Published in Nucleic Acids Res on July 25, 1979
Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information. Nucleic Acids Res (1981) 61.59
Codon catalog usage and the genome hypothesis. Nucleic Acids Res (1980) 11.97
Codon frequencies in 119 individual genes confirm consistent choices of degenerate bases according to genome type. Nucleic Acids Res (1980) 8.35
A mechanism for RNA splicing. Proc Natl Acad Sci U S A (1980) 7.76
Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs. Proc Natl Acad Sci U S A (1981) 6.67
The pitch of chromatin DNA is reflected in its nucleotide sequence. Proc Natl Acad Sci U S A (1980) 5.88
Some rules in the ordering of nucleotides in the DNA. Nucleic Acids Res (1980) 4.56
Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J (1986) 3.17
Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells. Proc Natl Acad Sci U S A (1980) 2.75
The preferential codon usages in variable and constant regions of immunoglobulin genes are quite distinct from each other. Nucleic Acids Res (1979) 1.83
Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma. Proc Natl Acad Sci U S A (1989) 1.78
Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes. J Exp Med (1985) 1.59
A new means of inducibly inactivating a cellular protein. Mol Cell Biol (1988) 1.30
mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain. Proc Natl Acad Sci U S A (1982) 1.28
Nucleic acid secondary structure prediction and display. Nucleic Acids Res (1986) 1.09
Computation of statistical secondary structure of nucleic acids. Nucleic Acids Res (1984) 1.06
A mouse immunoglobulin heavy chain deletion mutant: isolation of a cDNA clone and sequence analysis of the mRNA. Nucleic Acids Res (1980) 0.99
Double isotype production by a neoplastic B cell line. I. Cellular and biochemical characterization of a variant of BCL1 that expresses and secretes both IgM and IgG1. J Exp Med (1986) 0.95
Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic Acids Res (1980) 0.92
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
The use of thin acrylamide gels for DNA sequencing. FEBS Lett (1978) 40.52
The genome of simian virus 40. Science (1978) 24.46
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A (1978) 14.82
Molecular basis of base substitution hotspots in Escherichia coli. Nature (1978) 13.79
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell (1978) 9.73
Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing. Cell (1978) 8.20
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
Computer method for predicting the secondary structure of single-stranded RNA. Nucleic Acids Res (1978) 7.55
Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell (1978) 7.53
Sequence of chicken ovalbumin mRNA. Nature (1978) 6.73
The covalent structure of an entire gammaG immunoglobulin molecule. Proc Natl Acad Sci U S A (1969) 5.90
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. Nature (1979) 5.35
Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing. Cell (1978) 5.18
The primary sequence of rabbit alpha-globin mRNA. Cell (1978) 3.88
Insertion of a rabbit beta-globin gene sequence into an E. coli plasmid. Nucleic Acids Res (1975) 3.66
Doublet frequency analysis of fractionated vertebrate nuclear DNA. J Mol Biol (1976) 3.48
Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene. Nature (1978) 3.30
Genetics of immunoglobulins in the mouse. Adv Immunol (1967) 3.14
Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13
Darwinian evolution in the genealogy of haemoglobin. Nature (1975) 3.00
A general method for cloning eukaryotic structural gene sequences. Proc Natl Acad Sci U S A (1976) 2.84
Molecular evolution of human and rabbit beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.70
Bacterial cloning of plasmids carrying copies of rabbit globin messenger RNA. Nature (1976) 2.45
Molecular analysis of spontaneous somatic mutants. Nature (1977) 1.90
Variants of a mouse myeloma cell line that synthesize immunoglobulin heavy chains having an altered serotype. Proc Natl Acad Sci U S A (1975) 1.87
The complete sequence of the murine monoclonal immunoglobulin MOPC 173 (IgG2a): genetic implications. Ann Immunol (Paris) (1977) 1.82
Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain. J Biol Chem (1978) 1.43
Complete amino acid sequence of the alpha 2 heavy chain of a human IgA2 immunoglobulin of the A2m (2) allotype. Proc Natl Acad Sci U S A (1978) 1.35
Structure, function, and evolutionary relationships of Fc domains of human immunoglobulins A, G, M, and E. Science (1976) 1.22
Somatic mutants and antibody diversity. Immunol Rev (1977) 1.10
The translation in vitro of mRNA for immunoglobulin heavy chains. Eur J Biochem (1973) 1.09
Recombinant DNA clones constructed from immunoglobulin kappa light chain messenger RNA. Nucleic Acids Res (1978) 1.03
Determination of the primary structure of a mouse IgG2a immunoglobulin:amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function. Eur J Biochem (1974) 1.02
Spontaneous somatic mutations. Structural studies on mutant immunoglobulins. J Biol Chem (1978) 0.96
