Gene transfer and hepatic overexpression of the HDL receptor SR-BI reduces atherosclerosis in the cholesterol-fed LDL receptor-deficient mouse.

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Published in Arterioscler Thromb Vasc Biol on March 01, 2000

Authors

K F Kozarsky1, M H Donahee, J M Glick, M Krieger, D J Rader

Author Affiliations

1: Department of Molecular and Cellular Engineering, Institute for Human Gene Therapy, University of Pennsylvania Health System, Philadelphia, PA, USA. karen_f_kozarsky@sbphrd.com

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Disruptions in Golgi structure and membrane traffic in a conditional lethal mammalian cell mutant are corrected by epsilon-COP. J Cell Biol (1994) 1.97

Hip arthroscopy by the lateral approach. Arthroscopy (1987) 1.94

The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem Sci (1994) 1.93

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Isolation of Chinese hamster cell mutants defective in the receptor-mediated endocytosis of low density lipoprotein. J Mol Biol (1981) 1.77

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein. Proc Natl Acad Sci U S A (1991) 1.76

Replacement of endogenous cholesteryl esters of low density lipoprotein with exogenous cholesteryl linoleate. Reconstitution of a biologically active lipoprotein particle. J Biol Chem (1978) 1.71

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Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding. J Mol Biol (1974) 1.62

Use of a mutant cell line to study the kinetics and function of O-linked glycosylation of low density lipoprotein receptors. Proc Natl Acad Sci U S A (1988) 1.62

The prevention and treatment of ankle injuries. Am J Sports Med (1977) 1.61

MDR and PRP: a comparison of methods for high-order genotype-phenotype associations. Hum Hered (2004) 1.59

Randomized controlled trial of Ringer solution versus serum for partial exchange transfusion in neonatal polycythaemia. Eur J Pediatr (1995) 1.54

Structures and high and low affinity ligand binding properties of murine type I and type II macrophage scavenger receptors. J Lipid Res (1993) 1.53

Drosophila scavenger receptor CI is a pattern recognition receptor for bacteria. Immunity (2001) 1.52

Structure and cell surface maturation of the attachment glycoprotein of human respiratory syncytial virus in a cell line deficient in O glycosylation. J Virol (1989) 1.50

Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet-stabilized four-stranded helices. J Biol Chem (1993) 1.50

RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. Eur J Immunol (1993) 1.46

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Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogaster. Proc Natl Acad Sci U S A (1995) 1.45

The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain. J Biol Chem (1998) 1.43

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The collagenous domains of macrophage scavenger receptors and complement component C1q mediate their similar, but not identical, binding specificities for polyanionic ligands. J Biol Chem (1993) 1.39

The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism. Curr Opin Lipidol (2000) 1.39

Scavenger receptor class B, type I-mediated [3H]cholesterol efflux to high and low density lipoproteins is dependent on lipoprotein binding to the receptor. J Biol Chem (2000) 1.37

Plasma antigen levels of the lipoprotein-associated coagulation inhibitor in patient samples. Blood (1991) 1.37

Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)-deficient mice. J Clin Invest (2001) 1.37

Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein. J Acquir Immune Defic Syndr (1989) 1.37

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Cholesterol quantitation by GLC: artifactual formation of short-chain steryl esters. J Lipid Res (1995) 1.35

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Highly conductive molecular junctions based on direct binding of benzene to platinum electrodes. Phys Rev Lett (2008) 1.32

Mixed modelling to characterize genotype-phenotype associations. Stat Med (2005) 1.31

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Scavenger receptor BI--a cell surface receptor for high density lipoprotein. Curr Opin Lipidol (1997) 1.30

A single point mutation in epsilon-COP results in temperature-sensitive, lethal defects in membrane transport in a Chinese hamster ovary cell mutant. J Biol Chem (1996) 1.28

Complete airway obstruction during arthroscopic shoulder surgery. Anesth Analg (1993) 1.27

Letter: Adriamycin activating a recall phenomenon after radiation therapy. Ann Intern Med (1974) 1.23

Reconstituted low density lipoprotein: a vehicle for the delivery of hydrophobic fluorescent probes to cells. J Supramol Struct (1979) 1.23

Expression and regulation of human low-density lipoprotein receptors in Chinese hamster ovary cells. Nature (1984) 1.23

Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. J Biol Chem (2001) 1.23

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Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex. Proc Natl Acad Sci U S A (1999) 1.20

Isolation of three classes of conditional lethal Chinese hamster ovary cell mutants with temperature-dependent defects in low density lipoprotein receptor stability and intracellular membrane transport. J Biol Chem (1994) 1.19

Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis. Am Rev Respir Dis (1973) 1.17

LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function. J Cell Biol (1994) 1.17

Macrophages in Drosophila embryos and L2 cells exhibit scavenger receptor-mediated endocytosis. Proc Natl Acad Sci U S A (1992) 1.17

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Treatment of thyrotoxic storm with intravenous administration of propranolol. Ann Intern Med (1969) 1.14

Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1987) 1.14

pH dependence of tritium exchange with the C-2 protons of the histidines in bovine trypsin. Biochemistry (1976) 1.13

Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant. J Biol Chem (1987) 1.11

Inflammatory markers of coronary risk. N Engl J Med (2000) 1.10

Abnormal intracellular sorting of O-linked carbohydrate-deficient interleukin-2 receptors. Mol Cell Biol (1988) 1.10

Binding of high density lipoprotein (HDL) and discoidal reconstituted HDL to the HDL receptor scavenger receptor class B type I. Effect of lipid association and APOA-I mutations on receptor binding. J Biol Chem (2000) 1.10

Amphotericin B selection of mutant Chinese hamster cells with defects in the receptor-mediated endocytosis of low density lipoprotein and cholesterol biosynthesis. Proc Natl Acad Sci U S A (1983) 1.07

Formation of cholesterol monohydrate crystals in macrophage-derived foam cells. J Lipid Res (1994) 1.07