Published in Ann Intern Med on July 06, 1999
Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20
Effect of allopurinol in chronic kidney disease progression and cardiovascular risk. Clin J Am Soc Nephrol (2010) 4.06
Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken) (2010) 2.94
Uric acid and long-term outcomes in CKD. Am J Kidney Dis (2009) 2.86
Uric acid and inflammatory markers. Eur Heart J (2006) 2.81
Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts. BMJ (2013) 2.41
Dietary patterns and the risk of mortality: impact of cardiorespiratory fitness. Int J Epidemiol (2009) 2.38
Uric acid transport and disease. J Clin Invest (2010) 2.33
Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle. Nutr Metab (Lond) (2004) 2.13
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial. Arthritis Res Ther (2010) 2.07
Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Rheum (2009) 2.07
Prevalence of hyperuricemia and relation of serum uric acid with cardiovascular risk factors in a developing country. BMC Public Health (2004) 2.00
Epidemiology, risk factors, and lifestyle modifications for gout. Arthritis Res Ther (2006) 1.80
Relation between serum uric acid and carotid intima-media thickness in healthy postmenopausal women. Intern Emerg Med (2007) 1.72
The relationship between serum uric acid and chronic kidney disease among Appalachian adults. Nephrol Dial Transplant (2010) 1.60
Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. PLoS One (2008) 1.51
Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis. PLoS Med (2005) 1.50
Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease. Clin Rheumatol (2014) 1.50
Temporal relationship between uric acid concentration and risk of diabetes in a community-based study population. Am J Epidemiol (2014) 1.50
Association of Uric Acid With Vascular Stiffness in the Framingham Heart Study. Am J Hypertens (2014) 1.48
Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease. Clin Rheumatol (2015) 1.40
Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative. Ann Rheum Dis (2013) 1.39
Fenofibrate and losartan. Ann Rheum Dis (2003) 1.39
Association between hyperuricemia and incident heart failure among older adults: a propensity-matched study. Int J Cardiol (2009) 1.38
Uric acid, hyperuricemia and vascular diseases. Front Biosci (Landmark Ed) (2012) 1.38
Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease. PLoS One (2009) 1.36
Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease. Nephrol Dial Transplant (2008) 1.31
Hyperuricaemia, chronic kidney disease, and outcomes in heart failure: potential mechanistic insights from epidemiological data. Eur Heart J (2011) 1.26
The prevalence of hyperuricemia in China: a meta-analysis. BMC Public Health (2011) 1.25
Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes Care (2011) 1.23
Association of incident gout and mortality in dialysis patients. J Am Soc Nephrol (2008) 1.20
Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study. Heart (2002) 1.17
The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol (2013) 1.15
Serum uric acid is associated with carotid plaques: the National Heart, Lung, and Blood Institute Family Heart Study. J Rheumatol (2009) 1.11
Elevated serum uric acid concentrations independently predict cardiovascular mortality in type 2 diabetic patients. Diabetes Care (2009) 1.09
Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease? Br J Clin Pharmacol (2006) 1.09
Uric Acid and Cardiovascular Events: A Mendelian Randomization Study. J Am Soc Nephrol (2015) 1.08
The epidemiology of uric acid and fructose. Semin Nephrol (2011) 1.06
Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxid Redox Signal (2011) 1.05
Uric acid as one of the important factors in multifactorial disorders--facts and controversies. Biochem Med (Zagreb) (2012) 1.05
Absence of an association between serum uric acid and mortality from cardiovascular disease: NIPPON DATA 80, 1980-1994. National Integrated Projects for Prospective Observation of Non-communicable Diseases and its Trend in the Aged. Eur J Epidemiol (2001) 1.05
Plasma and dietary antioxidant status as cardiovascular disease risk factors: a review of human studies. Nutrients (2013) 1.02
Statins and cardiovascular outcomes in elderly and younger patients with coronary artery disease: a post hoc analysis of the GREACE study. Arch Med Sci (2013) 1.01
Gender and age impacts on the correlations between hyperuricemia and metabolic syndrome in Chinese. Clin Rheumatol (2010) 1.01
Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link? Arthritis Res Ther (2009) 0.98
A review of uric acid, crystal deposition disease, and gout. Adv Ther (2014) 0.97
Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study. BMC Cardiovasc Disord (2013) 0.97
Uric acid as a risk factor for cardiovascular disease and mortality in overweight/obese individuals. PLoS One (2013) 0.97
Association of serum uric acid with incident atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] study). Am J Cardiol (2011) 0.96
Risk factors for cardiovascular disease: one down, many more to evaluate. Ann Intern Med (1999) 0.94
Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988-1994 and 1999-2002. Am J Kidney Dis (2014) 0.93
Effect of serum insulin on the association between hyperuricemia and incident heart failure. Am J Cardiol (2010) 0.92
Potential role of uric Acid as a risk factor for cardiovascular disease. Korean J Intern Med (2010) 0.91
Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population. Heart Vessels (2013) 0.91
Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals. BMC Cardiovasc Disord (2014) 0.90
