Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes.

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Published in Proc Natl Acad Sci U S A on August 03, 1999

Authors

S Maas1, A P Gerber, A Rich

Author Affiliations

1: Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139, USA.

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Electron Microscope Studies of Ribosomal Clusters Synthesizing Hemoglobin. Science (1962) 5.74

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Simian virus 40 DNA directs synthesis of authentic viral polypeptides in a linked transcription-translation cell-free system. Proc Natl Acad Sci U S A (1975) 4.98

Translational control of protein synthesis in response to heat shock in D. melanogaster cells. Cell (1980) 4.82

Structural analysis of spermine and magnesium ion binding to yeast phenylalanine transfer RNA. Proc Natl Acad Sci U S A (1978) 4.52

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Isolation of Drosophila proteins that bind selectively to left-handed Z-DNA. Proc Natl Acad Sci U S A (1982) 2.01

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Non-identity of muscle and non-muscle actins. Biochem Biophys Res Commun (1975) 1.73

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound. Nature (1978) 1.73

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Pre-proparathyroid hormone. Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem (1976) 1.67

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Formation of Z-DNA in negatively supercoiled plasmids is sensitive to small changes in salt concentration within the physiological range. EMBO J (1983) 1.67

High-resolution x-ray diffraction patterns of crystalline transfer RNA that show helical regions. Proc Natl Acad Sci U S A (1971) 1.67

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Structural basis for stabilization of Z-DNA by cobalt hexaammine and magnesium cations. Biochemistry (1985) 1.64

The identification of polyribosomes synthesizing myosin. Proc Natl Acad Sci U S A (1967) 1.64

Bromination stabilizes poly(dG-dC) in the Z-DNA form under low-salt conditions. Biochemistry (1984) 1.63

A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments. Acta Crystallogr D Biol Crystallogr (1996) 1.62

Hydrogen bonding in yeast phenylalanine transfer RNA. Proc Natl Acad Sci U S A (1975) 1.60

5'-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation. Biochemistry (1983) 1.56

Transcription is associated with Z-DNA formation in metabolically active permeabilized mammalian cell nuclei. Proc Natl Acad Sci U S A (1991) 1.56

Transcriptional regulation of the human prointerleukin 1 beta gene. J Immunol (1987) 1.54

Drosophila Rrp1 protein: an apurinic endonuclease with homologous recombination activities. Proc Natl Acad Sci U S A (1991) 1.52

Binding of a Hoechst dye to d(CGCGATATCGCG) and its influence on the conformation of the DNA fragment. Biochemistry (1989) 1.51