RNA editing and hypermutation by adenosine deamination.

Antiviral actions of interferons. Clin Microbiol Rev (2001) 13.06

RNA editing by adenosine deaminases that act on RNA. Annu Rev Biochem (2001) 9.66

An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region. Genetics (1999) 5.87

RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA. Proc Natl Acad Sci U S A (2002) 3.41

A-to-I RNA editing and human disease. RNA Biol (2006) 3.32

Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA. EMBO J (1998) 3.23

Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. Proc Natl Acad Sci U S A (2001) 3.14

Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible. Proc Natl Acad Sci U S A (1999) 2.33

Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA. Mol Cell Biol (2000) 2.10

Long RNA hairpins that contain inosine are present in Caenorhabditis elegans poly(A)+ RNA. Proc Natl Acad Sci U S A (1999) 2.08

Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. EMBO J (1998) 1.98

HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project. Nucleic Acids Res (2002) 1.98

dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing. RNA (2000) 1.95

New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1. J Virol (2005) 1.78

Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. Hum Mol Genet (2011) 1.74

Predicting sites of ADAR editing in double-stranded RNA. Nat Commun (2011) 1.74

A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. RNA (2000) 1.71

RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA (2003) 1.70

RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. Genetics (2000) 1.67

CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain. Mol Cell Biol (2001) 1.56

Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen. Mol Cell Biol (1998) 1.53

Specificity of ADAR-mediated RNA editing in newly identified targets. RNA (2008) 1.51

In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site. RNA (2000) 1.47

Identification of a novel structural protein of arteriviruses. J Virol (1999) 1.42

The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein. Mol Biol Cell (2001) 1.38

tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J (2002) 1.38

The zalpha domain of the editing enzyme dsRNA adenosine deaminase binds left-handed Z-RNA as well as Z-DNA. Proc Natl Acad Sci U S A (2000) 1.35

The role of binding domains for dsRNA and Z-DNA in the in vivo editing of minimal substrates by ADAR1. Proc Natl Acad Sci U S A (2001) 1.30

Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Proc Natl Acad Sci U S A (1999) 1.25

The Zalpha domain from human ADAR1 binds to the Z-DNA conformer of many different sequences. Nucleic Acids Res (1998) 1.21

Identification of widespread ultra-edited human RNAs. PLoS Genet (2011) 1.16

A minor fraction of basic fibroblast growth factor mRNA is deaminated in Xenopus stage VI and matured oocytes. RNA (1999) 1.16

Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain. Mol Biol Cell (2002) 1.14

Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2. J Virol (2002) 1.14

Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing. RNA (2002) 1.11

RNA editing regulates transposon-mediated heterochromatic gene silencing. Nat Commun (2013) 1.07

RNA interference: advances and questions. Philos Trans R Soc Lond B Biol Sci (2002) 1.06

The RNA-editing enzyme ADAR1 is localized to the nascent ribonucleoprotein matrix on Xenopus lampbrush chromosomes but specifically associates with an atypical loop. J Cell Biol (1999) 0.99

Distinct in vivo roles for double-stranded RNA-binding domains of the Xenopus RNA-editing enzyme ADAR1 in chromosomal targeting. J Cell Biol (2003) 0.96

Identification of the chloroplast adenosine-to-inosine tRNA editing enzyme. RNA (2009) 0.96

ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus type 1-infected cells. J Virol (2004) 0.93

Altered A-to-I RNA editing in human embryogenesis. PLoS One (2012) 0.90

3'-UTR-located inverted Alu repeats facilitate mRNA translational repression and stress granule accumulation. Nucleus (2012) 0.89

Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches. Biochemistry (2011) 0.88

Identification of enzymes for adenosine-to-inosine editing and discovery of cytidine-to-uridine editing in nucleus-encoded transfer RNAs of Arabidopsis. Plant Physiol (2014) 0.87

Ethidium-dependent uncoupling of substrate binding and cleavage by Escherichia coli ribonuclease III. Nucleic Acids Res (2001) 0.86

Oligodendroglia are limited in type I interferon induction and responsiveness in vivo. Glia (2012) 0.86

A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules. Front Bioeng Biotechnol (2015) 0.85

Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues. RNA Biol (2013) 0.81

Inosine-containing RNA is a novel innate immune recognition element and reduces RSV infection. PLoS One (2011) 0.81

Kinetics of formation of hypoxanthine containing base pairs by HIV-RT: RNA template effects on the base substitution frequencies. Nucleic Acids Res (2001) 0.79

The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection. PLoS Genet (2016) 0.79

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity. Retrovirology (2014) 0.78

Next-generation sequencing: from understanding biology to personalized medicine. Biology (Basel) (2013) 0.78

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1. J Gen Virol (2012) 0.77

A screening protocol for identification of functional mutants of RNA editing adenosine deaminases. Curr Protoc Chem Biol (2012) 0.76

Identification of the long, edited dsRNAome of LPS-stimulated immune cells. Genome Res (2016) 0.76

RNA Editing-Systemic Relevance and Clue to Disease Mechanisms? Front Mol Neurosci (2016) 0.75

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human Diseases. Genes (Basel) (2016) 0.75