Published in J Biol Chem on July 18, 1997
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol (1997) 3.39
CHIP activates HSF1 and confers protection against apoptosis and cellular stress. EMBO J (2003) 2.78
The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69
HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J (1999) 2.36
The HSP70 family and cancer. Carcinogenesis (2013) 2.06
Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J (2001) 1.79
Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol (1999) 1.75
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli. Cell Stress Chaperones (2001) 1.47
Apoptosis and molecular targeting therapy in cancer. Biomed Res Int (2014) 1.47
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol (2000) 1.42
Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37
Heat shock protein hsp72 is a negative regulator of apoptosis signal-regulating kinase 1. Mol Cell Biol (2002) 1.35
Adenoviral transfer of HSP-70 into pulmonary epithelium ameliorates experimental acute respiratory distress syndrome. J Clin Invest (2002) 1.30
Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. J Neurochem (2009) 1.28
Inflammation, heat shock proteins, and type 2 diabetes. Cell Stress Chaperones (2008) 1.25
Selective cytotoxicity of intense nanosecond-duration electric pulses in mammalian cells. Biochim Biophys Acta (2010) 1.24
Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis. Mol Cell Biol (2002) 1.17
Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium. J Immunol (2012) 1.15
Innate immune signaling in the pathogenesis of necrotizing enterocolitis. Clin Dev Immunol (2013) 1.07
Loss of the inducible Hsp70 delays the inflammatory response to skeletal muscle injury and severely impairs muscle regeneration. PLoS One (2013) 1.06
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene (2011) 1.06
Molecular chaperones as rational drug targets for Parkinson's disease therapeutics. CNS Neurol Disord Drug Targets (2010) 1.04
Loss of Hsp70 in Drosophila is pleiotropic, with effects on thermotolerance, recovery from heat shock and neurodegeneration. Genetics (2005) 1.04
C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis. Cell Stress Chaperones (2005) 1.03
Hsp70 in cancer: back to the future. Oncogene (2014) 1.03
Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis. Biochem J (1999) 1.02
The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes. Cell Stress Chaperones (2014) 1.00
Epstein-Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones. J Gen Virol (2008) 1.00
Activation of the mitogen-activated protein kinase pathways by heat shock. Cell Stress Chaperones (2002) 0.98
The Chemical Biology of Molecular Chaperones--Implications for Modulation of Proteostasis. J Mol Biol (2015) 0.98
Dual role for Hsc70 in the biogenesis and regulation of the heme-regulated kinase of the alpha subunit of eukaryotic translation initiation factor 2. Mol Cell Biol (1999) 0.96
The human HSP70 family of chaperones: where do we stand? Cell Stress Chaperones (2016) 0.95
Inactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72. Mol Cell Biol (2003) 0.94
Impact of short-term heat stress on physiological responses and expression profile of HSPs in Barbari goats. Int J Biometeorol (2014) 0.93
Sage tea drinking improves lipid profile and antioxidant defences in humans. Int J Mol Sci (2009) 0.92
Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution. J Cell Biol (2000) 0.92
HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK. Cell Stress Chaperones (2000) 0.92
Molecular cochaperones: tumor growth and cancer treatment. Scientifica (Cairo) (2013) 0.92
Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy. Brain (2013) 0.91
Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132. PLoS One (2011) 0.91
HSP70 natively and specifically associates with an N-terminal dermcidin-derived peptide that contains an HLA-A*03 antigenic epitope. J Biol Chem (2011) 0.90
Tissue-level cytoprotection. Cell Stress Chaperones (2000) 0.90
DNAJB3/HSP-40 cochaperone is downregulated in obese humans and is restored by physical exercise. PLoS One (2013) 0.89
Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis. Cell Stress Chaperones (2008) 0.89
Transcriptional expression levels of cell stress marker genes in the Pacific oyster Crassostrea gigas exposed to acute thermal stress. Cell Stress Chaperones (2008) 0.89
