Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.

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Published in J Pharmacol Exp Ther on August 01, 1999

Authors

C C Chan1, S Boyce, C Brideau, S Charleson, W Cromlish, D Ethier, J Evans, A W Ford-Hutchinson, M J Forrest, J Y Gauthier, R Gordon, M Gresser, J Guay, S Kargman, B Kennedy, Y Leblanc, S Leger, J Mancini, G P O'Neill, M Ouellet, D Patrick, M D Percival, H Perrier, P Prasit, I Rodger

Author Affiliations

1: Departments of Pharmacology, Biochemistry and Molecular Biology, and Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, Kirkland, Quebec, Canada. chi_chung_chan@merck.com

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