Published in Mol Cell Biol on March 02, 2015
Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases. Invest Ophthalmol Vis Sci (2016) 0.77
PDGFRα Is a Key Regulator of T1 and T3's Differential Effect on SMA Expression in Human Corneal Fibroblasts. Invest Ophthalmol Vis Sci (2017) 0.75
Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia. Mol Cell Biol (2016) 0.75
Editing VEGFR2 Blocks VEGF-Induced Activation of Akt and Tube Formation. Invest Ophthalmol Vis Sci (2017) 0.75
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell (2007) 17.98
Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature (1994) 10.34
Proteins regulating Ras and its relatives. Nature (1993) 9.87
Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05
Cloning of bovine GAP and its interaction with oncogenic ras p21. Nature (1988) 5.56
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways. Cell (1992) 5.09
Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev (1994) 5.04
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell (1990) 4.85
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell (1993) 4.83
Molecular cloning of two types of GAP complementary DNA from human placenta. Science (1988) 4.39
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell (1994) 4.10
Binding of GAP to activated PDGF receptors. Science (1990) 3.89
The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites. Development (1997) 3.78
MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med (2010) 2.99
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J (1992) 2.79
PDGF signaling in cells and mice. Cytokine Growth Factor Rev (2004) 2.57
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). J Biol Chem (1990) 2.49
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol Cell Biol (1992) 2.11
Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res (2009) 1.92
Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol (2003) 1.91
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol (1996) 1.68
The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell (2001) 1.52
Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (1999) 1.49
Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem (2011) 1.48
Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors (1999) 1.43
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2007) 1.41
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
A role for Src in signal relay by the platelet-derived growth factor alpha receptor. J Biol Chem (1998) 1.28
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase. Mol Cell Biol (1993) 1.23
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap. Mol Cell Biol (1997) 1.14
Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy? Prog Retin Eye Res (2014) 1.12
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol (2010) 1.11
The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1. Mol Cell Biol (1995) 1.10
Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res (2004) 1.09
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol (2011) 1.06
Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions. J Biol Chem (1993) 1.02
A comparison of different cellular inocula in an experimental model of massive periretinal proliferation. Am J Ophthalmol (1982) 1.01
A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol (2011) 0.99
Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci (2009) 0.99
Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. Am J Pathol (2013) 0.98
TGFbeta1-dependent contraction of fibroblasts is mediated by the PDGFalpha receptor. Invest Ophthalmol Vis Sci (2002) 0.96
Expression of PDGFRα is a determinant of the PVR potential of ARPE19 cells. Invest Ophthalmol Vis Sci (2011) 0.96
Proliferative vitreoretinopathy: developments in pathogenesis and treatment. Compr Ophthalmol Update (2006) 0.92
Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J Biol Chem (2000) 0.91
The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP. Oncogene (1994) 0.89
Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. Exp Cell Res (1999) 0.84
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol Cell Biol (2013) 0.84