Published in Mol Cell Biol on October 01, 1999
Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b. J Virol (2000) 1.91
Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression. J Virol (2004) 1.50
Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication. J Virol (2002) 1.31
Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9. J Virol (2001) 1.28
Human cytomegalovirus DNA replication requires transcriptional activation via an IE2- and UL84-responsive bidirectional promoter element within oriLyt. J Virol (2004) 1.16
Novel immediate-early protein IE19 of human cytomegalovirus activates the origin recognition complex I promoter in a cooperative manner with IE72. J Virol (2002) 0.94
Role of noncovalent SUMO binding by the human cytomegalovirus IE2 transactivator in lytic growth. J Virol (2010) 0.88
Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products. J Virol (2010) 0.82
Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production. Am J Physiol Endocrinol Metab (2012) 0.82
Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α. PLoS One (2013) 0.78
Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator. Mol Immunol (2008) 0.75
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature (1993) 7.56
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell (1997) 5.78
trans-activation and autoregulation of gene expression by the immediate-early region 2 gene products of human cytomegalovirus. J Virol (1988) 4.69
A nonchromatographic assay for expression of the chloramphenicol acetyltransferase gene in eucaryotic cells. Anal Biochem (1986) 4.60
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element. J Virol (1989) 4.25
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell (1991) 4.24
Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins. J Virol (1990) 4.01
Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator. Genes Dev (1995) 3.81
NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation. EMBO J (1989) 3.58
PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity. Mol Cell Biol (1992) 3.32
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci U S A (1999) 3.04
The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev (1995) 2.97
Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1. J Virol (1995) 2.71
The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor. Mol Cell Biol (1994) 2.69
A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal. Nat Struct Biol (1999) 2.45
PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood (1996) 2.35
Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein. EMBO J (1994) 2.25
A new pattern for helix-turn-helix recognition revealed by the PU.1 ETS-domain-DNA complex. Nature (1996) 2.17
Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters. J Virol (1995) 2.16
Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus. Virology (1991) 1.99
Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J Virol (1994) 1.94
Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB. J Virol (1995) 1.85
Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection. Proc Natl Acad Sci U S A (1993) 1.84
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol (1993) 1.80
The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements. J Gen Virol (1992) 1.79
Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins. J Virol (1993) 1.73
PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene. Mol Cell Biol (1995) 1.70
Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. Science (1990) 1.63
Cooperative interaction of ets-1 with USF-1 required for HIV-1 enhancer activity in T cells. EMBO J (1998) 1.62
Detection of two tissue-specific DNA-binding proteins with affinity for sites in the mouse beta-globin intervening sequence 2. Mol Cell Biol (1988) 1.58
TAF-like functions of human cytomegalovirus immediate-early proteins. J Virol (1997) 1.54
The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations. J Virol (1995) 1.52
A direct physical association between ETS and AP-1 transcription factors in normal human T cells. Immunity (1995) 1.52
c-Jun is a JNK-independent coactivator of the PU.1 transcription factor. J Biol Chem (1999) 1.49
Modulation of interleukin 1 beta gene expression by the immediate early genes of human cytomegalovirus. J Clin Invest (1990) 1.46
The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction. Mol Cell Biol (1993) 1.45
Site-specific binding of the human cytomegalovirus IE2 86-kilodalton protein to an early gene promoter. J Virol (1994) 1.44
CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter. J Virol (1996) 1.43
The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site. J Virol (1996) 1.27
Monocyte expression of the human prointerleukin 1 beta gene (IL1B) is dependent on promoter sequences which bind the hematopoietic transcription factor Spi-1/PU.1. Mol Cell Biol (1995) 1.26
Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration. Immunology (1997) 1.25
The functional importance of a cap site-proximal region of the human prointerleukin 1 beta gene is defined by viral protein trans-activation. Mol Cell Biol (1992) 1.24
