Published in Genes Dev on February 01, 2001
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev (2002) 10.06
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J (2003) 9.55
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev (2002) 6.74
Unbiased location analysis of E2F1-binding sites suggests a widespread role for E2F1 in the human genome. Genome Res (2006) 6.54
Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol Cell Biol (2001) 5.61
Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol (2001) 5.03
Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer (2006) 3.34
The E2F family: specific functions and overlapping interests. EMBO J (2004) 3.33
Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs. J Virol (2001) 3.22
Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev (2003) 2.73
Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol (2007) 2.66
In vivo analysis of cell division, cell growth, and differentiation at the shoot apical meristem in Arabidopsis. Plant Cell (2003) 2.51
ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance. Mol Cell Biol (2004) 2.46
Rb is required for progression through myogenic differentiation but not maintenance of terminal differentiation. J Cell Biol (2004) 2.26
A genomic strategy to elucidate modules of oncogenic pathway signaling networks. Mol Cell (2009) 2.22
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev (2005) 2.14
E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes. EMBO J (2003) 2.14
Functional antagonism between E2F family members. Genes Dev (2001) 2.03
INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J (2002) 1.96
Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci U S A (2003) 1.89
E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1. Mol Cell Biol (2004) 1.85
Genome-wide identification of potential plant E2F target genes. Plant Physiol (2005) 1.85
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77
F-box protein Skp2: a novel transcriptional target of E2F. Oncogene (2006) 1.74
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev (2004) 1.72
Arabidopsis E2Fc functions in cell division and is degraded by the ubiquitin-SCF(AtSKP2) pathway in response to light. Plant Cell (2002) 1.67
Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J Virol (2006) 1.63
The identification of E2F1-specific target genes. Proc Natl Acad Sci U S A (2002) 1.63
Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO J (2002) 1.62
A comprehensive modular map of molecular interactions in RB/E2F pathway. Mol Syst Biol (2008) 1.61
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res (2005) 1.61
Retinoblastoma family genes. Oncogene (2006) 1.61
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol (2005) 1.61
Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol (2004) 1.57
Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms. Oncotarget (2011) 1.52
E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep (2005) 1.51
The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis. Plant Cell (2006) 1.49
Loss of dE2F compromises mitochondrial function. Dev Cell (2013) 1.47
Transcriptome profiling of the C. elegans Rb ortholog reveals diverse developmental roles. Dev Biol (2007) 1.47
Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets. Cell Cycle (2011) 1.46
Gene expression changes in response to E2F1 activation. Nucleic Acids Res (2002) 1.44
Analysis of the ultraviolet B response in primary human keratinocytes using oligonucleotide microarrays. Proc Natl Acad Sci U S A (2002) 1.43
Preoperative gene expression may be associated with neurocognitive decline after cardiopulmonary bypass. J Thorac Cardiovasc Surg (2014) 1.42
A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Genes Dev (2004) 1.42
CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma. Clin Cancer Res (2015) 1.42
The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene (2006) 1.41
MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC. PLoS One (2011) 1.40
E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes. PLoS One (2016) 1.39
Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol (2007) 1.37
Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts. Mol Cell Biol (2007) 1.37
Balancing the decision of cell proliferation and cell fate. Cell Cycle (2009) 1.36
Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol (2002) 1.36
E2F-1 represses transcription of the human telomerase reverse transcriptase gene. Nucleic Acids Res (2001) 1.35
Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. Carcinogenesis (2011) 1.35
BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas. Nucleic Acids Res (2006) 1.34
Distinctions in the specificity of E2F function revealed by gene expression signatures. Proc Natl Acad Sci U S A (2005) 1.34
Opposing roles of E2Fs in cell proliferation and death. Cancer Biol Ther (2004) 1.33
Commitment to a cellular transition precedes genome-wide transcriptional change. Mol Cell (2011) 1.31
E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis. Mol Cell Biol (2002) 1.30
Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest (2004) 1.29
Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling. Mol Cell Biol (2010) 1.29
The tobacco A-type cyclin, Nicta;CYCA3;2, at the nexus of cell division and differentiation. Plant Cell (2003) 1.28
Distinct and redundant functions of cyclin E1 and cyclin E2 in development and cancer. Cell Div (2010) 1.27
Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line. Mol Cancer Res (2009) 1.27
Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4. Mol Cell Biol (2002) 1.26
Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev (2011) 1.25
Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3. Cell Mol Life Sci (2010) 1.25
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions. Mol Cell Biol (2007) 1.24
Inactivation of E2F3 results in centrosome amplification. Cancer Cell (2003) 1.24
Inhibition of apoptosis by ATFx: a novel role for a member of the ATF/CREB family of mammalian bZIP transcription factors. Genes Dev (2002) 1.24
Transcriptional changes associated with breast cancer occur as normal human mammary epithelial cells overcome senescence barriers and become immortalized. Mol Cancer (2007) 1.24
The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1. EMBO J (2007) 1.23
Direct control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity. Mol Cell Biol (2006) 1.22
Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex. J Neurosci (2010) 1.21
Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors. Oncogene (2009) 1.21
The aryl hydrocarbon receptor binds to E2F1 and inhibits E2F1-induced apoptosis. Mol Biol Cell (2008) 1.21
Strategic attack on host cell gene expression during adenovirus infection. J Virol (2003) 1.21
Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol (2010) 1.21
Low E2F1 transcript levels are a strong determinant of favorable breast cancer outcome. Breast Cancer Res (2007) 1.17
SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival. Cancer Res (2008) 1.16
A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med (2008) 1.16
Conserved RB functions in development and tumor suppression. Protein Cell (2011) 1.15
EZ-Retrieve: a web-server for batch retrieval of coordinate-specified human DNA sequences and underscoring putative transcription factor-binding sites. Nucleic Acids Res (2002) 1.13
Constitutive E2F expression in tobacco plants exhibits altered cell cycle control and morphological change in a cell type-specific manner. Plant Physiol (2003) 1.12
Role of an atypical E2F transcription factor in the control of Arabidopsis cell growth and differentiation. Plant Cell (2004) 1.12
siRNA-mediated gene silencing: a global genome view. Nucleic Acids Res (2004) 1.12
NPAT expression is regulated by E2F and is essential for cell cycle progression. Mol Cell Biol (2003) 1.12
Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology. EMBO Mol Med (2009) 1.12
A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. J Neurosci (2012) 1.10
DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. PLoS One (2010) 1.10
lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development. Genetics (2004) 1.07
Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues. Mol Cell Biol (2007) 1.07
Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Oncogene (2007) 1.06
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage. Mol Cell Biol (2009) 1.06
Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. EMBO J (2005) 1.06
E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol (2009) 1.04
Inhibition of retinoblastoma protein degradation by interaction with the serpin plasminogen activator inhibitor 2 via a novel consensus motif. Mol Cell Biol (2003) 1.04
PRC2 during vertebrate organogenesis: a complex in transition. Dev Biol (2012) 1.04
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