Published in Cell on August 20, 1999
Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A (2006) 7.26
STIM proteins: dynamic calcium signal transducers. Nat Rev Mol Cell Biol (2012) 2.90
Modulation of Ca(2+) entry by polypeptides of the inositol 1,4, 5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP3R in store depletion-activated Ca(2+) entry. Proc Natl Acad Sci U S A (1999) 2.52
Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. J Biol Chem (2001) 1.99
Molecular properties and physiological roles of ion channels in the immune system. J Clin Immunol (2001) 1.85
An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cells. J Physiol (2001) 1.74
Transient receptor potential 1 regulates capacitative Ca(2+) entry and Ca(2+) release from endoplasmic reticulum in B lymphocytes. J Exp Med (2002) 1.73
Some assembly required: constructing the elementary units of store-operated Ca2+ entry. Cell Calcium (2007) 1.70
A homolog of voltage-gated Ca(2+) channels stimulated by depletion of secretory Ca(2+) in yeast. Mol Cell Biol (2000) 1.69
Insulin promotes rapid delivery of N-methyl-D- aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci U S A (2001) 1.63
New molecular players in capacitative Ca2+ entry. J Cell Sci (2007) 1.61
Single channel properties and regulated expression of Ca(2+) release-activated Ca(2+) (CRAC) channels in human T cells. J Cell Biol (2000) 1.54
A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure. Proc Natl Acad Sci U S A (2007) 1.52
Store-Operated Calcium Channels. Physiol Rev (2015) 1.46
TRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry. Proc Natl Acad Sci U S A (1999) 1.43
Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia. Am J Physiol Lung Cell Mol Physiol (2008) 1.42
Trans-SNARE interactions elicit Ca2+ efflux from the yeast vacuole lumen. J Cell Biol (2004) 1.40
The diacylgylcerol-sensitive TRPC3/6/7 subfamily of cation channels: functional characterization and physiological relevance. Pflugers Arch (2005) 1.40
Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. Biochem J (2000) 1.31
Store-operated Ca2+ entry: dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane. J Physiol (2003) 1.29
SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking. J Neurosci (2010) 1.29
The actin cytoskeleton in store-mediated calcium entry. J Physiol (2000) 1.29
Induction of maturation-promoting factor during Xenopus oocyte maturation uncouples Ca(2+) store depletion from store-operated Ca(2+) entry. J Cell Biol (2002) 1.25
TRP channels in hypertension. Biochim Biophys Acta (2007) 1.25
Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J (2000) 1.21
Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted. Biochem J (2000) 1.20
Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia. Pflugers Arch (2005) 1.20
Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction. Mol Biol Cell (2000) 1.19
Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis. Proc Natl Acad Sci U S A (2009) 1.17
Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. J Biol Chem (2003) 1.17
Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 1.15
Functional role of TRPC channels in the regulation of endothelial permeability. Pflugers Arch (2005) 1.13
Activation of calcium entry in human carcinoma A431 cells by store depletion and phospholipase C- dependent mechanisms converge on ICRAC-like calcium channels. Proc Natl Acad Sci U S A (2001) 1.09
Regulation of Ca2+-release-activated Ca2+ current (Icrac) by ryanodine receptors in inositol 1,4,5-trisphosphate-receptor-deficient DT40 cells. Biochem J (2001) 1.07
Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis. J Cell Biol (2010) 1.03
Airway smooth muscle as a target of asthma therapy: history and new directions. Respir Res (2006) 0.96
The store-operated calcium entry pathways in human carcinoma A431 cells: functional properties and activation mechanisms. J Gen Physiol (2003) 0.92
Store-operated channels regulate intracellular calcium in mammalian rods. J Physiol (2012) 0.92
Essential control of an endothelial cell ISOC by the spectrin membrane skeleton. J Cell Biol (2001) 0.92
TRP_2, a lipid/trafficking domain that mediates diacylglycerol-induced vesicle fusion. J Biol Chem (2008) 0.92
Capacitative Ca2+ entry is graded with degree of intracellular Ca2+ store depletion in bovine vascular endothelial cells. J Physiol (2000) 0.92
The transient receptor potential, TRP4, cation channel is a novel member of the family of calmodulin binding proteins. Biochem J (2001) 0.90
Coupling Ca2+ store release to Icrac channel activation in B lymphocytes requires the activity of Lyn and Syk kinases. J Cell Biol (2007) 0.90
Activation of the store-operated calcium current ICRAC can be dissociated from regulated exocytosis in rat basophilic leukaemia (RBL-1) cells. J Physiol (2003) 0.89
