Published in EMBO J on April 01, 1992
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J (1992) 5.84
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J (1993) 3.80
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol (1994) 3.42
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol (1994) 2.66
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma. EMBO J (1992) 2.47
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases. EMBO J (1993) 2.46
The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells. Proc Natl Acad Sci U S A (1993) 2.41
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol Cell Biol (1992) 2.11
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. Proc Natl Acad Sci U S A (1995) 2.08
The v-Src SH3 domain binds phosphatidylinositol 3'-kinase. Mol Cell Biol (1993) 1.96
Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Biochem J (1994) 1.94
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc Natl Acad Sci U S A (1992) 1.93
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. Mol Cell Biol (1993) 1.91
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. EMBO J (1993) 1.91
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively. Mol Cell Biol (1993) 1.88
The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Mol Cell Biol (1992) 1.87
Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol Cell Biol (1996) 1.85
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol Cell Biol (1993) 1.77
Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. EMBO J (1993) 1.76
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci U S A (1993) 1.76
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. EMBO J (1994) 1.68
Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol (1996) 1.68
Structural and functional studies on platelet-derived growth factor. EMBO J (1992) 1.64
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci U S A (1993) 1.58
Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts. EMBO J (1993) 1.52
Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells. Proc Natl Acad Sci U S A (1998) 1.47
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides. Mol Cell Biol (1993) 1.45
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol Cell Biol (1993) 1.44
Thr38 and Ser198 are Pto autophosphorylation sites required for the AvrPto-Pto-mediated hypersensitive response. EMBO J (2000) 1.40
SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence. Mol Cell Biol (1993) 1.38
Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell (2001) 1.36
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Mol Cell Biol (1994) 1.30
GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Mol Cell Biol (1992) 1.29
Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues. EMBO J (1997) 1.26
Tyrosine 785 is a major determinant of Trk--substrate interaction. EMBO J (1993) 1.25
Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1. Mol Biol Cell (1993) 1.24
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase. Mol Cell Biol (1993) 1.23
Mutations in the Caenorhabditis elegans let-23 EGFR-like gene define elements important for cell-type specificity and function. EMBO J (1994) 1.23
Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol Cell Biol (1996) 1.22
The chemotactic response to PDGF-BB: evidence of a role for Ras. J Cell Biol (1995) 1.20
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc Natl Acad Sci U S A (1993) 1.18
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. Mol Cell Biol (1994) 1.17
Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1. Mol Cell Biol (1994) 1.16
Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J Cell Biol (1996) 1.16
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation. Mol Cell Biol (1995) 1.15
Interactions of polyomavirus middle T with the SH2 domains of the pp85 subunit of phosphatidylinositol-3-kinase. J Virol (1992) 1.12
Autophosphorylation: a salient feature of protein kinases. Mol Cell Biochem (1993) 1.11
Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes. Mol Cell Biol (1993) 1.11
The GTPase-activating protein of Ras suppresses platelet-derived growth factor beta receptor signaling by silencing phospholipase C-gamma 1. Mol Cell Biol (1995) 1.10
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types. Mol Cell Biol (1993) 1.09
Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly. Biochem J (2006) 1.04
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. Mol Cell Biol (1996) 0.98
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem (2008) 0.97
New insights into protein-tyrosine kinase receptor signaling complexes. Protein Sci (1993) 0.94
Differential effects of carboxy-terminal sequence deletions on platelet-derived growth factor receptor signaling activities and interactions with cellular substrates. Mol Cell Biol (1992) 0.93
Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase. EMBO J (1996) 0.92
Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution. Proc Natl Acad Sci U S A (1992) 0.89
Phosphopeptide binding to the N-terminal SH2 domain of the p85 alpha subunit of PI 3'-kinase: a heteronuclear NMR study. Protein Sci (1994) 0.89
A critical role for PDGFRα signaling in medial nasal process development. PLoS Genet (2013) 0.89
En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Proc Natl Acad Sci U S A (1993) 0.88
Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling. J Cell Biol (1994) 0.85
Tyrosine 807 of the v-Fms oncogene product controls cell morphology and association with p120RasGAP. J Virol (1995) 0.83
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J (1999) 0.82
RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology. Mol Cell Biol (2015) 0.81
Genetic analysis of a phosphatidylinositol 3-kinase SH2 domain reveals determinants of specificity. Mol Cell Biol (1994) 0.80
Targeting receptor tyrosine kinases and their downstream signaling with cell-penetrating peptides in human pulmonary artery smooth muscle and endothelial cells. Chem Biol Drug Des (2014) 0.79
Analysis of mutant platelet-derived growth factor receptors expressed in PC12 cells identifies signals governing sodium channel induction during neuronal differentiation. Mol Cell Biol (1997) 0.78
A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A (2003) 0.78
Phosphatidylinositol 3'-kinase associates with p145c-kit as part of a cell type characteristic multimeric signalling complex. EMBO J (1993) 0.78
5,8-Dimethoxy-2-Nonylamino-Naphthalene-1,4-Dione Inhibits Vascular Smooth Muscle Cell Proliferation by Blocking Autophosphorylation of PDGF-Receptor β. Korean J Physiol Pharmacol (2013) 0.77
