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Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J (2000) 6.55

Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut (2003) 3.91

Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog (2004) 3.02

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J (2000) 2.17

Regulation of Raf-1 activation and signalling by dephosphorylation. EMBO J (2002) 1.99

Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling. Mol Cell Biol (2009) 1.81

Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta (2007) 1.64

Characterization of Ser338 phosphorylation for Raf-1 activation. J Biol Chem (2008) 1.48

B-Raf acts via the ROCKII/LIMK/cofilin pathway to maintain actin stress fibers in fibroblasts. Mol Cell Biol (2004) 1.28

Targeting prostate cancer based on signal transduction and cell cycle pathways. Cell Cycle (2008) 1.25

Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase. Mol Biol Cell (2006) 1.24

Thrombopoietin-mediated sustained activation of extracellular signal-regulated kinase in UT7-Mpl cells requires both Ras-Raf-1- and Rap1-B-Raf-dependent pathways. Mol Cell Biol (2001) 1.23

PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. EMBO J (2002) 1.21

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity. Mol Cell Biol (2002) 1.20

Inducible gene deletion reveals different roles for B-Raf and Raf-1 in B-cell antigen receptor signalling. EMBO J (2002) 1.19

DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol (2007) 1.06

Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Mol Cell Biol (2005) 1.04

Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. J Gastrointest Surg (2009) 1.04

Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. J Biol Chem (2009) 1.03

Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms. Mol Cell Biol (2002) 1.02

S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3. Mol Cell Biol (2001) 0.99

Heterogeneous nuclear ribonucleoprotein H blocks MST2-mediated apoptosis in cancer cells by regulating A-Raf transcription. Cancer Res (2010) 0.98

Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase. J Biol Chem (2011) 0.97

C-Raf is associated with disease progression and cell proliferation in a subset of melanomas. Clin Cancer Res (2009) 0.97

Regulation of Ras signaling specificity by protein kinase C. Mol Cell Biol (2001) 0.95

Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas. Mamm Genome (2005) 0.95

Use of a recombinant Salmonella enterica serovar Typhimurium strain expressing C-Raf for protection against C-Raf induced lung adenoma in mice. BMC Cancer (2005) 0.92

Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells. Br J Pharmacol (2004) 0.92

Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell (2005) 0.91

B-Raf-mediated signaling pathway regulates T cell development. Eur J Immunol (2008) 0.89

The importance of Raf dimerization in cell signaling. Small GTPases (2013) 0.88

Regulation of cellular proliferation, differentiation and cell death by activated Raf. Cell Commun Signal (2009) 0.88

Upregulation and maintenance of gap junctional communication in lens cells. Exp Eye Res (2008) 0.87

MEKK3 interacts with the PA28 gamma regulatory subunit of the proteasome. Biochem J (2003) 0.85

Cortical migration defects in mice expressing A-RAF from the B-RAF locus. Mol Cell Biol (2006) 0.84

A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis. Mol Biol Cell (2008) 0.81

Negative feedback regulation of the ERK1/2 MAPK pathway. Cell Mol Life Sci (2016) 0.81

Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylation. BMC Cancer (2010) 0.81

Molecular pathogenesis and targeted therapies in well-differentiated thyroid carcinoma. Endocrinol Metab (Seoul) (2014) 0.81

Fungal recognition enhances mannose receptor shedding through dectin-1 engagement. J Biol Chem (2011) 0.80

Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. Elife (2016) 0.79

Antisense oligonucleotide therapy in diabetic retinopathy. J Diabetes Sci Technol (2009) 0.78

A quantitative structure-activity relationship (QSAR) study of some diaryl urea derivatives of B-RAF inhibitors. Res Pharm Sci (2016) 0.75

cAMP-induced auditory supporting cell proliferation is mediated by ERK MAPK signaling pathway. J Assoc Res Otolaryngol (2010) 0.75