Activation of transcription by PU.1 requires both acidic and glutamine domains. Mol Cell Biol (1996) 1.22
Cytomegalovirus infection stimulates expression of monocyte-associated mediator genes. J Immunol (1989) 1.22
The immediate early genes of human cytomegalovirus upregulate expression of the cellular genes myc and fos. Am J Respir Cell Mol Biol (1992) 1.16
PU.1 can participate in an active enhancer complex without its transcriptional activation domain. Proc Natl Acad Sci U S A (1997) 1.10
The immediate early genes of human cytomegalovirus require only proximal promoter elements to upregulate expression of interleukin-1 beta. Am J Respir Cell Mol Biol (1992) 0.97
Regulation of expression of the IL-1 receptor antagonist (IL-1ra) gene by products of the human cytomegalovirus immediate early genes. J Immunol (1994) 0.91
The immediate early genes of human cytomegalovirus upregulate expression of the interleukin-2 and interleukin-2 receptor genes. Am J Respir Cell Mol Biol (1991) 0.89
Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences. J Virol (1995) 0.85
Cytomegalovirus modulates transcription factors necessary for the activation of the tumor necrosis factor-alpha promoter. Am J Respir Cell Mol Biol (1997) 0.84
A codon-based model of nucleotide substitution for protein-coding DNA sequences. Mol Biol Evol (1994) 19.91
Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene. Genetics (1998) 11.25
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci U S A (1984) 8.84
Mass screening for lung cancer with mobile spiral computed tomography scanner. Lancet (1998) 6.09
Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature (2013) 5.44
Estimation of primate speciation dates using local molecular clocks. Mol Biol Evol (2000) 5.06
Probability distribution of molecular evolutionary trees: a new method of phylogenetic inference. J Mol Evol (1996) 4.95
Accuracy and power of the likelihood ratio test in detecting adaptive molecular evolution. Mol Biol Evol (2001) 4.03
Advanced glycosylation end products in patients with diabetic nephropathy. N Engl J Med (1991) 3.81
The CLAVATA1 receptor-like kinase requires CLAVATA3 for its assembly into a signaling complex that includes KAPP and a Rho-related protein. Plant Cell (1999) 3.62
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat Genet (2001) 3.52
Microtubule-based transport systems in neurons: the roles of kinesins and dyneins. Annu Rev Neurosci (2000) 3.48
Control of pollen tube tip growth by a Rop GTPase-dependent pathway that leads to tip-localized calcium influx. Plant Cell (1999) 3.32
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci U S A (1999) 3.32
Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis. J Cell Biol (1998) 3.27
Immunization for Ebola virus infection. Nat Med (1998) 3.27
Total synthesis of taxol. Nature (1994) 3.22
Patterns of tuberculosis transmission in Central Los Angeles. JAMA (1997) 3.21
Interpretation of restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolates from a state with a large rural population. J Infect Dis (1997) 3.18
Genetic transformation of the extreme thermophile Thermus thermophilus and of other Thermus spp. J Bacteriol (1986) 3.16
Trial of a trial by media. Med J Aust (2002) 3.11
Demonstration of an early and a late phase of ischemic preconditioning in mice. Am J Physiol (1998) 3.11
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc Natl Acad Sci U S A (1999) 3.04
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron (2000) 2.94
Usefulness of the secondary probe pTBN12 in DNA fingerprinting of Mycobacterium tuberculosis. J Clin Microbiol (1996) 2.91
Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals. Proc Natl Acad Sci U S A (2001) 2.80
Rop GTPase-dependent dynamics of tip-localized F-actin controls tip growth in pollen tubes. J Cell Biol (2001) 2.80
PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins. J Biol Chem (2001) 2.67
Imaging time after Gd-DTPA injection is critical in using delayed enhancement to determine infarct size accurately with magnetic resonance imaging. Circulation (2001) 2.41
Periodic emission from the gamma-ray binary 1FGL J1018.6-5856. Science (2012) 2.40
The geography of availability and driving after drinking. Addiction (1996) 2.39
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Synthesis of epothilones A and B in solid and solution phase. Nature (1997) 2.35
Enhanced capacity of a widespread strain of Mycobacterium tuberculosis to grow in human macrophages. J Infect Dis (1999) 2.29
Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A (1988) 2.20
Results from 5 years of nationwide DNA fingerprinting of Mycobacterium tuberculosis complex isolates in a country with a low incidence of M. tuberculosis infection. J Clin Microbiol (1998) 2.19
Arabidopsis Rho-related GTPases: differential gene expression in pollen and polar localization in fission yeast. Plant Physiol (1998) 2.18
Multiple biological activities of human recombinant interleukin 1. J Clin Invest (1986) 2.16
Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord (2004) 2.15
Ossifying fibromas of the jaw bone: 20 cases. Dentomaxillofac Radiol (2010) 2.15