Serum uric acid as a prognostic marker in the setting of advanced vascular disease: a prospective study in the elderly. J Geriatr Cardiol (2015) 0.90
Galectin 9 is the sugar-regulated urate transporter/channel UAT. Glycoconj J (2004) 0.90
Diagnosis and management of gout: a rational approach. Postgrad Med J (2005) 0.89
Cardiovascular Health Score and the Risk of Cardiovascular Diseases. PLoS One (2015) 0.89
The role of uric acid in pediatric hypertension. J Ren Nutr (2007) 0.89
Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension. Kidney Blood Press Res (2012) 0.88
Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study. Medicine (Baltimore) (2015) 0.88
Uric acid in metabolic syndrome: From an innocent bystander to a central player. Eur J Intern Med (2015) 0.87
Elderly-onset gout: a review. Rheumatol Int (2007) 0.87
Higher circulating levels of uric acid are prospectively associated with better muscle function in older persons. Mech Ageing Dev (2008) 0.86
The C677 mutation in methylene tetrahydrofolate reductase gene: correlation with uric acid and cardiovascular risk factors in elderly Korean men. J Korean Med Sci (2004) 0.86
The effect of the interaction between obesity and drinking on hyperuricemia in Japanese male office workers. J Epidemiol (2009) 0.86
Long-term effects of L- and N-type calcium channel blocker on uric acid levels and left atrial volume in hypertensive patients. Heart Vessels (2016) 0.85
Severity of gouty arthritis is associated with Q-wave myocardial infarction: a large-scale, cross-sectional study. Clin Rheumatol (2006) 0.85
Uric acid, CKD, and cardiovascular disease: confounders, culprits, and circles. Am J Kidney Dis (2010) 0.85
Clinical characteristics of young-onset ischemic colitis. Dig Dis Sci (2012) 0.85
Serum uric Acid in smokers. Oman Med J (2008) 0.84
Hyperuricemia, Cardiovascular Disease, and Hypertension. Pulse (Basel) (2016) 0.84
Relationship Between Hyperuricemia and Cardiovascular Disease Risk Factors in a Chinese Population: A Cross-Sectional Study. Med Sci Monit (2015) 0.84
Relationship between hyperuricemia and lipid profiles in US adults. Biomed Res Int (2015) 0.84
Failure to consider the menstrual cycle phase may cause misinterpretation of clinical and research findings of cardiometabolic biomarkers in premenopausal women. Epidemiol Rev (2013) 0.84
Association between hyperuricemia, prediabetes, and prehypertension in the Croatian adult population--a cross-sectional study. BMC Cardiovasc Disord (2012) 0.83
Functional reconstitution, membrane targeting, genomic structure, and chromosomal localization of a human urate transporter. J Clin Invest (2001) 0.83
Effect of Urate-Lowering Therapy on All-Cause and Cardiovascular Mortality in Hyperuricemic Patients without Gout: A Case-Matched Cohort Study. PLoS One (2015) 0.83
Serum uric acid levels and long-term outcomes in chronic kidney disease. Heart Vessels (2013) 0.82
Association between serum uric acid level and metabolic syndrome components. J Diabetes Metab Disord (2015) 0.82
Metabolic syndrome and dietary components are associated with coronary artery disease risk score in free-living adults: a cross-sectional study. Diabetol Metab Syndr (2011) 0.82
Clinical value of serum uric Acid in patients with suspected coronary artery disease. Korean J Intern Med (2010) 0.82
Clinical problem solving based on the 1999 Canadian recommendations for the management of hypertension. CMAJ (1999) 0.82
Influence of Salt Intake on Association of Blood Uric Acid with Hypertension and Related Cardiovascular Risk. PLoS One (2016) 0.81
Allopurinol is an independent determinant of improved arterial stiffness in chronic kidney disease: a cross-sectional study. PLoS One (2014) 0.81
Effects of menopause and hormone replacement therapy on the associations of hyperuricemia with mortality. Atherosclerosis (2012) 0.81
Overweight modifies the longitudinal association between uric acid and some components of the metabolic syndrome: The Tromsø Study. BMC Cardiovasc Disord (2016) 0.81
Comorbidities in patients with crystal diseases and hyperuricemia. Rheum Dis Clin North Am (2014) 0.81
Suppression of Nitric Oxide Production and Cardiovascular Risk Factors in Healthy Seniors and Hypercholesterolemic Subjects by a Combination of Polyphenols and Vitamins. J Clin Exp Cardiolog (2012) 0.81
The associations of uric acid, cardiovascular and all-cause mortality in peritoneal dialysis patients. PLoS One (2014) 0.81
Relationship between uric acid and blood pressure in different age groups. Clin Hypertens (2015) 0.81
The association between serum uric acid levels, metabolic syndrome and cardiovascular disease in middle aged and elderly Chinese: results from the DYSlipidemia International Study. BMC Cardiovasc Disord (2015) 0.80
Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study. Lipids Health Dis (2011) 0.80
Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based study. PLoS One (2013) 0.80
Epidemiological associations between hyperuricemia and cardiometabolic risk factors: a comprehensive study from Chinese community. BMC Cardiovasc Disord (2015) 0.80
Serum uric Acid level and diverse impacts on regional arterial stiffness and wave reflection. Iran J Public Health (2012) 0.80
Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis. Sci Rep (2016) 0.80
Prediction of coronary heart disease using risk factor categories. Circulation (1998) 48.81
Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke (1991) 22.23
Cardiovascular disease risk profiles. Am Heart J (1991) 21.65
Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation (1998) 19.93