Chaperoning to the metabolic party: The emerging therapeutic role of heat-shock proteins in obesity and type 2 diabetes. Mol Metab (2014) 0.88
Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulin. FEBS Lett (2004) 0.88
Effects of schisandrin B pretreatment on tumor necrosis factor-alpha induced apoptosis and Hsp70 expression in mouse liver. Cell Stress Chaperones (2001) 0.87
The complex function of hsp70 in metastatic cancer. Cancers (Basel) (2013) 0.87
The chaperone balance hypothesis: the importance of the extracellular to intracellular HSP70 ratio to inflammation-driven type 2 diabetes, the effect of exercise, and the implications for clinical management. Mediators Inflamm (2015) 0.86
Molecular imaging-assisted optimization of hsp70 expression during laser-induced thermal preconditioning for wound repair enhancement. J Invest Dermatol (2008) 0.85
Exercise training-induced changes in inflammatory mediators and heat shock proteins in young tennis players. J Sports Sci Med (2013) 0.84
Role of inducible heat shock protein 70 in radiation-induced cell death. Cell Stress Chaperones (2001) 0.83
Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice. Comp Hepatol (2004) 0.83
Hsp72 expression enhances survival in adenosine triphosphate-depleted renal epithelial cells. Cell Stress Chaperones (2002) 0.83
Genome-wide identification of heat shock proteins (Hsps) and Hsp interactors in rice: Hsp70s as a case study. BMC Genomics (2014) 0.82
Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70. Cell Death Dis (2014) 0.82
DNAJB3/HSP-40 cochaperone improves insulin signaling and enhances glucose uptake in vitro through JNK repression. Sci Rep (2015) 0.81
TRAIL-induced apoptosis is enhanced by heat shock protein 70 expression. Cell Stress Chaperones (2006) 0.80
Interaction between the inducible 70-kDa heat shock protein and autophagy: effects on fertility and pregnancy. Cell Stress Chaperones (2015) 0.80
Heat shock protein 70 expression is associated with inhibition of renal tubule epithelial cell apoptosis during recovery from low-protein feeding. Cell Stress Chaperones (2006) 0.79
Possible involvement of MAP kinase pathways in acquired metal-tolerance induced by heat in plants. Planta (2008) 0.79
Heat shock protein 70 and the acute respiratory distress syndrome. J Anesth (2005) 0.79
Nonsteroidal anti-inflammatory drugs differentially affect the heat shock response in cultured spinal cord cells. Cell Stress Chaperones (2005) 0.78
Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis. PLoS One (2011) 0.78
Hsp70/nitric oxide relationship in apoptotic modulation during obstructive nephropathy. Cell Stress Chaperones (2008) 0.78
Hyperthermia combined with 5-fluorouracil promoted apoptosis and enhanced thermotolerance in human gastric cancer cell line SGC-7901. Onco Targets Ther (2015) 0.78
Effects of intracerebral hemorrhage and subsequent minimally invasive hematoma aspiration on expression of apoptosisrelated genes in rats. Int J Clin Exp Pathol (2015) 0.77
Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats. Age (Dordr) (2014) 0.77
Intramuscular heating through fluidotherapy and heat shock protein response. J Athl Train (2013) 0.77
Attenuation of okadaic acid-induced hyperphosphorylation of cytoskeletal proteins by heat preconditioning and its possible underlying mechanisms. Cell Stress Chaperones (2004) 0.76
Hsp70 architecture: the formation of novel polymeric structures of Hsp70.1 and Hsc70 after proteotoxic stress. PLoS One (2012) 0.76
Induction of heat-shock protein 70 expression by geranylgeranylacetone shows cytoprotective effects in cardiomyocytes of mice under humid heat stress. PLoS One (2014) 0.76
Induced hsp70 is in small, cytoplasmic complexes in a cell culture model of renal ischemia: a comparative study with heat shock. Cell Stress Chaperones (2000) 0.76
Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival. Prog Retin Eye Res (2016) 0.76
Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy. Cell Stress Chaperones (2015) 0.76
Heat-shock protein 70 modulates apoptosis signal-regulating kinase 1 in stressed hepatocytes of Mugil cephalus. Fish Physiol Biochem (2014) 0.76
The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70. Cell Stress Chaperones (2015) 0.75
