Published in Cell on December 01, 1978
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Codon catalog usage and the genome hypothesis. Nucleic Acids Res (1980) 11.97
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proc Natl Acad Sci U S A (1979) 9.31
Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type. Nucleic Acids Res (1980) 8.35
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Receptor editing in self-reactive bone marrow B cells. J Exp Med (1993) 5.49
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. J Exp Med (1982) 5.37
BKV splice sequences based on analysis of preferred donor and acceptor sites. Nucleic Acids Res (1979) 4.86
Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain. Nucleic Acids Res (1979) 4.74
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs. Proc Natl Acad Sci U S A (1984) 4.71
Nucleotide sequence divergence and functional constraint in mRNA evolution. Proc Natl Acad Sci U S A (1980) 4.71
Has the endosymbiont hypothesis been proven? Microbiol Rev (1982) 3.86
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med (1985) 3.54
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Exon shuffling generates an immunoglobulin heavy chain gene. Proc Natl Acad Sci U S A (1980) 2.80
Somatic rearrangements forming active immunoglobulin mu genes in B and T lymphoid cell lines. Proc Natl Acad Sci U S A (1980) 2.77
Site-specific recombinases: changing partners and doing the twist. J Bacteriol (1986) 2.71
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PCR-based cDNA library construction: general cDNA libraries at the level of a few cells. Nucleic Acids Res (1989) 2.48
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences. Proc Natl Acad Sci U S A (1982) 2.44
Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc Natl Acad Sci U S A (1983) 2.38
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Deletions in immunoglobulin mu chains. EMBO J (1982) 2.35
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Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments. Nucleic Acids Res (1980) 2.31
Patterns of somatic mutations in immunoglobulin variable genes. Genetics (1987) 2.24
Cell-type preference of immunoglobulin kappa and lambda gene promoters. EMBO J (1985) 2.22
Simple DNA sequences in homologous flanking regions near immunoglobulin VH genes: a role in gene interaction? Nucleic Acids Res (1982) 2.19
An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development. Nucleic Acids Res (1982) 2.15
Correct transcription of a cloned mouse immunoglobulin gene in vivo. Proc Natl Acad Sci U S A (1983) 2.14
Recombined flanks of the variable and joining segments of immunoglobulin genes. Proc Natl Acad Sci U S A (1982) 2.03
Recombination between antibody heavy chain variable-region genes: evidence for gene conversion. Proc Natl Acad Sci U S A (1983) 2.03
Novel models for RNA splicing that involve a small nuclear RNA. Proc Natl Acad Sci U S A (1981) 2.00
How antibodies fold. Trends Biochem Sci (2009) 1.88
The preferential codon usages in variable and constant regions of immunoglobulin genes are quite distinct from each other. Nucleic Acids Res (1979) 1.83
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Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors. Proc Natl Acad Sci U S A (1985) 1.80
The FLP recombinase of the Saccharomyces cerevisiae 2 microns plasmid attaches covalently to DNA via a phosphotyrosyl linkage. Mol Cell Biol (1985) 1.77
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Organization of four mouse lambda light chain immunoglobulin genes. Proc Natl Acad Sci U S A (1981) 1.73
Cloned pairs of variable region genes for immunoglobulin heavy chains isolated from a clone library of the entire mouse genome. Proc Natl Acad Sci U S A (1979) 1.71
Evolution of mouse immunoglobulin lambda genes. Proc Natl Acad Sci U S A (1982) 1.68
Multiple mRNA species for the precursor to an adenovirus-encoded glycoprotein: identification and structure of the signal sequence. Proc Natl Acad Sci U S A (1980) 1.66
Fine structure and evolution of the rat serum albumin gene. Mol Cell Biol (1981) 1.62
The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA. Nucleic Acids Res (1989) 1.60
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Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res (1994) 1.58
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene. Proc Natl Acad Sci U S A (1981) 1.55
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Two rearranged immunoglobulin kappa light chain genes in one mouse myeloma. Nucleic Acids Res (1980) 1.51
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III. Proc Natl Acad Sci U S A (1981) 1.50
Receptor selection in B and T lymphocytes. Annu Rev Immunol (2000) 1.49
Single amino acid substitution altering antigen-binding specificity. Proc Natl Acad Sci U S A (1982) 1.46
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Inhibition of immunoglobulin folding and secretion by dominant negative BiP ATPase mutants. Proc Natl Acad Sci U S A (1996) 1.41
Somatic mutation in a cultured mouse myeloma cell affects antigen binding. Proc Natl Acad Sci U S A (1982) 1.39
Molecular cloning of a human immunoglobulin lambda chain variable sequence. Nucleic Acids Res (1984) 1.39
DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes. Proc Natl Acad Sci U S A (1982) 1.38
An enhancer at the 3' end of the mouse immunoglobulin heavy chain locus. Nucleic Acids Res (1991) 1.38
Linkage of the four gamma subclass heavy chain genes. Proc Natl Acad Sci U S A (1981) 1.38
The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene. Nucleic Acids Res (1983) 1.34
T and B cells that recognize the same antigen do not transcribe similar heavy chain variable region gene segments. J Exp Med (1983) 1.31
Identification of a third type of lambda light chain in mouse immunoglobulins. Proc Natl Acad Sci U S A (1981) 1.31
Cloning of V region fragments from mouse liver DNA and localization of repetitive DNA sequences in the vicinity of immunoglobulin gene segments. Nucleic Acids Res (1980) 1.29
aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression. J Exp Med (1986) 1.27
Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins. Proc Natl Acad Sci U S A (1981) 1.25
Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype. Proc Natl Acad Sci U S A (1981) 1.24
Nucleotide sequence of the constant region of a chicken mu heavy chain immunoglobulin mRNA. Nucleic Acids Res (1983) 1.22