An investigation of coronary heart disease in families. The Framingham offspring study. Am J Epidemiol (1979) 18.84
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med (1990) 17.52
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med (1977) 15.39
The natural history of congestive heart failure: the Framingham study. N Engl J Med (1971) 13.94
Diabetes and cardiovascular disease. The Framingham study. JAMA (1979) 11.95
An updated coronary risk profile. A statement for health professionals. Circulation (1991) 11.71
Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA (1994) 11.63
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
The Framingham Offspring Study. Design and preliminary data. Prev Med (1975) 10.53
Probability of stroke: a risk profile from the Framingham Study. Stroke (1991) 10.14
Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation (1993) 9.24
Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension (2000) 8.84
Epidemiologic features of chronic atrial fibrillation: the Framingham study. N Engl J Med (1982) 8.62
Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med (1987) 8.09
The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol (1993) 8.01
The progression from hypertension to congestive heart failure. JAMA (1996) 7.56
Lifetime risk of developing coronary heart disease. Lancet (1999) 7.54
Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. Ann Intern Med (1971) 7.46
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health (1994) 7.38
Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 7.34
Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA (1986) 7.23
Relation of pooled logistic regression to time dependent Cox regression analysis: the Framingham Heart Study. Stat Med (1990) 7.00
Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol (1998) 6.76
Epidemiologic assessment of the role of blood pressure in stroke. The Framingham study. JAMA (1970) 6.42
Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation (1996) 6.20
Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA (2000) 6.00
Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J (1986) 5.89
Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke (1994) 5.83
Accuracy of death certificates for coding coronary heart disease as the cause of death. Ann Intern Med (1998) 5.63
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes (1974) 5.55
Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet (2001) 5.54
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study. Neurology (1978) 5.37
Diabetes and cardiovascular risk factors: the Framingham study. Circulation (1979) 5.32
Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol (1974) 5.11
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation (2001) 5.11
A general cardiovascular risk profile: the Framingham Study. Am J Cardiol (1976) 5.10
Natural history of angina pectoris in the Framingham study. Prognosis and survival. Am J Cardiol (1972) 5.05
Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation (1999) 5.04
Incidence and prognosis of unrecognized myocardial infarction. An update on the Framingham study. N Engl J Med (1984) 5.02
Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med (1999) 5.01
Cholesterol in the prediction of atherosclerotic disease. New perspectives based on the Framingham study. Ann Intern Med (1979) 4.94
Systolic versus diastolic blood pressure and risk of coronary heart disease. The Framingham study. Am J Cardiol (1971) 4.90
Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation (2000) 4.63
Some health benefits of physical activity. The Framingham Study. Arch Intern Med (1979) 4.63
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Comparisons of five health status instruments for orthopedic evaluation. Med Care (1990) 4.57
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation (1994) 4.52
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol (1998) 4.44
The somatic replication of DNA methylation. Cell (1981) 4.42
The epidemiology of gallbladder disease: observations in the Framingham Study. J Chronic Dis (1966) 4.15
Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J (1987) 4.12
Electrocardiographic left ventricular hypertrophy and risk of coronary heart disease. The Framingham study. Ann Intern Med (1970) 4.11
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA (1987) 4.05
Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation (1995) 4.04
Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum (1989) 4.02
The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings. Ann Intern Med (1990) 4.02
Changes in risk factors and the decline in mortality from cardiovascular disease. The Framingham Heart Study. N Engl J Med (1990) 3.99
Bone mass and the risk of breast cancer among postmenopausal women. N Engl J Med (1997) 3.96
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Impact of atrial fibrillation on mortality, stroke, and medical costs. Arch Intern Med (1998) 3.79
Cancer: improving early detection and prevention. A community practice randomised trial. BMJ (1992) 3.76
Diabetes and glucose tolerance as risk factors for cardiovascular disease: the Framingham study. Diabetes Care (1980) 3.70
An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study) Am J Cardiol (1992) 3.66
Fibrinogen and risk of cardiovascular disease. The Framingham Study. JAMA (1987) 3.59
Effects of ambient air pollution on nonelderly asthma hospital admissions in Seattle, Washington, 1987-1994. Epidemiology (1999) 3.57
Menopause and risk of cardiovascular disease: the Framingham study. Ann Intern Med (1976) 3.50
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation (1994) 3.44