The lack of Raf-1 kinase feedback regulation enhances antiapoptosis in cancer cells. Oncogene (2016) 0.75

Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05

Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88

Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A (1983) 4.82

Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res (2001) 4.20

Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature (1991) 4.04

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase. Genes Dev (1992) 3.46

Influenza virus propagation is impaired by inhibition of the Raf/MEK/ERK signalling cascade. Nat Cell Biol (2001) 2.93

Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature (1985) 2.82

Endothelial apoptosis in Braf-deficient mice. Nat Genet (1997) 2.77

Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem (1993) 2.70

Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus. Nature (1986) 2.64

The ins and outs of Raf kinases. Trends Biochem Sci (1994) 2.51

The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res (1986) 2.50

Induction of cell proliferation in quiescent NIH 3T3 cells by oncogenic c-Raf-1. Mol Cell Biol (1997) 2.37

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol Cell Biol (1992) 2.34

Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells. Infect Immun (1999) 2.26

Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol Cell Biol (1990) 2.24

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. Proc Natl Acad Sci U S A (1996) 2.21

Structure and biological activity of human homologs of the raf/mil oncogene. Mol Cell Biol (1985) 2.19

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res (1987) 1.98

Rescue of endogenous 30S retroviral sequences from mouse cells by baboon type C virus. J Virol (1978) 1.90

Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques. J Virol (1976) 1.87

Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Nature (1985) 1.77

Cell cycle targets of Ras/Raf signalling. Oncogene (1998) 1.75

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase. Oncogene (1994) 1.74

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation. J Biol Chem (1994) 1.74

Nucleotide sequence of avian retroviral oncogene v-mil: homologue of murine retroviral oncogene v-raf. Nature (1984) 1.68

Expression of raf oncogenes activates the PEA1 transcription factor motif. Mol Cell Biol (1989) 1.66

The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science (1984) 1.66

Detection of the myristylated gag-raf transforming protein with raf-specific antipeptide sera. Virology (1985) 1.64

Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl. Mol Cell Biol (1989) 1.64

3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Mol Cell Biol (1996) 1.63

Integration of transfected LTR sequences into the c-raf proto-oncogene: activation by promoter insertion. EMBO J (1985) 1.60

Primary structure of v-raf: relatedness to the src family of oncogenes. Science (1984) 1.56

Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature (1984) 1.56

New mammalian transforming retrovirus: demonstration of a polyprotein gene product. J Virol (1983) 1.55

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J (1990) 1.55

Endogenous oncornaviruses in chemically induced transformation. I. Transformation independent of virus production. Virology (1975) 1.55

T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway. J Biol Chem (1990) 1.53

The role of Raf-1 phosphorylation in signal transduction. Adv Cancer Res (1992) 1.53

Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. EMBO Rep (2001) 1.51

Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation. J Biol Chem (1990) 1.49

Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol. Oncogene (1992) 1.48

Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein. Cell Growth Differ (2000) 1.46

The Spir actin organizers are involved in vesicle transport processes. Curr Biol (2001) 1.45

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Mol Cell Biol (1993) 1.40

Expression of raf family proto-oncogenes in normal mouse tissues. Oncogene (1990) 1.40

Role of myc in the abrogation of IL3 dependence of myeloid FDC-P1 cells. Oncogene Res (1987) 1.38

Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation. Proc Natl Acad Sci U S A (2000) 1.36

Interleukin-3 and granulocyte-macrophage colony-stimulating factor mediate rapid phosphorylation and activation of cytosolic c-raf. J Biol Chem (1990) 1.36

Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter. J Virol (1996) 1.35

Rapid induction of hemopoietic neoplasms in newborn mice by a raf(mil)/myc recombinant murine retrovirus. J Virol (1985) 1.35

Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. Oncogene (1990) 1.33

Characterization of murine A-raf, a new oncogene related to the v-raf oncogene. Mol Cell Biol (1986) 1.32

Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase. J Biol Chem (2000) 1.31

Murine sarcoma growth factors affect the growth and morphology of cultured mouse epithelial cells. J Cell Physiol (1980) 1.30

Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. J Biol Chem (2001) 1.30

Erythropoietin induces Raf-1 activation and Raf-1 is required for erythropoietin-mediated proliferation. J Biol Chem (1991) 1.30

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism. J Cell Biol (1995) 1.29

Negative regulation of c-myc transcription involves myc family proteins. Oncogene Res (1988) 1.27

Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase. J Biol Chem (1993) 1.26

Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons. Nat Neurosci (2001) 1.25

Multiple signaling pathways regulate NF-kappaB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood (2001) 1.25

v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells. Oncogene (1994) 1.23

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis. Mech Dev (2000) 1.23

The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. J Biol Chem (1998) 1.21

Raf-1 is required for T cell IL2 production. EMBO J (1993) 1.20

Avian v-myc replaces chromosomal translocation in murine plasmacytomagenesis. Science (1987) 1.20

TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins. Plant J (2007) 1.19

Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. J Biol Chem (2000) 1.18

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals. Mol Cell Biol (2001) 1.16

Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. Am J Pathol (1999) 1.16

Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium. J Biol Chem (1994) 1.16

Interaction between Raf and Myc oncogenes in transformation in vivo and in vitro. J Cell Biochem (1986) 1.16

CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation. Immunity (1999) 1.15

The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells. Blood (1999) 1.15

Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. J Biol Chem (2000) 1.15

The p150-Spir protein provides a link between c-Jun N-terminal kinase function and actin reorganization. Curr Biol (2000) 1.14

Insulin activates the Raf-1 protein kinase. J Biol Chem (1990) 1.14

Insertion and truncation of c-myb by murine leukemia virus in a myeloid cell line derived from cultures of normal hematopoietic cells. J Virol (1987) 1.13

Regulation of c-myc expression by Ras/Raf signalling. Oncogene (1998) 1.13

The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion. Cancer Res (1999) 1.12

Generation of new mouse sarcoma viruses in cell culture. Science (1978) 1.12

High-intensity Raf signals convert mitotic cell cycling into cellular growth. Cancer Res (1998) 1.11

95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site. Mol Cell Biol (1992) 1.11

Plasma membrane-targeted Raf kinase activates NF-kappaB and human immunodeficiency virus type 1 replication in T lymphocytes. J Virol (1998) 1.10

v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation. Oncogene (1993) 1.10

Envelope gene sequence of two in vitro-generated mink cell focus-forming murine leukemia viruses which contain the entire gp70 sequence of the endogenous nonecotropic parent. J Virol (1984) 1.09

Generation of oncogenic mouse type C viruses: in vitro selection of carcinoma-inducing variants. Proc Natl Acad Sci U S A (1980) 1.09

Acquisition of oncogenicity by endogenous mouse type C viruses: effects of variations in env and gag genes. J Virol (1978) 1.09

Craf-1 protein kinase is essential for mouse development. Mech Dev (1998) 1.09

Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway. J Biol Chem (1994) 1.08

Recombinant murine retroviruses containing avian v-myc induce a wide spectrum of neoplasms in newborn mice. Proc Natl Acad Sci U S A (1986) 1.08

Induction of transformation and DNA synthesis after microinjection of raf proteins. Mol Cell Biol (1990) 1.08

Generation of oncogenic type C viruses: rapidly leukemogenic viruses derived from C3H mouse cells in vivo and in vitro. Proc Natl Acad Sci U S A (1978) 1.06

Probing structure and function of the raf protein kinase domain with monoclonal antibodies. Oncogene (1990) 1.06

Genome structure of mink cell focus-forming murine leukemia virus in epithelial mink lung cells transformed vitro by iododeoxyuridine-induced C3H/MuLV cells. J Virol (1983) 1.04