The amino acid sequence of "heavy chain disease" protein ZUC. Structure of the Fc fragment of immunoglobulin G3. Biochem Biophys Res Commun (1976) 0.94
Recognition of two subclasses of mouse IgGl (gamma F). Immunochemistry (1976) 0.93
Purification and sequence analysis of the mRNA coding for an immunoglobulin heavy chain. Eur J Biochem (1976) 0.92
Spontaneous somatic frameshift mutation in a mouse myeloma. J Mol Biol (1978) 0.90
Mouse immunoglobulin subclasses: cyanogen bromide fragments and partial sequence of a gamma1 chain. Eur J Biochem (1975) 0.86
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature (1998) 60.62
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
Globin mRNA sequences: analysis of base pairing and evolutionary implications. Cold Spring Harb Symp Quant Biol (1978) 13.15
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
A mechanism for RNA splicing. Proc Natl Acad Sci U S A (1980) 7.76
The DNA sequence and comparative analysis of human chromosome 20. Nature (2002) 7.40
Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol (1999) 7.16
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
Transcription during bacteriophage T4 development: requirements for late messenger synthesis. J Mol Biol (1968) 6.10
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
The contribution of lead-contaminated house dust and residential soil to children's blood lead levels. A pooled analysis of 12 epidemiologic studies. Environ Res (1998) 4.94
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
In vitro synthesis of bacteriophage lysozyme. Nature (1967) 4.71
The beneficial effects of early dexamethasone administration in infants and children with bacterial meningitis. N Engl J Med (1991) 3.94
Transcription during bacteriophage T4 development: synthesis and relative stability of early and late RNA. J Mol Biol (1968) 3.80
Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation (2002) 3.63
Does measured behavior reflect STD risk? An analysis of data from a randomized controlled behavioral intervention study. Project RESPECT Study Group. Sex Transm Dis (2000) 3.60
The concept and measurement of continuity in primary care. Am J Public Health (1980) 3.54
Immunoglobulin heavy chain genes: demethylation accompanies class switching. Proc Natl Acad Sci U S A (1981) 3.37
A new global mode of Earth deformation: seasonal cycle detected. Science (2001) 3.03
An SNP map of human chromosome 22. Nature (2000) 2.99
Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content. J Clin Invest (1973) 2.94
A general method for cloning eukaryotic structural gene sequences. Proc Natl Acad Sci U S A (1976) 2.84
Radiographic assessment of the knee joint in osteoarthritis. Ann Rheum Dis (1992) 2.75
Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease. J Neurosci (1985) 2.72
Defective ristocetin-induced platelet aggregation in von Willebrand's disease and its correction by factor VIII. J Clin Invest (1973) 2.71
The mechanism of the calcium signal and correlation with histamine release in 2H3 cells. J Biol Chem (1984) 2.58
Investigation of the organization of mammalian chromosomes at the DNA sequence level. Fed Proc (1976) 2.54
A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells. Nature (1985) 2.53
Mouse Cmu heavy chain immunoglobulin gene segment contains three intervening sequences separating domains. Nature (1980) 2.52
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
Anti-inflammatory drugs and Alzheimer disease. Lancet (1990) 2.31
Measurement of the unstable RNA in exponentially growing cultures of Bacillus subtilis and Escherichia coli. J Mol Biol (1968) 2.22
Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells. Proc Natl Acad Sci U S A (1987) 2.20
Transcription during bacteriophage T4 development: a demonstration that distinct subclasses of the "early" RNA appear at different times and that some are "turned off" at late times. J Mol Biol (1970) 2.17
The MHC haplotype project: a resource for HLA-linked association studies. Tissue Antigens (2002) 2.16
Arthritis in Saxon and mediaeval skeletons. Br Med J (Clin Res Ed) (1982) 2.12
Employment status, employment conditions, and limiting illness: prospective evidence from the British household panel survey 1991-2001. J Epidemiol Community Health (2004) 2.06
Studies of the aetiology of neonatal hepatitis and biliary atresia. Arch Dis Child (1977) 2.04
Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences. Genome Res (2001) 2.04
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A (2000) 2.04
Mutation rates in globin genes: the genetic load and Haldane's dilemma. Prog Nucleic Acid Res Mol Biol (1976) 2.02
Doctors accept a challenge: self-assessment exercises in continuing medical education. Br Med J (1979) 2.00
Nucleotide sequences of HS-alpha satellite DNA from kangaroo rat Dipodomys ordii and characterization of similar sequences in other rodents. Cell (1977) 2.00
Study of an additional 58 DNA markers in five human populations from four continents. Gene Geogr (1991) 1.98
Genetic organization of the region encoding regulation, biosynthesis, and transport of rhizobactin 1021, a siderophore produced by Sinorhizobium meliloti. J Bacteriol (2001) 1.97
