Published in J Mol Biol on June 18, 1999
Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passage. Antimicrob Agents Chemother (2000) 4.31
Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother (2001) 4.17
Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae. Antimicrob Agents Chemother (2002) 3.25
Characterization and molecular analysis of macrolide-resistant Mycoplasma pneumoniae clinical isolates obtained in Japan. Antimicrob Agents Chemother (2004) 2.84
Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae. Antimicrob Agents Chemother (2001) 2.22
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700). Antimicrob Agents Chemother (2009) 2.17
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus. Antimicrob Agents Chemother (2005) 2.14
In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae. Antimicrob Agents Chemother (2004) 1.78
Resistance to linezolid caused by modifications at its binding site on the ribosome. Antimicrob Agents Chemother (2011) 1.70
A conformational change in the ribosomal peptidyl transferase center upon active/inactive transition. Proc Natl Acad Sci U S A (2001) 1.57
Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus. Antimicrob Agents Chemother (2002) 1.49
Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother (2002) 1.47
Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA. J Bacteriol (2001) 1.33
Macrolide myths. Curr Opin Microbiol (2008) 1.33
Activity of the ketolide telithromycin is refractory to Erm monomethylation of bacterial rRNA. Antimicrob Agents Chemother (2002) 1.32
Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli. Mol Microbiol (2007) 1.24
Emergence of group A streptococcus strains with different mechanisms of macrolide resistance. Antimicrob Agents Chemother (2002) 1.21
The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous control. RNA (2003) 1.17
Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. EMBO J (2000) 1.13
Structural basis for cross-resistance to ribosomal PTC antibiotics. Proc Natl Acad Sci U S A (2008) 1.04
Multiple defects in translation associated with altered ribosomal protein L4. Nucleic Acids Res (2004) 1.03
Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics. J Mol Biol (2009) 1.00
Ketolide antimicrobial activity persists after disruption of interactions with domain II of 23S rRNA. Antimicrob Agents Chemother (2004) 0.97
Forced extraction of targeted components from complex macromolecular assemblies. Proc Natl Acad Sci U S A (2008) 0.94
Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus. Proc Natl Acad Sci U S A (2015) 0.94
Structure of 23S rRNA hairpin 35 and its interaction with the tylosin-resistance methyltransferase RlmAII. EMBO J (2003) 0.93
Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22. Proc Natl Acad Sci U S A (2008) 0.89
Mutations at the accommodation gate of the ribosome impair RF2-dependent translation termination. RNA (2010) 0.87
Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000-2013. J Infect Dis (2016) 0.87
Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing. J Antimicrob Chemother (2014) 0.86
Chemistry and biology of macrolide antiparasitic agents. J Med Chem (2011) 0.85
Linezolid Resistance in Staphylococci. Pharmaceuticals (Basel) (2010) 0.84
Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase. RNA (2004) 0.83
Molecular characterization of resistance to macrolides in Bartonella henselae. Antimicrob Agents Chemother (2006) 0.82
Molecular epidemiology and antimicrobial susceptibility of Clostridium difficile isolated from a university teaching hospital in Japan. Eur J Clin Microbiol Infect Dis (2014) 0.81
tRNAs as antibiotic targets. Int J Mol Sci (2014) 0.78
Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function. Nucleic Acids Res (2011) 0.78
Proteomic analysis of tylosin-resistant Mycoplasma gallisepticum reveals enzymatic activities associated with resistance. Sci Rep (2015) 0.75
Ribosomal mutations conferring macrolide resistance in Legionella pneumophila. Antimicrob Agents Chemother (2017) 0.75
In vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in Mycoplasma pneumoniae. Hippokratia (2015) 0.75
Ribosomal Antibiotics: Contemporary Challenges. Antibiotics (Basel) (2016) 0.75
Emergence and spread of moxifloxacin-resistant Clostridium difficile ribotype 231 in Sweden between 2006 and 2015. New Microbes New Infect (2016) 0.75