Computer-aided prediction of RNA secondary structures. Nucleic Acids Res (1982) 2.14
DNA fingerprinting with two probes decreases clustering of Mycobacterium tuberculosis. Am J Respir Crit Care Med (1997) 2.11
Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest (1999) 2.09
Efficient light harvesting through carotenoids. Photosynth Res (2000) 2.06
Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology (2001) 1.97
Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci U S A (2005) 1.95
The Rop GTPase switch controls multiple developmental processes in Arabidopsis. Plant Physiol (2001) 1.93
Substitution rate variation among sites in mitochondrial hypervariable region I of humans and chimpanzees. Mol Biol Evol (1999) 1.90
Simultaneous infection with multiple strains of Mycobacterium tuberculosis. Clin Infect Dis (2001) 1.90
Present-day crustal deformation in China constrained by global positioning system measurements. Science (2001) 1.87
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol (1993) 1.80
A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-containing proteins that act as Rop GTPase targets. Plant Cell (2001) 1.80
Chest radiographic findings in patients with tuberculosis with recent or remote infection. Am J Respir Crit Care Med (1997) 1.76
Preponderance of slightly deleterious polymorphism in mitochondrial DNA: nonsynonymous/synonymous rate ratio is much higher within species than between species. Mol Biol Evol (1998) 1.76
Myosin light chain phosphorylation affects the structure of rabbit skeletal muscle thick filaments. Biophys J (1996) 1.75
Taxon sampling and the accuracy of large phylogenies. Syst Biol (1998) 1.75
Transmission of Mycobacterium tuberculosis from medical waste. JAMA (2000) 1.67
Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation. Proc Natl Acad Sci U S A (1994) 1.67
Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. Nucleic Acids Res (1986) 1.66
Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1. J Biol Chem (1996) 1.66
Retracted Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circ Res (2001) 1.64
Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. J Biol Chem (1987) 1.64
Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways. J Immunol (1988) 1.61
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy. J Exp Med (1991) 1.59
Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution. Gene Ther (2010) 1.58
Elevated circulating endothelial microparticles and brachial-ankle pulse wave velocity in well-controlled hypertensive patients. J Hum Hypertens (2008) 1.57
Adenoviral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects. Cancer Gene Ther (2006) 1.56
5'-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation. Biochemistry (1983) 1.56
Structural features of the cytoplasmic region of CD4 required for internalization. EMBO J (1990) 1.56
Shear stress increases Cu/Zn SOD activity and mRNA expression in human endothelial progenitor cells. J Hum Hypertens (2007) 1.54
Transcriptional regulation of the human prointerleukin 1 beta gene. J Immunol (1987) 1.54
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ (2004) 1.54
Post-translational modifications of water-soluble human lens crystallins from young adults. J Biol Chem (1994) 1.53
Directed evolution of thermostable kanamycin-resistance gene: a convenient selection marker for Thermus thermophilus. J Biochem (1999) 1.53
The Rop GTPase: an emerging signaling switch in plants. Plant Mol Biol (2000) 1.53
How often do wrong models produce better phylogenies? Mol Biol Evol (1997) 1.52
The Rrop GTPase switch turns on polar growth in pollen. Trends Plant Sci (2000) 1.52
Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age. J Hum Hypertens (2006) 1.51
Thrombospondin 2, a matricellular protein with diverse functions. Matrix Biol (2000) 1.51
Studies on the molecular nature of human interleukin 1. J Immunol (1987) 1.50
Outcomes of maintenance therapy with tacrolimus versus azathioprine for active lupus nephritis: a multicenter randomized clinical trial. Lupus (2012) 1.50
Comparison of transfer ribonucleic acid structures using cobra venom and S1 endonucleases. Biochemistry (1982) 1.50
Strong constraints on the rare decays B(s)(0) → μ+ μ- and B0 → μ+ μ-. Phys Rev Lett (2012) 1.50
First observation of the decays B(0) → D(+)K(-)π(+)π(-) and B(-) → D(0)K(-)π(+)π(-). Phys Rev Lett (2012) 1.50
Human cathepsin S: chromosomal localization, gene structure, and tissue distribution. J Biol Chem (1994) 1.49
Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop-specific GTPase stimulation. Plant Physiol (2000) 1.49
The incidence of false-positive cultures for Mycobacterium tuberculosis. Am J Respir Crit Care Med (1997) 1.48
Kallistatin, a novel human tissue kallikrein inhibitor: levels in body fluids, blood cells, and tissues in health and disease. J Lab Clin Med (1996) 1.48
Effect of cellular filamentation on adventurous and social gliding motility of Myxococcus xanthus. Proc Natl Acad Sci U S A (1999) 1.47
Computer-aided nucleic acid secondary structure modeling incorporating enzymatic digestion data. Nucleic Acids Res (1984) 1.46