Published in Cell on April 01, 1981
Model for homologous recombination during transfer of DNA into mouse L cells: role for DNA ends in the recombination process. Mol Cell Biol (1984) 7.99
Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09
Inactivation of the maize transposable element Activator (Ac) is associated with its DNA modification. EMBO J (1987) 4.91
Molecular signals of epigenetic states. Science (2010) 4.81
CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J (1998) 4.61
DNA methylation and gene expression. Microbiol Rev (1991) 4.44
Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Cytosine methylation and mammalian development. Genes Dev (1999) 3.82
Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases. Nucleic Acids Res (1994) 3.76
Dynamics and memory of heterochromatin in living cells. Cell (2012) 3.75
DNA methylation and gene expression: endogenous retroviral genome becomes infectious after molecular cloning. Proc Natl Acad Sci U S A (1981) 3.70
Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res (1989) 3.63
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. EMBO J (1992) 3.06
In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci U S A (1982) 2.92
Recombination in mouse L cells between DNA introduced into cells and homologous chromosomal sequences. Proc Natl Acad Sci U S A (1985) 2.79
Genomic targeting with purified Cre recombinase. Nucleic Acids Res (1993) 2.74
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. Proc Natl Acad Sci U S A (1983) 2.64
Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci U S A (1982) 2.52
Roles of DNA adenine methylation in regulating bacterial gene expression and virulence. Infect Immun (2001) 2.42
The DNA methylation locus DDM1 is required for maintenance of gene silencing in Arabidopsis. Genes Dev (1998) 2.41
Effect of site-specific methylation on DNA modification methyltransferases and restriction endonucleases. Nucleic Acids Res (1989) 2.35
Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proc Natl Acad Sci U S A (2003) 2.35
Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns. Genome Res (2010) 2.25
Site-specific methylation: effect on DNA modification methyltransferases and restriction endonucleases. Nucleic Acids Res (1991) 2.18
Effect of regional DNA methylation on gene expression. Proc Natl Acad Sci U S A (1985) 2.11
DNA methylation. The effect of minor bases on DNA-protein interactions. Biochem J (1990) 2.09
DNA methylation affecting the expression of murine leukemia proviruses. J Virol (1982) 2.03
Preferential binding of estrogen-receptor complex to a region containing the estrogen-dependent hypomethylation site preceding the chicken vitellogenin II gene. Proc Natl Acad Sci U S A (1984) 2.03
Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci U S A (1982) 1.95
Studies of endogenous retroviruses reveal a continuing evolutionary saga. Nat Rev Microbiol (2012) 1.94
Homologous recombination between overlapping thymidine kinase gene fragments stably inserted into a mouse cell genome. Mol Cell Biol (1984) 1.88
Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine. Proc Natl Acad Sci U S A (1982) 1.84
DNA methylation in chicken alpha-globin gene expression. Proc Natl Acad Sci U S A (1982) 1.72
Fidelity of the methylation pattern and its variation in the genome. Genome Res (2003) 1.71
Methylation of simian virus 40 Hpa II site affects late, but not early, viral gene expression. Proc Natl Acad Sci U S A (1982) 1.65
DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle (2009) 1.64
The relationship between hypomethylation and CpG island methylation in colorectal neoplasia. Am J Pathol (2003) 1.60
Effect of site-specific methylation on DNA modification methyltransferases and restriction endonucleases. Nucleic Acids Res (1992) 1.44
The marks, mechanisms and memory of epigenetic states in mammals. Biochem J (2001) 1.43
Retracted Are there two DNA methyltransferase gene families in plant cells? A new potential methyltransferase gene isolated from an Arabidopsis thaliana genomic library. Nucleic Acids Res (1994) 1.39
Complete DNA methylation does not prevent polyoma and simian virus 40 virus early gene expression. Proc Natl Acad Sci U S A (1983) 1.39
Expression of transferred thymidine kinase genes is controlled by methylation. Proc Natl Acad Sci U S A (1982) 1.39
Distribution of 5-methylcytosine in the DNA of somatic and germline cells from bovine tissues. Nucleic Acids Res (1981) 1.38
DNA methylation associated with repeat-induced point mutation in Neurospora crassa. Mol Cell Biol (1995) 1.34
Specifically unmethylated cytidylic-guanylate sites in Herpesvirus saimiri DNA in tumor cells. J Virol (1982) 1.29
A population-epigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns. Proc Natl Acad Sci U S A (2005) 1.25
Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo. EMBO J (1991) 1.23
Genome-wide quantitative assessment of variation in DNA methylation patterns. Nucleic Acids Res (2011) 1.23
Effect of methylation on expression of microinjected genes. Proc Natl Acad Sci U S A (1982) 1.20
In vitro DNA methylation inhibits gene expression in transgenic tobacco. EMBO J (1990) 1.15
Changes in methylation pattern of albumin and alpha-fetoprotein genes in developing rat liver and neoplasia. Nucleic Acids Res (1983) 1.13
A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. Mol Cell Biol (1990) 1.13
Hypomethylation of hepatic nuclear DNA in rats fed with a carcinogenic methyl-deficient diet. Biochem J (1984) 1.12
Inheritance of DNA methylation in microinjected eggs of Xenopus laevis. Proc Natl Acad Sci U S A (1982) 1.12
DNA methylation pattern is determined by the intracellular level of the methylase. Proc Natl Acad Sci U S A (1984) 1.11
Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine, and characterization of an antigen associated with metastatic activity. Proc Natl Acad Sci U S A (1984) 1.10
