Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.

PubWeight™: 12.11‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMID 9306402)

Published in Nat Biotechnol on September 01, 1997

Authors

R Zufferey1, D Nagy, R J Mandel, L Naldini, D Trono

Author Affiliations

1: Salk Institute, La Jolla, CA 92037-1099, USA.

Articles citing this

(truncated to the top 100)

Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48

A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Sci Transl Med (2011) 12.58

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol (1998) 8.21

Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev (2006) 6.32

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J Virol (2003) 6.21

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol (1999) 5.35

Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A (2011) 4.81

Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes. J Exp Med (1999) 4.32

A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One (2009) 3.83

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo. Proc Natl Acad Sci U S A (2004) 3.78

Characterization of the early steps of hepatitis C virus infection by using luciferase reporter viruses. J Virol (2006) 3.75

Capsid is a dominant determinant of retrovirus infectivity in nondividing cells. J Virol (2004) 3.54

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol (2004) 3.45

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci U S A (2008) 3.44

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion. PLoS Pathog (2009) 2.92

CHD7 cooperates with PBAF to control multipotent neural crest formation. Nature (2010) 2.88

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. Nat Genet (2010) 2.50

High-titer human immunodeficiency virus type 1-based vector systems for gene delivery into nondividing cells. J Virol (1998) 2.47

KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading. PLoS Genet (2010) 2.44

The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A (2000) 2.42

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8. J Exp Med (2008) 2.40

DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission from dendritic cells to T cells. J Exp Med (2004) 2.38

Targeted cell entry of lentiviral vectors. Mol Ther (2008) 2.34

Analysis of hepatitis C virus superinfection exclusion by using novel fluorochrome gene-tagged viral genomes. J Virol (2007) 2.29

All three variable regions of the TRIM5alpha B30.2 domain can contribute to the specificity of retrovirus restriction. J Virol (2006) 2.26

Androgen receptor splice variants activate androgen receptor target genes and support aberrant prostate cancer cell growth independent of canonical androgen receptor nuclear localization signal. J Biol Chem (2012) 2.25

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion. J Clin Invest (2011) 2.25

SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24

Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A (2005) 2.21

Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Proc Natl Acad Sci U S A (2005) 2.21

DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication. J Virol (2007) 2.12

Repression by Groucho/TLE/Grg proteins: genomic site recruitment generates compacted chromatin in vitro and impairs activator binding in vivo. Mol Cell (2007) 2.12

Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev (2006) 2.10

HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature (2013) 2.06

Short-term exposure of multipotent stromal cells to low oxygen increases their expression of CX3CR1 and CXCR4 and their engraftment in vivo. PLoS One (2007) 2.06

Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J (2007) 1.98

Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1. J Virol (1998) 1.97

Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production. J Virol (2005) 1.97

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition. Gene Ther (2008) 1.94

As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity. J Virol (2003) 1.94

An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma. Blood (2008) 1.93

Non-invasive detection of a small number of bioluminescent cancer cells in vivo. PLoS One (2010) 1.92

HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation. Nature (2015) 1.85

Rb suppresses human cone-precursor-derived retinoblastoma tumours. Nature (2014) 1.83

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication. J Virol (2006) 1.82

Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A (1999) 1.80

Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7. EMBO J (2003) 1.80

Interaction with the p6 domain of the gag precursor mediates incorporation into virions of Vpr and Vpx proteins from primate lentiviruses. J Virol (1999) 1.79

The interaction of vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 In vivo mutation rate. J Virol (2000) 1.79

Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr? Retrovirology (2010) 1.76

A synonymous single nucleotide polymorphism in DeltaF508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein. J Biol Chem (2010) 1.75

Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies. PLoS Pathog (2012) 1.74

Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc Natl Acad Sci U S A (2006) 1.74

Restriction of feline immunodeficiency virus by Ref1, Lv1, and primate TRIM5alpha proteins. J Virol (2005) 1.71

Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules. J Cell Biol (2004) 1.71

Nek8 regulates the expression and localization of polycystin-1 and polycystin-2. J Am Soc Nephrol (2008) 1.70

Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms. Carcinogenesis (2008) 1.69

Cyclophilin A renders human immunodeficiency virus type 1 sensitive to Old World monkey but not human TRIM5 alpha antiviral activity. J Virol (2006) 1.69

Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol (2004) 1.67

Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis. Breast Cancer Res (2009) 1.67

Nuclear translocation of urokinase-type plasminogen activator. Blood (2008) 1.66

Trim-cyclophilin A fusion proteins can restrict human immunodeficiency virus type 1 infection at two distinct phases in the viral life cycle. J Virol (2006) 1.66

