Published in Lancet on November 13, 1999
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol (2005) 2.44
The safety and side effects of monoclonal antibodies. Nat Rev Drug Discov (2010) 2.23
IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest (2009) 1.87
Thyroid dysfunction from antineoplastic agents. J Natl Cancer Inst (2011) 1.86
The etiology of autoimmune thyroid disease: a story of genes and environment. J Autoimmun (2009) 1.81
Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model. Immunology (2009) 1.75
Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders. Springer Semin Immunopathol (2003) 1.40
B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis. J Clin Immunol (2009) 1.26
Therapeutic decisions in multiple sclerosis: moving beyond efficacy. JAMA Neurol (2013) 1.16
Immunopathogenesis of thyroid eye disease: emerging paradigms. Surv Ophthalmol (2010) 1.11
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol (2013) 1.11
Therapeutic implications of variable expression of CD52 on clonal cytotoxic T cells in CD8+ large granular lymphocyte leukemia. Haematologica (2009) 1.10
CAMPATH: from concept to clinic. Philos Trans R Soc Lond B Biol Sci (2005) 1.06
Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies. MAbs (2010) 1.06
Campath 1-H treatment in patients with aggressive relapsing remitting multiple sclerosis. J Neurol (2008) 1.05
Breaking tolerance to thyroid antigens: changing concepts in thyroid autoimmunity. Endocr Rev (2013) 1.05
Insights into the Mechanisms of the Therapeutic Efficacy of Alemtuzumab in Multiple Sclerosis. J Clin Cell Immunol (2013) 1.04
Challenges to achieving clinical transplantation tolerance. J Clin Invest (2001) 1.03
A transcription factor map as revealed by a genome-wide gene expression analysis of whole-blood mRNA transcriptome in multiple sclerosis. PLoS One (2010) 1.00
Dendritic cells infected with adenovirus expressing the thyrotrophin receptor induce Graves' hyperthyroidism in BALB/c mice. Clin Exp Immunol (2003) 0.99
Alemtuzumab in the treatment of multiple sclerosis: key clinical trial results and considerations for use. Ther Adv Neurol Disord (2015) 0.97
Acute effects of alemtuzumab infusion in patients with active relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm (2016) 0.93
Co-occurrence of autoimmune thyroid disease in a multiple sclerosis cohort. J Autoimmune Dis (2005) 0.91
Multiple sclerosis treatment and infectious issues: update 2013. Clin Exp Immunol (2014) 0.90
Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease. Clin Exp Immunol (2002) 0.88
Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis. J Neurol Neurosurg Psychiatry (2006) 0.88
Role of regulatory T cells in pathogenesis and biological therapy of multiple sclerosis. Mediators Inflamm (2013) 0.86
Opportunistic autoimmune disorders: from immunotherapy to immune dysregulation. Ann N Y Acad Sci (2010) 0.86
T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy (2010) 0.86
Monoclonal antibody therapy in multiple sclerosis: Paradigm shifts and emerging challenges. MAbs (2010) 0.86
Alemtuzumab in the treatment of IVIG-dependent chronic inflammatory demyelinating polyneuropathy. J Neurol (2010) 0.85
Alemtuzumab for Multiple Sclerosis. Curr Neurol Neurosci Rep (2016) 0.84
Alemtuzumab for the treatment of multiple sclerosis. Ther Clin Risk Manag (2015) 0.84
New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression. Ann N Y Acad Sci (2010) 0.84
Biologic therapies in non-rheumatic diseases: lessons for rheumatologists? Nat Rev Rheumatol (2011) 0.84
Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity. J Immunol (2011) 0.83
Toxicities of immunosuppressive treatment of autoimmune neurologic diseases. Curr Neuropharmacol (2011) 0.82
Multiple sclerosis and autoimmune diseases: epidemiology and HLA-DR association in North-east Italy. J Neurol (2006) 0.81
Innovative monoclonal antibody therapies in multiple sclerosis. Ther Adv Neurol Disord (2008) 0.80
Coordinating GWAS results with gene expression in a systems immunologic paradigm in autoimmunity. Curr Opin Immunol (2012) 0.80
Recent clinical trials and future therapies. J Neurol (2008) 0.79
Monoclonal antibodies in the therapy of multiple sclerosis: an overview. J Neurol (2008) 0.79
Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic Islet cell recipients with pretransplant TPO autoantibodies. Diabetes Care (2009) 0.78
New and Emerging Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: What is New and What is to Come. J Cent Nerv Syst Dis (2012) 0.77
Alemtuzumab in multiple sclerosis: latest evidence and clinical prospects. Ther Adv Chronic Dis (2013) 0.77
Diagnosis and disease modifying treatments in multiple sclerosis. Postgrad Med J (2005) 0.77
Monoclonal antibody therapies for the treatment of relapsing-remitting multiple sclerosis: differentiating mechanisms and clinical outcomes. Ther Adv Neurol Disord (2015) 0.76