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Reading frame switch caused by base-pair formation between the 3' end of 16S rRNA and the mRNA during elongation of protein synthesis in Escherichia coli. EMBO J (1988) 3.18
A single base change in the Shine-Dalgarno region of 16S rRNA of Escherichia coli affects translation of many proteins. Proc Natl Acad Sci U S A (1987) 2.62
Mutations in 16S ribosomal RNA disrupt antibiotic--RNA interactions. EMBO J (1989) 2.54
A conformational switch in Escherichia coli 16S ribosomal RNA during decoding of messenger RNA. Science (1997) 2.43
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Binding of ribosomal protein S1 of Escherichia coli to the 3' end of 16S rRNA. Proc Natl Acad Sci U S A (1975) 2.16
Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit. Proc Natl Acad Sci U S A (2001) 2.06
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The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22. Mol Cell (2001) 1.94
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A ribosomal ambiguity mutation in the 530 loop of E. coli 16S rRNA. Nucleic Acids Res (1992) 1.76
Ribosomal RNA and protein mutants resistant to spectinomycin. EMBO J (1990) 1.75
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Effects of mutagenesis of a conserved base-paired site near the decoding region of Escherichia coli 16 S ribosomal RNA. J Mol Biol (1990) 1.72
Regions of DNA involved in the stringent control of plasmid-encoded rRNA in vivo. Cell (1983) 1.65
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Spectinomycin resistance at site 1192 in 16S ribosomal RNA of E. coli: an analysis of three mutants. Biochimie (1987) 1.57
Two forms of the 30 S ribosomal subunit of Escherichia coli. J Biol Chem (1974) 1.51
Site-directed mutagenesis of Escherichia coli 23 S ribosomal RNA at position 1067 within the GTP hydrolysis centre. J Mol Biol (1988) 1.48
Site-directed mutagenesis of ribosomal RNA. Analysis of ribosomal RNA deletion mutants using maxicells. J Mol Biol (1982) 1.46
Mutations at U2555, a tRNA-protected base in 23S rRNA, affect translational fidelity. Proc Natl Acad Sci U S A (1993) 1.44
Enhancement of translation by the downstream box does not involve base pairing of mRNA with the penultimate stem sequence of 16S rRNA. Proc Natl Acad Sci U S A (1999) 1.43
Major rearrangements in the 70S ribosomal 3D structure caused by a conformational switch in 16S ribosomal RNA. EMBO J (1999) 1.32
Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophilus. J Mol Biol (2001) 1.32
Isolation of kasugamycin resistant mutants in the 16 S ribosomal RNA of Escherichia coli. J Mol Biol (1999) 1.29
Initiation factor IF 2 binds to the alpha-sarcin loop and helix 89 of Escherichia coli 23S ribosomal RNA. RNA (2001) 1.26
A single base mutation at position 2661 in E. coli 23S ribosomal RNA affects the binding of ternary complex to the ribosome. EMBO J (1990) 1.24
Mutations in helix 34 of Escherichia coli 16 S ribosomal RNA have multiple effects on ribosome function and synthesis. J Mol Biol (1994) 1.20
Mutations in the peptidyl transferase region of E. coli 23S rRNA affecting translational accuracy. Nucleic Acids Res (1994) 1.19
Interaction of ribosomal proteins S6, S8, S15 and S18 with the central domain of 16 S ribosomal RNA from Escherichia coli. J Mol Biol (1984) 1.18
A single base change at 726 in 16S rRNA radically alters the pattern of proteins synthesized in vivo. EMBO J (1990) 1.14
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Colicin E3 induced cleavage of 16S ribosomal ribonucleic acid; blocking effects of certain antibiotics. Biochemistry (1973) 1.10
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Nonsense suppressor and antisuppressor mutations at the 1409-1491 base pair in the decoding region of Escherichia coli 16S rRNA. Nucleic Acids Res (1995) 1.09
Altered discrimination of start codons and initiator tRNAs by mutant initiation factor 3. RNA (2001) 1.07
Mutations in 16S rRNA that affect UGA (stop codon)-directed translation termination. Proc Natl Acad Sci U S A (1991) 1.05
Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable. Nucleic Acids Res (2001) 1.04
Interaction between 16S ribosomal RNA and ribosomal protein S12: differential effects of paromomycin and streptomycin. Biochimie (1991) 1.03
Structural changes in the 530 loop of Escherichia coli 16S rRNA in mutants with impaired translational fidelity. Nucleic Acids Res (1995) 1.01
Some effects of antibiotics on bacterial polyribosomes as studied by gel electrophoresis. J Mol Biol (1973) 1.01
