Published in J Biol Chem on February 24, 2010
Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clin Cancer Res (2011) 1.00
Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res (2013) 0.95
Cyclin-dependent kinase-5 is a key molecule in tumor necrosis factor-α-induced insulin resistance. J Biol Chem (2011) 0.86
CAPNS1 regulates USP1 stability and maintenance of genome integrity. Mol Cell Biol (2013) 0.85
Deregulations in the cyclin-dependent kinase-9-related pathway in cancer: implications for drug discovery and development. ISRN Oncol (2013) 0.84
HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Mol Cell Biol (2012) 0.81
Aberrant expression of CDK5 infers poor outcomes for nasopharyngeal carcinoma patients. Int J Clin Exp Pathol (2015) 0.77
Identification of a lifespan extending mutation in the Schizosaccharomyces pombe cyclin gene clg1+ by direct selection of long-lived mutants. PLoS One (2013) 0.77
Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling. Exp Neurobiol (2016) 0.76
Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons. J Huntingtons Dis (2012) 0.75
Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China. Eur J Med Res (2016) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. Exp Cell Res (1965) 21.61
BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature (2005) 16.87
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature (2005) 15.83
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature (2006) 11.76
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
Tumour biology: senescence in premalignant tumours. Nature (2005) 10.15
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell (1992) 7.61
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev (1998) 5.60
A decade of CDK5. Nat Rev Mol Cell Biol (2001) 5.24
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science (1997) 4.97
Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol (2001) 4.81
Microarray analysis of replicative senescence. Curr Biol (1999) 4.25
A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res (1991) 4.07
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol (2000) 3.37
DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res (2002) 3.22
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol Cell (2001) 2.93
G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell (1991) 2.87
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res (1999) 2.67
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol (2002) 2.66
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol (1999) 2.64
Oncogenic ras and p53 cooperate to induce cellular senescence. Mol Cell Biol (2002) 2.61
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol Cell (2009) 2.58
Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science (1990) 2.28
Oncogene-induced senescence: putting the brakes on tumor development. Cancer Res (2006) 2.04
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem (2000) 1.88
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res (2005) 1.84
Cell senescence and cancer. Nat Rev Cancer (2001) 1.82
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci U S A (2001) 1.79
Extraneuronal roles of cyclin-dependent kinase 5. Bioessays (2006) 1.65
p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway. J Biol Chem (1998) 1.63
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
Requirement for p27(KIP1) in retinoblastoma protein-mediated senescence. Mol Cell Biol (2001) 1.51
p16 INK4a can initiate an autonomous senescence program. Oncogene (2000) 1.50
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways. PLoS Biol (2004) 1.44
Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene (1997) 1.34
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts. Mol Cell Biol (2000) 1.24
Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system. J Neurobiol (1998) 1.19
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Mol Cell (2003) 1.18
Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells. J Cell Sci (1997) 1.17
Cellular senescence requires CDK5 repression of Rac1 activity. Mol Cell Biol (2004) 1.10
Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation. Cancer Res (2004) 0.93
L6 myoblast differentiation is modulated by Cdk5 via the PI3K-AKT-p70S6K signaling pathway. Oncogene (2004) 0.89
Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. Cancer Res (2006) 0.88
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell (2006) 2.91
Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science (2005) 2.81
Cyclins and cdks in development and cancer: a perspective. Oncogene (2005) 2.58
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell (2010) 1.92
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma. J Cell Biol (2004) 1.88
Essential role of retinoblastoma protein in mammalian hair cell development and hearing. Proc Natl Acad Sci U S A (2006) 1.78
PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Pathol (2005) 1.67
A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. J Cell Biol (2009) 1.67
From cell cycle to differentiation: an expanding role for cdk6. Cell Cycle (2006) 1.62
Abrogation of the retinoblastoma tumor suppressor checkpoint during keratinocyte immortalization is not sufficient for induction of centrosome-mediated genomic instability. Cancer Res (2003) 1.48
A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res (2009) 1.48
P53 is a tumor suppressor gene. Cell (2004) 1.33
Role of the retinoblastoma protein in differentiation and senescence. Cancer Biol Ther (2003) 1.24
Multiple functions of D-type cyclins can antagonize pRb-mediated suppression of proliferation. Cell Cycle (2005) 1.23
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1-/- mice. Proc Natl Acad Sci U S A (2008) 1.22
Beyond the cell cycle: a new role for Cdk6 in differentiation. J Cell Biochem (2006) 1.20
Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence. Int J Cancer (2005) 1.20
Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype. Mol Cell (2003) 1.18
HES1 cooperates with pRb to activate RUNX2-dependent transcription. J Bone Miner Res (2006) 1.12
Cellular senescence requires CDK5 repression of Rac1 activity. Mol Cell Biol (2004) 1.10
A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One (2010) 1.02
pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development. BMC Dev Biol (2007) 0.99
Matrix metalloprotease-1a promotes tumorigenesis and metastasis. J Biol Chem (2012) 0.97
CDK6 kinase activity is required for thymocyte development. Blood (2011) 0.96
Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC. Cancer Res (2013) 0.95
Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs. Cell Cycle (2011) 0.95
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation. J Clin Invest (2013) 0.92
The retinoblastoma protein in osteoblast differentiation and osteosarcoma. Curr Mol Med (2006) 0.91
Loss of heterozygosity of chromosome 3p21 is associated with mutant TP53 and better patient survival in non-small-cell lung cancer. Cancer Res (2004) 0.90
Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells. Cancer Res (2006) 0.88
Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium. Cancer Res (2012) 0.87
Master or slave: the complex relationship of RBP2 and pRb. Cancer Cell (2005) 0.87
A role for the cyclin box in the ubiquitin-mediated degradation of cyclin G1. Cancer Res (2008) 0.86
Distinct subcellular distribution of cyclin dependent kinase 6. Cell Cycle (2009) 0.86
pRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73. Mol Cancer Res (2003) 0.86
The retinoblastoma protein, RB, is required for gastrointestinal endocrine cells to exit the cell cycle, but not for hormone expression. Dev Biol (2007) 0.83
Discrete phosphorylated retinoblastoma protein isoform expression in mouse tooth development. J Mol Histol (2012) 0.81
ERM proteins and Cdk5 in cellular senescence. Cell Cycle (2003) 0.81
Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop. J Biol Chem (2014) 0.79
Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: association with smoking, TP53, and survival. Cancer Genet Cytogenet (2005) 0.79
Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genes. J Biol Chem (2009) 0.78
The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development. Cancer Res (2007) 0.77
Loss of the retinoblastoma tumor suppressor protein in murine calvaria facilitates immortalization of osteoblast-adipocyte bipotent progenitor cells characterized by low expression of N-cadherin. Mol Cell Biol (2012) 0.76
Timing is everything: regulation of Cdk1 and aneuploidy. Dev Cell (2007) 0.76
Mitosis hit with an ATM transaction fee: aurora B-mediated activation of ATM during mitosis. Mol Cell (2011) 0.75