Autoimmune haemolytic anaemia emerging during Campath treatment in a patient with CD5 negative chronic lymphocytic leukaemia. Indian J Hematol Blood Transfus (2013) 0.75
Immunology. J Clin Pathol (2005) 0.75
Hepatitis C virus infection and thyroid autoimmune disorders: A model of interactions between the host and the environment. World J Hepatol (2016) 0.75
Guillain Barré syndrome precipitated by the use of antilymphocyte globulin in the treatment of severe aplastic anaemia. J Clin Pathol (2005) 0.75
Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Res (2017) 0.75
Remission of a CNS inflammatory disease accompanied by newly developed ANA and arthropathy during treatment with IFN-beta. J Neurol (2002) 0.75
Autoimmune Thyroid Diseases in Patients Treated with Alemtuzumab for Multiple Sclerosis: An Example of Selective Anti-TSH-Receptor Immune Response. Front Endocrinol (Lausanne) (2017) 0.75
Both cladribine and alemtuzumab may effect MS via B-cell depletion. Neurol Neuroimmunol Neuroinflamm (2017) 0.75
A global optimisation method for robust affine registration of brain images. Med Image Anal (2001) 27.87
Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging (2001) 25.22
Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57
Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol (2001) 24.36
Effect of general practitioners' advice against smoking. Br Med J (1979) 24.07
Entropic elasticity of lambda-phage DNA. Science (1994) 15.40
A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science (1995) 15.20
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet (2011) 10.62
Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature (1985) 9.62
Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ (1995) 9.26
Large-scale temporal gene expression mapping of central nervous system development. Proc Natl Acad Sci U S A (1998) 9.06
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet (2011) 8.24
DIMENSIONAL, OSMOTIC, AND CHEMICAL CHANGES OF ERYTHROCYTES IN STORED BLOOD. I. BLOOD PRESERVED IN SODIUM CITRATE, NEUTRAL, AND ACID CITRATE-GLUCOSE (ACD) MIXTURES. J Clin Invest (1947) 8.02
Influence of psychological response on survival in breast cancer: a population-based cohort study. Lancet (1999) 7.02
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature (2000) 5.86
OSMOMETRIC BEHAVIOR OF NORMAL HUMAN ERYTHROCYTES. J Clin Invest (1942) 5.63
Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation (1999) 5.62
"Infectious" transplantation tolerance. Science (1993) 4.98
Reshaping human antibodies for therapy. Nature (1988) 4.82
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
The factor structure and factor stability of the hospital anxiety and depression scale in patients with cancer. Br J Psychiatry (1991) 4.43
CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J Exp Med (1989) 4.19
Alcoholism: a controlled trial of "treatment" and "advice". J Stud Alcohol (1977) 4.14
Preventing opiate overdose fatalities with take-home naloxone: pre-launch study of possible impact and acceptability. Addiction (1999) 4.04
Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. Infect Immun (1987) 3.87
Systematic implementation of an advance directive program in nursing homes: a randomized controlled trial. JAMA (2000) 3.87
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med (1987) 3.82
A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities. Clin Genet (1975) 3.81
A number of different nuclear genes for the small subunit of RuBPCase are transcribed in petunia. Nucleic Acids Res (1983) 3.56
Death and survival in a cohort of heroin addicts from London clinics: a 22-year follow-up study. Addiction (1994) 3.47
Surveying general practitioners: does a low response rate matter? Br J Gen Pract (1997) 3.46
Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome. Nature (1991) 3.43
5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology (1987) 3.35
Findings of a national survey of the role of general practitioners in the treatment of opiate misuse: extent of contact with opiate misusers. Br Med J (Clin Res Ed) (1986) 3.33
Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site. J Biol Chem (1997) 3.19
Different roles for L3T4+ and Lyt 2+ T cell subsets in the control of an acute herpes simplex virus infection of the skin and nervous system. J Gen Virol (1987) 3.16
Comparison of questionnaire and laboratory tests in the detection of excessive drinking and alcoholism. Lancet (1982) 3.11
Functional analysis of T lymphocyte subsets in antiviral host defense. J Immunol (1987) 3.11
The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med (1996) 3.10
The next ten years of health spending: what does the future hold? The Health Expenditures Projection Team. Health Aff (Millwood) (1998) 3.04
Stigmatization of AIDS patients by physicians. Am J Public Health (1987) 3.03
Cervical HPV infection and neoplasia in a large population-based prospective study: the Manchester cohort. Br J Cancer (2004) 3.03
Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol (1993) 3.01