Functional Escherichia coli 23S rRNAs containing processed and unprocessed intervening sequences from Salmonella typhimurium. Nucleic Acids Res (1996) 1.00
Mutations at two invariant nucleotides in the 3'-minor domain of Escherichia coli 16 S rRNA affecting translational initiation and initiation factor 3 function. J Biol Chem (1996) 0.99
T7 RNA polymerase directed expression of the Escherichia coli rrnB operon. EMBO J (1986) 0.98
Structural and functional analysis of Escherichia coli ribosomes containing small deletions around position 1760 in the 23S ribosomal RNA. Nucleic Acids Res (1984) 0.96
Ribosome-catalyzed peptide-bond formation. Prog Nucleic Acid Res Mol Biol (1995) 0.95
Mutations at position A960 of E. coli 23 S ribosomal RNA influence the structure of 5 S ribosomal RNA and the peptidyltransferase region of 23 S ribosomal RNA. J Mol Biol (2000) 0.95
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A mutation in an Escherichia coli ribosomal RNA operon that blocks the production of precursor 23 S ribosomal RNA by RNase III in vivo and in vitro. J Mol Biol (1985) 0.91
A mutation at the universally conserved position 529 in Escherichia coli 16S rRNA creates a functional but highly error prone ribosome. RNA (1995) 0.90
Spontaneous erythromycin resistance mutation in a 23S rRNA gene, rrlA, of the extreme thermophile Thermus thermophilus IB-21. J Bacteriol (2001) 0.90
Genetic selection of rRNA mutations. Methods Mol Biol (1998) 0.89
Interaction of neomycin with ribosomes and ribosomal ribonucleic acid. Antimicrob Agents Chemother (1978) 0.89
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Detection of cation-specific conformational changes in ribosomal RNA by gel electrophoresis. Nucleic Acids Res (1975) 0.89
The importance of base pairing in the penultimate stem of Escherichia coli 16S rRNA for ribosomal subunit association. Nucleic Acids Res (1998) 0.89
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Isolation of eukaryotic initiation factor 2 from yeast Saccharomyces cerevisiae. J Biol Chem (1981) 0.87
The importance of conserved nucleotides of 23 S ribosomal RNA and transfer RNA in ribosome catalyzed peptide bond formation. J Biol Chem (1994) 0.87
Misled by sequence complementarity: does the DB-anti-DB interaction withstand scientific scrutiny? Mol Microbiol (1999) 0.87
The influence of base identity and base pairing on the function of the alpha-sarcin loop of 23S rRNA. Nucleic Acids Res (1996) 0.86
Genetic and comparative analyses reveal an alternative secondary structure in the region of nt 912 of Escherichia coli 16S rRNA. Proc Natl Acad Sci U S A (1995) 0.86
Mutations within the 23S rRNA coding sequence of E. coli which block ribosome assembly. EMBO J (1985) 0.84
Oligonucleotide directed mutagenesis of Escherichia coli 5S ribosomal RNA: construction of mutant and structural analysis. Nucleic Acids Res (1984) 0.84
Analysis of plasmid-coded ribosomal RNA maxicell techniques. Methods Enzymol (1988) 0.84
The alpha subunit of initiation factor 2 is phosphorylated in vivo in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1986) 0.84
Point mutations in the middle of 16S ribosomal RNA of E. coli produced by deletion loop mutagenesis. Nucleic Acids Res (1984) 0.83
Effects of mutagenesis of C912 in the streptomycin binding region of Escherichia coli 16S ribosomal RNA. Biochim Biophys Acta (1990) 0.83
Mutations in the conserved P loop perturb the conformation of two structural elements in the peptidyl transferase center of 23 S ribosomal RNA. J Mol Biol (1999) 0.82
Detection of cation-specific conformational changes in ribosomal RNA by gel electrophoresis. Nucleic Acids Res (1974) 0.81
Staphylococcus aureus domain V functions in Escherichia coli ribosomes provided a conserved interaction with domain IV is restored. RNA (2001) 0.79
Alterations in the peptidyltransferase and decoding domains of ribosomal RNA suppress mutations in the elongation factor G gene. RNA (2000) 0.77
A gel electrophoretic separation of bacterial ribosomal subunits with and without protein S1. Methods Enzymol (1979) 0.75
Probing ribosome structure and function by mutagenesis. Cold Spring Harb Symp Quant Biol (2001) 0.75
Effects of mutations at position 36 of tRNA(Glu) on missense and nonsense suppression in Escherichia coli. FEBS Lett (1995) 0.75
Electrophoretic transfer of DNA, RNA, and protein onto diazobenzyloxymethyl paper. Methods Enzymol (1983) 0.75