Uric acid transport and disease.

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol (2013) 3.00

Epidemiology of gout. Arthritis Res Ther (2010) 1.99

The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med (2013) 1.97

Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol (2015) 1.57

Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol (2011) 1.45

Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol (2012) 1.31

Renal transport of uric acid: evolving concepts and uncertainties. Adv Chronic Kidney Dis (2012) 1.26

The immune system's involvement in obesity-driven type 2 diabetes. Semin Immunol (2013) 1.25

Update on the phenotypic spectrum of Lesch-Nyhan disease and its attenuated variants. Curr Rheumatol Rep (2012) 1.16

The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality. BMC Nephrol (2013) 1.15

Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis. Biomark Med (2010) 1.13

The relationship between serum uric acid and spirometric values in participants in a health check: the Takahata study. Int J Med Sci (2011) 1.10

Review of hyperuricemia as new marker for metabolic syndrome. ISRN Rheumatol (2014) 1.08

Contribution of uric acid to cancer risk, recurrence, and mortality. Clin Transl Med (2012) 1.08

Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation. J Biol Chem (2011) 1.07

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation. Nat Commun (2015) 1.01

Fructose and uric acid: is there a role in endothelial function? Curr Hypertens Rep (2014) 1.01

SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria. Biopharm Drug Dispos (2014) 0.99

Serum uric acid is a GFR-independent long-term predictor of acute and chronic renal insufficiency: the Jerusalem Lipid Research Clinic cohort study. Nephrol Dial Transplant (2011) 0.97

Hyperuricemia causes pancreatic β-cell death and dysfunction through NF-κB signaling pathway. PLoS One (2013) 0.95

Uric acid is an independent risk factor for carotid atherosclerosis in a Japanese elderly population without metabolic syndrome. Cardiovasc Diabetol (2012) 0.95

Association between SLC2A9 transporter gene variants and uric acid phenotypes in African American and white families. Rheumatology (Oxford) (2010) 0.94

Association between Serum Uric Acid Level and Metabolic Syndrome and Its Sex Difference in a Chinese Community Elderly Population. Int J Endocrinol (2014) 0.93

Circadian rhythm reprogramming during lung inflammation. Nat Commun (2014) 0.92

The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. PLoS One (2012) 0.92

Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9. Nat Commun (2014) 0.92

The independent association between parathyroid hormone levels and hyperuricemia: a national population study. Arthritis Res Ther (2012) 0.92

Impaired response or insufficient dosage? Examining the potential causes of "inadequate response" to allopurinol in the treatment of gout. Semin Arthritis Rheum (2014) 0.91

Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout. QJM (2013) 0.90

Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals. BMC Cardiovasc Disord (2014) 0.90

Serum uric acid and 1-h postload glucose in essential hypertension. Diabetes Care (2011) 0.90

Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians. Eur J Hum Genet (2013) 0.88

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese. Nat Commun (2015) 0.86

Relationship between Serum Concentration of Uric Acid and Insulin Secretion among Adults with Type 2 Diabetes Mellitus. Int J Endocrinol (2011) 0.85

Clinical, Genetic, and Urinary Factors Associated with Uromodulin Excretion. Clin J Am Soc Nephrol (2015) 0.85

Increased serum levels of uric acid are associated with sudomotor dysfunction in subjects with type 2 diabetes mellitus. Exp Diabetes Res (2011) 0.85

Antioxidant and inflammatory response following high-fat meal consumption in overweight subjects. Eur J Nutr (2012) 0.84

The Hypouricemic Effect of Balanophora laxiflora Extracts and Derived Phytochemicals in Hyperuricemic Mice. Evid Based Complement Alternat Med (2012) 0.84

Gender-specific pathway differences in the human serum metabolome. Metabolomics (2015) 0.83

Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization. Mucosal Immunol (2015) 0.83

Serum uric acid levels and the risk of impaired fasting glucose: a prospective study in adults of north China. PLoS One (2013) 0.83

