Published in FEBS Lett on March 05, 1999
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A (2003) 7.64
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Proc Natl Acad Sci U S A (2005) 3.79
Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates. Proc Natl Acad Sci U S A (2005) 3.16
Kisspeptin signaling in the brain. Endocr Rev (2009) 2.83
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci U S A (2007) 2.66
Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology (2007) 1.98
Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab (2014) 1.23
Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci (2010) 1.20
A review of FMRFamide- and RFamide-like peptides in metazoa. Invert Neurosci (2010) 1.17
Neuroendocrine control by kisspeptins: role in metabolic regulation of fertility. Nat Rev Endocrinol (2011) 1.17
Coming of age in the kisspeptin era: sex differences, development, and puberty. Mol Cell Endocrinol (2010) 1.17
The kisspeptin-GnRH pathway in human reproductive health and disease. Hum Reprod Update (2014) 1.13
Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus. Neurotoxicology (2008) 1.13
Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats. Neurotoxicology (2009) 1.11
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br J Pharmacol (2007) 1.11
The KISS1 metastasis suppressor: mechanistic insights and clinical utility. Front Biosci (2006) 1.09
Sexual differentiation and the Kiss1 system: hormonal and developmental considerations. Peptides (2008) 1.04
Kisspeptin increases gamma-aminobutyric acidergic and glutamatergic transmission directly to gonadotropin-releasing hormone neurons in an estradiol-dependent manner. Endocrinology (2009) 1.03
From KISS1 to kisspeptins: An historical perspective and suggested nomenclature. Peptides (2008) 0.99
A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behavior in response to feeding cues. Proc Natl Acad Sci U S A (2008) 0.98
Kisspeptin-54 at high doses acutely induces testicular degeneration in adult male rats via central mechanisms. Br J Pharmacol (2009) 0.97
The Changes They are A-Timed: Metabolism, Endogenous Clocks, and the Timing of Puberty. Front Endocrinol (Lausanne) (2012) 0.97
Manganese stimulates luteinizing hormone releasing hormone secretion in prepubertal female rats: hypothalamic site and mechanism of action. J Physiol (2006) 0.97
New understandings of the genetic basis of isolated idiopathic central hypogonadism. Asian J Androl (2011) 0.96
International Union of Basic and Clinical Pharmacology. LXXVII. Kisspeptin receptor nomenclature, distribution, and function. Pharmacol Rev (2010) 0.95
Neuroanatomy of the kisspeptin signaling system in mammals: comparative and developmental aspects. Adv Exp Med Biol (2013) 0.94
Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands. ACS Med Chem Lett (2010) 0.93
GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner. PLoS One (2010) 0.93
Early growth response 3 (Egr-3) is induced by transforming growth factor-β and regulates fibrogenic responses. Am J Pathol (2013) 0.92
Multiple kisspeptin receptors in early osteichthyans provide new insights into the evolution of this receptor family. PLoS One (2012) 0.91
Kisspeptin neurones do not directly signal to RFRP-3 neurones but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. J Neuroendocrinol (2013) 0.89
Functional significance of GnRH and kisspeptin, and their cognate receptors in teleost reproduction. Front Endocrinol (Lausanne) (2013) 0.87
Kisspeptins and RFRP-3 Act in Concert to Synchronize Rodent Reproduction with Seasons. Front Neurosci (2013) 0.86
Organizational and activational effects of sex steroids on kisspeptin neuron development. Front Neuroendocrinol (2012) 0.86
Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus). Proc Natl Acad Sci U S A (2011) 0.85
KISS1R signals independently of Gαq/11 and triggers LH secretion via the β-arrestin pathway in the male mouse. Endocrinology (2014) 0.84
Social status regulates kisspeptin receptor mRNA in the brain of Astatotilapia burtoni. Gen Comp Endocrinol (2010) 0.83
Single-cell analyses reveal that KISS1R-expressing cells undergo sustained kisspeptin-induced signaling that is dependent upon an influx of extracellular Ca2+. Endocrinology (2012) 0.81
Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents. Front Endocrinol (Lausanne) (2014) 0.81
KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion. Eur J Histochem (2011) 0.81
Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells. Endocrinology (2015) 0.80
Kisspeptin signaling in the amygdala modulates reproductive hormone secretion. Brain Struct Funct (2015) 0.80
Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. BMC Cancer (2014) 0.80
Habenular kisspeptin modulates fear in the zebrafish. Proc Natl Acad Sci U S A (2014) 0.79
Expression and function of kisspeptin during mouse decidualization. PLoS One (2014) 0.79
The genes associated with gonadotropin-releasing hormone-dependent precocious puberty. Korean J Pediatr (2012) 0.79
Looking for the bird Kiss: evolutionary scenario in sauropsids. BMC Evol Biol (2014) 0.79
Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family? Front Endocrinol (Lausanne) (2014) 0.79
Development and Aging of the Kisspeptin-GPR54 System in the Mammalian Brain: What are the Impacts on Female Reproductive Function? Front Endocrinol (Lausanne) (2013) 0.78
Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis. Biol Sex Differ (2012) 0.78
Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes. Asian-Australas J Anim Sci (2012) 0.78
Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons. J Comp Neurol (2014) 0.77
Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Hippokratia (2008) 0.77
Kisspeptin signalling in the physiology and pathophysiology of the urogenital system. Nat Rev Urol (2015) 0.77
A "Timed" Kiss Is Essential for Reproduction: Lessons from Mammalian Studies. Front Endocrinol (Lausanne) (2016) 0.76
Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System. Endocrinol Metab (Seoul) (2016) 0.76
Hyperalgesic activity of kisspeptin in mice. Mol Pain (2011) 0.76
Kisspeptin in the medial amygdala and sexual behavior in male rats. Neurosci Lett (2016) 0.76
Kisspeptin signalling and its roles in humans. Singapore Med J (2015) 0.75
Kisspeptin modulates sexual and emotional brain processing in humans. J Clin Invest (2017) 0.75
Visualization of Kisspeptin Binding to Rat Hypothalamic Neurons. Acta Histochem Cytochem (2015) 0.75
The sequence of the human genome. Science (2001) 101.55
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science (1997) 13.61
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (1992) 9.96
Evolution and transmission of stable CTL escape mutations in HIV infection. Nature (2001) 6.57