Altered calcium signaling following traumatic brain injury. Front Pharmacol (2012) 0.89
Structure-function analysis of TRPV channels. Naunyn Schmiedebergs Arch Pharmacol (2005) 0.89
Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current I(CRAC) in rat basophilic leukaemia cells. J Physiol (2002) 0.88
Protein kinase C activates non-capacitative calcium entry in human platelets. J Physiol (2000) 0.87
Store-operated calcium signaling in neutrophils. J Leukoc Biol (2015) 0.87
A store-operated Ca(2+) influx pathway in the bag cell neurons of Aplysia. J Neurophysiol (2006) 0.86
On the activation mechanism of store-operated calcium channels. Pflugers Arch (2006) 0.85
Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells. Biochem J (2003) 0.85
Bacterial toxins and the nervous system: neurotoxins and multipotential toxins interacting with neuronal cells. Toxins (Basel) (2010) 0.81
Type-specific inositol 1,4,5-trisphosphate receptor localization in the vomeronasal organ and its interaction with a transient receptor potential channel, TRPC2. J Neurochem (2002) 0.81
Actin filaments play a permissive role in the inhibition of store-operated Ca2+ entry by extracellular ATP in rat brown adipocytes. Biochem J (2004) 0.79
A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets. J Physiol (2004) 0.79
Store depletion-induced calcium influx in rat cerebellar astrocytes. Br J Pharmacol (2002) 0.77
Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. PLoS One (2013) 0.77
Prolonged calcium influx after termination of light-induced calcium release in invertebrate photoreceptors. J Gen Physiol (2009) 0.75
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature (1997) 18.83
Crystal structure of the Aequorea victoria green fluorescent protein. Science (1996) 16.81
Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties. Proc Natl Acad Sci U S A (1972) 13.97
Improved green fluorescence. Nature (1995) 12.65
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J Cell Biol (1982) 11.87
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry (1980) 11.70
Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proc Natl Acad Sci U S A (1994) 10.50
On/off blinking and switching behaviour of single molecules of green fluorescent protein. Nature (1997) 9.97
Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92
Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr Biol (1996) 9.72
Specific covalent labeling of recombinant protein molecules inside live cells. Science (1998) 9.32
Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. J Biol Chem (2001) 9.27
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A (2000) 7.68
Circular permutation and receptor insertion within green fluorescent proteins. Proc Natl Acad Sci U S A (1999) 7.55
Understanding, improving and using green fluorescent proteins. Trends Biochem Sci (1995) 7.51
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J Biol Chem (1989) 7.22
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (2000) 6.98
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci U S A (1998) 6.73
Protein folding funnels: a kinetic approach to the sequence-structure relationship. Proc Natl Acad Sci U S A (1992) 6.63
Dynamic and quantitative Ca2+ measurements using improved cameleons. Proc Natl Acad Sci U S A (1999) 6.63
Calcium channels, stores, and oscillations. Annu Rev Cell Biol (1990) 6.12
The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A (2000) 5.88
A non-disruptive technique for loading calcium buffers and indicators into cells. Nature (1981) 5.72
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx. Nature (1993) 5.55
Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochim Biophys Acta (1980) 5.34
Cytoplasmic pH and free Mg2+ in lymphocytes. J Cell Biol (1982) 5.30
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proc Natl Acad Sci U S A (1997) 4.99
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature (1998) 4.93
Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol (2000) 4.87
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature (1982) 4.83
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2. Nature (1986) 4.21
Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter. Science (1998) 4.15
Is cytosolic ionized calcium regulating neutrophil activation? Science (1983) 3.97
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature (1987) 3.75
Electrical capacity of black lipid films and of lipid bilayers made from monolayers. Biochim Biophys Acta (1975) 3.65
The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains. J Virol (1996) 3.56
Changes of free calcium levels with stages of the cell division cycle. Nature (1985) 3.48
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature (1983) 3.47
