Published in Oncogene on September 17, 1998
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Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation. EMBO J (2003) 1.55
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Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. J Exp Med (2001) 1.50
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GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling. J Clin Invest (2007) 1.32
Ral GTPases contribute to regulation of cyclin D1 through activation of NF-kappaB. Mol Cell Biol (2000) 1.31
Stimulation of cell proliferation by endosomal epidermal growth factor receptor as revealed through two distinct phases of signaling. Mol Cell Biol (2003) 1.20
Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. Endocrinology (2003) 1.18
Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis. Future Oncol (2009) 1.17
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Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells. J Neurosci (2002) 1.14
Raf-1 serine 338 phosphorylation plays a key role in adhesion-dependent activation of extracellular signal-regulated kinase by epidermal growth factor. Mol Cell Biol (2005) 1.04
Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels. BMC Cell Biol (2006) 1.03
Natural biology of polyomavirus middle T antigen. Microbiol Mol Biol Rev (2001) 1.02
Nasopharyngeal carcinoma signaling pathway: an update on molecular biomarkers. Int J Cell Biol (2012) 0.98
P2Y(2) receptor-mediated proliferation of C(6) glioma cells via activation of Ras/Raf/MEK/MAPK pathway. Br J Pharmacol (2000) 0.97
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis (2015) 0.95
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. PLoS One (2008) 0.95
Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin. BMC Cancer (2010) 0.94
Active erk regulates microtubule stability in H-ras-transformed cells. Neoplasia (2001) 0.94
Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung. Cancer Med (2014) 0.93
Tautomycin suppresses growth and neuroendocrine hormone markers in carcinoid cells through activation of the Raf-1 pathway. Am J Surg (2009) 0.93
BRAF vs RAS oncogenes: are mutations of the same pathway equal? Differential signalling and therapeutic implications. Oncotarget (2014) 0.92
A critical function for B-Raf at multiple stages of myelopoiesis. Blood (2005) 0.92
Isoform-specific localization of A-RAF in mitochondria. Mol Cell Biol (2000) 0.92
Lipopolysaccharide enhances bradykinin-induced signal transduction via activation of Ras/Raf/MEK/MAPK in canine tracheal smooth muscle cells. Br J Pharmacol (2000) 0.91
Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy. Clin Cancer Res (2011) 0.91
Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathway. Br J Pharmacol (2001) 0.90
Regulation of cyclin-dependent kinase (Cdk) 2 Thr-160 phosphorylation and activity by mitogen-activated protein kinase in late G1 phase. Biochem J (2000) 0.90
Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain. J Virol (2001) 0.90
Cyclin D1 promotes neurogenesis in the developing spinal cord in a cell cycle-independent manner. Proc Natl Acad Sci U S A (2011) 0.88
Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2. J Cell Mol Med (2007) 0.84
Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. Exp Hematol (2008) 0.84
DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry. Mol Cell Biol (2003) 0.84
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway. Antioxid Redox Signal (2013) 0.83
The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis (2015) 0.81
Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells. Oncotarget (2015) 0.81
Tyr phosphatase-mediated P-ERK inhibition suppresses senescence in EIA + v-raf transformed cells, which, paradoxically, are apoptosis-protected in a MEK-dependent manner. Neoplasia (2011) 0.80
New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3. Hum Genomics (2013) 0.80
Signature of microsatellite instability, KRAS and BRAF gene mutations in German patients with locally advanced rectal adenocarcinoma before and after neoadjuvant 5-FU radiochemotherapy. J Gastrointest Oncol (2013) 0.79
RanBPM is an inhibitor of ERK signaling. PLoS One (2012) 0.79
Molecular targets and targeted therapies in bladder cancer management. World J Urol (2008) 0.78
Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation. Nucleic Acids Res (2015) 0.78
Analysis of k-ras nuclear expression in fibroblasts and mesangial cells. PLoS One (2010) 0.78
Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane. Int J Clin Exp Med (2015) 0.78
Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: relevance to intracellular signaling pathways. World J Gastroenterol (2005) 0.77
The C. elegans NR4A nuclear receptor gene nhr-6 promotes cell cycle progression in the spermatheca lineage. Dev Dyn (2015) 0.75
Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells. Int J Oncol (2017) 0.75
SPIN90 knockdown attenuates the formation and movement of endosomal vesicles in the early stages of epidermal growth factor receptor endocytosis. PLoS One (2013) 0.75
H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair. Oncotarget (2016) 0.75
Rnf2 knockdown reduces cell viability and promotes cell cycle arrest in gastric cancer cells. Oncol Lett (2017) 0.75
Raf-1 activates MAP kinase-kinase. Nature (1992) 7.05
Protein kinase C alpha activates RAF-1 by direct phosphorylation. Nature (1993) 5.23
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (1993) 4.88
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A (1983) 4.82
Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res (2001) 4.20
Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell (1996) 4.04
Raf-1 protein kinase is required for growth of induced NIH/3T3 cells. Nature (1991) 4.04
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Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins. Nature (1985) 2.82
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The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus. Nucleic Acids Res (1987) 1.98
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Endogenous ecotropic mouse type C viruses deficient in replication and production of XC plaques. J Virol (1976) 1.87
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3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways. Mol Cell Biol (1996) 1.63
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Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611. Nature (1984) 1.56
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Raf-1 kinase targets GA-binding protein in transcriptional regulation of the human immunodeficiency virus type 1 promoter. J Virol (1996) 1.35
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