Diuretic use in renal disease. Nat Rev Nephrol (2011) 0.82

Uric acid and IGF1 as possible determinants of FGF23 metabolism in children with normal renal function. Pediatr Nephrol (2012) 0.82

The effects of Artemisia deserti ethanolic extract on pathology and function of rat kidney. Avicenna J Phytomed (2014) 0.81

New and improved strategies for the treatment of gout. Int J Nephrol Renovasc Dis (2010) 0.81

A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria. PLoS One (2013) 0.80

FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways. Biochem J (2013) 0.80

Serum uric acid levels are associated with hypertension and metabolic syndrome but not atherosclerosis in Chinese inpatients with type 2 diabetes. J Hypertens (2015) 0.80

Naturally high plasma glucose levels in mourning doves (Zenaida macroura) do not lead to high levels of reactive oxygen species in the vasculature. Zoology (Jena) (2011) 0.79

Soluble Uric Acid Activates the NLRP3 Inflammasome. Sci Rep (2017) 0.79

Serum uric acid level and the incidence of metabolic syndrome in middle-aged Korean men: a 5-year follow-up study. J Prev Med Public Health (2014) 0.78

Association of serum uric acid with 2-hour postload glucose in Chinese with impaired fasting plasma glucose and/or HbA1c. PLoS One (2013) 0.78

Effect of urine pH changed by dietary intervention on uric acid clearance mechanism of pH-dependent excretion of urinary uric acid. Nutr J (2012) 0.78

Rationale and design of a multicenter randomized study for evaluating vascular function under uric acid control using the xanthine oxidase inhibitor, febuxostat: the PRIZE study. Cardiovasc Diabetol (2016) 0.78

Penicillamine neurotoxicity: an hypothesis. ISRN Neurol (2011) 0.77

Molecular basis of oxidative stress in gouty arthropathy. Clin Rheumatol (2015) 0.77

Predictors of preinterventional patency of infarct-related artery in patients with ST-segment elevation myocardial infarction: Importance of neutrophil to lymphocyte ratio and uric acid level. Exp Clin Cardiol (2013) 0.77

Tubular transport: core curriculum 2010. Am J Kidney Dis (2010) 0.76

Expression, purification, and structural insights for the human uric acid transporter, GLUT9, using the Xenopus laevis oocytes system. PLoS One (2014) 0.76

Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis. Sci Rep (2015) 0.76

The association of anthropometry indices with gout in Taiwanese men. BMC Endocr Disord (2013) 0.76

Genetic polymorphisms in the PDZK1 gene and susceptibility to gout in male Han Chinese: a case-control study. Int J Clin Exp Med (2015) 0.75

Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model. Biomed Res Int (2016) 0.75

A coronary artery disease-associated SNP rs6903956 contributed to asymptomatic hyperuricemia susceptibility in Han Chinese. Lipids Health Dis (2015) 0.75

Uric Acid Produces an Inflammatory Response through Activation of NF-κB in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders. Sci Rep (2015) 0.75

Monosodium urate crystals induce oxidative stress in human synoviocytes. Arthritis Res Ther (2016) 0.75

Gout: will the "King of Diseases" be the first rheumatic disease to be cured? BMC Med (2016) 0.75

Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy. World J Diabetes (2015) 0.75

Perinatal growth restriction decreases diuretic action of furosemide in adult rats. Eur J Pharmacol (2014) 0.75

Low serum levels of uric acid and albumin in patients with Guillain-Barre syndrome. Medicine (Baltimore) (2017) 0.75

Mid-gestational serum uric acid concentration effect on neonate birth weight and insulin resistance in pregnant women. Int J Crit Illn Inj Sci (2015) 0.75

Lesinurad: what the nephrologist should know. Clin Kidney J (2017) 0.75

Fasting plasma glucose and serum uric acid levels in a general Chinese population with normal glucose tolerance: A U-shaped curve. PLoS One (2017) 0.75