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet (1996) 3.00
p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res (1993) 2.99
Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr (2010) 2.91
Respiratory epithelial cell invasion by group B streptococci. Infect Immun (1992) 2.86
A randomised controlled trial of stress reduction for hypertension in older African Americans. Hypertension (1995) 2.85
TOPS: an internet-based system to prevent healthy subjects from over-volunteering for clinical trials. Eur J Clin Pharmacol (2012) 2.80
WWOX: a candidate tumor suppressor gene involved in multiple tumor types. Proc Natl Acad Sci U S A (2001) 2.79
Assessment of the efficacy and effectiveness of influenza vaccines in healthy children: systematic review. Lancet (2005) 2.78
Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers. Immunology (1990) 2.77
Health spending growth up in 1999; faster growth expected in the future. Health Aff (Millwood) (2001) 2.77
An intrinsic bond-centered electronic glass with unidirectional domains in underdoped cuprates. Science (2007) 2.76
Two-step glutamate dehydrogenase antigen real-time polymerase chain reaction assay for detection of toxigenic Clostridium difficile. J Hosp Infect (2009) 2.76
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet (2001) 2.76
Estimating numbers of homeless and homeless mentally ill people in north east Westminster by using capture-recapture analysis. BMJ (1994) 2.75
Self-reported overdose among injecting drug users in London: extent and nature of the problem. Addiction (1999) 2.72
Effect of psychiatric intervention in attempted suicide: a controlled study. Br Med J (1971) 2.70
Comparison of CT scan muscle measurements and isokinetic trunk strength in postoperative patients. Spine (Phila Pa 1976) (1989) 2.70
The effect of cash and other financial inducements on the response rate of general practitioners in a national postal study. Br J Gen Pract (1997) 2.70
The action of substances allied to 4:4'-diaminodiphenylsulphone in streptococcal and other infections in mice. Biochem J (1938) 2.69
Determining the common medical presenting problems to an accident and emergency department. Arch Dis Child (2001) 2.67
DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element. Nucleic Acids Res (1981) 2.67
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia (2010) 2.65
TRF1 is a dimer and bends telomeric DNA. EMBO J (1997) 2.64
Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61
Development of a questionnaire measure of adjustment to cancer: the MAC scale. Psychol Med (1988) 2.53
Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet (1988) 2.51
Development of an aspect of executive control: development of the abilities to remember what I said and to "do as I say, not as I do". Dev Psychobiol (1996) 2.47
Provision of treatment for multiple sclerosis. Lancet (1999) 2.44
Point prevalence of mental disorder in unconvicted male prisoners in England and Wales. BMJ (1996) 2.36
Deaths of drug addicts in the United Kingdom 1967-81. Br Med J (Clin Res Ed) (1985) 2.35
The care of HIV-infected adults in rural areas of the United States. J Acquir Immune Defic Syndr (2001) 2.34
Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review. J Med Screen (2007) 2.30
Recognition of HLA-B27 and related antigen by a monoclonal antibody. Hum Immunol (1982) 2.30
Effects of ramipril and vitamin E on atherosclerosis: the study to evaluate carotid ultrasound changes in patients treated with ramipril and vitamin E (SECURE). Circulation (2001) 2.30
Evaluation of the medical diagnostic imaging support system based on 2 years of clinical experience. J Digit Imaging (1995) 2.29
Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis. Ann Neurol (1999) 2.28
How Cooper pairs vanish approaching the Mott insulator in Bi2Sr2CaCu2O8+delta. Nature (2008) 2.27
Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients. Lancet (1998) 2.26
Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature (1986) 2.25
Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology (2005) 2.24
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution. Neurology (2007) 2.24
Seizures and status epilepticus in childhood cerebral malaria. QJM (1996) 2.22
Psychological response to breast cancer: effect on outcome. Lancet (1979) 2.20
Assessing operative skill. Needs to become more objective. BMJ (1999) 2.19
The development of a questionnaire to measure severity of alcohol dependence. Br J Addict Alcohol Other Drugs (1979) 2.16
Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis. Brain (1998) 2.16
Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc Natl Acad Sci U S A (1987) 2.12
Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J Clin Invest (1993) 2.10
Relationship between white matter fractional anisotropy and other indices of cerebral health in normal aging: tract-based spatial statistics study of aging. Neuroimage (2006) 2.09