Channel formation by antiapoptotic protein Bcl-2. Proc Natl Acad Sci U S A (1997) 3.45
Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron (2000) 3.44
Photochemically generated cytosolic calcium pulses and their detection by fluo-3. J Biol Chem (1989) 3.44
Lymphocyte membrane potential assessed with fluorescent probes. Biochim Biophys Acta (1980) 3.33
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem (1985) 3.31
Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium (1985) 3.23
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20
Diphtheria toxin forms transmembrane channels in planar lipid bilayers. Proc Natl Acad Sci U S A (1981) 3.17
Formation of bimolecular membranes from lipid monolayers. Methods Enzymol (1974) 3.09
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine). Proc Natl Acad Sci U S A (2000) 3.07
Controlling cell chemistry with caged compounds. Annu Rev Physiol (1993) 2.99
Fluorescent indicators for cytosolic sodium. J Biol Chem (1989) 2.89
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. Science (2000) 2.80
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A (2001) 2.77
Kinetic analysis of channel gating. Application to the cholinergic receptor channel and the chloride channel from Torpedo californica. Biophys J (1985) 2.77
Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat Struct Biol (1999) 2.75
Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes. J Physiol (1981) 2.75
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle. Proc Natl Acad Sci U S A (1985) 2.68
Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. J Cell Biol (1982) 2.67
Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion. FEBS Lett (1982) 2.60
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron (1988) 2.56
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55
De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. Neurology (2009) 2.53
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (1993) 2.51
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. J Cell Biol (1994) 2.48
The structure of the voltage-sensitive sodium channel. Inferences derived from computer-aided analysis of the Electrophorus electricus channel primary structure. FEBS Lett (1985) 2.48
Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3. Science (1991) 2.45
Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells. FEBS Lett (1996) 2.43
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proc Natl Acad Sci U S A (1999) 2.33
Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements. Biophys J (1988) 2.24
Fluorescent labeling of recombinant proteins in living cells with FlAsH. Methods Enzymol (2000) 2.24
Free calcium in Xenopus embryos measured with ion-selective microelectrodes. Nature (1980) 2.21
Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets. EMBO J (1987) 2.20
Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution. J Am Chem Soc (2001) 2.15
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem (2000) 2.15
Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr Biol (1996) 2.10
Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes. J Biol Chem (1989) 2.10
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proc Natl Acad Sci U S A (1988) 2.05
Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J Neurosci (1996) 1.99
Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells. Plant J (1999) 1.96
Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Sci STKE (2000) 1.96
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nat Genet (2001) 1.95
Rosy dawn for fluorescent proteins. Nat Biotechnol (1999) 1.94
Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons. Biophys J (1999) 1.93
Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other currently available sensors. J Neurosci Methods (1981) 1.90
Intracellular measurements of ion activities. Annu Rev Biophys Bioeng (1983) 1.90
Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuitm. Nature (1996) 1.89
A missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction. Proc Natl Acad Sci U S A (2001) 1.88
Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem (2001) 1.87
Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1. Proc Natl Acad Sci U S A (1999) 1.87
Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy. J Biomol NMR (1991) 1.82
Single-channel recordings from purified acetylcholine receptors reconstituted in bilayers formed at the tip of patch pipets. Biochemistry (1983) 1.82
The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2. J Neurosci (1988) 1.79
Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Biophys J (2000) 1.79
Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proc Natl Acad Sci U S A (2001) 1.74
Bcl-2 family proteins as ion-channels. Cell Death Differ (1998) 1.74