Up-regulation of Hsp72 and keratin16 mediates wound healing in streptozotocin diabetic rats. Biol Res (2015) 0.75
Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy. Cell Stress Chaperones (2016) 0.75
The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β. J Biol Chem (2012) 0.75
Role of dynamin-related protein 1-mediated mitochondrial fission in resistance of mouse C2C12 myoblasts to heat injury. J Physiol (2016) 0.75
Glucose activation of islets of Langerhans up-regulates Toll-like receptor 5: possible mechanism of protection. Clin Exp Immunol (2011) 0.75
Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach. Int J Mol Sci (2017) 0.75
HSP70 forms a stable cytotoxic complex with Tag7/PGRP-S. Dokl Biol Sci (2004) 0.75
Cloning and expression analysis of HSP70 gene from mangrove plant Kandelia obovata under cold stress. Ecotoxicology (2015) 0.75
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24
Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev (1998) 3.72
Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol (1997) 3.39
The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69
Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. Mol Cell Biol (1999) 1.75
Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.69
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J Biol Chem (1998) 1.67
Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging. FEBS Lett (1998) 1.57
Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis. Oncogene (2010) 1.45
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol Cell Biol (2000) 1.42
Oncogenic potential of Hsp72. Oncogene (1999) 1.42
The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol (1996) 1.30
Inducible overexpression of a toxic protein by an adenovirus vector with a tetracycline-regulatable expression cassette. J Virol (1998) 1.25
Role of molecular chaperones in neurodegenerative disorders. Int J Hyperthermia (2005) 1.16
Use of a dicistronic expression cassette encoding the green fluorescent protein for the screening and selection of cells expressing inducible gene products. Biotechniques (1997) 1.11
Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis. Oncogene (2011) 1.06
The function of HSP72 in suppression of c-Jun N-terminal kinase activation can be dissociated from its role in prevention of protein damage. J Biol Chem (1999) 1.05
Development and characterization of a rainbow trout liver cell line expressing cytochrome P450-dependent monooxygenase activity. Cell Biol Toxicol (1994) 1.05
Suppression of stress kinase JNK is involved in HSP72-mediated protection of myogenic cells from transient energy deprivation. HSP72 alleviates the stewss-induced inhibition of JNK dephosphorylation. J Biol Chem (2000) 1.02
The molecular chaperone DnaJ is required for the degradation of a soluble abnormal protein in Escherichia coli. J Biol Chem (2000) 1.01
New adenovirus vectors for protein production and gene transfer. Cytotechnology (1998) 1.01
Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1. J Cell Biol (2001) 1.00
Regulation of heat-induced apoptosis by Mcl-1 degradation and its inhibition by Hsp70. Cell Death Differ (2009) 0.98
Reduced thermotolerance in aged cells results from a loss of an hsp72-mediated control of JNK signaling pathway. Cell Stress Chaperones (1998) 0.97
Antisense globin RNA in mouse erythroid tissues: structure, origin, and possible function. Proc Natl Acad Sci U S A (1996) 0.97
Uncoupling of the synthesis of edited and unedited COIII RNA in Trypanosoma brucei. Nature (1990) 0.96
Ligation-mediated amplification of RNA from murine erythroid cells reveals a novel class of beta globin mRNA with an extended 5'-untranslated region. Nucleic Acids Res (1994) 0.95
Transcription of the 5'-terminal cap nucleotide by RNA-dependent DNA polymerase: possible involvement in retroviral reverse transcription. DNA Cell Biol (1995) 0.94
ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis. FEBS Lett (1999) 0.93
Identification of negative-strand complements to cytochrome oxidase subunit III RNA in Trypanosoma brucei. Proc Natl Acad Sci U S A (1991) 0.93
Adjuvant potential of aggregate-forming polyglutamine domains. Vaccine (2008) 0.92
HSP72 can protect cells from heat-induced apoptosis by accelerating the inactivation of stress kinase JNK. Cell Stress Chaperones (2000) 0.92
HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling. Oncogene (2010) 0.91
Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis. Cell Death Differ (2003) 0.91
Synthesis of globin RNA in enucleated differentiating murine erythroleukemia cells. J Cell Biol (1987) 0.87
Dose-dependent reduction of apoptosis in nutrient-limited cultures of NS/0 myeloma cells transfected with the E1B-19K adenoviral gene. Biotechnol Bioeng (1999) 0.85
Temperature ranges over which rainbow trout fibroblasts survive and synthesize heat-shock proteins. J Cell Physiol (1986) 0.85
Heat and sodium arsenite act synergistically on the induction of heat shock gene expression in Xenopus laevis A6 cells. Biochem Cell Biol (1987) 0.84
Use of a micromanipulator for high-efficiency cloning of cells co-expressing fluorescent proteins. Methods Cell Sci (2000) 0.83
Inhibition of pre-mRNA splicing by antisense RNA in vitro: effect of RNA containing sequences complementary to exons. Biochem Biophys Res Commun (1991) 0.83
Prime-boost vaccination with a combination of proteosome-degradable and wild-type forms of two influenza proteins leads to augmented CTL response. Vaccine (2008) 0.83
Culture of insect cells in helical ribbon impeller bioreactor. Biotechnol Bioeng (1991) 0.83
A possible mechanism responsible for the correction of transcription errors. Nucleic Acids Res (1979) 0.81
Transfer of purine metabolites between cells through the medium and via cell contacts in cocultures of HGPRT+ and HGPRT- cells. Exp Cell Res (1987) 0.81
Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia (2002) 0.81
Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. Apoptosis (2015) 0.81
Inhibition of pre-mRNA splicing by antisense RNA in vitro: effect of RNA containing sequences complementary to introns. Biochem Biophys Res Commun (1991) 0.80
Messenger RNA changes during differentiation of murine erythroleukemia cells. Exp Cell Res (1987) 0.79
The transfer of 5'-methylthioadenosine from B82 cells through the medium to CHW-1102 cells. Exp Cell Res (1983) 0.79
Evolutionarily conserved elements in the 5' untranslated region of beta globin mRNA mediate site-specific priming of a unique hairpin structure during cDNA synthesis. Nucleic Acids Res (1994) 0.79
A natural extracellular factor that induces Hsp72, inhibits apoptosis, and restores stress resistance in aged human cells. Exp Cell Res (1999) 0.78
Biochemistry below 0 degrees C: nature's frozen vertebrates. Braz J Med Biol Res (1996) 0.78
Induction and decay of thermotolerance in rainbow trout fibroblasts. J Cell Physiol (1987) 0.77
Pyrophosphate-condensing activity linked to nucleic acid synthesis. Nucleic Acids Res (1979) 0.77
Improved yields of the extracellular domain of the epidermal growth factor receptor produced using the baculovirus expression system by medium replacement following infection. Appl Microbiol Biotechnol (1995) 0.76
The elimination of miR-23a in heat-stressed cells promotes NOXA-induced cell death and is prevented by HSP70. Cell Death Dis (2015) 0.75
Separation by thin-layer chromatography of nucleotides from bases and nucleosides in trichloroacetic acid extracts of cells. J Chromatogr (1982) 0.75
[A study of the intracellular fate of recombinant human interleukin 2 in Escherichia coli]. Mol Biol (Mosk) (1990) 0.75
[Individual anatomical differences in the greater omentum of children of early age]. Arkh Anat Gistol Embriol (1967) 0.75
[Molecular chaperones: new proteins--new functions]. Mol Biol (Mosk) (1992) 0.75
The effect of phorbols on metabolic cooperation between human fibroblasts. Carcinogenesis (1982) 0.75
Heat shock gene expression in Xenopus laevis A6 cells in response to heat shock and sodium arsenite treatments. Biochem Cell Biol (1988) 0.75
[Oligomeric forms of recombinant interleukin-2]. Biokhimiia (1991) 0.75
Effect of saccharin on metabolic cooperation between human fibroblasts. Carcinogenesis (1983) 0.75
Established cell lines from different groups of vertebrates undergo metabolic cooperation with one another. In Vitro (1983) 0.75
Scale-up of recombinant virus and protein production in stirred-tank reactors. Methods Mol Biol (1995) 0.75
Interrelation between taxis and sporulation systems. FEBS Lett (1982) 0.75
[Cloning and characteristics of DNA sequences amplified in Djungarian hamster cells with multidrug resistance]. Mol Gen Mikrobiol Virusol (1987) 0.75