clones of murine sarcoma virus transformed BALB-3T3 cells. Virology (1970) 3.85
Growth control in cultured cells: selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability. Proc Natl Acad Sci U S A (1968) 3.78
Separation of murine cellular and murine leukaemia virus DNA polymerases. Nat New Biol (1971) 3.71
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science (1991) 3.69
Susceptibility of human diploid fibroblast strains to transformation by SV40 virus. Science (1966) 3.68
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature (1991) 3.68
Rat transforming growth factor type 1: structure and relation to epidermal growth factor. Science (1984) 3.62
Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells. Nature (1976) 3.56
Cell growth and the initiation of transformation by SV40. Proc Natl Acad Sci U S A (1966) 3.50
Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction. Proc Natl Acad Sci U S A (1980) 3.45
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Infectious C-type virus isolated from a baboon placenta. Nature (1974) 3.32
N.A.S. symposium: new evidence as the basis for increased efforts in cancer research. Proc Natl Acad Sci U S A (1972) 3.28
RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements. Proc Natl Acad Sci U S A (1970) 3.25
Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc Natl Acad Sci U S A (1983) 3.21
Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science (1989) 3.13
Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses. Nature (1985) 3.13
Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc Natl Acad Sci U S A (1990) 3.11
High frequency of SV40 transformation of mouse cell line 3T3. Virology (1966) 3.04
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem (1994) 3.03
Evolution of type C viral genes: evidence for an Asian origin of man. Nature (1976) 3.02
Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature (1983) 3.01
A distinct class of inducible murine type-C viruses that replicates in the rabbit SIRC cell line. Proc Natl Acad Sci U S A (1974) 3.00
Oncogenes in solid human tumours. Nature (1982) 3.00
Characterization of murine leukaemia virus-specific DNA present in normal mouse cells. Nat New Biol (1973) 2.98
Endogenous type-C RNA viruses of mammalian cells. Biochim Biophys Acta (1976) 2.95
Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis. Proc Natl Acad Sci U S A (1983) 2.95
Membrane receptors for murine leukemia viruses: characterization using the purified viral envelope glycoprotein, gp71. Cell (1976) 2.93
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.93
Homology between type-C viruses of various species as determined by molecular hybridization. Proc Natl Acad Sci U S A (1973) 2.90
Radiommunoassays for the 70,000-molecular-weight glycoproteins of endogenous mouse type C viruses: viral antigen expression in normal mouse tissues and sera. J Virol (1976) 2.82
Isolation of temperature-sensitive mutants of murine leukemia virus. Virology (1972) 2.78
Evolution of C-type viral genes: inheritance of exogenously acquired viral genes. Nature (1974) 2.77
Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc Natl Acad Sci U S A (1981) 2.74
Immunological characterization of primate C-type virus reverse transcriptases. Nat New Biol (1972) 2.73
Isolation from the asian mouse Mus caroli of an endogenous type C virus related to infectious primate type C viruses. Proc Natl Acad Sci U S A (1975) 2.71
Detection of baboon type C viral sequences in various primate tissues by molecular hybridization. J Virol (1974) 2.69
Mouse leukemia virus: "spontaneous" release by mouse embryo cells after long-term in vitro cultivation. Proc Natl Acad Sci U S A (1969) 2.68
Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses. J Virol (1972) 2.65
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism. Cell (1985) 2.59
Type C viruses of baboons: isolation from normal cell cultures. Cell (1974) 2.55
Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome. Science (1981) 2.51
Nucleic acid homology of murine type-C viral genes. J Virol (1974) 2.51
BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci U S A (1998) 2.50
Induction of cell division in medium lacking serum growth factor by SV40. Virology (1971) 2.48
Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A (1991) 2.48
Nature and distribution of feline sarcoma virus nucleotide sequences. J Virol (1979) 2.47
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature (1987) 2.46
The genome-associated, specific RNA binding proteins of avian and mammalian type C viruses. Cell (1977) 2.42
Cloning and sequence analysis of a cDNA for rat transforming growth factor-alpha. Nature (1985) 2.41
Properties of clonal lines of murine sarcoma virus transformed Balb-3T3 cells. Virology (1969) 2.40
Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters. Nature (1980) 2.38
RNA dependent DNA polymerase activity in mammalian cells. Nature (1971) 2.37
Genetic factors influencing C-type RNA virus induction. J Exp Med (1972) 2.36