Hepatic overexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMID 10553017)

Published in J Lipid Res on November 01, 1999

Authors

U J Tietge1, A Bakillah, C Maugeais, K Tsukamoto, M Hussain, D J Rader

Author Affiliations

1: Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Articles citing this

The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97

Genetic engineering of algae for enhanced biofuel production. Eukaryot Cell (2010) 2.97

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab (2010) 2.89

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res (2008) 2.21

FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice. J Clin Invest (2008) 2.16

IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA. Cell Metab (2008) 1.75

Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease. J Gastroenterol (2013) 1.56

Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. Hepatology (2009) 1.48

The role of the LDL receptor in apolipoprotein B secretion. J Clin Invest (2000) 1.46

Template to improve glycemic control without reducing adiposity or dietary fat. Am J Physiol Endocrinol Metab (2011) 1.25

MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med (2007) 1.14

FoxO1 integrates insulin signaling to VLDL production. Cell Cycle (2008) 1.12

The Hsp110 molecular chaperone stabilizes apolipoprotein B from endoplasmic reticulum-associated degradation (ERAD). J Biol Chem (2007) 1.07

Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. Schizophr Bull (2010) 1.06

Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes (2010) 1.01

Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J (2004) 1.01

Scavenger receptor BI facilitates hepatic very low density lipoprotein production in mice. J Lipid Res (2009) 1.00

Intracerebroventricular leptin regulates hepatic cholesterol metabolism. Biochem J (2004) 0.96

A role of apolipoprotein D in triglyceride metabolism. J Lipid Res (2010) 0.93

Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. J Lipid Res (2011) 0.89

ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res (2008) 0.88

The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells. Nucleic Acids Res (2014) 0.86

Acute suppression of apo B secretion by insulin occurs independently of MTP. Biochem Biophys Res Commun (2011) 0.84

Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice. J Lipid Res (2014) 0.83

Adaptation of enterocytic Caco-2 cells to glucose modulates triacylglycerol-rich lipoprotein secretion through triacylglycerol targeting into the endoplasmic reticulum lumen. Biochem J (2006) 0.82

Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. Am J Physiol Endocrinol Metab (2010) 0.81

Identification of a Novel Transcript and Regulatory Mechanism for Microsomal Triglyceride Transfer Protein. PLoS One (2016) 0.79

Cell Surface and Membrane Engineering: Emerging Technologies and Applications. J Funct Biomater (2015) 0.78

Gene therapy for lipid disorders. Curr Control Trials Cardiovasc Med (2000) 0.77

Discovery of Novel Splice Variants and Regulatory Mechanisms for Microsomal Triglyceride Transfer Protein in Human Tissues. Sci Rep (2016) 0.75

The effects of PCB126 on intra-hepatic mechanisms associated with non alcoholic fatty liver disease. J Diabetes Metab Disord (2015) 0.75

Sodium sulfite promotes the assembly and secretion of very low-density lipoprotein in HL-7702 hepatocytes. Toxicol Rep (2015) 0.75

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress. Cell Rep (2017) 0.75

Articles by these authors

Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol (1999) 9.22

Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface. Mol Microbiol (1997) 5.47

Cloning and sequencing of the metallothioprotein beta-lactamase II gene of Bacillus cereus 569/H in Escherichia coli. J Bacteriol (1985) 3.95

European S3-guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol (2009) 3.56

An improved colorimetric assay for interleukin 2. J Immunol Methods (1986) 3.39

Electron beam computed tomographic coronary calcium scanning: a review and guidelines for use in asymptomatic persons. Mayo Clin Proc (1999) 3.32

Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet (1994) 3.22

Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin. J Biol Chem (1980) 2.91

Regression of atherosclerosis induced by liver-directed gene transfer of apolipoprotein A-I in mice. Circulation (1999) 2.84

A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia. Nat Med (1995) 2.65

A novel endothelial-derived lipase that modulates HDL metabolism. Nat Genet (1999) 2.56

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice. J Clin Invest (1999) 2.54

Enzymatic control of pigmentation in mammals. FASEB J (1991) 2.47

Child abuse referral warning. Br Dent J (2006) 2.44

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science (1992) 2.24

The mammalian low-density lipoprotein receptor family. Annu Rev Nutr (1999) 2.21

A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus. EMBO J (1992) 2.19

Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cells. Infect Immun (2000) 2.11

