Published in EMBO J on February 01, 1992
gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand. J Exp Med (1998) 5.24
The transcription factor Sox10 is a key regulator of peripheral glial development. Genes Dev (2001) 4.40
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes. Proc Natl Acad Sci U S A (1999) 3.66
Identification of tyrosinase-related protein 2 as a tumor rejection antigen for the B16 melanoma. J Exp Med (1997) 3.07
Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes. J Exp Med (1995) 2.54
A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase. EMBO J (1992) 2.51
Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes. J Exp Med (1996) 2.31
The immunoregulatory mediator macrophage migration inhibitory factor (MIF) catalyzes a tautomerization reaction. Mol Med (1996) 2.21
Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes. J Cell Biol (1998) 2.20
Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol (1994) 2.13
Intracellular sorting and targeting of melanosomal membrane proteins: identification of signals for sorting of the human brown locus protein, gp75. J Cell Biol (1995) 1.76
Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. EMBO J (1994) 1.71
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia. Mol Cell Biol (1998) 1.62
Mutation in and lack of expression of tyrosinase-related protein-1 (TRP-1) in melanocytes from an individual with brown oculocutaneous albinism: a new subtype of albinism classified as "OCA3". Am J Hum Genet (1996) 1.59
Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: implication of the microphthalmia gene product. J Cell Biol (1996) 1.57
Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. Proc Natl Acad Sci U S A (2000) 1.41
The ocular albinism type 1 gene product is a membrane glycoprotein localized to melanosomes. Proc Natl Acad Sci U S A (1996) 1.28
Mouse silver mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Res (1995) 1.21
Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes. Proc Natl Acad Sci U S A (1994) 1.20
Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas. Am J Pathol (1997) 1.11
Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice. Mol Cell Biol (2004) 1.09
Unraveling the melanocyte. Am J Hum Genet (1993) 1.07
Fine structure mapping and deletion analysis of the murine piebald locus. Genetics (1994) 1.01
Melanization in living organisms: a perspective of species evolution. Protein Cell (2010) 0.96
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase. Biochem J (2001) 0.96
Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression. Proc Natl Acad Sci U S A (1995) 0.89
Probing into the role of conserved N-glycosylation sites in the Tyrosinase glycoprotein family. Glycoconj J (2008) 0.88
Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein. Biochem J (2005) 0.87
Oculocutaneous albinism. Arch Dis Child (1999) 0.86
Tumour immunogenicity, antigen presentation and immunological barriers in cancer immunotherapy. New J Sci (2014) 0.85
Mammalian tyrosinase-related protein-1 is recognized by autoantibodies from vitiliginous Smyth chickens. An avian model for human vitiligo. Am J Pathol (1995) 0.84
A new dopachrome-rearranging enzyme from the ejected ink of the cuttlefish Sepia officinalis. Biochem J (1994) 0.84
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase. Biochem J (1996) 0.83
Mouse chromosome 14. Mamm Genome (1992) 0.83
Molecular basis of dark-eyed albinism in the mouse. Proc Natl Acad Sci U S A (1994) 0.82
Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. Dev Dyn (2011) 0.81
Immunofluorescent identification of melanocytes in murine hair follicles. J Mol Histol (2006) 0.81
Broadening the repertoire of melanoma-associated T-cell epitopes. Cancer Immunol Immunother (2015) 0.79
Processing of tumor antigen differentially impacts the development of helper and effector CD4+ T-cell responses. Mol Ther (2010) 0.78
Comparison of the inhibitory effects of vitamin E analogues on melanogenesis in mouse B16 melanoma cells. Cytotechnology (2009) 0.78
Subcellular localization and function of melanogenic enzymes in the ink gland of Sepia officinalis. Biochem J (1997) 0.78
Critical Analysis of the Melanogenic Pathway in Insects and Higher Animals. Int J Mol Sci (2016) 0.77
Candidate Gene Analysis Suggests Untapped Genetic Complexity in Melanin-Based Pigmentation in Birds. J Hered (2016) 0.77
Ocular Albinism Type 1 Regulates Melanogenesis in Mouse Melanocytes. Int J Mol Sci (2016) 0.75
