Published in Nature on November 14, 1996
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc Natl Acad Sci U S A (2001) 2.36
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci U S A (1999) 1.73
Invertebrate central pattern generator circuits. Philos Trans R Soc Lond B Biol Sci (2010) 1.29
Modulation of stomatogastric rhythms. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2009) 1.26
Retrograde signaling at central synapses. Proc Natl Acad Sci U S A (2001) 1.08
Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. J Cell Sci (2010) 1.06
Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytes. J Physiol (2001) 1.05
The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei. Proc Natl Acad Sci U S A (2002) 1.04
A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity. PLoS Comput Biol (2010) 0.98
Reproducible and sustained regulation of Gαs signalling using a metazoan opsin as an optogenetic tool. PLoS One (2012) 0.97
A-kinase anchoring proteins: getting to the heart of the matter. Circulation (2010) 0.97
Pituitary adenylate cyclase 1 receptor internalization and endosomal signaling mediate the pituitary adenylate cyclase activating polypeptide-induced increase in guinea pig cardiac neuron excitability. J Neurosci (2013) 0.95
Imaging second messenger dynamics in developing neural circuits. Dev Neurobiol (2008) 0.95
Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies. Br J Pharmacol (2010) 0.93
The many dimensions of cAMP signaling. Proc Natl Acad Sci U S A (2001) 0.92
A novel conditional genetic system reveals that increasing neuronal cAMP enhances memory and retrieval. J Neurosci (2008) 0.91
Tonic dopamine induces persistent changes in the transient potassium current through translational regulation. J Neurosci (2011) 0.90
Peptide neuromodulation of synaptic dynamics in an oscillatory network. J Neurosci (2011) 0.89
A neural infrastructure for rhythmic motor patterns. Cell Mol Neurobiol (2005) 0.88
Biophysical techniques for detection of cAMP and cGMP in living cells. Int J Mol Sci (2013) 0.88
Signaling from the cytoplasm to the nucleus in striatal medium-sized spiny neurons. Front Neuroanat (2011) 0.88
Repetition priming of motoneuronal activity in a small motor network: intercellular and intracellular signaling. J Neurosci (2010) 0.88
cAMP signaling microdomains and their observation by optical methods. Front Cell Neurosci (2014) 0.86
Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Dev Neurosci (1998) 0.86
Crustacean dopamine receptors: localization and G protein coupling in the stomatogastric ganglion. J Neurochem (2007) 0.86
Computing with cyclic AMP. Nature (1996) 0.85
cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons. Cell Rep (2016) 0.83
Localization and function of Ih channels in a small neural network. J Neurophysiol (2011) 0.83
Dopaminergic tone regulates transient potassium current maximal conductance through a translational mechanism requiring D1Rs, cAMP/PKA, Erk and mTOR. BMC Neurosci (2013) 0.83
A simple mathematical model of second-messenger mediated slow excitatory postsynaptic potentials. J Comput Neurosci (2000) 0.79
The genetically encoded tool set for investigating cAMP: more than the sum of its parts. Front Pharmacol (2015) 0.75
Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition. Elife (2017) 0.75
A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem (1985) 90.20
Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature (1997) 18.83
Crystal structure of the Aequorea victoria green fluorescent protein. Science (1996) 16.81
Improved green fluorescence. Nature (1995) 12.65
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J Cell Biol (1982) 11.87
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry (1980) 11.70
Wavelength mutations and posttranslational autoxidation of green fluorescent protein. Proc Natl Acad Sci U S A (1994) 10.50
On/off blinking and switching behaviour of single molecules of green fluorescent protein. Nature (1997) 9.97
Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92
Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer. Curr Biol (1996) 9.72
Specific covalent labeling of recombinant protein molecules inside live cells. Science (1998) 9.32
Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications. J Biol Chem (2001) 9.27
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A (2000) 7.68
Circular permutation and receptor insertion within green fluorescent proteins. Proc Natl Acad Sci U S A (1999) 7.55
Understanding, improving and using green fluorescent proteins. Trends Biochem Sci (1995) 7.51
Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J Biol Chem (1989) 7.22
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (2000) 6.98
Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci U S A (1998) 6.73
Dynamic and quantitative Ca2+ measurements using improved cameleons. Proc Natl Acad Sci U S A (1999) 6.63
Calcium channels, stores, and oscillations. Annu Rev Cell Biol (1990) 6.12
The structure of the chromophore within DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci U S A (2000) 5.88
A non-disruptive technique for loading calcium buffers and indicators into cells. Nature (1981) 5.72
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx. Nature (1993) 5.55
Neutral carrier ion-selective microelectrodes for measurement of intracellular free calcium. Biochim Biophys Acta (1980) 5.34
Cytoplasmic pH and free Mg2+ in lymphocytes. J Cell Biol (1982) 5.30
Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proc Natl Acad Sci U S A (1997) 4.99
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression. Nature (1998) 4.93
Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. Methods Enzymol (2000) 4.87
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature (1982) 4.83
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2. Nature (1986) 4.21