Synergistic Uric Acid-Lowering Effects of the Combination of Chrysanthemum indicum Linne Flower and Cinnamomum cassia (L.) J. Persl Bark Extracts. Evid Based Complement Alternat Med (2017) 0.75

Phloretin attenuates hyperuricemia-induced endothelial dysfunction through co-inhibiting inflammation and GLUT9-mediated uric acid uptake. J Cell Mol Med (2017) 0.75

Interactive association of serum uric acid and total bilirubin with renal dysfunction among community-dwelling subjects. Int Urol Nephrol (2017) 0.75

ABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohort. J Korean Med Sci (2017) 0.75

Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower (Helianthus annuus) Head Extract in Gouty and Hyperuricemia Animal Models. Biomed Res Int (2017) 0.75

Inflammation and metabolic disorders. Nature (2006) 33.33

Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature (2006) 24.43

Uric acid and cardiovascular risk. N Engl J Med (2008) 12.20

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A (1981) 8.45

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33

The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol (2007) 6.81

Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med (1999) 6.72

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet (2008) 5.93

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89

Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature (2002) 5.62

Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA (2008) 5.59

Hyperuricemia induces endothelial dysfunction. Kidney Int (2005) 5.36

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Nat Genet (2008) 4.67

Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20

Gout epidemiology: results from the UK General Practice Research Database, 1990-1999. Ann Rheum Dis (2005) 3.53

Independent impact of gout on mortality and risk for coronary heart disease. Circulation (2007) 3.39

Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension (2003) 3.39

Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study. Am J Med (1987) 3.34

The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts. PLoS Genet (2007) 3.21

Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. J Rheumatol (2004) 3.17

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci U S A (2009) 3.13

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver. Hum Mol Genet (2009) 3.07

Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA (1991) 3.01

SLC2A9 is a high-capacity urate transporter in humans. PLoS Med (2008) 2.87

Obesity, weight change, hypertension, diuretic use, and risk of gout in men: the health professionals follow-up study. Arch Intern Med (2005) 2.80

Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol (2007) 2.71

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Hyperuricemia in childhood primary hypertension. Hypertension (2003) 2.39

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Serum uric acid in relation to age and physique in health and in coronary heart disease. Ann Intern Med (1951) 2.33

Long-term cardiovascular mortality among middle-aged men with gout. Arch Intern Med (2008) 2.32

The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). Mol Membr Biol (2002) 2.29

Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link? J Am Soc Nephrol (2005) 2.24

Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet (2008) 2.21

Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. J Biol Chem (2004) 2.18

Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome. Circ J (2005) 2.17

Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. J Biol Chem (2008) 2.09

New insights into renal transport of urate. Curr Opin Rheumatol (2007) 2.07

Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol (2005) 2.07

Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Rheum (2009) 2.07

Loss of urate oxidase activity in hominoids and its evolutionary implications. Mol Biol Evol (2002) 2.00

The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol (2002) 1.94

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Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). Genomics (2000) 1.72

Uric acid decreases NO production and increases arginase activity in cultured pulmonary artery endothelial cells. Am J Physiol Cell Physiol (2008) 1.69

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney Int (2007) 1.68

Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase. Biochem Pharmacol (2005) 1.66

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Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol (2007) 1.60

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Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes. Mol Endocrinol (2005) 1.59

Sex-specific association of the putative fructose transporter SLC2A9 variants with uric acid levels is modified by BMI. Diabetes Care (2008) 1.58

Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics (2008) 1.53

Homozygous SLC2A9 mutations cause severe renal hypouricemia. J Am Soc Nephrol (2009) 1.52

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Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors. J Clin Invest (2005) 1.56

GLUT2 is a high affinity glucosamine transporter. FEBS Lett (2002) 1.47

PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev (2008) 1.38

Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension. Diabetes (2004) 1.38

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Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc Natl Acad Sci U S A (2009) 1.23

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