Published in Nature on December 09, 1982
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Clinical and biological significance of aneuploidy in human tumours. J Clin Pathol (1984) 2.39
pp60c-src activation in human colon carcinoma. J Clin Invest (1989) 2.07
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci U S A (1984) 2.07
Transforming genes of human hematopoietic tumors: frequent detection of ras-related oncogenes whose activation appears to be independent of tumor phenotype. Proc Natl Acad Sci U S A (1983) 2.04
Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver. Mol Cell Biol (1984) 1.98
Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum. Br J Cancer (1984) 1.97
Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. Proc Natl Acad Sci U S A (1984) 1.95
Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes. Proc Natl Acad Sci U S A (1984) 1.89
Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes. Mol Cell Biol (1985) 1.85
Molecular cloning of an activated human oncogene, homologous to v-raf, from primary stomach cancer. Proc Natl Acad Sci U S A (1985) 1.83
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient. Proc Natl Acad Sci U S A (1984) 1.78
Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci U S A (1986) 1.71
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice. Proc Natl Acad Sci U S A (1985) 1.61
Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen. Proc Natl Acad Sci U S A (1985) 1.61
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. EMBO J (1984) 1.56
Chromosomal assignment of a family of human oncogenes. Proc Natl Acad Sci U S A (1983) 1.53
Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells. EMBO J (1985) 1.46
Frequency of molecular alterations affecting ras protooncogenes in human urinary tract tumors. Proc Natl Acad Sci U S A (1985) 1.43
Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells. Nucleic Acids Res (1983) 1.41
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c-Ha-ras-1 oncogene lies between beta-globin and insulin loci on human chromosome 11p. Am J Hum Genet (1984) 1.37
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Monoclonal antibodies of predefined specificity detect activated ras gene expression in human mammary and colon carcinomas. Proc Natl Acad Sci U S A (1984) 1.32
Activation of N-ras in a human melanoma cell line. Mol Cell Biol (1985) 1.30
Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts. EMBO J (1986) 1.28
Malignant transformation by ras and other oncogenes produces common alterations in inositol phospholipid signaling pathways. Proc Natl Acad Sci U S A (1988) 1.28
New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Mol Cell Biol (1985) 1.26
Growth factor requirements of oncogene-transformed NIH 3T3 and BALB/c 3T3 cells cultured in defined media. Mol Cell Biol (1986) 1.25
Four human carcinoma cell lines with novel mutations in position 12 of c-K-ras oncogene. Nucleic Acids Res (1986) 1.24
Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells. Proc Natl Acad Sci U S A (1984) 1.23
Isolation and characterization of a stage-specific transforming gene, Tlym-I, from T-cell lymphomas. Proc Natl Acad Sci U S A (1984) 1.20
Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. J Exp Med (1984) 1.20
TRKing down an old oncogene in a new era of targeted therapy. Cancer Discov (2014) 1.19
Activation of a human c-K-ras oncogene. Nucleic Acids Res (1984) 1.19
Transforming gene in human atherosclerotic plaque DNA. Proc Natl Acad Sci U S A (1986) 1.18
Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene. Mol Cell Biol (1983) 1.18
Effects of two major activating lesions on the structure and conformation of human ras oncogene products. Proc Natl Acad Sci U S A (1985) 1.17
Inherited susceptibility to retrovirus-induced transformation of Gardner syndrome cells. Am J Hum Genet (1983) 1.17
Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences. Proc Natl Acad Sci U S A (1988) 1.15
Immunohistochemical detection of the ras oncogene p21 product in an experimental tumour and in human colorectal neoplasms. Br J Cancer (1985) 1.15
An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov (2015) 1.13
Nucleotide sequence analysis of the BALB/c murine sarcoma virus transforming gene. J Virol (1985) 1.11
Enhanced c-Ki-ras expression associated with Friend virus integration in a bone marrow-derived mouse cell line. Proc Natl Acad Sci U S A (1986) 1.09
Human cancer and cellular oncogenes. Biochem J (1987) 1.07
Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. EMBO J (1984) 1.07
Molecular cloning of an oncogene from a human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1986) 1.03
Mechanism of activation of the human trk oncogene. Mol Cell Biol (1989) 1.03
The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions. Nucleic Acids Res (1984) 0.96
Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine. Mol Cell Biol (1986) 0.94
Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes. J Virol (1985) 0.92
Amplified DNA in Y1 mouse adrenal tumor cells: isolation of cDNAs complementary to an amplified c-Ki-ras gene and localization of homologous sequences to mouse chromosome 6. Nucleic Acids Res (1984) 0.92
NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line. Oncotarget (2015) 0.91
Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoprotein. Mol Cell Biol (1985) 0.90
Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon. Proc Natl Acad Sci U S A (1985) 0.90
Involvement of ras p21 in neurotrophin-induced response of sensory, but not sympathetic neurons. J Cell Biol (1993) 0.90
Identification by transfection of transforming sequences in DNA of human T-cell leukemias. Proc Natl Acad Sci U S A (1983) 0.88
Immunohistochemical detection of ras oncogene p21 product in benign and malignant mammary tissue in man. J Clin Pathol (1986) 0.88
Cellular oncogenes in neoplasia. J Clin Pathol (1987) 0.87
Oncogenes and tumor-suppressor genes. Environ Health Perspect (1991) 0.86
Differential methylation of the c-H-ras gene in normal mouse cells and during skin tumour progression. EMBO J (1985) 0.85
Common multigenic activation in different human neoplasias. EMBO J (1983) 0.82
Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1. Mamm Genome (1997) 0.81
Kirsten Ras* oncogene: significance of its discovery in human cancer research. Oncotarget (2016) 0.80
Molecular cloning and chromosome assignment of murine N-ras. Nucleic Acids Res (1984) 0.80
The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma. Br J Cancer (1986) 0.78
Expression of viral p21ras during acquisition of a transformed phenotype by rat adrenal cortex cells infected with Kirsten murine sarcoma virus. Mol Cell Biol (1986) 0.76
Structure and expression of oncogenes in surgical specimens of human breast carcinomas. Br J Cancer (1988) 0.76
Immunohistochemical staining of colorectal tissues with monoclonal antibodies to ras oncogene p21 product and carbohydrate determinant antigen 19-9. J Clin Pathol (1987) 0.76
Genetics of Bladder Malignant Tumors in Childhood. Curr Genomics (2016) 0.75
Oncogenes--implications for human cancer: a review. J R Soc Med (1984) 0.75
Somatic rearrangement of the tropomyosin-receptor-kinase (trk) oncogene is rare in gastrointestinal cancer. Br J Cancer (1988) 0.75
Lineage-specific and differentiation-stage-specific gene expression in normal and leukaemic human myeloid cells. J R Soc Med (1984) 0.75
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Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science (1991) 8.68
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nat Genet (1999) 8.53
A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells. Science (1971) 6.71
Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science (1985) 6.56
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A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature (1986) 5.88
Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 5.80
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (1982) 5.11
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol (1994) 5.02
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Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50
Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature (1985) 4.40
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Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38
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Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature (1996) 4.37
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PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature (1989) 4.36
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