Quantitation of transcription and clonal selection of single living cells with beta-lactamase as reporter. Science (1998) 4.15
Is cytosolic ionized calcium regulating neutrophil activation? Science (1983) 3.97
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. Nature (1987) 3.75
Changes of free calcium levels with stages of the cell division cycle. Nature (1985) 3.48
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature (1983) 3.47
Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron (2000) 3.44
Photochemically generated cytosolic calcium pulses and their detection by fluo-3. J Biol Chem (1989) 3.44
Lymphocyte membrane potential assessed with fluorescent probes. Biochim Biophys Acta (1980) 3.33
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem (1985) 3.31
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature (1995) 3.28
Measurement of cytosolic free Ca2+ in individual small cells using fluorescence microscopy with dual excitation wavelengths. Cell Calcium (1985) 3.23
Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol (2000) 3.20
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: coral red (dsRed) and yellow (Citrine). Proc Natl Acad Sci U S A (2000) 3.07
Controlling cell chemistry with caged compounds. Annu Rev Physiol (1993) 2.99
Fluorescent indicators for cytosolic sodium. J Biol Chem (1989) 2.89
Alteration of stimulus-specific guard cell calcium oscillations and stomatal closing in Arabidopsis det3 mutant. Science (2000) 2.80
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proc Natl Acad Sci U S A (2001) 2.77
Free calcium ions in neurones of Helix aspersa measured with ion-selective micro-electrodes. J Physiol (1981) 2.75
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle. Proc Natl Acad Sci U S A (1985) 2.68
Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. J Cell Biol (1982) 2.67
Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretion. FEBS Lett (1982) 2.60
Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Neuron (1988) 2.56
Free calcium in heart muscle at rest and during contraction measured with Ca2+ -sensitive microelectrodes. Nature (1980) 2.55
The preparation and properties of gonococcal pili. J Gen Microbiol (1977) 2.53
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (1993) 2.51
Fluorescence photooxidation with eosin: a method for high resolution immunolocalization and in situ hybridization detection for light and electron microscopy. J Cell Biol (1994) 2.48
Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP3. Science (1991) 2.45
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proc Natl Acad Sci U S A (1999) 2.33
Ca2+ binding kinetics of fura-2 and azo-1 from temperature-jump relaxation measurements. Biophys J (1988) 2.24
Fluorescent labeling of recombinant proteins in living cells with FlAsH. Methods Enzymol (2000) 2.24
Free calcium in Xenopus embryos measured with ion-selective microelectrodes. Nature (1980) 2.21
Sequential activation and lethal hit measured by [Ca2+]i in individual cytolytic T cells and targets. EMBO J (1987) 2.20
Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution. J Am Chem Soc (2001) 2.15
Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. J Biol Chem (2000) 2.15
Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr Biol (1996) 2.10
Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes. J Biol Chem (1989) 2.10
Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Proc Natl Acad Sci U S A (1988) 2.05
Activation of store-operated Ca2+ current in Xenopus oocytes requires SNAP-25 but not a diffusible messenger. Cell (1999) 2.02
Cameleon calcium indicator reports cytoplasmic calcium dynamics in Arabidopsis guard cells. Plant J (1999) 1.96
Measurement of molecular interactions in living cells by fluorescence resonance energy transfer between variants of the green fluorescent protein. Sci STKE (2000) 1.96
Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos. Nat Genet (2001) 1.95
Rosy dawn for fluorescent proteins. Nat Biotechnol (1999) 1.94
Video-rate scanning two-photon excitation fluorescence microscopy and ratio imaging with cameleons. Biophys J (1999) 1.93
Ca2+-selective electrodes: a novel PVC-gelled neutral carrier mixture compared with other currently available sensors. J Neurosci Methods (1981) 1.90
Intracellular measurements of ion activities. Annu Rev Biophys Bioeng (1983) 1.90
Mechanisms of pH regulation in the regulated secretory pathway. J Biol Chem (2001) 1.87
Discovery of very-high-energy gamma-rays from the Galactic Centre ridge. Nature (2006) 1.81
The stomatogastric nervous system: structure and function of a small neural network. Prog Neurobiol (1976) 1.80
Evaluation of the four-hour rapid 20E system for identification of members of the family Enterobacteriaceae. J Clin Microbiol (1984) 1.80
The concentration of cytosolic free calcium in vertebrate rod outer segments measured with fura-2. J Neurosci (1988) 1.79
Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proc Natl Acad Sci U S A (2001) 1.74
FRET for studying intracellular signalling. Trends Cell Biol (1993) 1.74
Crystal structure and photodynamic behavior of the blue emission variant Y66H/Y145F of green fluorescent protein. Biochemistry (1997) 1.74
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion. Mol Biol Cell (1993) 1.71
Hot nanotubes: stable heating of individual multiwall carbon nanotubes to 2000 k induced by the field-emission current. Phys Rev Lett (2002) 1.70
Radio imaging of the very-high-energy gamma-ray emission region in the central engine of a radio galaxy. Science (2009) 1.66
Fluorescence measurement and photochemical manipulation of cytosolic free calcium. Trends Neurosci (1988) 1.66
Organelle pH studies using targeted avidin and fluorescein-biotin. Chem Biol (2000) 1.64
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell (1996) 1.63