Published in Cell on April 02, 1999
Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol (2005) 2.98
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol (2000) 2.95
The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. J Cell Biol (2000) 2.90
Structure--function relationships in HIV-1 Nef. EMBO Rep (2001) 2.87
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol (2004) 2.31
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Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways. Microbiol Mol Biol Rev (2006) 2.25
HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc Natl Acad Sci U S A (2001) 2.14
The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components. Mol Biol Cell (2000) 2.11
Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. J Virol (2007) 1.90
Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol (2002) 1.85
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature (2015) 1.85
Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells. EMBO J (2003) 1.85
Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1. Retrovirology (2006) 1.71
Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest (2004) 1.71
Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol (2009) 1.70
Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proc Natl Acad Sci U S A (2007) 1.56
HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS Pathog (2008) 1.50
Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants? Viruses (2012) 1.48
Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation. J Virol (2000) 1.44
Multiplicity of human immunodeficiency virus infections in lymphoid tissue. J Virol (2004) 1.43
Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef. J Virol (2006) 1.41
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HIV dynamics with multiple infections of target cells. Proc Natl Acad Sci U S A (2005) 1.36
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5. J Virol (2006) 1.34
Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells. J Virol (2003) 1.32
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HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals. AIDS Res Hum Retroviruses (2010) 1.26
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Multiple endocytic trafficking pathways of MHC class I molecules induced by a Herpesvirus protein. EMBO J (2002) 1.23
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A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex. J Virol (2009) 1.17
Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabeta. J Virol (2005) 1.16
At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis. Biochem J (2009) 1.15
Lack of adaptation to human tetherin in HIV-1 group O and P. Retrovirology (2011) 1.14
p56Lck anchors CD4 to distinct microdomains on microvilli. Proc Natl Acad Sci U S A (2002) 1.10
HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elements. J Virol (2011) 1.10
A hydrophobic binding surface on the human immunodeficiency virus type 1 Nef core is critical for association with p21-activated kinase 2. J Virol (2006) 1.10
Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. J Virol (2005) 1.10
Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. Cell Logist (2011) 1.06
Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol (2004) 1.05
Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J Virol (2001) 1.05
Mechanisms of HIV-1 Nef function and intracellular signaling. J Neuroimmune Pharmacol (2011) 1.04
Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck. Proc Natl Acad Sci U S A (2004) 1.03
Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins. Mol Biol Cell (2002) 1.03
Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin. J Virol (2001) 1.01
The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation. J Biol Chem (2008) 1.01
Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein. Protein Sci (2000) 1.01
Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway. J Virol (2009) 1.00
Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain. J Virol (2001) 0.99
Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. PLoS Pathog (2011) 0.98
Timing the emergence of resistance to anti-HIV drugs with large genetic barriers. PLoS Comput Biol (2009) 0.97
Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates. J Virol (2001) 0.95
Design and use of an inducibly activated human immunodeficiency virus type 1 Nef to study immune modulation. J Virol (2001) 0.95
Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1. J Virol (2007) 0.95
CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates. J Neurovirol (2010) 0.94
The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway. J Biol Chem (2010) 0.94
Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1. J Virol (2004) 0.94
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner. PLoS One (2012) 0.93
Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity. Mol Biol Cell (2001) 0.92
HIV-1 Nef regulates the release of superoxide anions from human macrophages. Biochem J (2005) 0.92
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches. Mol Cell Proteomics (2013) 0.92
CD4 and MHC-I downregulation are conserved in primary HIV-1 Nef alleles from brain and lymphoid tissues, but Pak2 activation is highly variable. Virology (2006) 0.92
The activity of Nef on HIV-1 infectivity. Front Microbiol (2014) 0.90
HIV immune evasion disruption of antigen presentation by the HIV Nef protein. Adv Virus Res (2011) 0.89
Human immunodeficiency virus type 1 Nef mediates sustained membrane expression of tumor necrosis factor and the related cytokine LIGHT on activated T cells. J Virol (2000) 0.88
Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes. Clin Diagn Lab Immunol (2002) 0.88
Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase. J Virol (2009) 0.87
Autophagy and HIV. Semin Cell Dev Biol (2010) 0.87
The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation. J Biol Chem (2009) 0.87
The Mamu B 17-restricted SIV Nef IW9 to TW9 mutation abrogates correct epitope processing and presentation without loss of replicative fitness. Virology (2008) 0.86
The Vpu protein: new concepts in virus release and CD4 down-modulation. Curr HIV Res (2010) 0.86
A selective autophagy pathway that degrades gluconeogenic enzymes during catabolite inactivation. Commun Integr Biol (2009) 0.85
Detection of human immunodeficiency virus type 1 Nef and CD4 physical interaction in living human cells by using bioluminescence resonance energy transfer. J Virol (2005) 0.85
Taking multiple infections of cells and recombination into account leads to small within-host effective-population-size estimates of HIV-1. PLoS One (2011) 0.83
Down-modulation of CD8αβ is a fundamental activity of primate lentiviral Nef proteins. J Virol (2011) 0.83
Emergence of recombinant forms of HIV: dynamics and scaling. PLoS Comput Biol (2007) 0.82
Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor. J Biol Chem (2014) 0.80
Intra- and intersubtype alternative Pak2-activating structural motifs of human immunodeficiency virus type 1 Nef. J Virol (2006) 0.79
Down-regulation of CTLA-4 by HIV-1 Nef protein. PLoS One (2013) 0.79
In-silico designing of a potent analogue against HIV-1 Nef protein and protease by predicting its interaction network with host cell proteins. J Pharm Bioallied Sci (2013) 0.78
Human immunodeficiency virus type 1 nef expression prevents AP-2-mediated internalization of the major histocompatibility complex class II-associated invariant chain. J Virol (2008) 0.78
AP-2 Is the Crucial Clathrin Adaptor Protein for CD4 Downmodulation by HIV-1 Nef in Infected Primary CD4+ T Cells. J Virol (2015) 0.78
Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag. Virol J (2008) 0.78
The key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted during prolonged glucose starvation and is internalized following glucose re-feeding via the non-classical secretory and internalizing pathways in Saccharomyces cerevisiae. Plant Signal Behav (2013) 0.78
COPA and SLC4A4 are required for cellular entry of arginine-rich peptides. PLoS One (2014) 0.78
Remodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and Persistence. Viruses (2016) 0.77
Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation. J Gen Virol (2015) 0.77
High levels of anti-Nef antibodies may prevent AIDS disease progression in vertically HIV-1-infected infants. J Int AIDS Soc (2014) 0.76
HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling. Sci Rep (2016) 0.76
Modeling Viral Spread. Annu Rev Virol (2016) 0.75
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