Butyrate oxidation is impaired in the colonic mucosa of sufferers of quiescent ulcerative colitis. Gut (1994) 1.96
Insulin-induced hypoglycaemia in an accident and emergency department: the tip of an iceberg? Br Med J (Clin Res Ed) (1982) 1.91
Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J Neuropathol Exp Neurol (1996) 1.90
Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Exp Neurol (2001) 1.89
Exon shuffling and intron insertion in serine protease genes. Nature (1985) 1.87
Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel. Proc Natl Acad Sci U S A (1995) 1.83
High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia (2006) 1.81
Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda. Nat Genet (1999) 1.80
Controls and polarity of transcription during bacteriophage T4 development. J Mol Biol (1971) 1.77
Molecular biology. CACA sequences - the ends and the means? Nature (1983) 1.77
The semantics of procedures and diseases in SNOMED CT. Methods Inf Med (2006) 1.74
The Journal of Infection Control Nursing. Sterilisation in GP surgeries. Nurs Times (1989) 1.73
Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: evidence for cross-species transmission in the wild. J Virol (1994) 1.70
Patients attending STD clinics in an evolving health care environment. Demographics, insurance coverage, preferences for STD services, and STD morbidity. Sex Transm Dis (1997) 1.69
Reovirus-induced apoptosis requires activation of transcription factor NF-kappaB. J Virol (2000) 1.68
Gene transfer in intact animals. Nature (1980) 1.68
A postnatal fasting plasma glucose is useful in determining which women with gestational diabetes should undergo a postnatal oral glucose tolerance test. Diabet Med (2003) 1.66
Home blood-glucose measurements without reflectance meter. Lancet (1980) 1.65
Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Cell (1981) 1.65
The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. Nature (2001) 1.63
The isolation of a clone for human alpha 1-antitrypsin and the detection of alpha 1-antitrypsin in mRNA from liver and leukocytes. Biochem Biophys Res Commun (1983) 1.62
Sodium-lithium countertransport activity is linked to chromosome 5 in baboons. Hypertension (2001) 1.62
Retroposons defined. Nature (1983) 1.61
Polymerase chain reaction detection of small round-structured viruses from two related hospital outbreaks of gastroenteritis using inosine-containing primers. J Med Virol (1995) 1.61
Efficacy study of video-assisted thoracoscopic surgery pleurodesis for spontaneous pneumothorax. Ann Thorac Surg (2001) 1.59
Long-term ethanol administration methods for rats: advantages of inhalation over intubation or liquid diets. Behav Neural Biol (1979) 1.56
Neuroimmune mechanisms in Alzheimer disease pathogenesis. Alzheimer Dis Assoc Disord (1994) 1.55
Failure of macrophage activation in experimental obstructive jaundice: association with bacterial translocation. Br J Surg (1995) 1.55
Short Form 36 in the intensive care unit: assessment of acceptability, reliability and validity of the questionnaire. Anaesthesia (1997) 1.53
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia (2001) 1.53
Toxoplasma gondii-infected cells are resistant to multiple inducers of apoptosis. J Immunol (1998) 1.53
Intracellular pH of stimulated thymocytes measured with a new fluorescent indicator. J Biol Chem (1983) 1.53
The genomic sequence and analysis of the swine major histocompatibility complex. Genomics (2006) 1.53
Changes in quality of life after intensive care: comparison with normal data. Anaesthesia (1997) 1.50
Association between serum insulin growth factor-I (IGF-I) and a simple sequence repeat in IGF-I gene: implications for genetic studies of bone mineral density. J Clin Endocrinol Metab (1998) 1.49
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms. Proc Natl Acad Sci U S A (1981) 1.48
Proteus syndrome: an expanded phenotype. Am J Med Genet (1987) 1.47
Human T lymphocyte genetic modification with naked DNA. Mol Ther (2000) 1.47
The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor. Mol Psychiatry (2008) 1.46
Fibrinogen and platelets in the primary arrest of bleeding. Studies in two patients with congenital afibrinogenemia. N Engl J Med (1971) 1.46
Faecal incontinence in myotonic dystrophy. J Neurol Neurosurg Psychiatry (1998) 1.45
Eosinophilic fasciitis with myelodysplasia responsive to treatment with cyclosporin. Br J Dermatol (1997) 1.45
Chronic beryllium disease and beryllium sensitization at Rocky Flats: a case-control study. AIHAJ (2000) 1.45
Nucleotide sequencing of DNA: preliminary characterization of the products of specific cleavages at guanine, cytosine, or adenine residues (bacteriophage M13-ribosubstitution-DNA polymerase I-electrophoresis-two-dimensional fingerprinting). Proc Natl Acad Sci U S A (1972) 1.44
Differences in patterns of care of prostate cancer, New South Wales, 1991. Aust N Z J Surg (1996) 1.43
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A national survey of nurse practitioner chlamydia knowledge and treatment practices of female patients. Nurse Pract (1996) 1.40
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