Published in Rev Med Virol on August 19, 1999
Identifying the target cell in primary simian immunodeficiency virus (SIV) infection: highly activated memory CD4(+) T cells are rapidly eliminated in early SIV infection in vivo. J Virol (2000) 3.48
Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions. J Virol (2001) 2.06
Compensatory link between fusion and endocytosis of human immunodeficiency virus type 1 in human CD4 T lymphocytes. J Virol (2004) 2.06
Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc Natl Acad Sci U S A (2003) 1.69
Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex. J Virol (2003) 1.55
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction. J Biol Chem (2006) 1.51
Assembly of human immunodeficiency virus (HIV) antigens on bacteriophage T4: a novel in vitro approach to construct multicomponent HIV vaccines. J Virol (2006) 1.24
Critical role of human T-lymphotropic virus type 1 accessory proteins in viral replication and pathogenesis. Microbiol Mol Biol Rev (2002) 1.20
Compartmentalization of the gut viral reservoir in HIV-1 infected patients. Retrovirology (2007) 1.19
A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. J Virol (2009) 1.17
HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J Exp Med (2002) 1.08
Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription. J Virol (2001) 1.05
Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis. J Virol (2012) 1.00
Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation. J Virol (2001) 0.95
Lentiviral vectors interfering with virus-induced CD4 down-modulation potently block human immunodeficiency virus type 1 replication in primary lymphocytes. J Virol (2004) 0.90
Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment. J Virol (2004) 0.90
Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo. J Virol (2012) 0.88
HIV-1 Nef in macrophage-mediated disease pathogenesis. Int Rev Immunol (2012) 0.86
Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle. J Virol (2002) 0.84
Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex. J Virol (2005) 0.83
Intra-host competition between nef-defective escape mutants and wild-type human immunodeficiency virus type 1. Proc Biol Sci (2000) 0.82
Simultaneous assessment of CD4 and MHC-I downregulation by Nef primary isolates in the context of infection. J Virol Methods (2009) 0.81
Identification of cellular membrane proteins interacting with hepatitis B surface antigen using yeast split-ubiquitin system. Int J Med Sci (2005) 0.80
HIV-1 Nef perturbs artificial membranes: investigation of the contribution of the myristoyl anchor. Biophys J (2009) 0.80
Down-regulation of CTLA-4 by HIV-1 Nef protein. PLoS One (2013) 0.79
Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology. Infect Agent Cancer (2007) 0.78
Lipid Nanoparticles with Accessible Nickel as a Vaccine Delivery System for Single and Multiple His-tagged HIV Antigens. HIV AIDS (Auckl) (2009) 0.77
Inference of surface membrane factors of HIV-1 infection through functional interaction networks. PLoS One (2010) 0.77
The SCHOOL of nature: IV. Learning from viruses. Self Nonself (2010) 0.77
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nat Biotechnol (1997) 12.11
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol (1998) 8.21
Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J Virol (1993) 6.11
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell (1994) 5.92
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol (1999) 5.35
Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency. Cell (1990) 4.78
HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci U S A (1997) 4.59
Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol (1995) 4.45
HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell (1995) 4.41
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell (1995) 4.25
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (2000) 3.89
The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. Proc Natl Acad Sci U S A (1994) 3.65
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr Biol (1999) 2.97
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol (2000) 2.95
Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell (1999) 2.89
Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. J Virol (1996) 2.72
Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. Mol Cell (2001) 2.53
The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A (2000) 2.42
Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. J Exp Med (1990) 2.28
Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes. EMBO J (1998) 2.25
Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene (1995) 2.05
The plasma membrane as a combat zone in the HIV battlefield. Genes Dev (2000) 2.02
Substitutions in the protease (3Cpro) gene of poliovirus can suppress a mutation in the 5' noncoding region. J Virol (1990) 1.96
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum Gene Ther (2000) 1.81
The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. Immunity (1997) 1.78
The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunol Rev (1999) 1.77
Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1992) 1.76
Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency. J Virol (1992) 1.74
Characterization of human immunodeficiency virus type 1 Vif particle incorporation. J Virol (1996) 1.69
High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. Blood (2000) 1.63
Genomic instability in induced stem cells. Cell Death Differ (2011) 1.63
Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology (1996) 1.56
The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. J Virol (1997) 1.52
Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther (2000) 1.48