Structure of Human Tyrosinase Related Protein 1 Reveals a Binuclear Zinc Active Site Important for Melanogenesis. Angew Chem Int Ed Engl (2017) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77
A new method for predicting signal sequence cleavage sites. Nucleic Acids Res (1986) 37.19
An improved method for directly sequencing PCR amplified material using dimethyl sulphoxide. Nucleic Acids Res (1989) 10.50
PROSITE: a dictionary of sites and patterns in proteins. Nucleic Acids Res (1991) 9.18
X-ray-induced mutations in mice. Cold Spring Harb Symp Quant Biol (1951) 9.00
Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol (1982) 6.56
Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet (1991) 4.17
Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature (1991) 3.95
Cloning and expression of cDNA encoding mouse tyrosinase. Nucleic Acids Res (1986) 3.21
A cDNA encoding tyrosinase-related protein maps to the brown locus in mouse. Proc Natl Acad Sci U S A (1988) 2.72
Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO J (1988) 2.60
A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase. EMBO J (1992) 2.51
Conserved cysteine to serine mutation in tyrosinase is responsible for the classical albino mutation in laboratory mice. Nucleic Acids Res (1990) 2.13
Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin. Science (1982) 2.10
The many faces of epidermal growth factor repeats. New Biol (1990) 1.94
Detection of mutations in the tyrosinase gene in a patient with type IA oculocutaneous albinism. N Engl J Med (1990) 1.88
The molecular basis of brown, an old mouse mutation, and of an induced revertant to wild type. Genetics (1990) 1.66
Dopachrome oxidoreductase: a new enzyme in the pigment pathway. J Invest Dermatol (1984) 1.65
Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA. Jpn J Genet (1989) 1.61
Dopachrome conversion: a possible control point in melanin biosynthesis. J Invest Dermatol (1980) 1.57
Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Development (1990) 1.55
The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev (1990) 1.53
New regulators of melanin biosynthesis and the autodestruction of melanoma cells. Nature (1980) 1.38
A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine----serine substitution at position 85. Eur J Biochem (1990) 1.37
5,6-Dihydroxyindole is a melanin precursor showing potent cytotoxicity. Nature (1978) 1.31
The Drosophila gene Serrate encodes an EGF-like transmembrane protein with a complex expression pattern in embryos and wing discs. Development (1991) 1.26
Identification of the albino mutation of mouse tyrosinase by analysis of an in vitro revertant. Proc Natl Acad Sci U S A (1990) 1.26
Dopachrome conversion factor functions as an isomerase. Biochem Biophys Res Commun (1990) 1.22
Regulation of mammalian melanogenesis. I: Partial purification and characterization of a dopachrome converting factor: dopachrome tautomerase. Biochim Biophys Acta (1990) 1.22
Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene. J Invest Dermatol (1989) 1.20
The tyrosinase-related protein-1 gene has a structure and promoter sequence very different from tyrosinase. Nucleic Acids Res (1991) 1.17
A frequent tyrosinase gene mutation in classic, tyrosinase-negative (type IA) oculocutaneous albinism. Proc Natl Acad Sci U S A (1990) 1.14
Phenotypic rescue of mutant brown melanocytes by a retrovirus carrying a wild-type tyrosinase-related protein gene. Development (1990) 1.09
Reexamination of the structure of eumelanin. Biochim Biophys Acta (1986) 1.06
Molecular analysis of an extended family with type IA (tyrosinase-negative) oculocutaneous albinism. J Invest Dermatol (1991) 1.06
Molecular basis of tyrosinase-negative oculocutaneous albinism. A single base mutation in the tyrosinase gene causing arginine to glutamine substitution at position 59. J Biol Chem (1990) 1.05
Characterization of TRP-1 mRNA levels in dominant and recessive mutations at the mouse brown (b) locus. Genetics (1990) 1.04
Detection of point mutation in the tyrosinase gene of a Japanese albino patient by a direct sequencing of amplified DNA. Hum Genet (1990) 1.04
An interspecific backcross linkage map of the proximal half of mouse chromosome 14. Genomics (1990) 1.02
New regulatory factors for melanogenesis: developmental changes in neonatal mice of various genotypes. Dev Biol (1983) 0.99