Introduction and expression of the bacterial PaeR7 methylase gene in mammalian cells. Proc Natl Acad Sci U S A (1986) 1.10
In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity. Mol Cell Biol (1983) 1.08
DNA methyltransferase induced by frog virus 3. J Virol (1984) 1.07
Modulation of tk expression in mouse pericentromeric heterochromatin. Mol Cell Biol (1986) 1.05
Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor. Proc Natl Acad Sci U S A (1982) 1.05
Transformation of Tetrahymena thermophila with hypermethylated rRNA genes. Mol Cell Biol (1988) 1.03
Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect. Nucleic Acids Res (1985) 1.00
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer. Nature (2015) 0.99
Induction and maintenance of nonsymmetrical DNA methylation in Neurospora. Proc Natl Acad Sci U S A (2002) 0.98
Interclonal variation in methylation patterns for expressed and non-expressed genes. Nucleic Acids Res (1982) 0.98
Cytosine methylated DNA synthesized by Taq polymerase used to assay methylation sensitivity of restriction endonuclease HinfI. Nucleic Acids Res (1991) 0.97
Epigenetics and the developmental origins of inflammatory bowel diseases. Can J Gastroenterol (2012) 0.97
The hypermethylation and protein expression of p16 INK4A and DNA repair gene O6-methylguanine-DNA methyltransferase in various uterine cervical lesions. J Cancer Res Clin Oncol (2005) 0.95
Hemimethylation of DNA prevents chromatin expression. Proc Natl Acad Sci U S A (1990) 0.95
5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression. Mol Cell Biol (1992) 0.94
Methylation of single sites within the herpes simplex virus tk coding region and the simian virus 40 T-antigen intron causes gene inactivation. Mol Cell Biol (1994) 0.94
Methylation state and DNase I sensitivity of chromatin containing Moloney murine leukemia virus DNA in exogenously infected mouse cells. J Virol (1982) 0.94
Selection of strongly immunogenic "tum-" variants from tumors at high frequency using 5-azacytidine. J Exp Med (1984) 0.94
DNA methylation and differentiation. Environ Health Perspect (1989) 0.91
Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine. Mol Cell Biol (1984) 0.91
Methylation patterns in the gene for the alpha subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts. Nucleic Acids Res (1985) 0.88
DNA methylation and carcinogenesis in digestive neoplasms. World J Gastroenterol (1998) 0.87
Human DNA mismatch repair in vitro operates independently of methylation status at CpG sites. Nucleic Acids Res (2001) 0.85
Epigenetics and developmental plasticity across species. Dev Psychobiol (2012) 0.85
Effect of in vitro methylation at CpG sites on gene expression in a genome functioning autonomously in a vertebrate host. Nucleic Acids Res (1982) 0.85
A DNA microarray-based methylation-sensitive (MS)-AFLP hybridization method for genetic and epigenetic analyses. Mol Genet Genomics (2004) 0.84
Immunoglobulin gene expression and DNA methylation in murine pre-B cell lines. EMBO J (1984) 0.84
Transcription of methylated eukaryotic viral genes in a soluble in vitro system. Nucleic Acids Res (1984) 0.83
Integrating DNA methylation dynamics into a framework for understanding epigenetic codes. Bioessays (2013) 0.83
Epigenetic Alterations in Alzheimer's Disease. Front Behav Neurosci (2015) 0.83
Tissue specificity and organisation of CpG methylation in calf satellite DNA I. Nucleic Acids Res (1982) 0.82
Chemical carcinogen-induced decreases in genomic 5-methyldeoxycytidine content of normal human bronchial epithelial cells. Proc Natl Acad Sci U S A (1987) 0.81
Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes. Mol Cell Biol (1983) 0.80
Changes in structure and methylation pattern in a cluster of thymidine kinase genes. Mol Cell Biol (1984) 0.79
Microbiome-Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases. J Pediatr Gastroenterol Nutr (2016) 0.78
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet (2017) 0.78
Variation in genomic methylation in natural populations of chinese white poplar. PLoS One (2013) 0.76
DNA methylation and DNA methyltransferases. Epigenetics Chromatin (2017) 0.75
Treatment of human cell lines with 5-azacytidine may result in profound alterations in clonogenicity and growth rate. J Cell Biol (1985) 0.75
Epigenetic characteristics of the mitotic chromosome in 1D and 3D. Crit Rev Biochem Mol Biol (2017) 0.75
Prediction of coronary heart disease using risk factor categories. Circulation (1998) 48.81
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation (1998) 19.93
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
Functional homology of mammalian and yeast RAS genes. Cell (1985) 14.01
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol Cell Biol (1988) 13.78
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (1993) 12.74
In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell (1985) 11.63
Independent risk factors for atrial fibrillation in a population-based cohort. The Framingham Heart Study. JAMA (1994) 11.63
Cloning the differences between two complex genomes. Science (1993) 10.60
Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med (2001) 10.54
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell (1988) 10.29
Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation (1993) 9.24
The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol (1993) 8.01
Lifetime risk of developing coronary heart disease. Lancet (1999) 7.54
Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 7.34
Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science (1997) 7.31
Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell (1984) 6.87
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature (1982) 6.78
Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates. Am J Cardiol (1998) 6.76
Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med (1999) 6.72
Genetic and physical linkage of exogenous sequences in transformed cells. Cell (1980) 6.67
Genetic analysis of yeast RAS1 and RAS2 genes. Cell (1984) 6.60
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell (1987) 6.35
Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation (1996) 6.20
Relationship of symptom-onset-to-balloon time and door-to-balloon time with mortality in patients undergoing angioplasty for acute myocardial infarction. JAMA (2000) 6.00
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst (1997) 5.68
Accuracy of death certificates for coding coronary heart disease as the cause of death. Ann Intern Med (1998) 5.63
Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet (2001) 5.54
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature (1987) 5.46
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Structure and activation of the human N-ras gene. Cell (1983) 5.25
Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation (2001) 5.11
Is pulse pressure useful in predicting risk for coronary heart Disease? The Framingham heart study. Circulation (1999) 5.04
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol (1987) 5.03
Prevalence and clinical outcome of mitral-valve prolapse. N Engl J Med (1999) 5.01
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell (1985) 4.80
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell (1987) 4.74
Defining diastolic heart failure: a call for standardized diagnostic criteria. Circulation (2000) 4.63
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Echocardiographic predictors of nonrheumatic atrial fibrillation. The Framingham Heart Study. Circulation (1994) 4.52
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature (1983) 4.44
Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol (1998) 4.44
Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature (1980) 4.37
Complex formation between RAS and RAF and other protein kinases. Proc Natl Acad Sci U S A (1993) 4.30
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (1982) 4.30
Human-tumor-derived cell lines contain common and different transforming genes. Cell (1981) 4.29
Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell (1985) 4.23
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell (1990) 4.12
Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum (1997) 4.08
Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA (1987) 4.05
Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation (1995) 4.04
Bone mass and the risk of breast cancer among postmenopausal women. N Engl J Med (1997) 3.96
The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum (1995) 3.93
Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation (1998) 3.89
Cancer: improving early detection and prevention. A community practice randomised trial. BMJ (1992) 3.76
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell (1988) 3.72
Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell (1980) 3.66
An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study) Am J Cardiol (1992) 3.66
Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proc Natl Acad Sci U S A (1984) 3.64
Effects of ambient air pollution on nonelderly asthma hospital admissions in Seattle, Washington, 1987-1994. Epidemiology (1999) 3.57
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell (1986) 3.57
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proc Natl Acad Sci U S A (1983) 3.52
Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44
Reduced heart rate variability and mortality risk in an elderly cohort. The Framingham Heart Study. Circulation (1994) 3.44
New human transforming genes detected by a tumorigenicity assay. Mol Cell Biol (1984) 3.43
Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39
A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cells. Proc Natl Acad Sci U S A (1985) 3.29
ras proteins can induce meiosis in Xenopus oocytes. Cell (1985) 3.23
Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 3.19
Prevalence, clinical features and prognosis of diastolic heart failure: an epidemiologic perspective. J Am Coll Cardiol (1995) 3.19
Prognosis of left ventricular geometric patterns in the Framingham Heart Study. J Am Coll Cardiol (1995) 3.08
Impaired heart rate response to graded exercise. Prognostic implications of chronotropic incompetence in the Framingham Heart Study. Circulation (1996) 3.07
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int (1999) 2.95
Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet (1994) 2.95
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proc Natl Acad Sci U S A (1986) 2.92
Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension (1998) 2.86
Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem (1994) 2.82
Profile for estimating risk of heart failure. Arch Intern Med (1999) 2.81
Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med (1997) 2.81
Mitral annular calcification and the risk of stroke in an elderly cohort. N Engl J Med (1992) 2.77
Clinical Advisory Statement. Importance of systolic blood pressure in older Americans. Hypertension (2000) 2.76
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell (1986) 2.65
Echocardiographic criteria for left ventricular hypertrophy: the Framingham Heart Study. Am J Cardiol (1987) 2.60
Tumour promotor induces plasminogen activator. Nature (1976) 2.60
ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol (1999) 2.58
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev (1987) 2.58
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Mol Cell Biol (1989) 2.57
SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev (1988) 2.57
Total serum bilirubin and risk of cardiovascular disease in the Framingham offspring study. Am J Cardiol (2001) 2.57