Published in J Biol Chem on April 04, 1997
Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways. Genes Dev (2000) 1.15
Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol Cell Biol (1998) 1.14
SRY-box containing gene 17 regulates the Wnt/β-catenin signaling pathway in oligodendrocyte progenitor cells. J Neurosci (2011) 1.10
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One (2009) 1.09
Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. J Biol Chem (2008) 1.04
Inhibition of platelet-derived growth factor signalling induces autophagy in malignant glioma cells. Br J Cancer (2004) 1.02
Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol Biol Cell (2005) 1.00
Over-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathway. PLoS One (2012) 0.92
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol Cell Biol (2013) 0.84
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J (1999) 0.82
A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A (2003) 0.78
Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase. Proc Natl Acad Sci U S A (1999) 0.78
Kris DeMali: fixed on cell adhesion. Interview by Ruth Williams. J Cell Biol (2008) 0.75
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell (1995) 11.86
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell (1990) 4.83
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell (1993) 4.83
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (1994) 4.67
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev (1999) 3.09
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J (1992) 2.79
Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature (1994) 2.71
Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science (1994) 2.65
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science (1992) 2.41
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J Biol Chem (1995) 2.06
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol (1992) 2.00
Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol (2001) 1.99
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol (1993) 1.88
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol (1996) 1.68
Platelet-derived growth factor-induced H(2)O(2) production requires the activation of phosphatidylinositol 3-kinase. J Biol Chem (2000) 1.62
Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts. Biochem J (1997) 1.60
Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation. J Biol Chem (1991) 1.57
Identification of a putative Syp substrate, the PDGF beta receptor. J Biol Chem (1995) 1.55
Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (1999) 1.49
Evidence for distinct signaling properties and biological responses induced by the PDGF receptor alpha and beta subtypes. Growth Factors (1999) 1.43
Phosphoinositide 3-kinase regulates phospholipase Cgamma-mediated calcium signaling. J Biol Chem (1998) 1.40
Ligand-independent activation of the platelet-derived growth factor beta receptor: requirements for bovine papillomavirus E5-induced mitogenic signaling. Mol Cell Biol (1995) 1.38
Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells. Mol Cell Biol (1990) 1.38
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase. Cancer Res (1999) 1.37
Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1996) 1.35
PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol (1999) 1.31
Full activation of the platelet-derived growth factor beta-receptor kinase involves multiple events. J Biol Chem (1998) 1.31
A role for Src in signal relay by the platelet-derived growth factor alpha receptor. J Biol Chem (1998) 1.28
Induction of stress proteins in Sindbis virus- and vesicular stomatitis virus-infected cells. Virology (1983) 1.24
Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J Biol Chem (1999) 1.16
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol (1995) 1.15
Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol Cell Biol (1998) 1.14
Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis. J Biol Chem (1999) 1.14
Vascular endothelial growth factor and hepatocyte growth factor levels are differentially elevated in patients with advanced retinopathy of prematurity. Am J Pathol (2000) 1.13
A role for cadherin-5 in regulation of vascular endothelial growth factor receptor 2 activity in endothelial cells. Mol Biol Cell (1999) 1.13
Src-like adaptor protein (Slap) is a negative regulator of mitogenesis. Curr Biol (1998) 1.13
Corneal graft rejection is accompanied by apoptosis of the endothelium and is prevented by gene therapy with bcl-xL. Am J Transplant (2007) 1.12
Attenuation of experimental proliferative vitreoretinopathy by inhibiting the platelet-derived growth factor receptor. Invest Ophthalmol Vis Sci (2000) 1.11
The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1. Mol Cell Biol (1995) 1.10
D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor. Biochem J (1996) 1.06
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene (1994) 1.06
The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways. Blood (2001) 1.06
Growth factor-dependent signaling and cell cycle progression. FEBS Lett (2001) 1.05
Hepatocyte growth factor receptor in human RPE cells: implications in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (1999) 1.02