A stable system for the high-titer production of multiply attenuated lentiviral vectors. Mol Ther (2000) 1.43
Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol (2000) 1.38
Nef-mediated clathrin-coated pit formation. J Cell Biol (1997) 1.38
The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent. J Virol (1993) 1.34
The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity. J Virol (1998) 1.32
HIV-1 latency due to the site of proviral integration. Virology (1993) 1.23
Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer. Hum Gene Ther (2000) 1.14
Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina. Gene Ther (2003) 1.07
Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol Carcinog (1989) 1.06
Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription. Diabetologia (2003) 1.04
Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3. J Virol (1998) 1.04
Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors. Gene Ther (2001) 1.04
Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. Blood (2000) 1.03
Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res (1991) 1.02
Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. Hum Gene Ther (1999) 1.01
Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia (2006) 1.01
Applications of gene therapy to the CNS. Hum Mol Genet (1996) 1.00
Lineage- and stage-restricted lentiviral vectors for the gene therapy of chronic granulomatous disease. Gene Ther (2011) 1.00
Human immunodeficiency virus matrix tyrosine phosphorylation: characterization of the kinase and its substrate requirements. J Virol (1997) 0.99
Deletion of nef slows but does not prevent CD4-positive T-cell depletion in human immunodeficiency virus type 1-infected human-PBL-SCID mice. J Virol (1997) 0.97
Genetic analysis of susceptibility to spontaneous and UV-induced carcinogenesis in Xiphophorus hybrid fish. Mar Biotechnol (NY) (2001) 0.95
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. Mol Cell Neurosci (2000) 0.94
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression. Transl Psychiatry (2013) 0.94
Alternative oxidase in durum wheat mitochondria. Activation by pyruvate, hydroxypyruvate and glyoxylate and physiological role. Plant Cell Physiol (2001) 0.94
The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS. Neuroreport (2000) 0.93
Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas. Cancer Res (1988) 0.91
Intracellular immunization: trans-dominant mutants of HIV gene products as tools for the study and interruption of viral replication. AIDS Res Hum Retroviruses (1992) 0.90
Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. Gene Ther (1999) 0.90
Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using deepithelialized rat tracheas. Cancer Res (1987) 0.90
Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes. Transplant Proc (2005) 0.87
Epidermoid metaplasias of xenotransplanted human tracheobronchial epithelium. Carcinogenesis (1986) 0.86
When accessories turn out to be essential. Nat Med (1998) 0.86
Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis. Mol Biol Cell (1997) 0.86
Regulation of apoptosis in uterine leiomyomata. Endocrinology (1997) 0.85
Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences. J Virol (1995) 0.85
Genetic therapies for HIV infections: promise for the future. AIDS (1995) 0.85
MNU induction of neoplasia in a platyfish model. Lab Invest (2001) 0.84
Transduction of CD34+ cells with lentiviral vectors enables the production of large quantities of transgene-expressing immature and mature dendritic cells. J Gene Med (2001) 0.84
Lentiviral-mediated gene transfer into haematopoietic stem cells. J Intern Med (2001) 0.84
Genetic analysis of neoplasia induced by N-nitroso-N-methylurea in Xiphophorus hybrid fish. Mar Biotechnol (NY) (2001) 0.84
A lentiviral vector expressing a fusogenic glycoprotein for cancer gene therapy. Gene Ther (2000) 0.83
The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions. J Biol Chem (1999) 0.82
Lentiviral vectors for the gene therapy of lympho-hematological disorders. Curr Top Microbiol Immunol (2002) 0.80
Association of protein kinase C activation with induction of ornithine decarboxylase in murine but not human keratinocyte cultures. Mol Carcinog (1993) 0.80
Extraskeletal myxoid chondrosarcoma. A case report with histochemical and ultrastructural features. Appl Pathol (1983) 0.79
HIV-based vectors: getting the best out of the worst. J Gene Med (2000) 0.79
[Causes of death in cases of lymphoma, myeloma and Hodgkin disease. Study of 218 cases]. Schweiz Med Wochenschr (1983) 0.79
Inhibition of HIV-1 in cell culture by oligonucleotide-loaded nanoparticles. Pharm Res (2001) 0.78
Living in oblivion: HIV immune evasion. Semin Immunol (2001) 0.78
Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors. Cancer Res (1995) 0.77
Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells. J Gene Med (2001) 0.77
The multifaceted role of HIV Nef. Res Virol (1997) 0.77
Xiphophorus genetic linkage map: beginnings of comparative gene mapping in fishes. Mar Biotechnol (NY) (2001) 0.76
[The application of lentiviral vectors for tissue-specific gene manipulations]. Tsitologiia (2008) 0.76
Lentiviral vectors for the genetic modification of hematopoietic stem cells. Ernst Schering Res Found Workshop (2001) 0.76
[Thrombotic thrombocytopenic purpura treated with prostacyclin. Apropos of 2 case reports]. Schweiz Med Wochenschr (1986) 0.75
Liquorice intoxication caused by alcohol-free pastis. Lancet (1983) 0.75
[Pseudo-Conn's syndrome due to intoxication with nonalcoholic pastis]. Schweiz Med Wochenschr (1983) 0.75
[Aggressive therapy in a case of Moschowitz syndrome]. Nouv Rev Fr Hematol (1984) 0.75
Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3-->42.1. Cytogenet Cell Genet (1995) 0.75