Homozygous tyrosinase gene mutation in an American black with tyrosinase-negative (type IA) oculocutaneous albinism. Am J Hum Genet (1991) 0.97
Tyrosinase gene mutations associated with type IB ("yellow") oculocutaneous albinism. Am J Hum Genet (1991) 0.96
Three different frameshift mutations of the tyrosinase gene in type IA oculocutaneous albinism. Am J Hum Genet (1991) 0.95
Functional analysis of the cDNA encoding human tyrosinase precursor. Biochem Biophys Res Commun (1989) 0.92
Mouse coat colour mutations: a molecular genetic resource which spans the centuries. Bioessays (1991) 0.90
An efficient recombination system for chromosome engineering in Escherichia coli. Proc Natl Acad Sci U S A (2000) 17.30
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics (2001) 15.03
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature (1992) 12.92
Recombineering: a powerful new tool for mouse functional genomics. Nat Rev Genet (2001) 8.35
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell (1994) 7.23
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell (1990) 6.94
Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J Virol (1982) 6.56
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron (1997) 6.16
TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell (2000) 6.07
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron (1995) 6.03
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. Science (1993) 5.50
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron (1995) 5.43
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron (1996) 5.30
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron (1996) 5.14
CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science (1993) 5.04
Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell (1993) 5.00
Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature (1981) 4.77
Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng (2001) 4.64
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron (1997) 4.49
Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol (1991) 4.42
Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron (1997) 4.33
A genetic linkage map of the mouse: current applications and future prospects. Science (1993) 4.24
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev (1994) 4.19
Development and applications of a molecular genetic linkage map of the mouse genome. Trends Genet (1991) 4.17
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet (1998) 4.06
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin. Hum Mol Genet (1999) 4.06
Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. Nature (1994) 3.99
Novel myosin heavy chain encoded by murine dilute coat colour locus. Nature (1991) 3.95
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. Development (1995) 3.90
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J (1995) 3.78
Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell (1988) 3.75
The promise of comparative genomics in mammals. Science (1999) 3.67
The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol (1992) 3.66
Excision of the DBA ecotropic provirus in dilute coat-color revertants of mice occurs by homologous recombination involving the viral LTRs. Cell (1983) 3.66
Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. J Exp Med (2000) 3.51
Comparative anchor tagged sequences (CATS) for integrative mapping of mammalian genomes. Nat Genet (1997) 3.47
microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev (1994) 3.44
A reappraisal of non-consensus mRNA splice sites. Nucleic Acids Res (1991) 3.44
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev (1994) 3.42
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev (1994) 3.40
The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells. Nat Genet (1995) 3.40
An improved colorimetric assay for interleukin 2. J Immunol Methods (1986) 3.39
Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature (1984) 3.37
The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform. J Cell Biol (1997) 3.34
Cooperative activation of Hoxa and Pbx1-related genes in murine myeloid leukaemias. Nat Genet (1996) 3.32
Direct interaction of microtubule- and actin-based transport motors. Nature (1999) 3.25
Leukaemia disease genes: large-scale cloning and pathway predictions. Nat Genet (1999) 3.19
Anchored reference loci for comparative genome mapping in mammals. Nat Genet (1993) 3.19
A vector for expressing foreign genes in the brains and hearts of transgenic mice. Genet Anal (1996) 3.18