A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion. Proc Natl Acad Sci U S A (1990) 1.21
Evidence supporting somatic assembly of the DNA segments (minigenes), coding for the framework, and complementarity-determining segments of immunoglobulin variable regions. J Exp Med (1979) 1.19
Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus. J Exp Med (1995) 1.18
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Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin gene of mouse. Nucleic Acids Res (1982) 1.17
DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain. Nucleic Acids Res (1981) 1.16
Immunoglobulin J chain gene from the mouse. Proc Natl Acad Sci U S A (1986) 1.16
Complete sequence of a chicken lambda light chain immunoglobulin derived from the nucleotide sequence of its mRNA. Proc Natl Acad Sci U S A (1983) 1.15
Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate. J Exp Med (1987) 1.13
Idiotypic selection of an antibody mutant with changed hapten binding specificity, resulting from a point mutation in position 50 of the heavy chain. EMBO J (1986) 1.12
Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors. J Exp Med (1982) 1.12
The in vivo association of BiP with newly synthesized proteins is dependent on the rate and stability of folding and not simply on the presence of sequences that can bind to BiP. J Cell Biol (1999) 1.10
Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020. J Immunol (2011) 1.10
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Somatic mutation in constant regions of mouse lambda 1 light chains. Proc Natl Acad Sci U S A (1991) 1.08
Analysis of immunoglobulin (Ig) isotype diversity and IgM/D memory in the response to phenyl-oxazolone. J Exp Med (2000) 1.07
Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts. J Exp Med (1983) 1.06
Early pre-B-cell transformation induced by the v-fms oncogene in long-term mouse bone marrow cultures. Mol Cell Biol (1989) 1.06
Two types of immunoglobulin-negative Abelson murine leukemia virus-transformed cells: implications for B-lymphocyte differentiation. Proc Natl Acad Sci U S A (1986) 1.03
Deletions of immunoglobulin C kappa region characterized by the circular excision products in mouse splenocytes. J Exp Med (1991) 1.02
Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences. Mol Cell Biol (1989) 1.00
Structure of a third murine immunoglobulin lambda light chain variable region that is expressed in laboratory mice. Proc Natl Acad Sci U S A (1987) 0.99
Analysis of immunoglobulin heavy chain V-region genes belonging to the V NP-gene family. Nucleic Acids Res (1984) 0.99
Restricted association of V and J-C gene segments for mouse lambda chains. Proc Natl Acad Sci U S A (1984) 0.98
Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains. EMBO J (1987) 0.98
Somatic generation of antibody diversity. Nature (1983) 28.06
RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell (1983) 18.86
Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature (1979) 11.83
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Nature (1980) 10.19
B lineage--specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science (1985) 9.73
A complete immunoglobulin gene is created by somatic recombination. Cell (1978) 8.53
Subregion- and cell type-restricted gene knockout in mouse brain. Cell (1996) 8.02
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature (1998) 7.76
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell (1996) 6.96
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Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell (1993) 5.99
Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from chromosome translocation in B lymphoid tumours. EMBO J (1983) 5.93
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BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell (1999) 5.63
Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. J Exp Med (1982) 5.37
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Evidence for a differential avidity model of T cell selection in the thymus. Cell (1994) 5.24
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature (1984) 5.19
Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.03
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell (1992) 4.76
Reduced stress defense in heme oxygenase 1-deficient cells. Proc Natl Acad Sci U S A (1997) 4.74
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Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A (1997) 4.63
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Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes. Nature (1981) 4.26
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature (1981) 4.19
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Cell-type-specific contacts to immunoglobulin enhancers in nuclei. Nature (1985) 3.94
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Homing of a gamma delta thymocyte subset with homogeneous T-cell receptors to mucosal epithelia. Nature (1990) 3.55
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Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen. Nature (1993) 3.47
Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron (2001) 3.47
A third rearranged and expressed gene in a clone of cytotoxic T lymphocytes. Nature (1984) 3.46
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Activation of the c-myc gene by translocation: a model for translational control. Proc Natl Acad Sci U S A (1983) 3.36
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell (1994) 3.35
Cloning of an immunoglobulin variable region gene from mouse embryo. Proc Natl Acad Sci U S A (1977) 3.21
Cell type-specific enhancer element associated with a mouse MHC gene, E beta. Nature (1984) 3.16
Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 3.09
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science (1997) 2.98
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Exon shuffling generates an immunoglobulin heavy chain gene. Proc Natl Acad Sci U S A (1980) 2.80
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Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature (2000) 2.60
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Transcriptionally active DNA region that rearranges frequently in murine lymphoid tumors. Proc Natl Acad Sci U S A (1982) 2.16
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