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions. PLoS One (2013) 1.65

Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol (1999) 1.64

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. Proc Natl Acad Sci U S A (2004) 1.63

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A (2011) 1.61

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol (2008) 1.61

The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest (2007) 1.61

Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytes. J Virol (2001) 1.60

Minimum requirements for efficient transduction of dividing and nondividing cells by feline immunodeficiency virus vectors. J Virol (1999) 1.58

Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop. PLoS Biol (2010) 1.56

Unintegrated lentivirus DNA persistence and accessibility to expression in nondividing cells: analysis with class I integrase mutants. J Virol (2004) 1.56

Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors. BMC Mol Biol (2004) 1.56

Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death. J Virol (2005) 1.56

Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA. J Virol (2004) 1.56

Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS One (2012) 1.55

ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int (2010) 1.54

An active TRIM5 protein in rabbits indicates a common antiviral ancestor for mammalian TRIM5 proteins. J Virol (2007) 1.54

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells. Cancer Cell (2015) 1.52

The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. J Virol (2012) 1.52

Vpu and Tsg101 regulate intracellular targeting of the human immunodeficiency virus type 1 core protein precursor Pr55gag. J Virol (2006) 1.50

Hepatitis C virus hijacks P-body and stress granule components around lipid droplets. J Virol (2011) 1.47

Integration-deficient lentiviral vectors: a slow coming of age. Mol Ther (2009) 1.47

Premature termination codons in PRPF31 cause retinitis pigmentosa via haploinsufficiency due to nonsense-mediated mRNA decay. J Clin Invest (2008) 1.45

Sequences in the cytoplasmic tail of the gibbon ape leukemia virus envelope protein that prevent its incorporation into lentivirus vectors. J Virol (2001) 1.45

Cell cycle requirements for transduction by foamy virus vectors compared to those of oncovirus and lentivirus vectors. J Virol (2004) 1.44

Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments. Cell (2016) 1.43

Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55(gag) associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100. J Virol (2003) 1.43

DNA-Dependent protein kinase is not required for efficient lentivirus integration. J Virol (2000) 1.43

MicroRNA-124 is a subventricular zone neuronal fate determinant. J Neurosci (2012) 1.43

20 years of Nature Biotechnology biomedical research. Nat Biotechnol (2016) 1.42

CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood (2007) 1.42

A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Mol Cell Proteomics (2010) 1.41

Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector. J Virol (2001) 1.41

Over-expression of CKS1B activates both MEK/ERK and JAK/STAT3 signaling pathways and promotes myeloma cell drug-resistance. Oncotarget (2010) 1.40

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol (2000) 1.38

Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number. PLoS One (2016) 1.38

Advanced modular self-inactivating lentiviral expression vectors for multigene interventions in mammalian cells and in vivo transduction. Nucleic Acids Res (2002) 1.37

Articles by these authors

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95

A third-generation lentivirus vector with a conditional packaging system. J Virol (1998) 16.07

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. J Virol (1998) 8.21

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences. Nat Genet (2000) 6.12

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J Virol (1993) 6.11

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell (1994) 5.92

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol (1999) 5.35

Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol (1992) 5.04

Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latency. Cell (1990) 4.78

Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors. Nat Genet (1997) 4.72

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Proc Natl Acad Sci U S A (1997) 4.59

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J Virol (1995) 4.45

HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Cell (1995) 4.41

HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Cell (1995) 4.25

Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med (2001) 4.02

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science (2000) 3.89

The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes. Proc Natl Acad Sci U S A (1994) 3.65

Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr Biol (1999) 2.97

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat Cell Biol (2000) 2.95

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell (1999) 2.89

Role of the karyopherin pathway in human immunodeficiency virus type 1 nuclear import. J Virol (1996) 2.72

Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: interference with early steps of viral replication. Mol Cell (2001) 2.53

The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc Natl Acad Sci U S A (2000) 2.42

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures. J Cell Biol (1984) 2.36

Lipopolysaccharide is a potent monocyte/macrophage-specific stimulator of human immunodeficiency virus type 1 expression. J Exp Med (1990) 2.28

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes. EMBO J (1998) 2.25

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking. J Virol (1999) 2.25

Cloning and characterization of murine p16INK4a and p15INK4b genes. Oncogene (1995) 2.05

RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. EMBO J (1994) 2.04

The plasma membrane as a combat zone in the HIV battlefield. Genes Dev (2000) 2.02

Detection of phosphotyrosine-containing proteins in the detergent-insoluble fraction of RSV-transformed fibroblasts by azobenzene phosphonate antibodies. EMBO J (1984) 1.98