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia. Nature (1993) 2.05

The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest (2001) 2.04

Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse. Arterioscler Thromb Vasc Biol (2000) 2.02

Child abuse referral warning. Br Dent J (2006) 2.01

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med (1998) 1.98

Sphincter-sparing treatment for distal rectal adenocarcinoma. Ann Surg Oncol (1999) 1.95

Characterization of new membrane lipoproteins and their precursors of Escherichia coli. J Biol Chem (1981) 1.94

Religious circumcision: a Muslim view. BJU Int (1999) 1.93

Tyrosinases from two different loci are expressed by normal and by transformed melanocytes. J Biol Chem (1991) 1.90

Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene (2010) 1.87

Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology (1999) 1.80

Bacillus cereus 569/H beta-lactamase I: cloning in Escherichia coli and signal sequence determination. FEBS Lett (1983) 1.75

Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet (1999) 1.75

Discitis in young children. J Bone Joint Surg Br (2001) 1.72

Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. Hepatology (2000) 1.69

The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest (1997) 1.67

Control of axillary bud initiation and shoot architecture in Arabidopsis through the SUPERSHOOT gene. Genes Dev (2001) 1.66

Mechanism of signal peptide cleavage in the biosynthesis of the major lipoprotein of the Escherichia coli outer membrane. J Biol Chem (1982) 1.59

MDR and PRP: a comparison of methods for high-order genotype-phenotype associations. Hum Hered (2004) 1.59

Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer. Ann Thorac Surg (2000) 1.58

Characterization of eight beta-lactamases of Gram-negative bacteria. J Bacteriol (1982) 1.57

Phase II evaluation of oral estramustine and oral etoposide in hormone-refractory adenocarcinoma of the prostate. J Clin Oncol (1994) 1.56

Evolution of hepatitis B virus polymerase gene mutations in hepatitis B e antigen-negative patients receiving lamivudine therapy. Hepatology (2000) 1.55

Treatment of plasma cell cheilitis with griseofulvin. J Am Acad Dermatol (1994) 1.52

Habitat segregation and biochemical activities of marine members of the family vibrionaceae. Appl Environ Microbiol (1985) 1.51

Induction of T-helper cell response to hepatitis B core antigen in chronic hepatitis B: a major factor in activation of the host immune response to the hepatitis B virus. Hepatology (1995) 1.50

Measurement of the depth of maximum of extensive air showers above 10{18} eV. Phys Rev Lett (2010) 1.48

Determination of the pKa and pH-solubility behavior of an ionizable cyclic carbamate, (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4- (trifluoromethyl)-2H-3,1-benzoxazin-2-one (DMP 266). Pharm Dev Technol (1996) 1.47

Carbenicillin-hydrolyzing penicillinases of Proteus mirabilis and the PSE-type penicillinases of Pseudomonas aeruginosa. Microbiol Immunol (1983) 1.47

Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation (2001) 1.46

Overexpression of secretory phospholipase A(2) causes rapid catabolism and altered tissue uptake of high density lipoprotein cholesteryl ester and apolipoprotein A-I. J Biol Chem (2000) 1.45

Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice. J Immunol (2000) 1.43

Serum immunoreactive trypsin in beta-thalassaemia major. J Clin Pathol (1981) 1.41

Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis. J Bacteriol (1991) 1.41

Taxanes: an overview of the pharmacokinetics and pharmacodynamics. Urology (1999) 1.39

Slime production and adherence by coagulase-negative staphylococci. J Hosp Infect (1991) 1.39

Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus. Atherosclerosis (2001) 1.39

Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells. Biochem Biophys Res Commun (2001) 1.39

Diagnosis and laparoscopic management of 12 consecutive cases of ovarian pregnancy and review of literature. J Minim Invasive Gynecol (2009) 1.39

Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples. Blood (1991) 1.37

A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family. J Med Genet (2004) 1.37

Excitation-contraction coupling in rat ventricular myocytes after formamide-induced detubulation. Am J Physiol (1999) 1.36

