Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness.

PubWeight™: 1.16‹?› | Rank: Top 10%

🔗 View Article (PMC 1866897)

Published in Am J Pathol on September 01, 1999

Authors

M Kunz1, A Hartmann, E Flory, A Toksoy, D Koczan, H J Thiesen, N Mukaida, M Neumann, U R Rapp, E B Bröcker, R Gillitzer

Author Affiliations

1: Department of Dermatology, Institut für Medizinische Strahlenkunde und Zellforschung, Institute of Pathology, University of Würz, Germany.

Articles citing this

NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J Virol (2004) 3.52

Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol (2002) 2.81

Potentiation of inflammatory CXCL8 signalling sustains cell survival in PTEN-deficient prostate carcinoma. Eur Urol (2012) 1.69

Molecular responses to hypoxia in tumor cells. Mol Cancer (2003) 1.43

Role of nuclear factor-kappa B in melanoma. Cancer Metastasis Rev (2005) 1.41

Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics (2009) 1.35

Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation. Cancer Res (2007) 1.31

Hyperbaric oxygen therapy for malignancy: a review. World J Surg (2006) 1.01

Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas. Am J Pathol (2003) 1.00

Chemokines and the microenvironment in neuroectodermal tumor-host interaction. Semin Cancer Biol (2008) 0.99

The role of constitutive NF-kappaB activity in PC-3 human prostate cancer cell invasive behavior. Clin Exp Metastasis (2000) 0.92

Activity of sputum p38 MAPK is correlated with airway inflammation and reduced FEV1 in COPD patients. Med Sci Monit (2013) 0.87

Selective upregulation of interleukin-8 by human rhabdomyosarcomas in response to hypoxia: therapeutic implications. Int J Cancer (2010) 0.83

CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy. Int J Mol Med (2015) 0.81

Hypoxia/reoxygenation induction of monocyte chemoattractant protein-1 in melanoma cells: involvement of nuclear factor-kappaB, stimulatory protein-1 transcription factors and mitogen-activated protein kinase pathways. Biochem J (2002) 0.80

Modulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion, and metastasis. Cancer Med (2012) 0.80

Overexpression of cytoglobin gene inhibits hypoxic injury to SH-SY5Y neuroblastoma cells. Neural Regen Res (2013) 0.78

Circulating biomarkers of response to sunitinib in gastroenteropancreatic neuroendocrine tumors: current data and clinical outlook. Mol Diagn Ther (2012) 0.78

Immunoediting of leukocyte functions within the tumor microenvironment promotes cancer metastasis development. Biorheology (2009) 0.78

The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases. Mediators Inflamm (2016) 0.77

Transrectal ultrasound-integrated spectral optical tomography of hypoxic progression of a regressing tumor in a canine prostate. Technol Cancer Res Treat (2011) 0.77

Aqueous immune mediators in malignant uveal melanomas in comparison to benign pigmented intraocular tumors. Graefes Arch Clin Exp Ophthalmol (2016) 0.75

Articles cited by this

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res (1983) 124.30

Angiogenic factors. Science (1987) 15.22

What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst (1990) 13.41

Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol (1991) 10.58

Mitogen-activated protein kinase pathways. Curr Opin Cell Biol (1997) 9.10

The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem (1995) 8.32

AP-1 function and regulation. Curr Opin Cell Biol (1997) 8.29

Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science (1992) 7.92

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem (1996) 7.37

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med (1997) 6.86

Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res (1974) 3.96

Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem (1996) 3.80

Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun (1987) 3.77

Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem (1995) 3.69

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J Biol Chem (1990) 3.33

Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol (1997) 3.02

Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol (1995) 2.99

Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J Immunol (1989) 2.95

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. J Biol Chem (1992) 2.77

How tumors become angiogenic. Adv Cancer Res (1996) 2.63

The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. A quantitative histologic study. Am J Pathol (1988) 2.53

IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor. J Immunol (1993) 2.44

The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J Immunol (1997) 2.41

Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res (1994) 2.28

Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A (1988) 2.25

Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. Am J Pathol (1997) 2.15

Neovascularization in human cutaneous melanoma: a quantitative morphological and Doppler ultrasound study. Eur J Cancer Clin Oncol (1986) 2.12

Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol (1992) 2.08

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression. J Biol Chem (1994) 2.02

Identification of C5ades arg and an anionic neutrophil-activating peptide (ANAP) in psoriatic scales. J Invest Dermatol (1986) 1.96

Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem Biophys Res Commun (1993) 1.93

Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells. J Immunol (1996) 1.86

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem (1991) 1.84

Biology of tumor progression in human melanocytes. Lab Invest (1987) 1.61

Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8. Biochem Biophys Res Commun (1990) 1.48

Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells. Biochem J (1997) 1.46

Differential expression of chemokines in patients with localized and diffuse cutaneous American leishmaniasis. J Infect Dis (1996) 1.44

Upper keratinocytes of psoriatic skin lesions express high levels of NAP-1/IL-8 mRNA in situ. J Invest Dermatol (1991) 1.43

Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med (1997) 1.39

Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene. J Virol (1997) 1.35

Angiogenesis and tumor progression of melanoma. Quantification of vascularity in melanocytic nevi and cutaneous malignant melanoma. Lab Invest (1992) 1.34

Establishment and characterization of a human melanoma cell line (MV3) which is highly metastatic in nude mice. Int J Cancer (1991) 1.28

Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load. Melanoma Res (1995) 1.28

Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts. J Biol Chem (1988) 1.27

Extent of vascularization as a prognostic indicator in thin (< 0.76 mm) malignant melanomas. Am J Pathol (1994) 1.27

The interleukin-8-receptor family: from chemokines to malaria. Immunol Today (1994) 1.26

Regulation of interleukin-8 expression in human melanoma cells by the organ environment. Cancer Res (1995) 1.21

A comparison of post-receptor signal transduction events in Jurkat cells transfected with either IL-8R1 or IL-8R2. Chemokine mediated activation of p42/p44 MAP-kinase (ERK-2). FEBS Lett (1995) 1.12

The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B. Eur J Biochem (1995) 1.09

Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Oncogene (1999) 1.07

Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types. Biochim Biophys Acta (1995) 1.06

Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lymphocytes. J Biol Chem (1999) 1.03

Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter. Mol Cell Biol (1997) 1.02

IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro. Cytokine (1995) 1.02

Characterization of the role of melanoma growth stimulatory activity (MGSA) in the growth of normal melanocytes, nevocytes, and malignant melanocytes. J Cell Biochem (1990) 1.00

Interleukin-8 and de novo mammalian angiogenesis. Cell Prolif (1996) 0.95

Little difference. Nature (1996) 0.77

Articles by these authors

Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu Rev Immunol (1991) 10.58

Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05

Neurostimulation for Parkinson's disease with early motor complications. N Engl J Med (2013) 6.37

Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen (2000) 6.24

Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23

Detection and in situ identification of representatives of a widely distributed new bacterial phylum. FEMS Microbiol Lett (1997) 5.20

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88

Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86

Krüppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci U S A (1994) 4.84

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A (1983) 4.82

CICATRIZATION OF WOUNDS : I. THE RELATION BETWEEN THE SIZE OF A WOUND AND THE RATE OF ITS CICATRIZATION. J Exp Med (1916) 4.58

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc Natl Acad Sci U S A (1993) 4.23

Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma. J Exp Med (1999) 4.20

Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res (2001) 4.20

Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature (1991) 4.04

The biology of cell locomotion within three-dimensional extracellular matrix. Cell Mol Life Sci (2000) 3.70

Functional organization of the outer membrane of escherichia coli: phage and colicin receptors as components of iron uptake systems. J Supramol Struct (1976) 3.53

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev (1992) 3.46

Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol (1994) 3.35

Botulinum toxin for palmar hyperhidrosis. Lancet (1997) 3.17

Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant (2007) 3.02

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat Cell Biol (2001) 2.93

Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity (2000) 2.93

Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature (1985) 2.82

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene. J Biol Chem (1992) 2.77

Endothelial apoptosis in Braf-deficient mice. Nat Genet (1997) 2.77

Are long-chain polyunsaturated fatty acids essential nutrients in infancy? Lancet (1995) 2.73

Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem (1993) 2.70

Routine coronary angiography in diabetic nephropathy patients before transplantation. Am J Transplant (2006) 2.68

Effects of the intensity of immunosuppressive therapy on outcome of treatment for CMV disease in organ transplant recipients. Am J Transplant (2010) 2.66

Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature (1986) 2.64

Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev Biol (1999) 2.64

Multiple mutation analyses in single tumor cells with improved whole genome amplification. Am J Pathol (1999) 2.62

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation. EMBO J (1997) 2.57

The ins and outs of Raf kinases. Trends Biochem Sci (1994) 2.51

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res (1986) 2.50

Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci (2000) 2.49

Tetracycline-reversible silencing of eukaryotic promoters. Mol Cell Biol (1995) 2.48

Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res (1998) 2.44

G proteins in Ustilago maydis: transmission of multiple signals? EMBO J (1997) 2.42

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature (1993) 2.38

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol Cell Biol (1997) 2.37

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol (1992) 2.34

IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol (2001) 2.32

Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol Psychiatry (2009) 2.29

Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells. Infect Immun (1999) 2.26

Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol Cell Biol (1990) 2.24

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A (1996) 2.21

Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun (1997) 2.20

Structure and biological activity of human homologs of the raf/mil oncogene. Mol Cell Biol (1985) 2.19

Sustained improvement of renal graft function for two years in hypertensive renal transplant recipients treated with nifedipine as compared to lisinopril. Transplantation (2001) 2.13

Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology (2007) 2.09

Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. Am J Pathol (1998) 2.09

Stimulation of the subthalamic nucleus in Parkinson's disease: a 5 year follow up. J Neurol Neurosurg Psychiatry (2005) 2.08

In Situ Localization of Azospirillum brasilense in the Rhizosphere of Wheat with Fluorescently Labeled, rRNA-Targeted Oligonucleotide Probes and Scanning Confocal Laser Microscopy. Appl Environ Microbiol (1995) 2.05

Outpatient coronary angiography with 4 French catheters. J Invasive Cardiol (1999) 2.02

Long-term cardiac outcomes in renal transplant recipients receiving fluvastatin: the ALERT extension study. Am J Transplant (2005) 2.01

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res (1987) 1.98

Regulation of nitrogenase activity by ammonium chloride in Azospirillum spp. J Bacteriol (1986) 1.98

Doppler examination of the allografted kidney. Acta Radiol (2003) 1.97

The role of glial reaction and inflammation in Parkinson's disease. Ann N Y Acad Sci (2003) 1.94

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response. J Virol (2001) 1.92

Gene expression profiling of the nervous system in murine experimental autoimmune encephalomyelitis. Brain (2001) 1.91

Rescue of endogenous 30S retroviral sequences from mouse cells by baboon type C virus. J Virol (1978) 1.90

Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques. J Virol (1976) 1.87

Visualization of N-acylhomoserine lactone-mediated cell-cell communication between bacteria colonizing the tomato rhizosphere. Appl Environ Microbiol (2001) 1.86

Cell migration strategies in 3-D extracellular matrix: differences in morphology, cell matrix interactions, and integrin function. Microsc Res Tech (1998) 1.86

T cell-mediated Fas-induced keratinocyte apoptosis plays a key pathogenetic role in eczematous dermatitis. J Clin Invest (2000) 1.85

Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements. J Biol Chem (1991) 1.84

Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease. Neurology (2002) 1.84

Acute severe isovolemic anemia impairs cognitive function and memory in humans. Anesthesiology (2000) 1.82

Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid. Arch Dermatol (2000) 1.82

Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog (1999) 1.81

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol (2001) 1.81

In situ analysis of microbial consortia in activated sludge using fluorescently labelled, rRNA-targeted oligonucleotide probes and confocal scanning laser microscopy. J Microsc (1994) 1.80

Isotype-specific functions of Raf kinases. Exp Cell Res (1999) 1.79

Demographic, morphological, and clinical characteristics of 1289 patients with brain arteriovenous malformation. Stroke (2000) 1.79

Amoeboid leukocyte crawling through extracellular matrix: lessons from the Dictyostelium paradigm of cell movement. J Leukoc Biol (2001) 1.78

Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Nature (1985) 1.77

A monoclonal antibody to a differentiation antigen present on mature human macrophages and absent from monocytes. J Immunol (1985) 1.76

A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus. EMBO J (1986) 1.75

Cell cycle targets of Ras/Raf signalling. Oncogene (1998) 1.75

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene (1994) 1.74

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem (1994) 1.74

Hailey-Hailey disease. Eradication by dermabrasion. Arch Dermatol (1994) 1.73

Emended description of Herbaspirillum; inclusion of [Pseudomonas] rubrisubalbicans, a milk plant pathogen, as Herbaspirillum rubrisubalbicans comb. nov.; and classification of a group of clinical isolates (EF group 1) as Herbaspirillum species 3. Int J Syst Bacteriol (1996) 1.73

Pregnancy and birth after kidney donation: the Norwegian experience. Am J Transplant (2008) 1.69

Strong expression of the lymphoattractant C-X-C chemokine Mig is associated with heavy infiltration of T cells in human malignant melanoma. J Pathol (1999) 1.68

Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf. Nature (1984) 1.68

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation. Biochim Biophys Acta (1995) 1.67

Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res (2000) 1.67

The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science (1984) 1.66

Expression of raf oncogenes activates the PEA1 transcription factor motif. Mol Cell Biol (1989) 1.66

Smoking and cancer-related gene expression in bronchial epithelium and non-small-cell lung cancers. J Pathol (2006) 1.66

Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines. Chem Immunol (1992) 1.65