Neuroligin 1: a splice site-specific ligand for beta-neurexins. Cell (1995) 5.97
Integrating genotype and phenotype information: an overview of the PharmGKB project. Pharmacogenetics Research Network and Knowledge Base. Pharmacogenomics J (2001) 5.94
Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J (2001) 5.28
HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation (2000) 4.96
The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med (1993) 4.88
Arbitrarily primed PCR fingerprinting of RNA. Nucleic Acids Res (1992) 4.78
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A (2001) 4.58
Diffusion of the Interspecies Electron Carriers H(2) and Formate in Methanogenic Ecosystems and Its Implications in the Measurement of K(m) for H(2) or Formate Uptake. Appl Environ Microbiol (1989) 4.53
The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell (1997) 4.47
Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity (2000) 4.44
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39
Structures, alternative splicing, and neurexin binding of multiple neuroligins. J Biol Chem (1996) 4.31
Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res (1995) 4.28
Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques (1994) 4.24
Junction adhesion molecule is a receptor for reovirus. Cell (2001) 4.00
Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex. Genes Dev (1998) 3.84
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. J Biol Chem (2000) 3.75
Role of nitric oxide in the vascular effects of local warming of the skin in humans. J Appl Physiol (1985) (1999) 3.65
Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury. J Biol Chem (1996) 3.65
Timing of cyclin D1 expression within G1 phase is controlled by Rho. Nat Cell Biol (2001) 3.63
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates. Proc Natl Acad Sci U S A (1997) 3.59
Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature (1999) 3.57
Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology (2004) 3.54
Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase. Proc Natl Acad Sci U S A (1985) 3.50
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med (2001) 3.44
Response regulator output in bacterial chemotaxis. EMBO J (1998) 3.40
Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell (1989) 3.33
Alternative initiation of translation and time-specific phosphorylation yield multiple forms of the essential clock protein FREQUENCY. Cell (1997) 3.32
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature (2000) 3.26
Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature (1998) 3.22
Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem (2000) 3.22
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res (1997) 3.21
Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. Radiology (2000) 3.06
IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J (1998) 2.99
Activation of a mitogen-activated protein kinase pathway is involved in disease resistance in tobacco. Proc Natl Acad Sci U S A (2001) 2.98
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93
Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92
Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91
Dbp5p, a cytosolic RNA helicase, is required for poly(A)+ RNA export. EMBO J (1998) 2.90
Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem (2000) 2.89
Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation. Oncogene (2012) 2.82
Structure of the adenylyl cyclase catalytic core. Nature (1997) 2.81
Prevention of corticosteroid osteoporosis. A comparison of calcium, calcitriol, and calcitonin. N Engl J Med (1993) 2.80
Interlocked feedback loops contribute to the robustness of the Neurospora circadian clock. Proc Natl Acad Sci U S A (2001) 2.77
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res (1995) 2.74
Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes. J Cell Biol (2001) 2.73
Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem (2000) 2.71
The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 2.70
The regulation of reactive oxygen species production during programmed cell death. J Cell Biol (1998) 2.62
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene (1993) 2.59
The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci (1998) 2.58
Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease. J Biol Chem (1986) 2.54
The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Cell (2000) 2.53
Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985) (1998) 2.53
The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50
Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant. Plant Cell (1998) 2.48
Soybean nodulin genes: Analysis of cDNA clones reveals several major tissue-specific sequences in nitrogen-fixing root nodules. Proc Natl Acad Sci U S A (1983) 2.48
On the use of thiol-modifying agents to determine channel topology. Neuropharmacology (1996) 2.47
Increased thermal stability of proteins in the presence of naturally occurring osmolytes. Biochemistry (1992) 2.47
Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem (1997) 2.47
Profiling serine hydrolase activities in complex proteomes. Biochemistry (2001) 2.46
Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature (1991) 2.41
The human olfactory receptor repertoire. Genome Biol (2001) 2.41
A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Establishment, maintenance and description of cell lines from the tick Ixodes scapularis. J Parasitol (1994) 2.36
Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Neuron (1997) 2.34
Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53. J Clin Invest (1997) 2.31
The transcriptome of the arbuscular mycorrhizal fungus Glomus intraradices (DAOM 197198) reveals functional tradeoffs in an obligate symbiont. New Phytol (2011) 2.29
Effect of a media-led education campaign on breast and cervical cancer screening among Vietnamese-American women. Prev Med (1999) 2.28
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev (1997) 2.26
Acute motor axonal neuropathy: a frequent cause of acute flaccid paralysis in China. Ann Neurol (1993) 2.23
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures. J Cell Biol (2001) 2.23
Odd-parity superconductivity in Sr2RuO4. Science (2004) 2.22
Systemic gene expression after intravenous DNA delivery into adult mice. Science (1993) 2.21
Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition. J Biol Chem (1994) 2.21
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A (2001) 2.21
Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2. Proc Natl Acad Sci U S A (2000) 2.20
Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora. EMBO J (2001) 2.19
Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity (1999) 2.18