Published in J Biol Chem on November 26, 1999
The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci U S A (2000) 3.55
Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer (2009) 3.33
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. EMBO J (2002) 2.02
PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. Mol Cell Biol (2001) 1.85
CoAA, a nuclear receptor coactivator protein at the interface of transcriptional coactivation and RNA splicing. Mol Cell Biol (2004) 1.77
Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function. J Biol Chem (2005) 1.63
Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry (2007) 1.55
Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes. Proc Natl Acad Sci U S A (2004) 1.44
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A (2000) 1.43
A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol Cell Biol (2000) 1.41
Kinetic mechanism of protein arginine methyltransferase 1. Biochemistry (2008) 1.32
Novel transcription coactivator complex containing activating signal cointegrator 1. Mol Cell Biol (2002) 1.29
Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. J Biol Chem (2009) 1.28
Regulation of PPARgamma function by TNF-alpha. Biochem Biophys Res Commun (2008) 1.21
Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol (2002) 1.20
Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. Proc Natl Acad Sci U S A (2001) 1.19
The nuclear hormone receptor coactivator NRC is a pleiotropic modulator affecting growth, development, apoptosis, reproduction, and wound repair. Mol Cell Biol (2004) 1.16
Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis. Am J Physiol Gastrointest Liver Physiol (2011) 1.12
Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol (2003) 1.12
ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity. Mol Endocrinol (2009) 1.09
Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice. Mol Cell Biol (2003) 1.09
Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol (2004) 1.08
CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein v-Rel. J Virol (2008) 1.08
Cross-kingdom inhibition of breast cancer growth by plant miR159. Cell Res (2016) 1.07
Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol (2002) 1.07
Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation. Mol Endocrinol (2009) 1.06
Nuclear receptor coactivators: structural and functional biochemistry. Biochemistry (2010) 1.06
Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice. Mol Cell Biol (2007) 1.05
Coactivators in PPAR-Regulated Gene Expression. PPAR Res (2010) 1.04
NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. Mol Cell Biol (2002) 1.03
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1. Nucl Recept Signal (2010) 0.98
Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. Cancer Res (2008) 0.96
Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development. Nucl Recept Signal (2008) 0.95
Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation. Dev Cell (2012) 0.91
Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensing. Am J Pathol (2004) 0.91
Cdc25B functions as a novel coactivator for the steroid receptors. Mol Cell Biol (2001) 0.90
Yorkie promotes transcription by recruiting a histone methyltransferase complex. Cell Rep (2014) 0.90
The roles of sex steroid receptor coregulators in cancer. Mol Cancer (2002) 0.90
Histone methylases MLL1 and MLL3 coordinate with estrogen receptors in estrogen-mediated HOXB9 expression. Biochemistry (2011) 0.90
Requirement for MLL3 in p53 regulation of hepatic expression of small heterodimer partner and bile acid homeostasis. Mol Endocrinol (2011) 0.89
PPARG: Gene Expression Regulation and Next-Generation Sequencing for Unsolved Issues. PPAR Res (2010) 0.88
Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2. Mol Cell Biol (2006) 0.88
Characterization of ASC-2 as an antiatherogenic transcriptional coactivator of liver X receptors in macrophages. Mol Endocrinol (2009) 0.85
NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor. J Biol Chem (2010) 0.84
The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6. Elife (2014) 0.84
Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms. Int J Biol Sci (2011) 0.81
Absent, small or homeotic 2-like protein (ASH2L) enhances the transcription of the estrogen receptor α gene through GATA-binding protein 3 (GATA3). J Biol Chem (2014) 0.81
Structure-based virtual screening and identification of a novel androgen receptor antagonist. J Biol Chem (2012) 0.80
Use of suppressor mutants to probe the function of estrogen receptor-p160 coactivator interactions. Mol Cell Biol (2001) 0.80
9-Cis-retinoic acid induces growth inhibition in retinoid-sensitive breast cancer and sea urchin embryonic cells via retinoid X receptor α and replication factor C3. Mol Endocrinol (2012) 0.80
PRIP promotes tumor formation through enhancing serum-responsive factor-mediated FOS expression. J Biol Chem (2009) 0.79
PRIC295, a Nuclear Receptor Coactivator, Identified from PPARα-Interacting Cofactor Complex. PPAR Res (2010) 0.78
Identification of a breast cancer susceptibility locus at 4q31.22 using a genome-wide association study paradigm. PLoS One (2013) 0.78
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. J Med Chem (2012) 0.78
Role of UTX in retinoic acid receptor-mediated gene regulation in leukemia. Mol Cell Biol (2014) 0.77
The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases. Microbiol Mol Biol Rev (2016) 0.76
Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases. J Exp Neurosci (2016) 0.76
Small-molecule hormones: molecular mechanisms of action. Int J Endocrinol (2013) 0.75
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AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science (1997) 8.05
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