Published in Growth Factors on January 01, 1999
Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest (2005) 4.74
Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling. Proc Natl Acad Sci U S A (1999) 1.39
A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progression. Cancer Res (2004) 1.36
Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells. Mol Cell Biol (2005) 1.35
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors. Mol Ther (2004) 1.26
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Platelet-derived growth factor gene delivery stimulates ex vivo gingival repair. Tissue Eng (2003) 1.16
Gene therapeutics for periodontal regenerative medicine. Dent Clin North Am (2006) 1.09
Effect of rhPDGF-BB delivery on mediators of periodontal wound repair. Tissue Eng (2006) 1.09
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol (2011) 1.06
Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells. Br J Cancer (2004) 1.02
Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering. J Periodontol (2001) 1.02
RhoB regulates PDGFR-beta trafficking and signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.02
Inhibitory effects of resveratrol on PDGF-BB-induced retinal pigment epithelial cell migration via PDGFRβ, PI3K/Akt and MAPK pathways. PLoS One (2013) 0.99
Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity. J Dent Res (2001) 0.99
Nanofibrous scaffolds incorporating PDGF-BB microspheres induce chemokine expression and tissue neogenesis in vivo. PLoS One (2008) 0.98
Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia (2009) 0.98
Advanced reconstructive technologies for periodontal tissue repair. Periodontol 2000 (2012) 0.94
Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progression. Biochem J (2012) 0.92
Tyrosine kinase inhibitor SU6668 represses chondrosarcoma growth via antiangiogenesis in vivo. BMC Cancer (2007) 0.92
Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β. Pulm Circ (2011) 0.87
Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction. J Periodontal Res (2008) 0.86
Regulation of the proliferation and differentiation of Leydig stem cells in the adult testis. Biol Reprod (2014) 0.83
Mammary tumors that become independent of the type I insulin-like growth factor receptor express elevated levels of platelet-derived growth factor receptors. BMC Cancer (2011) 0.83
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J (1999) 0.82
Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets (2015) 0.81
RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology. Mol Cell Biol (2015) 0.81
Phase I and pharmacokinetic study of TSU-68, a novel multiple receptor tyrosine kinase inhibitor, by twice daily oral administration between meals in patients with advanced solid tumors. Cancer Chemother Pharmacol (2010) 0.81
Leucine motif-dependent tyrosine autophosphorylation of type III receptor tyrosine kinases. J Biol Chem (2006) 0.80
Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase Cγ 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo. J Am Coll Cardiol (2011) 0.80
Multi-omics analysis reveals regulators of the response to PDGF-BB treatment in pulmonary artery smooth muscle cells. BMC Genomics (2016) 0.75
Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges. Arch Med Sci (2015) 0.75
[Growth factors]. Z Rheumatol (2007) 0.75
MiR-339 inhibits proliferation of pulmonary artery smooth muscle cell by targeting FGF signaling. Physiol Rep (2017) 0.75
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell (1995) 11.86
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell (1993) 4.83
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (1994) 4.67
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev (1999) 3.09
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J (1992) 2.79
Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature (1994) 2.71
Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science (1994) 2.65
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science (1992) 2.41
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J Biol Chem (1995) 2.06
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol (1992) 2.00
Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol (2001) 1.99
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol (1993) 1.88
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol (1996) 1.68
Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem (2000) 1.62
Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation. J Biol Chem (1991) 1.57
Identification of a putative Syp substrate, the PDGF beta receptor. J Biol Chem (1995) 1.55
Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (1999) 1.49
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem (1998) 1.40
Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol Cell Biol (1995) 1.38
Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells. Mol Cell Biol (1990) 1.38
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res (1999) 1.37
Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1996) 1.35
PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol (1999) 1.31
Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. J Biol Chem (1998) 1.31
A role for Src in signal relay by the platelet-derived growth factor alpha receptor. J Biol Chem (1998) 1.28
Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J Biol Chem (1999) 1.16
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol (1995) 1.15
Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol Cell Biol (1998) 1.14
Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. J Biol Chem (1999) 1.14
A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells. Mol Biol Cell (1999) 1.13
Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Am J Pathol (2000) 1.13
Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Curr Biol (1998) 1.13
Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL. Am J Transplant (2007) 1.12
Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Invest Ophthalmol Vis Sci (2000) 1.11
The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1. Mol Cell Biol (1995) 1.10
D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor. Biochem J (1996) 1.06
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene (1994) 1.06
The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways. Blood (2001) 1.06
Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase. J Biol Chem (1997) 1.05
Growth factor-dependent signaling and cell cycle progression. FEBS Lett (2001) 1.05
Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (1999) 1.02
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol Cell Biol (1996) 0.98
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases. Cell Growth Differ (1991) 0.97
PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Curr Biol (2000) 0.95
Cultured endothelial cells do not respond to a platelet-derived growth-factor-like protein in an autocrine manner. Biochim Biophys Acta (1985) 0.94
Platelet-derived growth factor induces a long-term inhibition of N-methyl-D-aspartate receptor function. J Biol Chem (1996) 0.93
Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage. Gene Ther (2011) 0.92
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Biochem Biophys Res Commun (1997) 0.91
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma. FASEB J (1999) 0.91
Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J Biol Chem (2000) 0.91
The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP. Oncogene (1994) 0.89
A new member of an old family. Nat Cell Biol (2000) 0.88
Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor. J Biol Chem (1994) 0.88
Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways. J Biol Chem (1999) 0.86
Platelet-derived growth factor receptor is a novel modulator of type A gamma-aminobutyric acid-gated ion channels. Mol Pharmacol (1995) 0.86
Multiple roles for Src in a PDGF-stimulated cell. Exp Cell Res (1999) 0.85
Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. Exp Cell Res (1999) 0.84
Roles of platelet-derived growth factor in the developing and mature nervous systems. Brain Res Brain Res Rev (1997) 0.84
The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs. J Biol Chem (1997) 0.84
Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochem Biophys Res Commun (1996) 0.83
PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene (1997) 0.83
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J (1999) 0.82
[Viral vectors for gene delivery to corneal endothelial cells]. Klin Monbl Augenheilkd (2011) 0.81
Growth factor-dependent signaling and cell cycle progression. Chem Rev (2001) 0.81
A comparison of the platelet-derived growth factor-dependent tyrosine kinase activity in sparse and confluent fibroblasts. J Cell Physiol (1986) 0.79
Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene (2000) 0.79
The kinase-inactive PDGF beta-receptor mediates activation of the MAP kinase cascade via the endogenous PDGF alpha-receptor in HepG2 cells. Oncogene (1996) 0.79
A novel endoproteolytic processing activity in mitochondria of erythroid cells and the role in heme synthesis. Blood (2000) 0.78
Advances in a gene therapy-based approach to treat proliferative vitreoretinopathy. Arch Soc Esp Oftalmol (2003) 0.78
Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Mol Carcinog (1999) 0.77
Comparison of the phosphorylation events in membranes from proliferating vs. quiescent endothelial cells. J Cell Physiol (1987) 0.77
Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy. Diabetologia (2013) 0.76
Expression of PDGF, VEGF and their receptors in non-small cell lung tumor cell lines. Int J Oncol (1996) 0.75
The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. Exp Cell Res (2001) 0.75
[Pathophysiologic significance of growth factors and new therapeutic concepts in cardiovascular disease]. Med Klin (Munich) (1999) 0.75