Substitutions in the protease (3Cpro) gene of poliovirus can suppress a mutation in the 5' noncoding region. J Virol (1990) 1.96

Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors. Hum Gene Ther (2002) 1.95

Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J Gene Med (2001) 1.85

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor). Oncogene (1994) 1.81

Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration. Proc Natl Acad Sci U S A (2001) 1.81

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease. Hum Gene Ther (2000) 1.81

Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci U S A (1999) 1.80

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane. Immunity (1997) 1.78

The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors. Immunol Rev (1999) 1.77

Blocked early-stage latency in the peripheral blood cells of certain individuals infected with human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1992) 1.76

Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. J Neurosci (2000) 1.74

Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency. J Virol (1992) 1.74

A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A (1992) 1.70

Characterization of human immunodeficiency virus type 1 Vif particle incorporation. J Virol (1996) 1.69

High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. Blood (2000) 1.63

Genomic instability in induced stem cells. Cell Death Differ (2011) 1.63

Efficient lentiviral transduction of liver requires cell cycling in vivo. Nat Genet (2000) 1.62

Mutational analysis of HIV-1 Nef: identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology (1996) 1.56

The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. J Virol (1997) 1.52

Reversible immortalization of human primary cells by lentivector-mediated transfer of specific genes. Mol Ther (2000) 1.48

Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. J Biol Chem (1991) 1.48

In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice. Nat Med (2001) 1.46

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Res (2000) 1.45

A stable system for the high-titer production of multiply attenuated lentiviral vectors. Mol Ther (2000) 1.43

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro. J Virol (2000) 1.38

Nef-mediated clathrin-coated pit formation. J Cell Biol (1997) 1.38

'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo. Gene Ther (2003) 1.35

The Nef protein of primate lentiviruses. Rev Med Virol (1999) 1.34

The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent. J Virol (1993) 1.34

The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity. J Virol (1998) 1.32

Transduction of human CD34+ CD38- bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors. Mol Ther (2000) 1.27

Pseudotyped human lentiviral vector-mediated gene transfer to airway epithelia in vivo. Gene Ther (2000) 1.24

HIV-1 latency due to the site of proviral integration. Virology (1993) 1.23

Distribution of AAV-TK following intracranial convection-enhanced delivery into rats. Cell Transplant (2000) 1.21

Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. Neuron (1999) 1.19

Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cells. Mol Cell Biol (1986) 1.17

Heterotransplantation of human glioblastoma multiforme and meningioma to nude mice. Proc Soc Exp Biol Med (1977) 1.17

Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene. Cell Mol Biol (Noisy-le-grand) (1994) 1.15

Reversal of pathology in the entire brain of mucopolysaccharidosis type VII mice after lentivirus-mediated gene transfer. Hum Gene Ther (2000) 1.14

Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse. Biochem Biophys Res Commun (2005) 1.13

Interaction of human immunodeficiency virus-derived vectors with wild-type virus in transduced cells. J Virol (1999) 1.13

A new-generation stable inducible packaging cell line for lentiviral vectors. Hum Gene Ther (2001) 1.12

Molecular characteristics of HGF-SF and its role in cell motility and invasion. EXS (1993) 1.10

HIV-1-derived lentiviral vectors. Curr Top Microbiol Immunol (2002) 1.10

Immunological detection of proteins phosphorylated at tyrosine in cells stimulated by growth factors or transformed by retroviral-oncogene-coded tyrosine kinases. Eur J Biochem (1986) 1.09

Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nat Biotechnol (1998) 1.09

Receptor for bombesin with associated tyrosine kinase activity. Mol Cell Biol (1986) 1.08

Lentivirus-mediated gene transfer into hematopoietic repopulating cells in baboons. Gene Ther (2002) 1.07

Limited transgene immune response and long-term expression of human alpha-L-iduronidase in young adult mice with mucopolysaccharidosis type I by liver-directed gene therapy. Hum Gene Ther (2006) 1.07

Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina. Gene Ther (2003) 1.07

Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol Carcinog (1989) 1.06

Osteoclasts and monocytes have similar cytoskeletal structures and adhesion property in vitro. J Anat (1983) 1.05

Hepatocyte growth factor is a regulator of monocyte-macrophage function. J Immunol (2001) 1.05

Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3. J Virol (1998) 1.04

Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors. Gene Ther (2001) 1.04

Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription. Diabetologia (2003) 1.04

Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells. Blood (2000) 1.03

Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res (1991) 1.02

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia (2006) 1.01

Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector. Hum Gene Ther (1999) 1.01

Applications of gene therapy to the CNS. Hum Mol Genet (1996) 1.00