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol Cell Biol (1996) 0.98
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases. Cell Growth Differ (1991) 0.97
Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen: a role for Fyn in T cell signal transduction. Eur J Immunol (1995) 0.96
PDGF initiates two distinct phases of protein kinase C activity that make unequal contributions to the G0 to S transition. Curr Biol (2000) 0.95
Cultured endothelial cells do not respond to a platelet-derived growth-factor-like protein in an autocrine manner. Biochim Biophys Acta (1985) 0.94
Alterations in monovalent cation transport in Sindbis virus-infected chick cells. Virology (1984) 0.93
Platelet-derived growth factor induces a long-term inhibition of N-methyl-D-aspartate receptor function. J Biol Chem (1996) 0.93
Anti-apoptotic gene therapy prolongs survival of corneal endothelial cells during storage. Gene Ther (2011) 0.92
Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF. Biochem Biophys Res Commun (1997) 0.91
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma. FASEB J (1999) 0.91
Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. J Biol Chem (2000) 0.91
Effect of tunicamycin on the development of the cytopathic effect in Sindbis virus-infected avian fibroblasts. Virology (1985) 0.90
Interactions between the middle T antigen of polyomavirus and host cell proteins. Cold Spring Harb Symp Quant Biol (1988) 0.90
The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP. Oncogene (1994) 0.89
A new member of an old family. Nat Cell Biol (2000) 0.88
Activation of phospholipase C-gamma is necessary for stimulation of phospholipase D by platelet-derived growth factor. J Biol Chem (1994) 0.88
Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways. J Biol Chem (1999) 0.86
Platelet-derived growth factor receptor is a novel modulator of type A gamma-aminobutyric acid-gated ion channels. Mol Pharmacol (1995) 0.86
Multiple roles for Src in a PDGF-stimulated cell. Exp Cell Res (1999) 0.85
Phosphospecific antibodies reveal temporal regulation of platelet-derived growth factor beta receptor signaling. Exp Cell Res (1999) 0.84
Effect of incubation time on the generation of defective-interfering particles during undiluted serial passage of sindbis virus in Aedes albopictus and chick cells. Virology (1979) 0.84
Roles of platelet-derived growth factor in the developing and mature nervous systems. Brain Res Brain Res Rev (1997) 0.84
The platelet-derived growth factor beta receptor triggers multiple cytoplasmic signaling cascades that arrive at the nucleus as distinguishable inputs. J Biol Chem (1997) 0.84
Effects of overexpressing wild-type and mutant PDGF receptors on translocation of GLUT4 in transfected rat adipose cells. Biochem Biophys Res Commun (1996) 0.83
PLC-gamma activation is required for PDGF-betaR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells. Oncogene (1997) 0.83
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J (1999) 0.82
[Viral vectors for gene delivery to corneal endothelial cells]. Klin Monbl Augenheilkd (2011) 0.81
Growth factor-dependent signaling and cell cycle progression. Chem Rev (2001) 0.81
The kinase-inactive PDGF beta-receptor mediates activation of the MAP kinase cascade via the endogenous PDGF alpha-receptor in HepG2 cells. Oncogene (1996) 0.79
A comparison of the platelet-derived growth factor-dependent tyrosine kinase activity in sparse and confluent fibroblasts. J Cell Physiol (1986) 0.79
Connecting signaling and cell cycle progression in growth factor-stimulated cells. Oncogene (2000) 0.79
Alterations in focal adhesion kinase activity and associated proteins during malignant conversion of mouse keratinocytes. Mol Carcinog (1999) 0.79
A novel endoproteolytic processing activity in mitochondria of erythroid cells and the role in heme synthesis. Blood (2000) 0.78
Advances in a gene therapy-based approach to treat proliferative vitreoretinopathy. Arch Soc Esp Oftalmol (2003) 0.78
Sindbis virus infection increases hexose transport in quiescent cells. Virology (1986) 0.78
Comparison of the phosphorylation events in membranes from proliferating vs. quiescent endothelial cells. J Cell Physiol (1987) 0.77
Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks the assembly of peptide-MHC class II complexes. Int Immunol (1997) 0.77
Reduced receptor expression for platelet-derived growth factor and epidermal growth factor in dividing mouse lung epithelial cells. Mol Carcinog (1999) 0.77
Regression activity that is naturally present in vitreous becomes ineffective as patients develop proliferative diabetic retinopathy. Diabetologia (2013) 0.76
Membrane-mediated alterations of intracellular Na+ and K+ in lytic-virus-infected and retrovirus-transformed cells. Biosci Rep (1982) 0.75
[Pathophysiologic significance of growth factors and new therapeutic concepts in cardiovascular disease]. Med Klin (Munich) (1999) 0.75
The requirement of tyrosines 579 and 581 for maximal ligand-dependent activation of the betaPDGFR is influenced by noncytoplasmic regions of the receptor. Exp Cell Res (2001) 0.75
Expression of PDGF, VEGF and their receptors in non-small cell lung tumor cell lines. Int J Oncol (1996) 0.75