Pediatric urolithiasis: developing nation perspectives. J Urol (2002) 1.36

Encephalitis and retarded growth of chicks caused by Sitiawan virus, a new isolate belonging to the genus Flavivirus. Am J Trop Med Hyg (2001) 1.35

Cloning and sequencing of the blaZ gene encoding beta-lactamase III, a lipoprotein of Bacillus cereus 569/H. J Bacteriol (1987) 1.34

Genetic analysis of type E botulinum toxin-producing Clostridium butyricum strains. Appl Environ Microbiol (2000) 1.32

Mixed modelling to characterize genotype-phenotype associations. Stat Med (2005) 1.31

Molecular and phenotypic variability in the congenital alveolar proteinosis syndrome associated with inherited surfactant protein B deficiency. J Pediatr (1994) 1.30

Racial disparity in incidence patterns and outcome of kidney cancer. Urology (2003) 1.30

The inherent cytotoxicity of melanin precursors: a revision. Biochim Biophys Acta (1994) 1.29

Removal of the financial barrier to health care: does it impact on prostate cancer at presentation and survival? A comparative study between black and white men in a Veterans Affairs system. Urology (1995) 1.28

Cotton leaf curl disease is associated with multiple monopartite begomoviruses supported by single DNA beta. Arch Virol (2003) 1.28

Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium. Biol Reprod (1997) 1.27

Chylomicron assembly and catabolism: role of apolipoproteins and receptors. Biochim Biophys Acta (1996) 1.23

Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem (2001) 1.23

Management of pediatric urolithiasis in Pakistan: experience with 1,440 children. J Urol (2003) 1.19

Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function. Biochem Biophys Res Commun (1999) 1.19

Excitatory amino acids in the rostral ventrolateral medulla support blood pressure in spontaneously hypertensive rats. Hypertension (2000) 1.19

Clinical outcome and virological characteristics of hepatitis B-related acute liver failure in the United States. J Viral Hepat (2005) 1.19

Identification of a genetic determinant of pathogenicity in chicken anaemia virus. J Gen Virol (2001) 1.19

A mitogenomic perspective on the basal teleostean phylogeny: resolving higher-level relationships with longer DNA sequences. Mol Phylogenet Evol (2001) 1.17

Effects of growth state and amines on cytoplasmic and vacuolar pH, phosphate and polyphosphate levels in Saccharomyces cerevisiae: a 31P-nuclear magnetic resonance study. Biochim Biophys Acta (1987) 1.17

Influence of water temperature and feeding regime on otolith growth in Anguilla japonica glass eels and elvers: does otolith growth cease at low temperatures? J Fish Biol (2009) 1.17

Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: prognostic significance and comparative analysis in primary and metastatic tumors. Clin Cancer Res (2001) 1.17

The tyrosinase gene family--interactions of melanogenic proteins to regulate melanogenesis. Cell Mol Biol Res (1994) 1.17

Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (1999) 1.16

The delivery of antisense therapeutics. Adv Drug Deliv Rev (2000) 1.15

Prostate cancer: molecular biology of early progression to androgen independence. Endocr Relat Cancer (1999) 1.15

Sustained response after a 2-year course of lamivudine treatment of hepatitis B e antigen-negative chronic hepatitis B. J Viral Hepat (2004) 1.15

Pathology of fatal highly pathogenic H5N1 avian influenza virus infection in large-billed crows (Corvus macrorhynchos) during the 2004 outbreak in Japan. Vet Pathol (2006) 1.14

Cefoxitin, N-formimidoyl thienamycin, clavulanic acid, and penicillanic acid sulfone as suicide inhibitors for different types of beta-lactamases produced by gram-negative bacteria. J Antibiot (Tokyo) (1982) 1.13

Clinical utility of serum HER-2/neu testing on the Bayer Immuno 1 automated system in breast cancer. Anticancer Res (2001) 1.13

Endogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomach. Neurogastroenterol Motil (2007) 1.12

Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis. J Clin Invest (2001) 1.11

Imported parakeets harbor H9N2 influenza A viruses that are genetically closely related to those transmitted to humans in Hong Kong. J Virol (2001) 1.11

Mobilisation into cotton and spread of a recombinant cotton leaf curl disease satellite. Arch Virol (2006) 1.11

Inflammatory markers of coronary risk. N Engl J Med (2000) 1.10