A preclinical study demonstrating the efficacy of nilotinib in inhibiting the growth of pediatric high-grade glioma. J Neurooncol (2015) 0.76
Association of the insulin receptor and phosphatidylinositol 3-kinase requires a third component. Biochem J (1994) 0.76
Involvement of a phosphotyrosine protein phosphatase in the suppression of platelet-derived growth factor receptor autophosphorylation in ras-transformed cells. Biochem J (1993) 0.75
Human airway smooth muscle cell proliferation from asthmatics is negatively regulated by semaphorin3A. Oncotarget (2016) 0.75
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Improved retroviral vectors for gene transfer and expression. Biotechniques (1989) 19.48
Oncogenes and signal transduction. Cell (1991) 14.84
SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins. Science (1991) 12.93
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (1986) 7.90
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature (1985) 7.10
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell (1991) 6.28
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell (1987) 5.87
EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism for EGF receptor signaling. Cell (1989) 5.68
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell (1991) 5.65
Autophosphorylation sites on the epidermal growth factor receptor. Nature (1984) 5.11
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell (1990) 4.85
Expression of human class II major histocompatibility complex antigens using retrovirus vectors. Proc Natl Acad Sci U S A (1987) 4.84
Association between the PDGF receptor and members of the src family of tyrosine kinases. Cell (1990) 4.83
cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. Cell (1991) 4.76
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell (1989) 4.52
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle. Nature (1989) 4.25
Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science (1989) 4.21
Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. Science (1990) 4.21
Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci U S A (1990) 4.13
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science (1989) 4.08
Presence of an SH2 domain in the actin-binding protein tensin. Science (1991) 4.03
An 81 kd protein complexed with middle T antigen and pp60c-src: a possible phosphatidylinositol kinase. Cell (1987) 4.03
Signal transduction by the platelet-derived growth factor receptor. Science (1989) 3.94
Binding of GAP to activated PDGF receptors. Science (1990) 3.89
Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction. Oncogene (1988) 3.70
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem (1989) 3.33
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol (1991) 3.20
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature (1989) 3.09
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J (1990) 3.05
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem (1988) 2.90
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J (1990) 2.76
Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C. Proc Natl Acad Sci U S A (1989) 2.75
Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis. Cell (1989) 2.71
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex. Mol Cell Biol (1990) 2.71
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. Proc Natl Acad Sci U S A (1991) 2.69
Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regul (1990) 2.31
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3'-kinase SH2 domains: a model for SH2-mediated receptor-target interactions. EMBO J (1992) 2.29
An investigation of protein subunit and domain interfaces. Protein Eng (1988) 2.18
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc Natl Acad Sci U S A (1988) 2.06
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor. Mol Cell Biol (1990) 1.95
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. EMBO J (1989) 1.81
Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J (1989) 1.76
The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor. Mol Cell Biol (1991) 1.76
Ligand-induced dimerization of the platelet-derived growth factor receptor. Monomer-dimer interconversion occurs independent of receptor phosphorylation. J Biol Chem (1989) 1.59
Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit. Cell Regul (1991) 1.55
Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformational change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis. Mol Cell Biol (1989) 1.54
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol Cell Biol (1991) 1.42
A specific combination of substrates is involved in signal transduction by the kit-encoded receptor. EMBO J (1991) 1.39
Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase. Mol Cell Biol (1991) 1.20
Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity. J Biol Chem (1988) 1.17
Platelet-derived growth factor (PDGF)-induced disulfide-linked dimerization of PDGF receptor in living cells. Mol Cell Biol (1991) 1.10
Geometry of interaction of metal ions with sulfur-containing ligands in protein structures. Biochemistry (1989) 1.05
Academic information in the academic health sciences center. Roles for the library in information management. J Med Educ (1982) 28.04
Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell (1993) 16.91
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
Detection and quantification of phosphotyrosine in proteins. Methods Enzymol (1983) 11.89
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell (1995) 11.86
Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu Rev Biochem (1986) 9.17
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature (1985) 8.36
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J (1997) 5.49
Regulation, substrates and functions of src. Biochim Biophys Acta (1996) 5.45
Pyrene actin: documentation of the validity of a sensitive assay for actin polymerization. J Muscle Res Cell Motil (1983) 5.36
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells. Cell (1981) 5.08
Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J (1999) 5.05
Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell (1993) 4.83
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (1994) 4.67
The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid. Cell (1982) 4.66
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell (1989) 4.52
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane. Nature (1984) 4.27
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src. Mol Cell Biol (1986) 3.99
Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol (1996) 3.97
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature (1991) 3.97
Binding of GAP to activated PDGF receptors. Science (1990) 3.89
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem (1984) 3.88
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol (1995) 3.79
A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Cell (1994) 3.77
Ultrastructural analysis of the dynactin complex: an actin-related protein is a component of a filament that resembles F-actin. J Cell Biol (1994) 3.74
Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron (1999) 3.70
Utility of a lung biopsy for the diagnosis of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2001) 3.69
Neuronal position in the developing brain is regulated by mouse disabled-1. Nature (1997) 3.60
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling. Nat Immunol (2000) 3.58
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol (1999) 3.46
Movement of cortical actin patches in yeast. J Cell Biol (1996) 3.40
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1982) 3.28
Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae. J Cell Biol (2000) 3.25
Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Nature (1997) 3.22
Quantitative analysis of the effect of Acanthamoeba profilin on actin filament nucleation and elongation. Biochemistry (1984) 3.15
c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF. Genes Dev (1999) 3.09
In vitro translation of immediate early, early, and late classes of RNA from vaccinia virus-infected cells. Virology (1979) 2.97
Disruption of the actin cytoskeleton in yeast capping protein mutants. Nature (1990) 2.94
Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. J Cell Biol (2000) 2.94
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins. Cell (1982) 2.92
Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. Mol Cell Biol (1993) 2.87
Requirements for phosphorylation of MAP kinase during meiosis in Xenopus oocytes. Science (1992) 2.83
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J (1990) 2.76
Regulation of chemotaxis by the platelet-derived growth factor receptor-beta. Nature (1994) 2.71
Visualization and molecular analysis of actin assembly in living cells. J Cell Biol (1998) 2.70
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol Cell Biol (1994) 2.66
Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites. Science (1994) 2.65
Expression of the vaccinia virus genome: analysis and mapping of mRNAs encoded within the inverted terminal repetition. Cell (1980) 2.63
Protein kinase C phosphorylates pp60src at a novel site. Cell (1985) 2.63
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein. J Cell Biol (1986) 2.63
Hybridization selection and cell-free translation of mRNA's encoded within the inverted terminal repetition of the vaccinia virus genome. J Virol (1981) 2.48
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus. Nature (1983) 2.47
Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-alpha signal transduction. J Biol Chem (1998) 2.42
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science (1992) 2.41
Statistical quality control of radioimmunoassays. J Clin Endocrinol Metab (1968) 2.41
Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways. Mol Cell Biol (1999) 2.39
Extension of the transcriptional and translational map of the left end of the vaccinia virus genome to 21 kilobase pairs. J Virol (1981) 2.39
Kinetic evidence for a monomer activation step in actin polymerization. Biochemistry (1983) 2.38
Effects of CapZ, an actin capping protein of muscle, on the polymerization of actin. Biochemistry (1989) 2.38
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem (1997) 2.37
Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts. Mol Cell Biol (1991) 2.36
Tissue engineering: orthopedic applications. Annu Rev Biomed Eng (1999) 2.36
Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. Curr Top Microbiol Immunol (1983) 2.32
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen. Mol Cell Biol (1986) 2.32
Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic (2001) 2.31
Rho family members: activators of MAP kinase cascades. Cell (1995) 2.29
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J Biol Chem (1992) 2.29
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Mol Cell Biol (1984) 2.28
Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src. Mol Cell Biol (1985) 2.25
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function. Proc Natl Acad Sci U S A (1994) 2.22
Discovering carcinogens in the occupational environment: a novel epidemiologic approach. J Natl Cancer Inst (1981) 2.18
A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Nature (1998) 2.18
Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast. J Cell Biol (1992) 2.18
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J Biol Chem (1998) 2.16
Capping protein levels influence actin assembly and cell motility in dictyostelium. Cell (1995) 2.15
The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol Cell Biol (1999) 2.15
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J Biol Chem (1993) 2.13
Purification, characterization, and immunofluorescence localization of Saccharomyces cerevisiae capping protein. J Cell Biol (1992) 2.13
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol Cell Biol (1992) 2.11
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
Deletion of the vaccinia virus growth factor gene reduces virus virulence. J Virol (1988) 2.10
Methods to measure actin polymerization. Methods Enzymol (1982) 2.09
Role of actin and Myo2p in polarized secretion and growth of Saccharomyces cerevisiae. Mol Biol Cell (2000) 2.09
Drug-induced pulmonary disease. Part 1: Cytotoxic drugs. Am Rev Respir Dis (1986) 2.08
Microinjection of gelsolin into living cells. J Cell Biol (1987) 2.06
Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking. J Biol Chem (1995) 2.06
Identification and characterization of cellular targets for tyrosine protein kinases. J Biol Chem (1983) 2.03
Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning. Genes Dev (1999) 2.02
Differential localization and sequence analysis of capping protein beta-subunit isoforms of vertebrates. J Cell Biol (1994) 2.00
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol (1992) 2.00
Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol (2001) 1.99
Assembly and function of the actin cytoskeleton of yeast: relationships between cables and patches. J Cell Biol (1998) 1.98